LEUKOTRIENE RECEPTOR ANTAGONISTS IN DIFFERENT PHENOTYPES OF BRONCHIAL ASTHMA

Objective: to study the effectiveness of leukotriene receptor antagonists in the treatment foratopic pathology in children.Material and methods. 224 children with allergic diseases were prescribed to take montelucast for 3– 6 months.Results. Taking montelucast has lead to positive clinical dynamics in 75 % of the cases.A significant reduction of the eosinophil count was achieved on days 10–15 of the therapy. The Cys-LTC4/D4/E4 indices came to normal after a one-month course of montelucast therapy in 40.3 % of cases in children with bronchial asthma, in 63.3 % of cases in children with allergic rhinitis and in 60.5 % of cases in children with atopic dermatitis.Conclusions. The use of montelucast has significantly enhanced the control incidencerate ofallergic diseases in children.

Clinical Evaluation of Leukotriene Receptor Antagonists in Preventing Common Cold-like Symptoms in Bronchial Asthma Patients

Allergology International ◽

10.2332/allergolint.o-06-473 ◽

2007 ◽

Vol 56 (3) ◽

pp. 263-267 ◽

Cited By ~ 5

Author(s):

Takahiko Horiguchi ◽

Daisuke Ohira ◽

Kashin Kobayashi ◽

Masahiro Hirose ◽

Junichi Miyazaki ◽

...

Keyword(s):

Bronchial Asthma ◽

Clinical Evaluation ◽

Common Cold ◽

Receptor Antagonists ◽

Asthma Patients ◽

Addition of Leukotriene Receptor Antagonists to Inhaled Corticosteroids Improved QOL of Patients with Bronchial Asthma Surveyed in Suburban Tokyo, Japan

Allergology International ◽

10.2332/allergolint.10-oa-0296 ◽

2011 ◽

Vol 60 (4) ◽

pp. 473-481 ◽

Cited By ~ 1

Author(s):

Nobuharu Ohshima ◽

Hirotoshi Matsui ◽

Yoshinori Matsui ◽

Masahiro Kawashima ◽

Masahiro Shimada ◽

...

Keyword(s):

Bronchial Asthma ◽

Inhaled Corticosteroids ◽

Receptor Antagonists ◽

195 The Impact of Administration of Leukotriene Receptor Antagonists, Pranlukast-EK to Infants with Bronchial Asthma

World Allergy Organization Journal ◽

10.1097/01.wox.0000411952.04837.57 ◽

2012 ◽

Vol 5 ◽

pp. S64-S65

Author(s):

Norifumi Ogawa ◽

Kentaro Mikami ◽

Masahiko Sato ◽

Kenniti Mezawa ◽

Satoshi Iwata ◽

...

Keyword(s):

Bronchial Asthma ◽

Receptor Antagonists ◽

Leukotriene Receptor ◽

The Impact

TARGET THERAPY OF BRONCHIAL ASTHMA WITH LEUKOTRIENE RECEPTOR AGONISTS

Rossiiskii Allergologicheskii ZHurnal ◽

10.36691/rja625 ◽

2013 ◽

Vol 10 (5) ◽

pp. 46-54

Author(s):

N M Nenasheva

Keyword(s):

Bronchial Asthma ◽

Target Therapy ◽

Receptor Antagonists ◽

Cysteinyl Leukotrienes ◽

Asthma Phenotypes ◽

Receptor Agonists ◽

This article describes the features of asthma phenotypes such as asthma in smokers and asthma and obesity. The role of cysteinyl leukotrienes is discussed in the formation of inflammation in these phenotypes of asthma. The leukotriene receptor antagonists, including montelukast are effective in therapy of this category of patients.