scholarly journals Correlation of microelements like plasma copper and zinc concentrations with female infertility

2017 ◽  
Vol 6 (6) ◽  
pp. 2351
Author(s):  
Ritu Bawa ◽  
Smita Tyagi
Keyword(s):  
Systemic Disease ◽  
Venous Blood ◽  
Unexplained Infertility ◽  
Female Infertility ◽  
Reproductive Age ◽  
Control Group ◽  
Copper And Zinc ◽  
Plasma Copper ◽  
Zinc Concentrations ◽  
The Difference

Background: The aim of present study was to determine the role of trace elements copper and zinc and impairment of infertility.Methods: The study was a randomized, comparative, clinical trial where study group included 74 patients with primary or secondary infertility and control group included 20 patients who were fertile females of reproductive age group having no gynaecological or systemic disease. Venous blood samples were taken and plasma copper and zinc concentrations were measured.Results: In the normal fertile non-pregnant healthy female’s plasma copper ranged from 98.78 - 169.2 mcg% (mean 124.72 mcg%). In patients of unexplained infertility plasma copper was found to be low. It ranged from 63.0 - 145.14 mcg% (mean 95.5 mcg%) difference being statistically significant, (P<0.001). The difference in plasma zinc concentration in both group was not statically significant (P>0.05).Conclusions: Our results show that copper deficiency might have a role to play in the etiogenesis of otherwise unexplained infertility. We can also conclude that zinc deficiency may not play a significant role in female infertility.

scholarly journals Association between HLA-A gene polymorphism and early-onset preeclampsia in Chinese pregnant women early-onset

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yuanyuan Zheng ◽  
Cui Ma ◽  
Xiaowei Liu ◽  
Shaowen Wu ◽  
Weiyuan Zhang ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Early Onset ◽  
Venous Blood ◽  
Susceptibility Gene ◽  
Control Group ◽  
Sequencing Platform ◽  
Significant Difference ◽  
The Difference ◽  
Early Onset Preeclampsia ◽  
Idiopathic Disease

Abstract Background Preeclampsia is an idiopathic disease during pregnancy. This study explores the correlation between HLA-A polymorphism and the onset of preeclampsia. Methods The Illumina HiSeq2500 sequencing platform was used to genotyping HLA-A allele in venous blood DNA of 50 preeclampsia pregnant women and 48 normal pregnant women and umbilical cord blood DNA of their children of Han nationality in China. The frequencies and distributions of alleles and genotypes among the mothers and their children were compared between the two groups. The differences of frequencies and distributions of genotypes were compared between the two groups according to the mothers’ genotype compatibility. Results Twenty HLA-A alleles were detected in preeclampsia pregnant women and normal pregnant women; 21 HLA-A alleles were found in preeclampsia group fetuses and 22 HLA-A alleles in control group fetuses. There was no statistical difference in the HLA-A genes’ frequency between the two groups of pregnant women and their fetuses. When the sharing antigen was 1, the number of maternal-fetal pairs in the preeclampsia group was more than that in the control group; the difference was statistically significant (P < 0.05). The frequency of neither mother nor fetus carrying the HLA-A * 24: 02 gene in the preeclampsia group was significantly lower than that in the control group (P < 0.05). HLA-A gene homozygosity in fetuses of early-onset preeclampsia group was substantially higher than that of the control group (P = 0.0148); there is no significant difference in pregnant women’s genes homozygosity between early-onset preeclampsia group and the control group. Conclusions HLA-A * 24: 02 may be a susceptibility gene for early preeclampsia.

scholarly journals The Difference of ACE and ACE2 Gene Expression in Patients With Acute Aortic Dissection and Coronary Heart Disease

2021 ◽  
Author(s):  
Yang Li ◽  
Long Mao ◽  
Zongwei Xiao ◽  
Sandeep Bhushan
Keyword(s):  
Gene Expression ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Arterial Wall ◽  
Acute Aortic Dissection ◽  
Venous Blood ◽  
Control Group ◽  
The Difference ◽  
Group 2 ◽  
Ace2 Gene

Abstract BackgroundTo explore whether there is a difference in the expression of ACE and ACE2 genes in patients with acute AD and CHD. MethodsBlood samples from 68 patients, including 34 cases of acute AD (including Stanford type A and B), 21 cases of CHD, and 13 cases of control group. 2 ml of venous blood is submitted for plasma ACE concentration. The arterial wall tissue was taken during the operation for mRNA detection. ResultsThe ACE concentration in the AD group was (17.9 ± 7. 9) U / L, in the CHD group was (33.5 ± 8.1) U / L, and the ACE concentration in the control group was (38.4) ±4.8) U/L, statistically significant (P<0.05). The expression of ACE gene in the AD group was (0.2265 ± 0.3783); the expression in the CHD group was (7.085 7 ± 7.692 9), with significant (P < 0. 05). The expression of ACE2 gene in the AD group was (0.766 2 ± 0.858 6); in the CHD group was (9.612 7 ± 11.542 6), and the difference was significant (P < 0. 05). The expression of the ratio of ACE / ACE2 in the AD group was (0.413 8 ± 0.448); the expression in the CHD group was (0.811 1 ± 0.256 3), the difference was statistically significant (P <0. 001). ConclusionPlasma ACE concentration, ACE and ACE2 gene expression are significantly reduced in acute AD. The imbalance of ACE and ACE2 expression may be involved in the pathogenesis of AD.

Effects of (±)-sotalol, (±)-propranolol, and (−)-propranolol on norepinephrine release upon hepatic nerve stimulation in the dog liver in vivo

1985 ◽  
Vol 63 (11) ◽  
pp. 1423-1428
Author(s):  
Nobuharu Yamaguchi
Keyword(s):  
Nerve Stimulation ◽  
Venous Blood ◽  
Experimental Period ◽  
Inhibitory Effect ◽  
Control Group ◽  
Beta Blocking ◽  
Hepatic Venous Blood ◽  
The Difference ◽  
Dog Liver

The study was carried out to determine whether the diminished release of norepinephrine (NE) upon sympathetic activation in the presence of sotalol can be attributed to the blockade of beta-adrenoceptors in the liver. NE release from the liver was measured in hepatic venous blood collected during direct hepatic nerve stimulation in anesthetized dogs. The mean basal NE concentration in hepatic venous and aortic blood was 0.046 ± 0.003 and 0.244 ± 0.041 ng/mL, respectively. NE release increased significantly as stimulation frequency increased, while aortic NE concentration remained unchanged. The increasing response of NE release upon stimulation in the vehicle control group remained stable during the whole experimental period. In dogs treated with sotalol (5 mg/kg, i.v.), NE release was reduced approximately by 30–43%, and the difference was statistically significant (P < 0.01) at 8 Hz. (±)-Propranolol (2.5 mg/kg, i.v.) tended to diminish it, but the difference was not significant. (−)-Propranolol (0.1 mg/kg, i.v.) did not alter NE release at any frequency tested. The beta-blocking action of these drugs in the liver, as determined by the antagonism against the hepatic arterial vasodilating response to isoproterenol, was most effective with (±)-propranolol (100%), followed by (−)-propranolol (90%) and sotalol (70%). The results suggest that the inhibitory effect of sotalol on NE release may be related to a mechanism other than its beta-blocking action in the dog liver.

scholarly journals Serum Alpha-(1, 3)-Fucosyltransferase IV, Copper, and Zinc Levels in Patients with Colorectal Cancer and Healthy Controls

2020 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Roya Abbasi Natajomrani ◽  
Durdi Qujeq ◽  
Vahid Hosseini ◽  
Reza Hajihosseini
Keyword(s):  
Colorectal Cancer ◽  
Clinical Symptoms ◽  
Venous Blood ◽  
Serum Copper ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Healthy Controls ◽  
Copper And Zinc ◽  
The Mean ◽  
Zinc Levels

Background: Colorectal cancer (CRC) has no significant clinical symptoms at the early stages, and the molecular differences in the serum of the patients and healthy subjects could be assessed to identify the biological markers that indicate the detection of this cancer at the levels of the biological system. Objectives: The present study aimed to assess the concentrations of the alpha-(1, 3)-fucosyltransferase IV (FUT4) enzyme and copper (Cu) and zinc (Zn) as biological elements. Methods: This case-control study was conducted on 40 patients with CRC, including 20 men and 20 women. A metal-free sterile tube was used to collect five milliliters of venous blood. The enzyme-linked immunosorbent assay (ELISA) based on the Biotin double-antibody sandwich technology was used to measure the human FUT4 in the sera. In addition, plasma zinc and copper values were determined using Zist Chem Diagnostics kits. Results: The mean FUT4 levels in the CRC patients was slightly higher than the control group (P = 0.17), and the mean serum copper and zinc levels of these patients were lower than the control group with a significance difference in this regard (P < 0.001). In addition, the AUC of FUT4, copper, and zinc was 0.58, 0.80, and 0.77, respectively. Conclusions: According to the results, the altered levels of FUT4, copper, and zinc in the serum of the CRC patients compared to the healthy controls could be an indicator associated with the CRC disease course. Furthermore, the unusual changes in the FUT4, copper, and zinc levels may signify CRC development, which plays a key role in the diagnosis and monitoring of this cancer.

scholarly journals Pre-conception preparation at the antiphospholipid syndrome as way to improve reproductive health

2014 ◽  
Vol 2 ◽  
Author(s):  
Gulyash Tanysheva ◽  
Saule Kabylova ◽  
Sholpan Kinayatova ◽  
Aizat Zhumazhanova
Keyword(s):  
Reproductive Health ◽  
Antiphospholipid Syndrome ◽  
Placental Insufficiency ◽  
Reproductive Age ◽  
Control Group ◽  
Study Group ◽  
Pregnancy And Childbirth ◽  
Pregnancy And Delivery ◽  
The Difference ◽  
Term Labor

Introduction: Reproductive health is characterized by the condition of the woman in association with the course of pregnancy and childbirth. In this case, the absence of disease plays a fundamental role. Unfortunately, conditions that can negatively impact reproductive health and cause deterioration of pregnancy and delivery outcomes are frequent in women of reproductive age. Antiphospholipid syndrome (APS) is one of the leading conditions that can negatively affect reproductive health and lead to various complications in pregnancy including fetal loss.Materials and methods: We assessed the effectiveness of pre-conception preparing, including traditional therapy of APS in conjunction with system enzyme therapy (SET) and plasmapheresis sessions. We conducted a study in two groups: women with APS and pre-conception preparing (n = 49) and the control group were women without pre-conception preparing (n = 46).Results: The effect of pre-conception preparing in women with APS was assessed by the course and outcome of pregnancy. The total number of women with complications of pregnancy were 39.1% lower in the study group compared to the control group. Risk of miscarriage in the basic group observed 68.7 % less frequently compared to the  control group. The frequency of pre-eclampsia was 63.5 % less in the study group compared to the control group. We observed significantly lower rates of placental insufficiency in the study group and the difference in this parameter reached 65.2%. The risk of pre-term birth was 59.4 % lower in the study group compared to the control group.Conclusion: We concluded that pre-conception preparing in women with APS increases the possibility of physiological course pregnancy. Pre-conception preparing reduces the incidence of miscarriage, pre-term labor, and the development of pre-eclampsia, and placental insufficiency.

scholarly journals Biliary and plasma copper and zinc in pregnant Simmental and Angus cattle

2013 ◽  
Vol 80 (1) ◽  
Author(s):  
S. Ravi Gooneratne ◽  
Bernard Laarveld ◽  
Kumar K. Pathirana ◽  
David A. Christensen
Keyword(s):  
Bile Flow ◽  
Copper Concentration ◽  
Zinc Concentration ◽  
Post Partum ◽  
Full Term ◽  
Copper Excretion ◽  
Angus Cattle ◽  
Copper And Zinc ◽  
Plasma Copper ◽  
Zinc Concentrations

Three each of 3-year-old Angus and Simmental heifers, surgically modified to collect bile, were used to measure the effects of pregnancy and breed on bile flow, biliary copper and zinc excretion and plasma copper and zinc concentrations. Bile copper excretion was significantly higher at 7-mo of pregnancy when samples from both breeds were pooled. From then onwards it declined to its lowest, one week post-partum. During pregnancy, plasma copper concentration increased slightly, reaching its highest level at 7-mo of pregnancy and then decreased slightly until full term. In pooled samples from both breeds, the correlation between increase in bile copper excretion and plasma copper concentration from 0 to 7-mo of pregnancy was high (r = 0.85) and significant (p < 0.05). Plasma zinc concentration decreased to the lowest level around 6-mo of pregnancy but increased thereafter until full term. In cows that were dried off one week after parturition, major shifts in bile and plasma copper and zinc parameters occurred at one week following and these coincided with a marked decline of bile flow and bile copper and zinc excretion. By 3-mo post-partum, biliary copper and zinc excretion and plasma copper and zinc concentrations had reached levels observed prior to pregnancy. When the data from all samples were pooled, the bile flow and bile copper excretion were significantly (p < 0.05) higher in Simmental, and plasma copper and zinc concentration higher in the Angus.

Modulation of plasma copper and zinc concentrations by disease states in ruminants

1976 ◽  
Vol 99 (20) ◽  
pp. 396-397 ◽  
Author(s):  
W. Corrigall ◽  
A. Dalgarno ◽  
L. Ewen ◽  
R. Williams
Keyword(s):  
Disease States ◽  
Copper And Zinc ◽  
Plasma Copper ◽  
Zinc Concentrations

scholarly journals Copper and zinc concentrations in atherosclerotic plaque and serum in relation to lipid metabolism in patients with carotid atherosclerosis

2015 ◽  
Vol 72 (9) ◽  
pp. 801-806 ◽  
Author(s):  
Nebojsa Tasic ◽  
Danijela Tasic ◽  
Petar Otasevic ◽  
Mirjana Veselinovic ◽  
Vladimir Jakovljevic ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Atherosclerotic Plaque ◽  
Carotid Atherosclerosis ◽  
Density Lipoprotein ◽  
Atomic Absorption Spectrophotometry ◽  
Control Group ◽  
High Concentration ◽  
Copper And Zinc ◽  
Atherosclerotic Stenosis ◽  
Zinc Concentrations

Background/Aim. Some oligoelements are now investigated as possibly having a role in atherosclerosis. The aim of this study was to compare the concentrations of copper and zinc in the serum and carotid plaque and parameters of lipid metabolism in patients with different morphology of carotid atherosclerotic plaque. Methods. Carotid endarterectomy due to the significant atherosclerotic stenosis was performed in 91 patients (mean age 64 ? 7). The control group consisted of 27 patients (mean age 58 ? 9), without carotid atherosclerosis. Atheroscletoric plaques were divided into four morphological groups, according to ultrasonic and intraoperative characteristics. Copper and zinc concentrations in the plaque, carotid artery and serum were measured by atomic absorption spectrophotometry. Results. Serum copper concentrations were statistically significantly higher in the patients with hemorrhagic in comparison to those with calcified plaque (1.2 ? 0.9 ?mol/L vs 0.7 ? 0.2 ?mol/L, respectively; p = 0.021). Zinc concentrations were statistically significantly lower in plaques of the patients with fibrolipid in comparison to those with calcified plaques (22.1 ? 16.3 ?g/g vs 38.4 ? 25.8 ?g/g, respectively; p = 0.024). A negative significant correlation was found for zinc and triglycerides in the serum in all the patients (r = -0.52, p = 0.025). In the control group we also demonstrated a positive significant correlation for low-density lipoprotein cholesterol and copper in the serum (r = 0.54, p = 0.04). Conclusion. The data obtained in the current study are consistent with the hypothesis that high copper and lower zinc levels may contribute to atherosclerosis and its sequelae as factors in a multifactorial disease. Further studies are necessary in order to conclude whether high concentration of copper and zinc in the serum could be risk factors for atherosclesrosis.

scholarly journals Effect of nutrition on copper and zinc concentrations in human milk

2018 ◽  
Vol 7 (1) ◽  
pp. 96
Author(s):  
Sharmila M. Mane ◽  
Neelam J. Patil ◽  
Sachin A. Patharkar ◽  
Megha G. Bangar
Keyword(s):  
Trace Elements ◽  
Nutritional Status ◽  
Human Milk ◽  
Maternal Nutritional Status ◽  
Prior Informed Consent ◽  
Copper And Zinc ◽  
Group I ◽  
Zinc Concentrations ◽  
The Mean ◽  
The Difference

Background: The gross composition of human milk is remarkably constant among women of varying nutritional status. Reliable information is now available on the content, and the principal factor affecting it, of most of the trace elements on human milk. However, for some of the trace elements, there is still a wide variation in reported values in the literature, which is due at least in part, to analytical difficulties. Hence this study was taken up to find out if maternal nutritional status influences the copper and zinc concentrations in colostrum of mother.Methods: Total of 100 mothers were enrolled in the study after obtaining prior informed consent. They were divided into 2 groups - group I had 50 malnourished mothers and group II had 50 well-nourished mothers. Sample digestion was attempted with different quantities of various acids. Analysis of digested colostrum was carried out for copper and zinc.Results: The mean levels of copper and zinc were slightly more among well-nourished than malnourished women. Values of copper were significantly higher in the colostrum of well-nourished as compared to that of the malnourished mothers.Conclusions: The parameters of weight, height weight/height ratio and hemoglobin varied significantly between the well-nourished and malnourished mothers. The difference in milk content of malnourished and well-nourished mothers is not significant for zinc. However, copper levels were significantly higher in well-nourished mothers.

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