scholarly journals A study of spectrum and outcome of liver diseases in pregnant women at BRD medical college

2017 ◽  
Vol 6 (8) ◽  
pp. 3641
Author(s):  
Amrita Tiwari ◽  
Vani Aditya ◽  
Reena Srivastava ◽  
Geeta Gupta
Keyword(s):  
Liver Disease ◽  
Pregnant Women ◽  
Hyperemesis Gravidarum ◽  
Antenatal Clinic ◽  
Fetal Outcome ◽  
Medical College ◽  
Acute Fatty Liver ◽  
One Year ◽  
Labour Room ◽  
In Pregnancy

Background: Different spectrum of liver disease can affect outcome of pregnancy. The incidence of liver disorders in pregnancy varies in different parts of the world. The present study was designed to see the incidence, spectrum, and outcome of liver disease in pregnancy.Methods: All pregnant women with deranged liver profile, attending antenatal clinic and labour room in the department of Obstetrics and Gynecology of BRD Medical College over the period of one year (August 2015 to July 2016) were included in the study. Enrolled cases were followed up till discharge in respect to maternal and fetal outcome.Results: Liver disease was found in 214 (2.37%) cases out of 9011 pregnancies. Pregnancy specific liver disease was the most common type (85.98%). Among pregnancy specific liver disease Hypertensive disorders of pregnancy was the commonest abnormality (66.35%). Rest were Cholestasis, Acute viral hepatitis, Chronic liver disease, Hyperemesis gravidarum, Acute fatty liver of pregnancy. Out of 214, 22 patients dropped out. Overall maternal and perinatal mortality were 13.02% and 29.17% respectively.Conclusions: Liver disease in pregnancy is not uncommon and it can seriously affect pregnancy outcome if not treated properly on time. Early diagnosis (by clinical suspicion and blood investigation) and timely intervention can improve maternal and fetal outcome in pregnancy with liver disease.

The liver in pregnancy

2013 ◽  
pp. 309-318
Author(s):  
Daniel Marks ◽  
Marcus Harbord
Keyword(s):  
Liver Disease ◽  
Hyperemesis Gravidarum ◽  
Gallstone Disease ◽  
Liver Function Tests ◽  
The Other ◽  
Liver Disorders ◽  
Hepatic Rupture ◽  
Chiari Syndrome ◽  
Acute Fatty Liver ◽  
In Pregnancy

Liver disease in pregnancy Liver function tests in pregnancy Hyperemesis gravidarum Obstetric cholestasis Acute fatty liver of pregnancy Pre-eclampsia HELLP syndrome Spontaneous hepatic rupture Gallstone disease Pancreatitis Budd–Chiari syndrome Viral hepatitis Pre-existing cirrhotic liver disease A number of liver disorders are unique to, or more likely to occur in, pregnancy. These should be considered alongside the other causes of liver disease that occur in non-pregnant patients. Transient mild derangements of LFT are common and rarely require further assessment beyond repeat monitoring to ensure normalization. However, liver disorders in pregnancy often present non-specifically and, therefore. all patients merit formal clinical assessment....

scholarly journals Prevalence of thyroid disorders in pregnancy

2018 ◽  
Vol 7 (9) ◽  
pp. 3493
Author(s):  
Sangeeta Pahwa ◽  
Sabia Mangat
Keyword(s):  
Pregnant Women ◽  
Subclinical Hypothyroidism ◽  
First Trimester ◽  
Antenatal Clinic ◽  
Fetal Outcome ◽  
Overt Hypothyroidism ◽  
Thyroid Disorders ◽  
Subclinical Hyperthyroidism ◽  
Thyroid Screening ◽  
In Pregnancy

Background: Thyroid disorders are among the common endocrine problems in pregnant women. Often overlooked in pregnancy due to nonspecific symptoms and hyper-metabolic state of pregnancy. Western literature shows prevalence of hypothyroidism in pregnancy as 2.5% and hypothyroidism as 0.1-0.4%. There is paucity of data on prevalence of thyroid disorders in India pregnant population. This study was carried out to know prevalence of thyroid disorders in pregnant women in Indian population.Methods: One hundred pregnant women attending antenatal clinic in first trimester were registered. Detailed history and examination was done. Apart from routine basic and obstetrical investigations, TSH, FT3 and FT4 level estimation was done.Results: Prevalence of thyroid dysfunction was high in this study in first trimester pregnant women, with subclinical hypothyroidism in 6%, overt hypothyroidism in 2%, subclinical hyperthyroidism 2 % and overt hyperthyroidism 0%.Conclusions: Prevalence of thyroid disorders, especially subclinical hypothyroidism (6%), overt hypothyroidism (2%) and subclinical hyperthyroidism (2%) was high. To prevent adverse effects on maternal and fetal outcome, we are emphasizing the importance of routine antenatal thyroid screening.

scholarly journals Maternal Outcome of Anemic Pregnant Mother at Private Hospitals in Dhaka City

2021 ◽  
Vol 33 (2) ◽  
pp. 102-107
Author(s):  
Muhammad Zahangir
Keyword(s):  
Pregnant Women ◽  
Total Sample ◽  
Fetal Outcome ◽  
Maternal Outcome ◽  
Dhaka City ◽  
College Hospital ◽  
Private Hospitals ◽  
Medical College ◽  
Medicine Today ◽  
In Pregnancy

Introduction: The study carried out among the pregnant women who had anemia during pregnancy with the objectives to determine their maternal outcome at private hospitals in Dhaka city. Materials and Methods: The total sample size was 110. Data was collected by interviewing the respondents with a structured pre-tested questionnaire. The study was conducted in pregnant women with anemia at or after 28 weeks of gestation and had delivered at Obstetrics Department of Ad-Din Barrister Rafique ul-Huq Hospital, Jurain and Bashundhara Ad-Din Medical College Hospital South Keranigonj. Results: Most of the respondents (38.2%) belonged to the age group between 16-20 years. The mean age was 23.74±5.127 years. Almost (49.1%) up to primary & (38.2%) were up to secondary/higher secondary level. Most of the respondents were homemaker (87.3%); Monthly income means was 19340.91±12459.647. Most (90.9%) of the respondents had received ANC and 79.1% respondent’s hemoglobin level was below 10 gm. /dl. Among them 90.9% of the respondent’s fetal outcome were healthy & alive baby. More than half (51.8%) of the respondent’s baby were _ 2.5 kg birth weight. Study also shows that 55.5% respondents had anemia after delivery, 28.2% had sickness and 22.7% were sulfured with complications after delivery. There was a significant relationship with low birth weights (LBW) to less high education. Conclusion: All women should be given advice regarding diet in pregnancy with details of foods rich in iron. Dietary changes alone are not sufficient to correct an existing iron deficiency in pregnancy and iron supplements are necessary. Medicine Today 2021 Vol.33(2): 102-107

scholarly journals A study of thrombocytopenia in pregnancy

2020 ◽  
Vol 9 (3) ◽  
pp. 1115
Author(s):  
Komal Modi ◽  
Jaydeep Chaudhari ◽  
Disha Vaja
Keyword(s):  
Platelet Count ◽  
Mode Of Delivery ◽  
Antenatal Clinic ◽  
Fetal Outcome ◽  
Medical College ◽  
Single Donor ◽  
Gestational Thrombocytopenia ◽  
Low Platelet Count ◽  
Labour Room ◽  
Donor Plasma

Background: Thrombocytopenia is defined as low platelet count and if it is present during pregnancy can jeopardize the maternal and fetal outcome. Thrombocytopenia occurs in 6-15% of pregnancies. Causes of thrombocytopenia include gestational, idiopathic thrombocytopenia, preeclampsia, HELLP, DIC, malignancy and marrow failure. Aim of this study was to find out the common causes of thrombocytopenia in this hospital and management being used.Methods: Data was collected form those women who came to the antenatal clinic (booked) and labour room (unbooked) in the department of obstetrics and gynecology, GMERS Medical College and Hospital, Sola, Ahmedabad. Data of a total of 75 pregnant women were collected during the period of July 2018 to June 2019.Results: There were 66.67% cases of gestational thrombocytopenia, 13.33% related to preeclampsia, 8% in Eclamptic patients, 2.67% in HELLP and DIC, 6.67 in ITP, and lastly 2.67% in dengue cases. There were number of associated complication whether directly related (PPH) or part of the disorder. PPH was observed in 22.67% which is maximum among all complications. Other complications were part of major associated illness i.e. liver failure (6.67%), renal failure (5.3%), DIC (5.3%) and HELLP (8%).Conclusions: Mode of delivery was not influenced by platelet count, but for obstetric indications. Management of patients was as per the diagnosis. Single donor plasma is preferable to random donor plasma. PPH was the commonest complication and we should be wary of that.

scholarly journals Prevalence of Anaemia Among Pregnant Women in Third Trimester and Its Effect on Pregnancy Outcome at Tertiary Level Teaching Hospital, Birgunj

Med Phoenix ◽  
2020 ◽  
Vol 5 (1) ◽  
pp. 54-63
Author(s):  
Ravi Kumar Shah ◽  
Jagat Prasad Deep ◽  
Zarin Rahman ◽  
Pravin Shah ◽  
Neha Nayak ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Teaching Hospital ◽  
Antenatal Clinic ◽  
Fetal Outcome ◽  
Third Trimester ◽  
Cross Sectional ◽  
National Medical ◽  
Anaemia In Pregnancy ◽  
In Pregnancy

Background: Anaemia in pregnancy is a global health challenge. It is the commonest medical disorder of pregnancy and a major cause of morbidity and mortality in developing countries. Main cause of anaemia in obstetrics is iron deficiency. There are specific risks for the mother and the fetus such as intrauterine growth retardation, prematurity, and blood transfusion. Hence, the importance of giving iron in the antenatal period and to be continued postnatally. Objectives: The study was conducted to determine the overall prevalence of anaemia among pregnant women presenting in third trimester and its effect on pregnancy outcome. Methods: This is a cross sectional descriptive study done at National Medical College & Teaching Hospital from September 2015 to August 2016. During the study period 2048 pregnant women attended antenatal clinic in third trimester. Among 2048, 1200 were booked cases and out of these women with haemoglobin less than 11gm/dl were labeled as anaemia. The prevalence was calculated along with the maternal and fetal outcome. Result: Among 2048, 1200 were booked cases, 368 (30.66%) were anemic, 66.30% were multigravida, 67.93% in age group of 21-30 years, 284 patients came for delivery. In 14.08% patients there was preterm labour, apgar score less than 7 in 66.19% babies. Majority of neonate weighed between 2.0 - 2.5kg (49.29%). Perinatal deaths were 2.81%. Conclusion: Anaemia in pregnancy need awareness about early and regular antenatal care with oral iron supplementation. Correction of anaemia will reduce the maternal and fetal complications.  

scholarly journals Prevalence and outcome of hypothyroidism in women attending antenatal clinic at J. J. M Medical College

2017 ◽  
Vol 6 (8) ◽  
pp. 3537
Author(s):  
Sapna I. S. ◽  
Zainab Mehazeena
Keyword(s):  
Heart Disease ◽  
Pregnant Women ◽  
Maternal Morbidity ◽  
Negative Impact ◽  
Antenatal Clinic ◽  
Hypothyroid Patient ◽  
Medical College ◽  
Thyroid Screening ◽  
Tsh Levels ◽  
In Pregnancy

Background: Pregnancy induces physiological and metabolic changes, when overlapped with endocrine imbalance leads to undesirable consequences for both mother and fetus. Thyroid pathology has major negative impact on both mother and fetus. Hypothyroidism may be pre-existent or may begin during pregnancy; severity depends on how early and appropriately treatment is initiated. Aim of this study is to evaluate the prevalence of hypothyroidism in pregnancy and its outcome.Methods: 150 pregnant women obstetric files were studied based on their TSH value, women with TSH levels greater than 3mIU/ml who were on L-Thyroxin were included. All others who had diabetes, collagen disease, heart disease with pregnancy were excluded from the study.Results: Prevalence of hypothyroidism in pregnancy is 1.2%.Conclusions: Hypothyroidism presents with complex and serious complications with increase in maternal morbidity and perinatal mortality. To identify potential and overt hypothyroid patient thyroid screening is must during pregnancy. TSH levels should be kept less than 2mIU/L for adequate control.

scholarly journals Asymptomatic bacteriuria among pregnant women attending antenatal clinic at a tertiary care centre

2020 ◽  
Vol 9 (2) ◽  
pp. 528
Author(s):  
Barun K. Basumatary ◽  
Bijoy K. Dutta ◽  
Nabina Choudhury
Keyword(s):  
Pregnant Women ◽  
Bacterial Species ◽  
Tertiary Care ◽  
Asymptomatic Bacteriuria ◽  
Antibiotic Sensitivity ◽  
Antenatal Clinic ◽  
Tertiary Care Centre ◽  
Gram Negative Organisms ◽  
One Year ◽  
In Pregnancy

Background: The term asymptomatic bacteriuria is defined as the presence of > 100,000 colonies of a single bacterial species per millilitre of urine (105 cfu /mL), cultured from clean catch midstream sample in the absence of declared symptoms. The aim of this study was to know the incidence of asymptomatic bacteriuria in pregnancy and the various factors influencing it, to identify the pathogens and their antibiotic susceptibility patterns.Methods: Clean catch mid-stream urine samples were collected from 3000 pregnant women (all trimesters) aged between 18-35 years of age attending the antenatal OPD in GMCH, Guwahati for a period of one year (July 2018-June2019).  Identification of organisms and antibiotic sensitivity tests were performed as per standard methods.Results: In our study, incidence of asymptomatic bacteriuria was found to be 12.1%. Most women (52.89%) were in the age group of (20-30) years, mostly in second trimester (47.1%). Gram negative organisms were the commonest organisms isolated; among which Escherichia coli (56.75%) was the principal urinary pathogen followed by Klebsiella sp (14.33%) and Staphylococcus saprophyticus (12.67%). The isolates were most sensitive to Nitrofurantoin (87.88%).Conclusions: Asymptomatic bacteriuria is common in pregnancy. Once ASB is recognized during pregnancy, it should be appropriately treated with antibiotics and promptly followed up.

scholarly journals Prevalence and Factors Associated with Anemia among Pregnant Women Attending Antenatal Clinic at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Angesom Gebreweld ◽  
Aster Tsegaye
Keyword(s):  
Pregnant Women ◽  
Addis Ababa ◽  
Antenatal Clinic ◽  
Folic Acid Supplementation ◽  
Factors Associated ◽  
Medical College ◽  
Iron Folic Acid Supplementation ◽  
Iron Folic Acid ◽  
Prevalence Of Anemia ◽  
In Pregnancy

Background. In pregnancy, anemia is an important factor associated with an increased risk of maternal, fetal, and neonatal mortality, poor pregnancy outcomes, and impaired cognitive development, particularly in developing countries like Ethiopia. This study aimed to assess prevalence and factors associated with anemia among pregnant women attending antenatal clinic at St. Paul’s Hospital Millennium Medical College, Addis Ababa, Ethiopia. Method. A cross-sectional health facility based study was conducted on 284 pregnant women to assess prevalence and factors associated with anemia at St. Paul’s Hospital Millennium Medical College from June to August 2014. Data on sociodemographic and clinical characteristics of the study participants were collected using a pretested structured questionnaire by interview and review of medical records. About 4 ml of venous blood was collected from each subject for peripheral blood film and complete blood counts (CBC). Binary Logistic regression analysis had been used to check for association between dependent and independent variables. In all cases, P value less than 0.05 was considered statistically significant. Result. The prevalence of anemia was found to be 11.6% (95 % CI; 7.8%-14.8%). Pregnant women in the second [AOR (95% CI), 6.72 (1.17-38.45), and P=0.03] and third trimester [AOR (95% CI), 8.31 (1.24-55.45), and P=0.029] were more likely to be anemic when compared to pregnant women in their first trimester. Pregnant women who did not receive iron/folic acid supplementation [AOR (95%CI), 4.03(1.49-10.92), and P=0.01] were more likely to be anemic when compared to pregnant women who did take supplementations. Conclusion. In this study the prevalence of anemia in pregnancy was low compared to the findings of others. Gestational age (trimester) and iron/folic acid supplementation were statistically associated with anemia. Therefore, iron supplementation and health education to create awareness about the importance of early booking for antenatal care are recommended to reduce anemia.

scholarly journals Pregnancy outcomes in women with liver disease: Is pregnancy safe? A cross-sectional study

2020 ◽  
Author(s):  
Reza Shekarriz-Foumani ◽  
Fakhrolmolouk Yassaee ◽  
Sara Tarokh ◽  
Mahbobeh Taheri
Keyword(s):  
Liver Transplantation ◽  
Liver Disease ◽  
Pregnant Women ◽  
Premature Birth ◽  
Liver Diseases ◽  
Antenatal Clinic ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
In Pregnancy

Background: There is evidence suggesting that the pregnancy outcome may be affected by some medical conditions, such as liver diseases. Objective: The present study aimed to investigate the prevalence of liver disease and its outcomes in pregnant women referred to antenatal clinic in the hospital. Materials and Methods: In this cross-sectional study, all pregnant women with abnormal liver function test attending antenatal clinic affiliated to Shahid Beheshti University of Medical Sciences were recruited from August 2017 to July 2018. All participants were followed-up until delivery with respect to the maternal and neonatal outcome. Results: Of a total of 7,121 pregnant women recruited in the study, 110 (1.58%) women were detected with a liver disease; of these, 105 women were diagnosed with pregnancy-specific liver diseases, including HELLP syndrome (10.9%), preeclampsia (50.98%), partial HELLP (0.9%), eclampsia (0.9%), acute fatty liver (9.1%), intra-hepatic cholestasis 25 (22.7%), and 5 women the non-pregnancy-specific liver disease, including Liver transplantation (2.7%), and Autoimmune hepatitis (1.8%). Prevalence of the premature birth was 64.5% in pregnancy-specific liver disease, but no premature birth was detected in cases with liver transplantation. We found that neonatal mortality was significantly associated with neonatal prematurity (p = 0.013), IUGR (p < 0.001), placental pathology (p = 0.04), we had no maternal mortality. Conclusion: Liver disease is not uncommon in pregnancy. This study demonstrated that pregnancy is safe in women with liver disease. Key words: Liver diseases, Maternal, Outcome, Neonatal, Pregnancy.

scholarly journals Pregnancy-related liver pathology: hyperemesis gravidarum, cholestatic hepatosis of pregnancy, preeclampsia/eclampsia, HELLP-syndrome, acute fatty liver of pregnancy

2021 ◽  
Vol 1 ◽  
pp. 7-16
Author(s):  
О.V. Golyanovskiy ◽  
N.E.  Geints ◽  
V.V.  Mekhedko ◽  
S.V.  Frolov
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Pregnant Women ◽  
Liver Dysfunction ◽  
Hellp Syndrome ◽  
Liver Diseases ◽  
Hyperemesis Gravidarum ◽  
Late Pregnancy ◽  
Risk Groups ◽  
Acute Fatty Liver

Liver disease associated with pregnancy affects up to 3% of women and is a common cause of dysfunction during pregnancy. Severe liver dysfunction is associated with high rates of maternal and infant morbidity and mortality.Therefore, it is important to know about liver diseases the woman suffered before pregnancy in order to adequately manage the pregnancy and reduce the number of complications during delivery. Research and recent advances in medicine tend to improve the consequences, but so far they have not shown significant reduction of the maternal and perinatal morbidity rates against the background of this pathology. Liver diseases that are characteristic for pregnancy can be classified into those of early pregnancy (hyperemesis gravidarum) and those of late pregnancy (preeclampsia/eclampsia, intrahepatic cholestasis of pregnant women; hemolysis, increased activity of liver enzymes) HELLP-syndrome, acute fatty liver disease of pregnant women - AFLP, liver rupture / infarction).The results of modern studies used in the practice of medical care for pregnant women with concomitant pathology have significantly improved the pregnancy and delivery outcomes, but the number of complications among the mother and the fetus is still high. In this article, we offer an overview of liver diseases complicated by pregnancy with a detailed presentation of their aetiology, pathogenesis, diagnosis, and treatment. The risk groups of pregnant women with the potential possibility of liver dysfunction development have also been identified.

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