scholarly journals Safety and efficacy of ferric carboxymaltose in anaemic antenatal women: a prospective study

2021 ◽  
Vol 10 (5) ◽  
pp. 1837
Author(s):  
Supriya Jamkhandi ◽  
Rajesh Tile
Keyword(s):  
Fetal Heart ◽  
Ferric Carboxymaltose ◽  
Prospective Clinical Study ◽  
Efficacy And Safety ◽  
Third Trimester ◽  
Effective Treatment Option ◽  
Heart Monitoring ◽  
Moderate Anemia ◽  
Post Infusion ◽  
A Prospective Study

Background: Anemia is one of the most common nutritional deficiency disorders affecting the pregnant women, and is a worldwide problem. In India, prevalence ranges from 23.6%-61.4% and contributes to 80% of maternal mortality as a direct or indirect cause. This study aims to assess the efficacy and safety of intravenous ferric carboxymaltose in antenatal women with moderate anemia in the second and third trimester of pregnancy.Methods: Prospective clinical study; total of 100 antenatal women with moderate anemia in second and third trimester were included in the study from January 2019 to September 2019 and given 1000mg of intravenous ferric carboxymaltose injection. Efficacy was assessed by rate of improvement in hemoglobin at 3 and 6 weeks post infusion. Safety analysis was done by assessing the adverse drug reactions and fetal heart monitoring during the infusion.Results: A total 100 antenatal women with median gestational age of 28week at presentation received 1000mg of intravenous ferric carboxymaltose. There was rise in hemoglobin from 8.3gm% before injection to 11.12gm% 6 weeks post infusion, showing a mean rise of 2.8gm%. There were no reports of drug related major adverse effects in the mother or the fetus.Conclusions: From this study, ferric carboxymaltose is found to be safe and effective treatment option for anemia in pregnancy.

scholarly journals Transient accelerations of fetal heart rate analyzed by computerized cardiotocography in the third trimester of pregnancy

2014 ◽  
Vol 60 (3) ◽  
pp. 270-275
Author(s):  
Ana Luisa Fernandes Lauletta ◽  
Roseli Mieko Yamamoto Nomura ◽  
Seizo Miyadahira ◽  
Rossana Pulcineli Vieira Francisco ◽  
Marcelo Zugaib
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Fetal Heart ◽  
Third Trimester ◽  
The Third ◽  
Before And After ◽  
Gestational Week ◽  
A Prospective Study ◽  
Low Risk Women ◽  
Singleton Pregnancies

Objective: the aim of this study was to investigate the patterns of transient FHR accelerations (10 bpm and 15 bpm) in the third trimester of pregnancy, comparing the occurrence of this event before and after the 32nd gestational week. Methods: This is a prospective study comparing the results of the computerized cardiotocography of 46 low-risk women with singleton pregnancies, maternal age between 18 and 40 years, gestational age between 28 and 40 weeks, absence of maternal morbidity and adequate fetal growth according to ultrasound. Computed Cardiotocography (8002 Sonicaid System and Fetal Care System) was performed for 30 minutes to analyze the variables of FHR. Results: twenty-three pregnant women underwent cardiotocography before 32 weeks (mean = 29.9 weeks, SD = 1.4 weeks) and were compared with 23 pregnant women who were examined after 32 weeks (mean = 36.3 weeks, SD = 2.5 weeks). Regarding the characteristics of FHR, fetuses evaluated between 32 1/7 weeks and 40 weeks showed a significantly greater number of accelerations above 15 bpm (median = 5, variation 0-18) than the group of pregnant women from 28 to 32 weeks (median = 4, variation 0 to 10; P = 0.048). There was a significant positive correlation between the number of accelerations above 15 bpm and the gestational age at examination (rho = 0.33; P = 0.026). Conclusion: computerized cardiotocography showed an association regarding the number of transient accelerations greater than 15 bpm in the assessment of both periods before and after 32 weeks of gestational age, suggesting the influence of the maturation of the fetal autonomic nervous system with pregnancy progression.

Antenatal electronic fetal heart monitoring for extremely and very preterm newborns

2019 ◽  
Vol 4 (26) ◽  
pp. 20
Author(s):  
Ali Saphia ◽  
George Alexandru Filipescu ◽  
Anca A. Simionescu
Keyword(s):  
Fetal Heart ◽  
Very Preterm ◽  
Heart Monitoring ◽  
Preterm Newborns

EFFICACY AND SAFETY OF MOROCTOCOG ALFA IN AN OPEN, MULTICENTER, PROSPECTIVE, CLINICAL STUDY IN CHILDREN 2 TO 6 YEARS OF AGE WITH SEVERE HEMOPHILIA A

2021 ◽  
Vol 100 (6) ◽  
pp. 154-161
Author(s):  
M.A. Timofeeva ◽  
◽  
V.V. Lebedev ◽  
O.I. Plaksina ◽  
N.I. Zozulya ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Hemophilia A ◽  
Prospective Clinical Study ◽  
Study Group ◽  
Haemophilia A ◽  
Severe Hemophilia ◽  
Efficacy And Safety ◽  
Prophylactic Dose ◽  
Traumatic Bleeding ◽  
Post Traumatic

The purpose of the study was to assess the efficacy, safety and pharmacokinetics of the moroctocog alfa (Octofactor) in children aged 2-6 with haemophilia A. Materials and methods of research : six patients between 2 and 6 years of age (average age 4.3±0.8 years) were included in the open multicenter prospective clinical trial. The efficacy of the drug was assessed against the background of the introduction of 30±10 IU/kg every 2–3 days, the safety was assessed by the frequency and causality of adverse reactions. Results: 7 post-traumatic bleeding was registered. The average prophylactic dose of the drug is 37.84±7.13 IU/kg. The dose of the drug for stopping bleeding was 1000 IU. 2 adverse events have been reported that are not related to moroсtocog alfa. Conclusion: the obtained data indicate the efficacy and safety of moroсtocog alfa in the study group of patients.

A PROSPECTIVE STUDY TO EVALUATE THE SURGICAL MANAGEMENT OF PROXIMAL HUMERUS FRACTURES BY LOCKING PLATES

2021 ◽  
pp. 10-12
Author(s):  
Anurag Rathore ◽  
Garvita Solanki
Keyword(s):  
External Rotation ◽  
Functional Results ◽  
Average Score ◽  
Prospective Clinical Study ◽  
Locking Plates ◽  
Statistical Parameters ◽  
Functional Scores ◽  
Minimum Score ◽  
Comminuted Fractures ◽  
A Prospective Study

BACKGROUND: This prospective clinical study was performed to evaluate the efcacy and functional outcome in proximal humeral fractures following surgery with locking plates. MATERIAL & METHODS: from August 2013 to April 2015, 32 patients were enrolled in this study following exclusion and inclusion criteria. The evaluation parameters included Time taken for fracture union, functional scores, radiographs of the shoulder and ROM (Range of motion- exion, abduction, internal and external rotation etc.). Patients were followed up regularly at 6 weeks, 12 weeks, 24 weeks and 12 months. Functional results were evaluated using Neer's score. All data were collected and analyzed with the help of suitable statistical parameters. RESULTS: The nal results were evaluated by using NEER'S Score. In our study, the minimum score was 65 and maximum was 94. The average score was 83.9 (Mean ± S.D. : 83.875 ± 6.73). We had excellent results in 6(18.75%) patients, 19(59.375%) had satisfactory results, 7(21.875%) patients had unsatisfactory results but none of the case is failure in our study. CONCLUSION: Open reduction and internal xation with Locking Compression Plates, has given good results and it is the implant of choice now-a-days particularly in comminuted fractures and in osteoporotic bones in elderly patients.

scholarly journals Use of Seton in Management of High Variety of Anal Fistula

2017 ◽  
Vol 8 (2) ◽  
pp. 100-104
Author(s):  
Mohammad Noor A Alam ◽  
Sharmin Abbasi
Keyword(s):  
Anal Fistula ◽  
Low Cost ◽  
Dentate Line ◽  
Internal Opening ◽  
Efficacy And Safety ◽  
Medical College ◽  
Small Channel ◽  
A Prospective Study ◽  
Low Rate

Background: Anal fistula is an abnormal communicative small channel that has an internal opening and an external opening and connected by the primary track. Our study evaluate the effectiveness of seton in high variety anal fistula.Objectives: Evaluation the efficacy and safety of seton as surgical management of high anal fistula. Methods: This is a prospective study done on 57 patients in BIRDEM hospital and some other clinic of Dhaka city in 3 years period with high variety of anal fistula which is above the dentate line and were treated with seton .Outcome measured during follow up period were- successfully healed, recurrence, incontinence, percentage of complications and patients satisfaction.Result: Among 57 patients mean age was 38.2+_6.8 years. Overall outcome of the patients showed-fistula completely healed in 51 patients, incontinence occurred in 2 patients and recurrence occurred in 4 patients.Conclusion: Seton is relatively safe, effective and low cost for the management of high anal fistula with low rate of incontinence. It can therefore, be recommended as the standard of treatment for high variety fistula in ano.Anwer Khan Modern Medical College Journal Vol. 8, No. 2: Jul 2017, P 100-104

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