scholarly journals A study of cardiological autonomic neuropathy in Type 2 Diabetes Mellitus with reference to QT interval for its diagnosis

2019 ◽  
Vol 7 (7) ◽  
pp. 2574
Author(s):  
Lakshmi Priya Inapakolla ◽  
Ramgopal Teja Kotla
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Neuropathy ◽  
Autonomic Dysfunction ◽  
Cardiovascular Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
P Value ◽  
Qtc Interval ◽  
Duration Of Diabetes ◽  
Cardiac Autonomic Dysfunction

Background: Presence of cardiac autonomic neuropathy (CAN) is responsible for silent myocardial infarction and sudden death in diabetics. Hence recognizing cardiac dysautonomia early, which is asymptomatic will help to delay or arrest its progression.Methods: A cross-sectional study to evaluate the Prevalence of Cardiovascular Autonomic Neuropathy in Type 2 diabetes and correlate it with duration of Diabetes and to investigate the relationship between cardiac autonomic dysfunction and corrected QT interval.Results: In the study population, the prevalence of definite CAN was 8%, 24% and 58% in group A, B and C respectively. The prevalence of definite CAN increases with increase in duration of diabetes. P value <0.001 significant.Conclusions: A significant correlation is present between Cardiovascular autonomic dysfunction and QTc prolongation. QTc interval in the ECG can be used to diagnose Cardiovascular autonomic neuropathy with a reasonable sensitivity and specificity.

scholarly journals Diabetic Cardiac Autonomic Dysfunction and Its Relationship with Duration of Diabetes

2016 ◽  
Vol 11 (1) ◽  
pp. 1-5
Author(s):  
Phurpa ◽  
Sultana Ferdousi
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Dysfunction ◽  
Negative Relationship ◽  
Duration Of Diabetes ◽  
Cardiac Autonomic Dysfunction ◽  
Male Patients ◽  
Relationship Of ◽  
The Relationship

Background: Duration of diabetes may have an important influence on cardiac autonomic dysfunction in type 2 diabetes mellitus.Objective: To assess the relationship of cardiac autonomic dysfunction in type 2 diabetes mellitus(T2DM) with the duration of diabetes.Methods: This crosssectional study was carried out from January to December 2015 on 54 long-term T2DM male patients aged 45 to 55 years, selected from the Endocrinology OPD of BSMMU, Dhaka. Thirty age matched recently diagnosed male T2DM patients(RT2DM) were control. Cardiac autonomic function was assessed by Heart Rate Variability(HRV). HRV measures were obtained by RMS multi channel polyrite-D. For statistical analysis, unpaired t-test and Pearson’s correlation coefficient test were used.Results: Mean RR, SDNN, and HF nu were significantly lower (p < 0.001) whereas, mean HR, LF nu and LF/HF were significantly (p < 0.001) higher in LT2DM than those of RT2DM. SDNN, RMSSD and variance showed significant (p < 0.001) negative correlation with the duration of diabetes.Conclusions: Duration of diabetes had strong negative relationship with the diabetic cardiac autonomic dysfunction.Bangladesh Soc Physiol. 2016, June; 11(1): 1-5

scholarly journals Cardiac Autonomic Neuropathy and QTc Interval in Type 2 Diabetes

Heart India ◽  
2015 ◽  
Vol 3 (1) ◽  
pp. 8
Author(s):  
JayaprasadNarayana Pillai ◽  
Suresh Madhavan
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy ◽  
Qtc Interval

scholarly journals EVALUATION OF AUTONOMIC DYSFUNCTION BY HEART RATE VARIABILITY ANALYSIS IN TYPE 2 DIABETES MELLITUS

2016 ◽  
Vol 10 (1) ◽  
pp. 309
Author(s):  
Phurpa Nil Nil ◽  
Sultana - Ferdousi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 2 Diabetes Mellitus ◽  
Autonomic Neuropathy ◽  
Autonomic Dysfunction ◽  
Cardiac Autonomic Neuropathy ◽  
Heart Rate Variability Analysis

ABSTRACTObjective: Cardiac autonomic neuropathy (CAN) is a severe and common, yet highly underdiagnosed, complication of Type 2 diabetes mellitus(T2DM). Subclinical CAN may have reduced heart rate variability (HRV) but normal Ewing battery test. This study was performed to evaluate theimportance of 5 minutes HRV for the detection of autonomic dysfunction in T2DM without (CAN-T2DM).Methods: This cross-sectional observational study was conducted at the Department of Physiology, Bangabandhu Sheikh Mujib Medical University(BSMMU) on 30 recently diagnosed T2DM (RT2DM) and 54 long-term CAN-male T2DM patients (LT2DM), aged 45-55 years, from the EndocrinologyOut Patient Department of BSMMU, Dhaka. 30 age and body mass index matched apparently healthy male subjects were control. Ewing battery testwas used to rule out CAN positive T2DM. HRV data were recorded by a polyrite-D and analyzed by software. HRV was assessed by time domainmethod. For statistical analysis, ANOVA and unpaired t-test were used.Results: Mean RR, standard deviation of NN intervals (SDNN) (p<0.05), and root mean square of the successive differences (RMSSD) were significantly(p<0.001) lower, and mean HR and SDNN/RMSSD were (p<0.001) significantly higher in LT2DM compared to RT2DM and control. In addition, SDNNwas also significantly (p<0.05) lower in RT2DM than that of control.Conclusions: Results conclude that autonomic dysfunction may occur in both LT2DM and RT2DM patients without neuropathy and 5 minutes HRVtest is an important tool for detecting subclinical CAN.Keywords: Type 2 diabetes mellitus, Cardiac autonomic neuropathy, Heart rate variability.

321-OR: A Genetic Locus on Chromosome 1p36 Associated with Cardiovascular Autonomic Neuropathy in Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 321-OR
Author(s):  
YALING TANG ◽  
HETAL SHAH ◽  
XIUQIN SUN ◽  
BRUCE A. PERKINS ◽  
MICHAEL J. WAGNER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Neuropathy ◽  
Genetic Locus ◽  
Cardiovascular Autonomic Neuropathy ◽  
Chromosome 1P36

542-P: Association of Cardiac Autonomic Dysfunction with Plasma Lipid Metabolites in Recent-Onset Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 542-P
Author(s):  
GIDON J. BÖNHOF ◽  
ALEXANDER STROM ◽  
KLAUS STRASSBURGER ◽  
BIRGIT KNEBEL ◽  
JORG KOTZKA ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Dysfunction ◽  
Plasma Lipid ◽  
Recent Onset ◽  
Onset Type ◽  
Cardiac Autonomic Dysfunction ◽  
Lipid Metabolites

scholarly journals Heart rate variability evaluation in the assessment of cardiac autonomic neuropathy in patients with type 2 diabetes

Cor et Vasa ◽  
2018 ◽  
Vol 60 (4) ◽  
pp. e335-e344 ◽  
Author(s):  
Rudolf Metelka ◽  
Lubica Cibičková ◽  
Jaromíra Gajdová ◽  
Ondřej Krystyník
Keyword(s):  
Type 2 Diabetes ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Autonomic Neuropathy ◽  
Cardiac Autonomic Neuropathy

scholarly journals The Association Between Continuous Glucose Monitoring-derived Metrics, Including Time in Range, and Cardiovascular Autonomic Neuropathy in Outpatients With Type 2 Diabetes

2020 ◽  
Author(s):  
Min Young Kim ◽  
Gyuri Kim ◽  
Ji Yun Park ◽  
Min Sun Choi ◽  
Ji Eun Jun ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Autonomic Neuropathy ◽  
Autonomic Function ◽  
Glucose Monitoring ◽  
Glycemic Variability ◽  
Cardiovascular Autonomic Neuropathy ◽  
Inverse Association ◽  
International Consensus ◽  
Time In Range

Abstract BackgroundContinuous glucose monitoring (CGM)-derived metrics including time in range (TIR) are attracting attention as new indicators of glycemic control and diabetes complications beyond hemoglobin A1c. This study investigated the association between CGM-derived TIR, hyperglycemia, hypoglycemia metrics, and cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes.MethodsA total of 284 patients with type 2 diabetes who underwent CGM for three days and autonomic function tests within three months based on outpatient data were recruited. The definition of CGM-derived metrics was subject to the most recent international consensus. CAN was defined as an abnormal case in two or more parasympathetic and the severity of CAN was estimated as the sum of the scores of the five cardiovascular autonomic function tests.ResultsMultiple logistic regression analysis revealed that the odds ratio of definite CAN was 0.876 [95% confidence interval (CI): 0.79–0.98] per 10% increase in the TIR of 70 to 180 mg/dL, after adjusting for age, sex, diabetes duration, any medications, and glycemic variability. A 10% increase in TIR was significantly inversely associated with the presence of advanced CAN (OR: 0.89, 95% CI: 0.81–0.98). In addition, there was a strong inverse association between a 10% increase in the TIR and the total CAN score (p for trend = 0.001). Among the metrics of hyperglycemia, a time above range (TAR) of greater than 180 mg/dL was also independently correlated with the presence of definite CAN (OR: 1.013, 95% CI: 1.00–1.02) and advanced CAN (OR: 1.01, 95% CI: 1.00–1.02).ConclusionsA TIR value of 70 to 180 mg/dL and a TAR value of greater than 180 mg/dL were significantly associated with cardiovascular autonomic neuropathy in outpatients with type 2 diabetes.

scholarly journals Intensive risk factor management and cardiovascular autonomic neuropathy in type 2 diabetes: the ACCORD Trial

2020 ◽  
Author(s):  
Yaling Tang ◽  
Hetal Shah ◽  
Carlos Roberto Bueno Junior ◽  
Xiuqin Sun ◽  
Joanna Mitri ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Type 2 Diabetes ◽  
Cardiovascular Risk ◽  
Autonomic Neuropathy ◽  
Pressure Control ◽  
Cardiovascular Autonomic Neuropathy ◽  
Risk Factor Management ◽  
Traditional Risk Factors ◽  
Intensive Blood Pressure

<b>Objectives: </b>The effects of preventive interventions on cardiovascular autonomic neuropathy (CAN) remain unclear. We examined the effect of intensively treating traditional risk factors for CAN, including hyperglycemia, hypertension, and dyslipidemia, in persons with type 2 diabetes (T2D) and high cardiovascular risk participating in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial. <p><b>Research Design and Methods: </b>CAN was defined as heart rate variability indices below the 5<sup>th</sup> percentile of the normal distribution. Of 10,250 ACCORD participants, 71% (n=7,275) had a CAN evaluation at study entry and at least once after randomization. The effects of intensive interventions on CAN were analyzed among these subjects through generalized linear mixed models. </p> <p><b>Results: </b>As compared to standard intervention, intensive glucose treatment reduced CAN risk by 16% (OR=0.84, 95%CI 0.75–0.94, p=0.003) – an effect driven by individuals without cardiovascular disease (CVD) at baseline (OR= 0.73, 95%CI 0.63–0.85, p<0.0001) rather than those with CVD (OR=1.10, 95%CI 0.91–1.34, p=0.34) (p for interaction=0.001). Intensive blood pressure intervention decreased CAN risk by 25% (OR=0.75, 95% CI 0.63–0.89, p=0.001), especially in patients ≥65 years old (OR=0.66, 95% CI 0.49–0.88, p=0.005) (p for interaction =0.05). Fenofibrate did not have a significant effect on CAN (OR=0.91, 95%CI 0.78–1.07, p=0.26). </p> <p><b>Conclusions: </b> These data confirm a beneficial effect of intensive glycemic therapy and demonstrate, for the first time, a similar benefit of intensive blood pressure control on CAN in T2D. A negative CVD history identifies T2D patients who especially benefit from intensive glycemic control for CAN prevention. </p>

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