scholarly journals Analysis of frequency and risk factors for intrauterine growth restriction

2017 ◽  
Vol 4 (1) ◽  
pp. 11
Author(s):  
Abha Shrestha
Keyword(s):  
Risk Factors ◽  
Intrauterine Growth Restriction ◽  
Perinatal Outcome ◽  
Neonatal Intensive Care ◽  
Adult Life ◽  
Growth Restriction ◽  
University Hospital ◽  
Singleton Pregnancy ◽  
Maternal Risk ◽  
Intrauterine Growth

<p class="abstract"><strong>Background:</strong> <span lang="EN-IN">Intrauterine growth restricted (IUGR) fetuses are at greater risk of developing fetal hypoxia, neonatal complications, impaired neurodevelopment, and also neonatal intensive care unit stay and neonatal mortality. They are also known to develop metabolic syndrome in adult life. So, the main objective of this study was to find out the frequency of intrauterine growth restriction, to identify the maternal and placental risk factors associated with intrauterine growth restriction and its perinatal outcome amongst pregnant women attending the Obstetric Outpatient Department in Dhulikhel Hospital, Kathmandu University Hospital</span>.</p><p class="abstract"><strong>Methods:</strong> <span lang="EN-IN">A prospective study was conducted from June 2011 to June 2017, at Dhulikhel Hospital, Kathmandu University Hospital, Kavre, Nepal. A singleton pregnancy, above 28 weeks of gestation with clinical diagnosis of IUGR and confirmed by ultrasonography were included in the study. The statistical analysis was performed by Statistical Package of Social Sciences (SPSS) 20.0 software. </span><span lang="EN-IN"> </span></p><p class="abstract"><strong>Results:</strong> <span lang="EN-IN">Maternal risk factors like preeclampsia, anaemia, low pregnancy body mass index and placental factors like retroplacental hemorrhage were mainly responsible for intrauterine growth restriction</span>.</p><p class="abstract"><strong>Conclusions:</strong> <span lang="EN-IN">Antenatal risk factors responsible for IUGR are important for the management of IUGR pregnancies and to prevent adverse perinatal outcome. </span></p>

Risk Factors for Intrauterine Growth Restriction: 9 Years Analysis in Tertiary Care Hospital

2019 ◽  
Vol 2 (1) ◽  
pp. 77-82
Author(s):  
Abha Shrestha ◽  
N Pradhan ◽  
B Kayastha
Keyword(s):  
Risk Factors ◽  
Intrauterine Growth Restriction ◽  
Tertiary Care ◽  
Adult Life ◽  
Growth Restriction ◽  
Optimal Time ◽  
Care Hospital ◽  
Singleton Pregnancy ◽  
Maternal Risk ◽  
Intrauterine Growth

Background: Intrauterine growth restricted (IUGR) fetuses are at higher risk of developing neonatal complications and also known to develop metabolic syndrome in adult life. So, an early antenatal detection, choosing the optimal time and method of delivery and intervention when required could minimize the risk significantly. Objective: To find out the prenatal outcome and the maternal and placental risk factors. Methods: A prospective study was conducted from January 2010 to January 2019, at a Teaching Hospital. A singleton pregnancy, above 28 weeks of gestation with clinical diagnosis of IUGR and confirmed by ultrasonography were included in the study. The statistical analysis was performed by Statistical Package of Social Sciences (SPSS) 23.0 software. Results: Maternal risk factors like low pregnancy body mass index, preeclampsia, anaemia, hypothyroidism and placental factors like retro placental hemorrhage were mainly responsible for intrauterine growth restriction. Conclusions: The early identification of risk factors and management of the same antenatal is an important issue to prevent adverse prenatal outcomes associated with IUGR.

scholarly journals Parental factors associated with intrauterine growth restriction

2015 ◽  
Vol 143 (11-12) ◽  
pp. 701-706 ◽  
Author(s):  
Monica Hăşmăşanu ◽  
Sorana Bolboacă ◽  
Tudor Drugan ◽  
Melinda Matyas ◽  
Gabriela Zaharie
Keyword(s):  
Risk Factors ◽  
Intrauterine Growth Restriction ◽  
Newborn Infants ◽  
Significant Risk ◽  
Growth Restriction ◽  
University Hospital ◽  
Control Group ◽  
Parental Factors ◽  
Intrauterine Growth ◽  
Significant Difference

Introduction. Linear growth failure is caused by multiple factors including parental factors. Objective. The aim of this study was to evaluate parental risk factors for intrauterine growth restriction (IUGR) on a population of Romanian newborn infants in a tertiary level maternity facility for a period of 2.5 years. Methods. A retrospective matched case-control study was conducted in the Emergency County Hospital of Cluj-Napoca, a university hospital in North-Western Romania. The sample was selected from 4,790 infants admitted to the Neonatal Ward at 1st Gynecology Clinic between January 2012 and June 2014. Results. The age of mothers was significantly lower in the IUGR group compared to controls (p=0.041). A significantly higher percentage of mothers had hypertension in the IUGR group compared to those in the control group (p<0.05). No other significant differences were identified with regard to the investigated characteristics of mothers between IUGR infants compared to controls (p>0.13). The age of fathers of infants with IUGR proved significantly lower compared to controls (p=0.0278). The analysis of infants? comorbidities revealed no significant difference between groups for respiratory distress, hyperbilirubinemia, hypocalcaemia, and heart failure (p>0.27). Intracranial hemorrhage, necrotizing enterocolitis and hypoglycemia were significantly higher in the IUGR group compared to controls. The logistic regression identified hypertension as a significant risk factor for IUGR (OR=2.4, 95% CI [1.3-4.5]). Conclusion. Although the age of the mothers and fathers proved significantly lower in the IUGR group compared to controls, only hypertension in the mothers proved significant risk factors for IUGR.

scholarly journals Maternal socio-demographic determinants and fetal outcome of intrauterine growth restriction

2018 ◽  
Vol 7 (9) ◽  
pp. 3843
Author(s):  
Arpita Singh ◽  
Ambujam K.
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Maternal Risk ◽  
Intrauterine Growth ◽  
Factors Associated ◽  
Increased Risk ◽  
Uterine Growth ◽  
Intra Uterine Growth Restriction

Background: Intrauterine Growth Restriction is a major neonatal health issue. It is associated with increased risk of perinatal morbidity and mortality. Maternal factors are the major contributing factors of IUGR and studying these factors can help in preventing IUGR and reducing perinatal mortality. The objective is to study the maternal sociodemographic risk factors associated with Intra uterine growth restriction.Methods: This is a Case-control study conducted in the Department of Obstetrics and Gynaecology, GMC Thrissur. 115 cases of Intra Uterine Growth Restriction were compared to 115 controls. Data was collected by interviewing the mother using structured questionnaire which is pretested and by persual of antenatal records. Intra Uterine Growth Restriction is defined as occurring if the sonographic estimated fetal weight <10th percentile for that gestational age. Chi Square test was used for the analysis of data.Results: Low socio-economic status and malnutrition (BMI<18.5) were significant socio-demographic factors associated with fetal growth restriction. Mean birth weight in IUGR group was 1.8kg compared to 2.9kg in control group. Female fetuses were more commonly associated with IUGR. Intra Uterine Growth Restricted babies had lower Apgar scores (<7) and had more chances for NICU admission.Conclusions: By studying the maternal risk factors associated with Intra Uterine Growth Restriction, we could identify the high-risk group. Early predictive studies could be done in these high-risk pregnancies with focus on good antenatal care to reduce the problem of IUGR in the community.

scholarly journals Factores de riesgo asociados a retraso del crecimiento intrauterino

2021 ◽  
Vol 2 (5) ◽  
pp. 6423-6440
Author(s):  
Ricardo Salas Flores ◽  
Brian González Pérez ◽  
Verónica Olvera Mendoza ◽  
Raúl de León Escobedo ◽  
Hebert Huerta Martínez ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gestational Age ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Maternal Risk ◽  
Intrauterine Growth ◽  
Linear Association ◽  
Factores De Riesgo ◽  
Clinical Records ◽  
Hospital General

INTRODUCCION: El crecimiento de un feto se considera restringido si el peso es dos desviaciones estándar menor que el de la media correspondiente a su edad gestacional, está por debajo del percentil 3 para su misma edad gestacional, o se estanca, es decir, no alcanza el tamaño que le corresponde por su potencial biológico. OBJETIVO: Identificar los factores de riesgo asociados con la restricción del crecimiento intrauterino en recién nacidos vivos. METODOS: Estudio observacional, descriptivo, transversal y retrospectivo. Se revisaron los expedientes clínicos  de madres cuyo producto haya nacido vivo con un peso igual o menor a 2500 gramos en el periodo comprendido de Enero del 2012 a Diciembre del 2013, en el Hospital General Regional N° 6 (HGR#6) del IMSS. El análisis de los datos obtenidos se llevó a cabo mediante regresión lineal, estadística descriptiva y mediante medidas de tendencia central, para variables continuas, variables categóricas, porcentajes y frecuencias. RESULTADOS: El análisis estadístico realizado demostró una asociación lineal significativamente fuerte de 94 %  entre las anormalidades placentarias y el RCIU (p=0.000) IC 95%, DE 127.9-425.0. Así mismo existe asociación lineal moderada entre la Hipertensión arterial crónica y RCIU en un 47% (p= 0.013) IC 95%  DE 25.9-205.5 CONCLUSIONES: Los factores de riesgo maternos son los que se asocian con mayor frecuencia a RCIU en recién nacidos vivos del HGR #6 del IMSS.   INTRODUCTION: The growth of a fetus is considered restricted if the weight is two standard deviations less than that of the mean corresponding to its gestational age, is below the 3rd percentile for the same gestational age, or is stagnant, that is, it does not reach the size that corresponds to it due to its biological potential. OBJECTIVE: To identify the risk factors associated with intrauterine growth restriction in live newborns. METHODS: Observational, descriptive, cross-sectional and retrospective study. The clinical records of mothers whose product was born alive with a weight equal to or less than 2500 grams in the period from January 2012 to December 2013 were reviewed at the Hospital General Regional N ° 6 (HGR # 6) of the IMSS. The analysis of the data obtained was carried out using linear regression, descriptive statistics and measures of central tendency, for continuous variables, categorical variables, percentages and frequencies. RESULTS: The statistical analysis performed showed a strong significant linear association of 94% between placental abnormalities and intrauterine growth restriction (IUGR) (p = 0.000) 95% CI, SD 127.9-425.0. Likewise, there is a moderate linear association between chronic arterial hypertension and IUGR in 47% (p = 0.013) 95% CI SD 25.9-205.5 CONCLUSIONS: Maternal risk factors are those most frequently associated with IUGR in live newborns from HGR # 6 of the IMSS.

scholarly journals Maternal and Placental Risk Factors associated with Intrauterine Growth Restriction and the Perinatal Outcomes

2015 ◽  
Vol 7 (3) ◽  
pp. 176-181 ◽  
Author(s):  
Valsa CA Thekkedathu
Keyword(s):  
Risk Factors ◽  
Statistical Analysis ◽  
Intrauterine Growth Restriction ◽  
Perinatal Outcomes ◽  
Growth Restriction ◽  
Chronic Hypertension ◽  
Maternal Risk ◽  
Intrauterine Growth ◽  
Factors Associated ◽  
The Impact

ABSTRACT Objectives Identifying the factors responsible for the intrauterine growth restriction (IUGR) is very important, so that early interventions could be suggested to improve the perinatal outcome. The major objectives of this study are to analyze the impact of risk factors, specifically the maternal and placental risk factors, on IUGR and the perinatal outcomes. Materials and methods A prospective study was done on 60 women with IUGR pregnancies from January 2013 to January 2014, at Pushpagiri Medical College Hospital, Thiruvalla. Inclusion criteria were: singleton pregnancies, above the gestational age of 28 weeks, clinically diagnosed IUGR and confirmed subsequently on ultrasound. The statistical analysis was performed utilizing Statistical Package of the Social Sciences (SPSS) software and the significance level of p-value < 0.05 was accepted as statistically significant. Results Statistical analysis shows that maternal risk factors like chronic hypertension, pre-eclampsia, low socioeconomic status of mother, overt diabetes, anemia, gestational diabetes mellitus, low prepregnancy body mass index and hypothyroidism were significantly associated with IUGR. In this study, placental factors like chorangiomatosis, increased syncytial knotting, villous infarction, increased perivillous fibrinoid deposition, accelerated villous maturation, retroplacental hemorrhage and acute chorioamnionitis were significantly associated with IUGR. Conclusion Alertness toward antenatal risk factors for poor pregnancy outcome is important for the optimal management of IUGR pregnancies. Despite antenatal recognition of IUGR and associated risk factors, not all perinatal deaths can be prevented. How to cite this article Thekkedathu VCA. Maternal and Placental Risk Factors associated with Intrauterine Growth Restriction and the Perinatal Outcomes. J South Asian Feder Obst Gynae 2015;7(3):176-181.

scholarly journals Maternal risk factors associated with intrauterine growth restriction: hospital based study

2016 ◽  
Vol 4 (12) ◽  
pp. 2125-2129 ◽  
Author(s):  
Dr. Neetika Ashwani ◽  
◽  
Dr. Aruna Rekha Neela ◽  
Dr. Suresh Babu Mendu ◽  
Dr. Suresh C. Kumar ◽  
...  
Keyword(s):  
Risk Factors ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Maternal Risk Factors ◽  
Maternal Risk ◽  
Intrauterine Growth ◽  
Factors Associated

Intrauterine Programming of Adult Disease: Identification of Cardinal Genes Associated with Hypertension, Obesity and Metabolic Syndrome

2021 ◽  
Vol 89 (1) ◽  
pp. 27-36
Author(s):  
Iván Acevedo Monterrosa ◽  
Damián A. Soria ◽  
Analía Tomat ◽  
Rosana Elesgaray ◽  
Cristina Arranz ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Intrauterine Growth Restriction ◽  
Adult Life ◽  
Treatment Strategies ◽  
Interaction Network ◽  
Growth Restriction ◽  
Adult Disease ◽  
Intrauterine Growth ◽  
Significant Gene ◽  
Obesity Hypertension

Background: Intrauterine growth restriction is an abnormal fetal development characterized by a fetal growth rate lower than the potential genetic growth for the gestational age. This condition represents a major burden for public health systems, as it increases short and long-term morbidity and mortality in the offspring, particularly because of its association with the development of cardiovascular and metabolic disease in adult life. Objectives: The aim of the present study was to identify possible cardinal genes involved in intrauterine growth restriction associated with the development of obesity, hypertension and metabolic syndrome using bioinformatics tools. Methods: A total of 343 genes involved in the phenotypes of interest were obtained and 20 genes were identified as significantly relevant in the interaction network analysis. Specifically, four of these identified genes encode for growth factors or their receptors, VEGFA, PDGFRB, IGF1R and EGFR. We also identified genes related to insulin and cardiovascular homeostasis as CTNNB1, APP, MYC and MDMD2. Cluster analysis provided the most significant gene ontology terms, including those related to the biological processes of proliferation and programmed cell death, intercellular communication, protein metabolism and development of the cardiovascular system. Conclusions: The genes found in this study could be useful as putative biomarkers for the presence of cardiovascular and metabolic disorders associated with intrauterine growth restriction, or as potential therapeutic targets for treatment strategies directed to the patient's genotype.

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