scholarly journals Glycogen Phosphorylase-a is a Common Target for Anti-Diabetic Effect of Iridoid and Secoiridoid Glycosides

2013 ◽  
Vol 16 (4) ◽  
pp. 530 ◽  
Author(s):  
Hitesh B Vaidya ◽  
Abeer A Ahmed ◽  
Ramesh K Goyal ◽  
Sukhinder K Cheema
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Glycogen Phosphorylase ◽  
Docking Studies ◽  
Chemical Components ◽  
Active Components ◽  
Active Chemical ◽  
Treatment Of Diabetes ◽  
Secoiridoid Glycosides ◽  
Common Target

Purpose. Diabetes mellitus is characterized by hyperglycemia resulting from defects in insulin secretion, action or both. The use of medicinal plants for the treatment of diabetes mellitus dates back from the Ebers papyrus of about 1550 B.C. One of the major problems with herbal drugs is that the active ingredients are not well defined. It is important to know the active components and their molecular interactions which will help to analyze their therapeutic efficacy and also to standardize the product. There are a number of medicinal plants known for their anti-diabetic effect that possess similarities in their active chemical components, e.g. iridoid and secoiridoid glycosides. Methods. In this study, we have compared the structure of various iridoid and secoiridoid glycosides to design a novel pharmacophore. We further developed a structure-activity relationship for the inhibition of glycogen phosphorylase-a. Conclusion. By using docking studies, we are proposing, for the first time, that inhibition of glycogen phosphorylase-a activity is a common target for iridoids and secoiridoids to elicit anti-diabetic effects. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

scholarly journals A Review on Ethno-pharmacology of Antidiabetic Plants

2018 ◽  
pp. 1-22
Author(s):  
M. A. Omoirri ◽  
O. M. Odigie ◽  
K. O. Gbagbeke ◽  
I. F. Ajegi ◽  
J. O. Oseyomon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Blood Glucose ◽  
Side Effects ◽  
Medicinal Plants ◽  
Metabolic Disorder ◽  
Developing Nations ◽  
Active Components ◽  
Treatment Of Diabetes ◽  
Antidiabetic Plants

Abnormally emanates from difficulty in insulin secretion, Diabetes mellitus (DM) is known to be a metabolic disorder that causes an increase of blood glucose in blood streams. The lack of effective modern treatments, the lifelong treatment with modern medicines, overtime, its associated health side effects, and its expensive prices among others are the challenging existing realities that devastate the health and economic burdens its sufferers, especially in developing nations. Today, this has prompted the search for cheap, safe, and reliable drugs from medicinal plants. This study reviewed existing information on medicinal plants used for the treatment of diabetes mellitus from various sources. Several documents (published and unpublished papers, books among others) were consulted in compilation of this review. It is found that there is a wide, yet uneven support for active components of major medicinal.

scholarly journals TRADITIONAL MEDICINAL SYSTEMS FOR TREATMENT OF DIABETES MELLITUS: A REVIEW

2018 ◽  
Vol 10 (5) ◽  
pp. 7
Author(s):  
Dimple . ◽  
Ashwani Kumar ◽  
Vikas Kumar ◽  
Vidisha Tomer
Keyword(s):  
Diabetes Mellitus ◽  
Functional Foods ◽  
Medical Science ◽  
Herbal Medicines ◽  
Diabetes Treatment ◽  
Active Components ◽  
The World ◽  
Increasing Trend ◽  
Current Scenario ◽  
Treatment Of Diabetes

Diabetes mellitus (DM) is a chronic disease which has clinched the world. More than 300 million people of the world are suffering from this disease and the number is still increasing at a rapid rate as modern medical science has no permanent solution for the disease. Current scenario of the nutraceuticals has increased patient’s faith on the traditional medicinal system and world nutraceutical industry is estimated to reach $285.0 billion by 2021. The increasing trend of nutraceuticals in diabetes treatment makes it important to collect the traditional knowledge of medicines under one heading as it can help researchers to formulate new functional foods and nutraceuticals which can either lower down the risk or cure DM. In addition, the discussion of market available food products, their active components and possible health benefits can help the patients to understand the herbal medicines in a better way.

scholarly journals Phytotherapy for diabetes mellitus; A review of Middle Eastern and North African folk medicinal plants

2020 ◽  
Vol 10 (1) ◽  
pp. 1-13
Author(s):  
Sara S Abouzekry ◽  
Marwa T Badawy ◽  
Nada M Ezzelarab ◽  
Ahmed Abdellatif
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Middle Eastern ◽  
Folk Medicine ◽  
North African ◽  
Active Components ◽  
Large Numbers ◽  
Few Data ◽  
Pharmacologically Active ◽  
Further Development

Diabetes mellitus (DM) is considered as one of the most common metabolic disorders affecting huge number of people worldwide. Despite the availability of large numbers of drugs in the market to treat the disease, there is still a need for new sources to deal with the problem and avoid side effects. In the pursuit of discovering safer and more effective anti-diabetic drugs, herbal and folk medicine drugs from regions all over the world have captured researchers’ interest. Middle Eastern and North African medicinal plants contain a variety of pharmacologically active components that have shown to possess promising anti-diabetic potential. However, few data have been reported about medicinal plants from these regions in comparison to plants from other regions. Anti-diabetic medicinal plants from the MENA (the Middle East and North Africa) region, their role in controlling DM, and suggested mechanisms for the anti-diabetic activity of some medicinal plants are discussed in this review. Many of these plants have not been fully investigated and characterized, yet they have great potential for further development as anti-diabetic drugs.

Antidiabetic Activity (Anti-Hyperglycemic Activity, Anti-Hyperlipidemic Activity)/Agents From Medicinal Plants

2020 ◽  
pp. 25-48
Author(s):  
Manish Singh Sansi ◽  
Daraksha Iram ◽  
Kapil Singh Narayan ◽  
Sandeep Kumar ◽  
Om Prakash ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Secretion ◽  
Medicinal Plants ◽  
Insulin Receptor ◽  
Antidiabetic Activity ◽  
Insulin Deficiency ◽  
Receptor Function ◽  
Synthetic Drugs ◽  
Treatment Of Diabetes ◽  
Insulin Receptor Kinase

Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in insulin secretion and by decreased insulin secretion by the organ. Insulin deficiency causes the DM. Synthetic drugs are widely used in the treatment of diabetes, but they have some side effects. The antihyperglycemic and antihyperlipedemic effects of the plants are related to their ability to maintain pancreatic function. Medicinal plants constituents such as glycosides, alkaloids, terpenoids, and flavonoids mitigate DM. B. ciliata inhibits the α-glucosidase and α-amylase. Cinnamon extracts improve insulin receptor function by activating insulin receptor kinase and inhibiting insulin receptor phosphatase, which lead to an increase in insulin sensitivity. Morinda lucida also had the highest antioxidant activity, and it also inhibited the α-glucosidase. Many plants have also been shown to antihyperlipedemic effects. Finally, it can be concluded that medicinal plants have that ability to treat or prevent DM.

scholarly journals Medicinal plants for treatment of diabetes mellitus

2000 ◽  
Vol 15 (S1) ◽  
pp. 169-177 ◽  
Author(s):  
R. Shukia ◽  
S. B. Sharma ◽  
D. Puri ◽  
K. M. Prabhu ◽  
P. S. Murthy
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Treatment Of Diabetes

Medicinal plants in the supplementary treatment of diabetes mellitus

2011 ◽  
Vol 5 (7) ◽  
pp. 1738
Author(s):  
Manuelle Arias Piriz ◽  
Marcos Klering Mesquita ◽  
Teila Ceolin ◽  
Caroline Vasconcellos Lopes ◽  
Rita Maria Heck
Keyword(s):  
Diabetes Mellitus ◽  
Medicinal Plants ◽  
Rio Grande ◽  
Ethics Committee ◽  
Rio Grande Do Sul ◽  
Treatment Of Diabetes ◽  
Supplementary Treatment ◽  
Positive Results ◽  
De Medicina ◽  
Structured Questionnaire

ABSTRACTObjective: to list the main medicinal plants used by ecological farmers from southern Rio Grande do Sul in the supplementary treatment of diabetes mellitus. Method: it was performed a study with qualitative approach of  exploratory and descriptive kind. The study subjects were farmers who sell their products at the ecological fair of Pelotas. Data were collected using semi-structured questionnaire. The interviews were recorded with consent of farmers and the plants were georeferenced and photographed for taxonomic  identification. The project was approved by the Ethics Committee of the Faculty of Medicine at 072/2007 opinion. Results: ten plants were mentioned in the treatment of diabetes mellitus. According to the literature, six of them had positive results in animals or humans as hypoglycemiants, and the other plants are indicated to treat various other symptoms. Conclusion: medicinal plants can act as an adjuvant of the medicamentous therapy in reducing glicemy of the disease carriers, taking into account the legal and safe precepts for using and importance of nurses in advising on the correct use of these therapies. Descriptors: phytotherapy; rural health; diabetes mellitus; nursing.RESUMOObjetivo: listar as principais plantas medicinais utilizadas por agricultores ecológicos do sul do Rio Grande do Sul no tratamento complementar do diabetes mellitus. Método: foi realizado um estudo de abordagem qualitativa do tipo exploratório e descritivo. Os sujeitos foram agricultores que comercializam seus produtos na feira ecológica de Pelotas. Os dados foram coletados utilizando questionário semi-estruturado. As entrevistas foram gravadas com consentimento dos agricultores e as plantas georreferenciadas e fotografadas para identificação taxonômica. O projeto foi aprovado pelo Comitê de Ética da Faculdade de Medicina por meio do parecer 072/2007. Resultados: foram citadas dez plantas utilizadas no tratamento de diabetes mellitus. De acordo com a literatura, seis delas obtiveram resultados positivos em animais ou humanos como hipoglicemiantes, as demais são indicadas para tratar outros diversos sintomas. Conclusão: as plantas medicinais podem atuar como adjuvantes da terapia medicamentosa na redução da glicemia de portadores da doença, levando-se em conta os preceitos legais e seguros da utilização e a importância dos enfermeiros no aconselhamento sobre o correto uso destas terapias. Descritores: fitoterapia; saúde da população rural; diabetes mellitus; enfermagem. RESUMENObjetivo: elaborar una lista de las principales plantas medicinales utilizadas por los agricultores ecológicos del sur de Río Grande do Sul en el tratamiento suplementario de la diabetes mellitus. Método: se realizó un estudio com um abordaje cualitativo de naturaleza exploratoria y descriptiva. Los sujetos de estudio fueron los agricultores que venden sus productos en la feria ecológica de Pelotas. Los datos fueron recolectados a través de cuestionario semi-estructurado. Las entrevistas fueron grabadas con el consentimiento de los agricultores y las plantas georeferenciados y fotografiados para su identificación taxonómica. El proyecto fue aprobado por el Comité de Ética de la Facultad de Medicina de la opinión 072/2007. Resultados: diez plantas fueron mencionadas en el tratamiento de la diabetes mellitus. De acuerdo con la literatura, seis de ellos tuvieron resultados positivos en animales o seres humanos como agentes hipoglucemiantes, los otros están indicados para el tratamiento de varios otros síntomas. Conclusión: las plantas medicinales pueden actuar como adyuvante a la terapia medicamentosa en la reducción de la glicemia en los portadores de la enfermedad, teniendo en cuenta los preceptos legales y seguros de la iutilización y la importancia de las enfermeras en el aconsejamiento sobre el correcto uso de estas terapias. Descriptores: fitoterapia; salud rural; diabetes mellitus; enfermería.

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