scholarly journals A Case Report of Duodenal Psammomatous Somatostatinoma

2018 ◽  
Vol 13 (3) ◽  
pp. 187
Author(s):  
Ayman Fisal Ahmed Foad ◽  
Hyder Osman Mirghani
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Serum Levels ◽  
Ampulla Of Vater ◽  
Normal Serum ◽  
Complete Resection ◽  
Psammoma Bodies ◽  
Initial Attempt ◽  
Nuclear Features

Somatostatinoma is a neuroendocrine tumor; its incidence in the duodenum around the ampulla of Vater is rare, and it is often not associated with secretory manifestation. We report a case of a female with an ampullary (Vater) tumor displaying neuroendocrine nuclear features, psammoma bodies, and the positivity for immunohistochemical panel of neuroendocrine tumors. Our patient presented with some features compatible with somatostatin secretion associated syndrome; albeit with normal serum levels of the hormone. Initial attempt of complete resection failed, and the involved margins were revised with a subsequent surgery, and the patient showed an uneventful course on follow-up for 2 years.

scholarly journals Posttraumatic Intramuscular Nodular Fasciitis in a 7-Year-Old Boy: Case Report and Review of the Literature

2021 ◽  
pp. 1-4
Author(s):  
Markus Denzinger ◽  
Markus Denzinger ◽  
Sandra Steininger ◽  
Niels Zorger ◽  
Patricia Reis Wolfertstetter ◽  
...  
Keyword(s):  
Case Report ◽  
Rare Disease ◽  
Complete Resection ◽  
Primary Resection ◽  
Histopathological Diagnosis ◽  
Nodular Fasciitis ◽  
Pectoralis Muscle ◽  
Conservative Approach ◽  
Review Of The Literature

Nodular fasciitis is a rare disease, and its diagnosis is difficult. We present a case report of a seven-year-old child with progredient swelling of the left pectoralis muscle three weeks after trauma. After histopathological diagnosis, we performed complete resection. Normally, a conservative approach with regular follow-up is regarded as appropriate since nodular fasciitis does have the capability to regress spontaneously. Since recent publications indicate the possibility of malignant transformation, the complete primary resection also has to be discussed as therapy of choice.

scholarly journals Comprehensive Treatment of Mediastinal Neuroendocrine Tumor: A Case Report

2021 ◽  
Author(s):  
Qi Yu ◽  
Zhen Li ◽  
Xinwei Han
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Surgical Resection ◽  
Neuroendocrine Tumors ◽  
Tumor Recurrence ◽  
Transcatheter Arterial Chemoembolization ◽  
Comprehensive Treatment ◽  
Drug Eluting ◽  
Arterial Chemoembolization

Abstract Neuroendocrine tumors in the mediastinum are relatively rare. We report a patient with mediastinal neuroendocrine tumor that was successfully resected after descending stage by drug-eluting embolic transcatheter arterial chemoembolization had been performed. No tumor recurrence was found in the 1-year follow-up after surgical resection.

Recommendations for Monitoring Lithium Therapy

1983 ◽  
Vol 17 (5) ◽  
pp. 346-350 ◽  
Author(s):  
Ronald B. Salem
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Serum Levels ◽  
Normal Serum ◽  
Lithium Therapy ◽  
Organ Systems

The literature concerning side effects of normal serum levels of lithium on various organ systems is reviewed. Suggestions for monitoring and managing these adverse effects are discussed. A table is presented that provides recommendations for evaluation prior to initiation and during follow-up of therapy.

scholarly journals A meta-analysis of the effect of lowering serum levels of GH and IGF-I on mortality in acromegaly

2008 ◽  
Vol 159 (2) ◽  
pp. 89-95 ◽  
Author(s):  
I M Holdaway ◽  
M J Bolland ◽  
G D Gamble
Keyword(s):  
Meta Analysis ◽  
Serum Levels ◽  
Somatostatin Analogues ◽  
Normal Serum ◽  
Mortality Data ◽  
Standardized Mortality Ratio ◽  
Endocrine Society ◽  
Igf I ◽  
Serum Gh

ObjectiveFormal studies of acromegaly have found increased mortality associated with the disorder, although reduction of serum levels of GH and IGF-I by treatment appears to improve survival. A meta-analysis of mortality studies in acromegaly has thus been performed to assess the effect of lowering serum GH and IGF-I on survival.Design and methodsMedline was searched for studies under ‘acromegaly’, ‘mortality’ and ‘cause of death’ (1965–2008), and abstracts of recent meetings of the US Endocrine Society were hand searched. Studies were restricted to those presenting mortality data according to serum GH and IGF-I at last follow-up, and with mortality expressed as a standardized mortality ratio (SMR).ResultsPatients with random serum GH <2.5 μg/l following treatment, mostly measured by standard RIA, had mortality close to expected levels (SMR 1.1, 95% confidence interval (CI) 0.9–1.4) compared with an SMR of 1.9 (95% CI 1.5–2.4) for those with final GH >2.5 μg/l. Similarly, a normal serum IGF-I for age and sex at last follow-up after treatment was associated with an SMR of 1.1 (95% CI 0.9–1.4) compared with an SMR of 2.5 (95% CI 1.6–4.0) for those with continued IGF-I elevation. There was a significant trend for reduced mortality in series reporting frequent use of somatostatin analogues and in studies reporting high (>70%) rates of biochemical remission after treatment.ConclusionsClinicians treating acromegalic patients should aim for random serum GH <2.5 μg/l measured by RIA (probably <1 μg/l measured by modern sensitive immunoassay) and normal serum IGF-I values, to restore the elevated mortality of the condition to normal levels.

Solitary Cardiac Low-Grade Neuroendocrine Tumor: A Case Report and Review of the Literature

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S47-S47
Author(s):  
M Kavesh ◽  
P Drew ◽  
B Stewart
Keyword(s):  
Neuroendocrine Tumor ◽  
Frozen Section ◽  
Mitotic Rate ◽  
Complete Resection ◽  
Low Grade ◽  
Primary Tumors ◽  
Radiotracer Uptake ◽  
Pet Ct ◽  
The Right

Abstract Introduction/Objective Primary tumors of the heart are uncommon; even rarer are primary cardiac neuroendocrine tumors. To our knowledge, only two cases have been described to date, both being high-grade tumors. We report a solitary low-grade neuroendocrine tumor of the heart, unexpectedly discovered on the wall of the right ventricle in a 44-year-old man during aortic valve repair for infectious bacterial endocarditis. Results Frozen section was sent intraoperatively and showed a plasmacytoid neoplasm. Final pathology of the biopsies showed a tumor composed of both cohesive and discohesive plasmacytoid cells separated by a vascular network and strands of fibrosis. Neither necrosis nor a mitotic rate greater than 2 mitoses per 2 mm2 were seen. The tumor showed strong reactivity for AE1/3, synaptophysin and CDX2 with focal reactivity for chromogranin-A and CD56, confirming the diagnosis of a low-grade neuroendocrine tumor. Both an esophagogastroduodenoscopy and colonoscopy were performed and showed no evidence of a primary gastrointestinal tumor. PET-CT DOTATATE performed after complete resection of the tumor showed no abnormal radiotracer uptake. The possibility of an intestinal neuroendocrine tumor undetected by DOTATATE PET-CT with a single known metastasis to the heart was considered. This too, on the basis of the literature, was considered exceedingly rare. Complete resection of this patient’s tumor was considered sufficient treatment; the patient was advised to follow up annually with medical oncology. Conclusion The presentation and management of a solitary cardiac low-grade neuroendocrine tumor has not previously been described in the literature.

scholarly journals Prognostic Analysis and Influencing Serum Biomarkers of Patients With Resectable Pancreatic Adenosquamous Cancer

2021 ◽  
Vol 10 ◽  
Author(s):  
Yusheng Shi ◽  
Xinjing Wang ◽  
Weize Wu ◽  
Junjie Xie ◽  
Jiabin Jin ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Survival Rate ◽  
Demographic Data ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Serum Levels ◽  
Pancreatic Disease ◽  
Normal Serum ◽  
Adenosquamous Cancer

ObjectivesThere are few reports about the survival rate of patients with pancreatic adenosquamous cancer (PASC). This study evaluated and analyzed prognostic factors of patients with resectable pancreatic adenosquamous cancer (rPASC), which might fulfill the blank in the research of PASC.MethodsIn this study, we identified and analyzed 55 patients who were diagnosed with rPASC from January 2013 to May 2019 at the Pancreatic Disease Center of the Shanghai Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine. Age, sex, BMI, tumor position, and other important demographic data were collected and analyzed. The follow-up was updated by December 31th, 2019 with a median follow-up of nine months.ResultsAmong the 55 patients, 23 (41.8%) patients were female, and the mean age was 62.0 ± 10.3 years. The median overall survival (OS) time was 10 ± 2.1 months, and the median disease-free survival (DFS) time was 4 ± 0.9 months. The 1-year, 3-year, and 5-year survival rates were 40.9, 17.5, and 11.6%, respectively. The multivariate analysis showed that normal serum level of Ca199 (HR = 0.464, 95% CI = 0.222–0.970, P = 0.041) and Ca125 (HR = 0.441, 95% CI = 0.233–0.835, P = 0.012) were independent favorable prognostic factors.ConclusionPatients with rPASC had poor survival. The 5-year survival rate was only 11.6%. Normal serum levels of Ca199 and Ca125 were independent favorable prognostic factors that predicted prognosis.

scholarly journals Neuroendocrine tumor of the ampulla of Vater with distant cystic lymph node metastasis: a case report

2016 ◽  
Vol 2 (1) ◽  
Author(s):  
Mariko Tsukagoshi ◽  
Yasuo Hosouchi ◽  
Kenichiro Araki ◽  
Yasushi Mochida ◽  
Ryusuke Aihara ◽  
...  
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Neuroendocrine Tumor ◽  
Ampulla Of Vater ◽  
Node Metastasis

A Calcitonin-Producing Neuroendocrine Tumor of the Larynx: A Case Report

1993 ◽  
Vol 79 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Luigi Insabato ◽  
Gaetano De Rosa ◽  
Luigi Maria Terracciano ◽  
Giovanni Lupoli ◽  
Daniela Montedoro ◽  
...  
Keyword(s):  
Case Report ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Carcinoma ◽  
Normal Serum ◽  
Calcitonin Level ◽  
Neck Node ◽  
Serum Calcitonin ◽  
Carcinoma Of The Larynx

A moderately differentiated neuroendocrine carcinoma of the larynx is described. Although the patient had normal serum calcitonin level 36 months before, its level was elevated at the time the neck node was removed. This study supports the hypothesis that a diagnosis of calcitonin-producing neuroendocrine tumor of the larynx with increased plasma calcitonin is possible and should be considered to avoid unnecessary thyroidectomy.

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