Treatment of Patients with Refractory Functional Dyspepsia Using Nardostachys jatamansi (D.Don) DC. Hydroalcoholic Extract: A Case Series

Functional dyspepsia (FD) is a highly prevalent condition with high impact on healthcare costs. Considering the complimentary therapies options like phytotherapy, this study aimed to investigate the efficacy and safety of Nardostachys jatamansi (D.Don) DC. extract in sixteen FD patients. The subjects received capsules of 500 mg N. Jatamansi, 3 times daily before meals for 30 days. The severity of early satiation and postprandial fullness were assessed by self-report of improvement at least 50% of symptoms and other FD symptoms assessed by Gastrointestinal Symptom Rating Scale (GSRS) before intervention and at end of treatment. The mean GSRS score level decreased significantly after intervention among study population. Five patients had chief complaint of early satiety and post prandial fullness who all of them reported 50% improvement. According to the results N. jatamansi seems to be effective in patients with refractory FD. Randomized clinical studies seem to be required.

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Topical Mastic Oil for Treatment of Functional Dyspepsia: A Randomized Triple-Blind Controlled Trial

Galen Medical Journal ◽

10.31661/gmj.v10i0.1965 ◽

2021 ◽

Vol 10 ◽

pp. 1965

Author(s):

Mahsa Baradaran Sattarzadeh ◽

Asie Shojaii ◽

Mohssen Nassiri Toosi ◽

Mehri Abdollahi-Fard ◽

Foroogh Alborzi Avanaki ◽

...

Keyword(s):

Functional Dyspepsia ◽

Epigastric Pain ◽

Controlled Trial ◽

Study Groups ◽

Control Group ◽

Test Results ◽

Postprandial Fullness ◽

Friedman's Test ◽

Early Satiation ◽

Better Than

Background: The main goal of the present study was to evaluate the effect of topical mastic oil, compared to placebo on treatment of functional dyspepsia (FD). Materials and Methods: Sixty-three patients with FD were included. Thirty-two subjects received the topical mastic oil (10 drops/TDS after meal) with massage and 31 patients received topical sesame oil with massage. Both groups received pantoprazole (40 mg daily) along with oil and massage. The severity of early satiation, postprandial fullness, epigastric pain and epigastric burning was assessed after 4 weeks using the Visual Analogue Scale (VAS) as well as frequency of symptoms. Satisfaction with the treatment was also assessed using a researcher-made questionnaire. Changes in the severity of symptoms were evaluated by Friedman’s test. Results: Mean and standard deviation of age of the subjects were equal to 36.95±13.64 and 50 (79.4%) patients were female. Both groups experienced a significant decrease in the severity of all the four symptoms (P<0.001). The percentage of decrease in the severity of early satiation was significantly higher in the mastic group than the control group (76.03±34.91% vs. 37.24±38.86%, P=0.003). No significant differences were found in the percentage of decrease in the severity of postprandial fullness, epigastric pain and burning between the study groups (P=0.05, 0.06, and 0.13, respectively). The frequency of symptoms was decreased similarly in both groups. Satisfaction with the treatment was reported to be significantly higher in the mastic group than the sesame group (P=0.01). There were no intolerable side effects in both groups. Conclusion: Mastic oil reduced early satiation better than the placebo. In addition, satisfaction with the treatment was higher in the mastic group than the sesame group. [GMJ.2021;10:e1965]

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The association between eating rate and functional dyspepsia in Iranian adults

10.21203/rs.2.23971/v1 ◽

2020 ◽

Author(s):

Parvane Saneei ◽

Ammar Hassanzadeh Keshteli ◽

Hamid Rasad ◽

Hamed Daghaghzadeh ◽

Awat Feizi ◽

...

Keyword(s):

Functional Dyspepsia ◽

Epigastric Pain ◽

Large Population ◽

Cross Sectional Study ◽

Dietary Habit ◽

Eating Rate ◽

Cross Sectional ◽

Postprandial Fullness ◽

Gastrointestinal Health ◽

Early Satiation

Abstract Objective: This study aimed to investigate the association between eating rate and functional dyspepsia (FD) in a large population of Iranian adults.Methods: In this cross-sectional study, we assessed eating rate of 4763 Iranian adults using a dietary habit questionnaire. We used a modified validated version of the Rome III questionnaire to assess gastrointestinal health. FD was defined as having one or more of the following characteristics: bothersome postprandial fullness, early satiation and/or epigastric pain or epigastric burning. Needed information on meal frequency, meal regularity, intra-meal fluid drinking as well as on other potential confounders was obtained by using a pre-tested questionnaire.Results: Functional dyspepsia was prevalent in 15.2% (n=703) of the studied population. Lunch and total eating rate was associated with greater odds of having FD(OR: 1.37; 95% CI: 1.04-1.8) and (OR: 1.45; 95% CI: 1-2.11), respectively). However, this relationship weakened after adjusting for confounding factors. No significant relationship was found between dinner eating rate and FD in both crude and adjusted models (OR: 1.23; 95% CI: 0.83-1.51). There was no significant relation between lunch, dinner or total eating rate and risk of postprandial fullness, early satiation or epigastric pain either in crude or adjusted models. Eating rate was not related to severity or frequency of FD components.Conclusions: Fast eating was associated with greater odds of FD. However, there was no association between fast eating with postprandial fullness and epigastria pain. Further studies, particularly prospective ones, are required to confirm these relations.

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Dysphagia characteristics in Huntington’s disease patients: insights from the Fiberoptic Endoscopic Evaluation of Swallowing and the Swallowing Disturbances Questionnaire

CNS Spectrums ◽

10.1017/s1092852918001037 ◽

2018 ◽

Vol 24 (04) ◽

pp. 413-418 ◽

Cited By ~ 5

Author(s):

Yael Manor ◽

Yael Oestreicher-Kedem ◽

Alona Gad ◽

Jennifer Zitser ◽

Achinoam Faust-Socher ◽

...

Keyword(s):

Huntington's Disease ◽

Huntington’S Disease ◽

Rating Scale ◽

Oropharyngeal Dysphagia ◽

Case Series ◽

Solid Food ◽

Self Report ◽

Endoscopic Evaluation ◽

Retrospective Case ◽

Tertiary Referral Center

BackgroundHuntington’s disease (HD) is a neurodegenerative disease characterized by increasing dysphagia as the disease progresses. Specific characteristics of the HD dysphagia are not well defined.ObjectiveTo characterize the swallowing disturbances of HD patients, to evaluate the feasibility of Fiberoptic Endoscopic Evaluation of Swallowing (FEES) in assessing dysphagia in HD patients, and to discern the relation between FEES findings and patients’ self-report on dysphagia symptoms and swallowing related quality of life (SWAL-QOL).MethodA retrospective case series in a tertiary referral center. All recruited HD patients underwent Bed Side Swallowing Evaluation (BSE), FEES, the Unified Huntington’s Disease Rating Scale (UHDRS), and the Montreal Cognitive Assessment (MoCA). All completed the Swallowing Disturbances Questionnaire (SDQ) and the SWAL-QOL questionnaire.ResultsFourteen HD patients were recruited. All were able to complete the FEES study. The FEES demonstrated delayed swallowing reflex, solid food residues, and pre/post swallowing spillage in most patients (50%, 53.5%, 83.3%, and 87.5%, respectively). The mean SDQ score was 13.2. Significant correlations were found between the SWAL-QOL fear of eating score; the SDQ oral, pharyngeal, and total scores; and the FEES parameters of pureed and solid food bolus flow time. Significant correlations were also found between the total UHDRS score, the volitional cough score, and the SWAL-QOL disease burden score.ConclusionHD patients exhibit prominent unique oropharyngeal dysphagia features that may serve as a marker of disease progression. The FEES and the SDQ are valuable tools for detecting these features in HD patients with swallowing disturbance.

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Impact of improvement of sleep disturbance on symptoms and quality of life in patients with functional dyspepsia

BMC Gastroenterology ◽

10.1186/s12876-021-01659-y ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Fumihiko Nakamura ◽

Shiko Kuribayashi ◽

Fumio Tanaka ◽

Noriyuki Kawami ◽

Yasuhiro Fujiwara ◽

...

Keyword(s):

Quality Of Life ◽

Sleep Disturbance ◽

Functional Dyspepsia ◽

Rating Scale ◽

Short Form ◽

Sleep Medication ◽

Gastrointestinal Symptom Rating Scale ◽

Sf 36 ◽

Gi Symptoms

Abstract Background/aims Functional dyspepsia (FD) is often comorbid with sleep disturbance. However, it is not fully understood how sleep disturbance affects the pathophysiology of FD. We aimed to investigate the relationship between FD and sleep disturbance. Methods We prospectively enrolled 20 FD patients with sleep disturbance between December 2018 and July 2019. Patients took sleep aids for 4 weeks and filled out questionnaires before and after taking sleep aids. Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Athens Insomnia Scale (AIS) were used to evaluate the severity of their sleep disturbance. Modified Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease (mFSSG), Gastrointestinal Symptom Rating Scale (GSRS), and the Japanese version of Patient Assessment of Constipation Quality of Life (JPAC-QOL) were used to evaluate the severity of GI symptoms. Short-Form 36-Item Health Survey (SF-36) was used to evaluate QOL. Pre- and post-sleep medication values of questionnaires were compared. Results Among 20 enrolled patients, 16 completed the study protocol. Zolpidem, eszopiclone, and suvorexant were administered to six, nine, and one patient, respectively. Each median total score of questionnaires (pre-/post-sleep medication, respectively) was as follows: PSQI, 10.0/8.5; ESS, 12.5/5.0; AIS, 10.0/4.0; mFSSG, 21.0/16.0; GSRS, 44.0/31.0 (Pain in GSRS, 11.0/5.0); JPAC-QOL, 26.0/15.5; SF-36, 63.9/71.9. All of these results showed statistically significant differences between pre- and post-sleep medication (p < 0.05). Conclusions Improvement of sleep disturbance by administration of sleep aids resulted in improvement of GI symptoms and QOL in patients with FD. This effect may be related to pain modification.

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Changes in the Seroprevalence of Helicobacter pylori among the Lithuanian Medical Students over the Last 25 Years and Its Relation to Dyspeptic Symptoms

Medicina ◽

10.3390/medicina57030254 ◽

2021 ◽

Vol 57 (3) ◽

pp. 254

Author(s):

Ieva Renata Jonaityte ◽

Eglė Ciupkeviciene ◽

Paulius Jonaitis ◽

Juozas Kupcinskas ◽

Janina Petkeviciene ◽

...

Keyword(s):

Helicobacter Pylori ◽

Rating Scale ◽

Western World ◽

Serological Tests ◽

Gastrointestinal Symptom Rating Scale ◽

Significant Difference ◽

Dyspeptic Symptoms ◽

Study Population ◽

H Pylori ◽

Symptom Rating

Background and Objectives: The prevalence of Helicobacter pylori infection is decreasing in the Western world, while remaining high in developing countries. There is limited up-to-date information about the prevalence of H. pylori in Central and Eastern Europe. The aim of our study was to assess the seroprevalence of H. pylori and its trend over the past 25 years among students of the Lithuanian University of Health Sciences (LUHS) and to assess its relation to dyspeptic symptoms. Materials and Methods: In the years 1995, 2012, 2016 and 2020, students from Medical and Nursing Faculties of LUHS were tested for the presence of antibodies against H. pylori by performing serological tests from finger capillary blood. In addition, in the years 2012, 2016 and 2020, the students completed a gastrointestinal symptom rating scale (GSRS) questionnaire in order to assess dyspeptic symptoms. The study population consisted of 120 students in the year 1995 (mean age—21.3 ± 1.0 years), 187 students in the year 2012 (mean age—22.4 ± 0.7 years), 262 students in the year 2016 (mean age—20.4 ± 1.0 years) and 148 students in the year 2020 (mean age—20.4 ± 1.7 years). Results: The seroprevalence for H. pylori was positive in 62 (51.7%) students in 1995, in 57 (30.4%) students in 2012, in 69 (26.3%) students in 2016 and in 21 (14.2%) students in 2020. The statistically significant difference was found between all study years, except between 2012 and 2016. There were no significant differences in frequency and intensity of upper dyspeptic symptoms between H. pylori positive and negative students. Conclusions: Over the last 25 years the seroprevalence of H. pylori among students of LUHS has decreased significantly. No consistent differences in dyspeptic symptoms among H. pylori positive and negative subgroups were found.

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AsdamarinTM relieves functional dyspepsia in healthy adults in only 7 days: A randomized, double-blind, placebo-controlled pilot study

Annals of Clinical Gastroenterology and Hepatology ◽

10.29328/journal.acgh.1001028 ◽

2021 ◽

Vol 5 (1) ◽

pp. 018-024

Author(s):

Daguet David ◽

Venkataramana Sudeep Heggar ◽

Thomas Justin V ◽

Kodimule Shyam Prasad

Keyword(s):

Placebo Group ◽

Pilot Study ◽

Functional Dyspepsia ◽

Rating Scale ◽

Short Form ◽

Health Concern ◽

Healthy Human ◽

Double Blind ◽

Double Blind Placebo ◽

Gastrointestinal Symptom Rating Scale

Functional dyspepsia (FD) is a prevalent global health concern increasing with years. Inspired by the Traditional Chinese Medicine (TCM) liver-stomach disharmony syndrome in order to find a quick natural alternative treatment, a Ferula asafoetida-Silybum marianum (Asdamarin™) combined extract has been developed and proved its rapid efficiency and its safety with a 7-day randomized, double-blind, placebo-controlled pilot study (CTRI/2018/05/013993 dated 21/05/2018) conducted on 70 healthy human volunteers (aged 18–60 years) supplemented with 250 mg / twice a day of either a placebo or Asdamarin™. Subjects were evaluated from baseline to the end of the study (EOS) through changes in Gastrointestinal Symptom Rating Scale (GSRS), changes in Glasgow Dyspepsia Severity Score (GDSS) and changes in the short form of Nepean Dyspepsia Index (NDI-SF) for Quality of Life. Compared to the baseline a significant reduction (p < 0.001) of GDSS questionnaire score was noted in the Asdamarin™ group (from 5.66 ± 3.1 at baseline to 5.09 ± 2.8 at the End Of Study (EOS)) compared to placebo group (from 2.77 ± 1.3 baseline to 2.69 ± 1.3 EOS), a significant decrease (p < 0.001) of GSRS score noted in the Asdamarin™ group (from 32.11 ± 8.6 baseline to 19.11 ± 5.4 EOS) compared to the placebo group (from 25.23 ± 3.6 baseline to 23.2 ± 4.9 EOS), and a significant reduction (p < 0.001) of NDI-SF scoring was noted in the Asdamarin™ group (from 15.74 ± 4.1 baseline to 11.54 ± 2.1 EOS) compared to placebo group (from 12.54 ± 3.2 baseline to 11.63 ± 2.6 EOS). Asdamarin™ has been found safe and very well tolerated during the study.

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Validity and Reliability of the Persian Version of Leeds Dyspepsia Questionnaire

10.31661/gmj.v8i0.1609 ◽

2019 ◽

Vol 8 ◽

Author(s):

Sepideh Batebi ◽

Abbas Masjedi Arani ◽

Mahdi Jafari ◽

Amir Sadeghi ◽

Mohsen Saberi Isfeedvajani ◽

...

Keyword(s):

Functional Dyspepsia ◽

Rating Scale ◽

Assessment Tool ◽

Clinical Care ◽

Severity Index ◽

Validity And Reliability ◽

Care Services ◽

Gastrointestinal Symptom Rating Scale ◽

Great Specificity ◽

Valid Assessment

Background: It is essential in clinical care services to measure the symptoms of functional dyspepsia both in the primary examination and treatment outcomes. No valid assessment tool is already available for functional dyspepsia in Iran. The present study aimed at evaluating the reliability, validity, and responsiveness of the Leeds dyspepsia questionnaire (LDQ). Materials and Methods: The LDQ was completed by 67 subjects with no dyspepsia symptoms and 93 subjects with certain functional dyspepsia diagnosed via endoscopy by a gastroenterologist and other clinical assessments. After definite diagnosis of functional dyspepsia, the participants were assessed by the LDQ. The psychometric characteristics of the questionnaire were then documented to investigate its reliability, validity, and responsiveness. Results: The internal consistency of the LDQ ranged from 0.80 to 0.89 and its test-retest reproducibility was 0.96. The LDQ was significantly correlated with all domains of dyspepsia symptom severity index (DSSI) and also with some of the domains of gastrointestinal symptom rating scale (GSRS). The LDQ had a sensitivity of 90.3% with a great specificity and a very good predictive validity. Moreover, a significant responsiveness to changes was observed (P<0.05). Conclusion: The LDQ is a valid, reliable, reproducible, and self-rated instrument responsive to change, which can be used to measure the frequency and severity of functional dyspepsia symptoms in clinical trials. [GMJ.2019;8:e1609]

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Diffi culties of diff erential diagnosis in functional dyspepsia

Clinical Medicine (Russian Journal) ◽

10.30629/0023-2149-2021-99-3-208-212 ◽

2021 ◽

Vol 99 (3) ◽

pp. 208-212

Author(s):

A. A. Sheptulin ◽

S. S. Kardasheva ◽

A. A. Kurbatova

Keyword(s):

Functional Dyspepsia ◽

Epigastric Pain ◽

Diagnostic Errors ◽

Postprandial Fullness ◽

Comprehensive Examination ◽

Early Satiation ◽

Rome Iv

Dyspepsia syndrome is understood as a complex of symptoms, including epigastric pain and epigastric burning, postprandial fullness and early satiation. In cases when organic diseases cannot be detected in patients as the cause of these symptoms, the term functional dyspepsia (FD) should be used. Rome IV criteria of FD in the absence of “alarm symptoms” consider it possible to make a diagnosis of FD without instrumental examination (fi rst of all, without esophagogastroduodenoscopy). The recommendations of the Russian Gastroenterological Association emphasize that this approach leads to serious diagnostic errors, and therefore the diagnosis of PD should be considered as a diagnosis of exclusion, which can be made only after a comprehensive examination of patients.

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Changes in Psychological Symptoms and Heart Rate Variability During EMDR Treatment: A Case Series of Subthreshold PTSD

Journal of EMDR Practice and Research ◽

10.1891/1933-3196.4.1.3 ◽

2010 ◽

Vol 4 (1) ◽

pp. 3-11 ◽

Cited By ~ 7

Author(s):

Alessandra Frustaci ◽

Gaetano A. Lanza ◽

Isabel Fernandez ◽

Massimo di Giannantonio ◽

Gino Pozzi

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Psychological Symptoms ◽

Trauma Exposure ◽

Case Series ◽

Self Report ◽

Holter Ecg ◽

End Of Treatment ◽

Report Symptom

Elevated psychophysiological parameters and heightened physiological reactivity to trauma-related cues are acquired changes following trauma exposure. Measuring improvement in these variables is an appropriate evaluation of outcome in treatment studies. Heart Rate Variability (HRV) is a computerized measure of physiological responsivity derived from Holter ECG recording. Four female outpatients with persistent post-traumatic symptoms and personal impairment following “small t” trauma exposure underwent a course of EMDR treatment and were assessed at baseline, end of treatment, day 30 and day 90 of follow-up, using self-report symptom scales and 90-min Holter ECG recordings. Symptom scores decreased between baseline and end of treatment, with improvement maintained at follow-up. Several HRV measures changed favorably in different recording intervals. HRV is a feasible and sensitive method to measure physiological changes in the treatment of individuals distressed by “small t” trauma. Further investigation is advisable to expand these preliminary data.

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Crisis Occurrence and Resolution in Patients with Severe and Persistent Mental Illness

Crisis ◽

10.1027/0227-5910.26.4.160 ◽

2005 ◽

Vol 26 (4) ◽

pp. 160-169 ◽

Cited By ~ 4

Author(s):

Paul S. Links ◽

Rahel Eynan ◽

Jeffrey S. Ball ◽

Aiala Barr ◽

Sean Rourke

Keyword(s):

Mental Illness ◽

Suicide Ideation ◽

Rating Scale ◽

Psychiatric Symptoms ◽

Self Report ◽

Community Treatment ◽

Persistent Mental Illness ◽

Crisis Events ◽

Symptom Distress Scale ◽

Distress Scale

Abstract. Assertive community treatment appears to have limited impact on the risk of suicide in persons with severe and persistent mental illness (SPMI). This exploratory prospective study attempts to understand this observation by studying the contribution of suicidality to the occurrence of crisis events in patients with SPMI. Specifically, an observer-rated measure of the need for hospitalization, the Crisis Triage Rating Scale, was completed at baseline, crisis occurrence, and resolution to determine how much the level of suicidality contributed to the deemed level of crisis. Second, observer-ratings of suicidal ideation, the Modified Scale for Suicide Ideation, and psychopathology and suicidality, Brief Psychiatric Rating Scale, were measured at baseline, crisis occurrence, and resolution. A self-report measure of distress, the Symptom Distress Scale, was completed at baseline, crisis occurrence, and resolution. Finally, the patients' crisis experiences were recorded qualitatively to compare with quantitative measures of suicidality. Almost 40% of the subjects experienced crisis events and more than a quarter of these events were judged to be severe enough to warrant the need for hospitalization. Our findings suggest that elevation of psychiatric symptoms is a major contributor to the crisis occurrences of individuals with SPMI; although the risk of suicide may have to be conceived as somewhat separate from crisis occurrence.

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