Single Nucleotide Polymorphisms in T-Cadherin Gene (CDH13) Have Cumulative Effect on Body Mass in Patients With Ischemic Heart Disease

Kardiologiia ◽  
2015 ◽  
Vol 11_2015 ◽  
pp. 12-15 ◽  
Author(s):  
A.V. Balatsky Balatsky ◽  
D.Yu. Konovalov Konovalov ◽  
L.M. Samokhodskaya Samokhodskaya ◽  
T.N. Kochegura Kochegura ◽  
K.A. Rubina Rubina ◽  
...  
Keyword(s):  
Heart Disease ◽  
Single Nucleotide Polymorphisms ◽  
Ischemic Heart Disease ◽  
Body Mass ◽  
Cumulative Effect ◽  
Ischemic Heart ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

scholarly journals Coagulation Factors and the Risk of Ischemic Heart Disease

2018 ◽  
Vol 11 (1) ◽  
Author(s):  
Jie V. Zhao ◽  
C. Mary Schooling
Keyword(s):  
Heart Disease ◽  
Single Nucleotide Polymorphisms ◽  
Confidence Interval ◽  
Ischemic Heart Disease ◽  
Plasminogen Activator ◽  
Odds Ratio ◽  
Coagulation Factors ◽  
Ischemic Heart ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide

Background: Coagulation plays a role in ischemic heart disease (IHD). However, which coagulation factors are targets of intervention is unclear. We assessed how genetically predicted vWF (von Willebrand factor), ETP (endogenous thrombin potential), FVIII (factor VIII), d -dimer, tPA (tissue-type plasminogen activator), and PAI (plasminogen activator inhibitor)-1 affected IHD. We similarly estimated effects on lipids to determine whether any associations were independent of lipids. Methods and Results: Separate sample instrumental variable analysis with genetic instruments, that is, Mendelian randomization, was used to obtain unconfounded estimates of effects on IHD using extensively genotyped studies of coronary artery disease/myocardial infarction, CARDIoGRAMplusC4D Metabochip (64 374 cases, 130 681 controls) and CARDIoGRAMplusC4D 1000 Genomes (60 801 cases, 123 504 controls), and on lipids using the Global Lipids Genetics Consortium Results (n=196 475). Genetically predicted ETP was positively associated with IHD (odds ratio, 1.05 per log-transformed SD; 95% confidence interval, 1.03–1.07) based on 15 single-nucleotide polymorphisms, as were vWF (odds ratio, 1.05 per SD; 95% confidence interval, 1.02–1.08) and FVIII (odds ratio, 1.06 per SD; 95% confidence interval, 1.03–1.09) based on 16 and 6 single-nucleotide polymorphisms, respectively, but the latter associations were null after considering pleiotropy. vWF and FVIII were associated with higher LDL (low-density lipoprotein) cholesterol, but not after considering pleiotropy. Genetically predicted d -dimer, tPA, and PAI-1 were not clearly associated with IHD or lipids based on 3, 3, and 5 single-nucleotide polymorphisms, respectively. Conclusions: ETP may affect IHD. Assessing the role of its drivers in more precisely phenotyped studies of IHD could be worthwhile.

scholarly journals The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

PLoS Medicine ◽  
2012 ◽  
Vol 9 (5) ◽  
pp. e1001212 ◽  
Author(s):  
Børge G. Nordestgaard ◽  
Tom M. Palmer ◽  
Marianne Benn ◽  
Jeppe Zacho ◽  
Anne Tybjærg-Hansen ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Body Mass ◽  
Disease Risk ◽  
Ischemic Heart ◽  
Mendelian Randomisation ◽  
Elevated Body Mass Index ◽  
Ischemic Heart Disease Risk ◽  
Heart Disease Risk
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