Structural-morphological changes of the connective tissue of the vaginal mucosa and perineal skin in women with stress urinary incontinence

Urologiia ◽  
2017 ◽  
Vol 5_2017 ◽  
pp. 15-20 ◽  
Author(s):  
V.N. Pavlov Pavlov ◽  
A.G. Yashchuk Yashchuk ◽  
A.A. Kazikhinurov Kazikhinurov ◽  
I.I. Musin Musin ◽  
R.M. Zauinullina Zauinullina ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Connective Tissue ◽  
Morphological Changes ◽  
Vaginal Mucosa ◽  
Perineal Skin

Role of proteoglycans in the organization of periurethral connective tissue in women with stress urinary incontinence

Maturitas ◽  
2007 ◽  
Vol 58 (4) ◽  
pp. 395-405 ◽  
Author(s):  
Elisabetta Trabucco ◽  
Marie Soderberg ◽  
Luigi Cobellis ◽  
Marco Torella ◽  
Birgitta Bystrom ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Connective Tissue

scholarly journals Morphological analysis of interstitial Cajal cells and mast cells in experimental hyperactivity bladder and stress incontinence under influence of pharmacocorrection

2018 ◽  
Vol 24 (2) ◽  
pp. 5-13
Author(s):  
O.I. Iatsyna ◽  
S.V. Vernygorodskyi ◽  
F.I. Kostyev
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Functional Activity ◽  
Morphological Changes ◽  
Bladder Wall ◽  
Experimental Models ◽  
Quantitative Composition ◽  
High Concentration ◽  
Cajal Cells ◽  
Immunohistochemical Methods

The existing data indicate the multifactorial mechanisms of development of the overactive bladder (OAB) symptom, but the issue of OAB pathogenesis remains unclear. In more recent times, the neurogenic theory of OAB genesis has being accompanied by the increasing attention to the study of morphological changes that occur in the smooth myocytes of the detrusor and their interaction with the extracellular matrix. Therefore, the objective of our study became the evaluation of distribution of interstitial Cajal cells (ICC) and basophilic granulocytes (BG) in the structural elements of the bladder wall under stress urinary incontinence and its overactivity before and after treatment with Mirabegron, Spasmex, Quercetin and combination thereof with testosterone and estradiol, using histochemical and immunohistochemical methods. The experimental models of OAB and stress urinary incontinence (SUI) presented the increase in the amount and functional activity of BG revealed by histological and immunohistochemical methods, as well as ICC at all terms of OAB monitoring, while the SUI presented with high concentration and functional activity of BG only after 14 days of the experiment. After 28 days, we observed a sharp decrease of the parameters, indicating decompensation and depletion of the functional activity. The number of ICC decreased under SUI after both 14 days and 28 days of the experiment. The group of experimental animals receiving Spasmex and its combination with hormones, presented no significant effect on the quantitative and qualitative composition of BG and ICC at OAB and SUI on Day 14 of the experiment, but the combination with testosterone demonstrated statistically reliable (p<0.001) reduction of BG and ICC expression in the muscle layer of the bladder after 14 days, and unreliable after 28 days of the experiment (p>0.05). The administration of Mirabegron alone and especially its combination with testosterone and estradiol presented positive trends in histochemical and immunohistochemical expression of BG and ICC. The experiment proved high efficacy of Quercetin in combination with testosterone and estradiol under OAB and SUI, confirmed by stabilization of the functional activity of BG and ICC quantitative composition.

scholarly journals Effect of Er:YAG Laser for Women with Stress Urinary Incontinence

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Kun-Ling Lin ◽  
Shih-Hsiang Chou ◽  
Cheng-Yu Long
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Laser Treatment ◽  
Bladder Neck ◽  
Er:Yag Laser ◽  
Female Stress Urinary Incontinence ◽  
Yttrium Aluminium Garnet ◽  
Vaginal Mucosa ◽  
Neck Mobility ◽  
Bladder Neck Mobility

Purpose. The aim of our study is to assess efficacy of noninvasive erbium-doped yttrium aluminium garnet laser (Er:YAG laser) for female stress urinary incontinence (SUI). Materials and Methods. Forty-one women with SUI were included in the study and scheduled for vaginal Er:YAG laser treatment. The procedure was performed with a 2940 nm, Er:YAG laser (Fotona Smooth ™ XS, Fotona, Ljubljana, Slovenia), designed to heat up the vaginal mucosa to around 60°C. All subjects had a baseline and 6 months’ posttreatment assessment that included perineal sonography and lower urinary tract symptoms. Results. Significant improvements in both urinary frequency and incontinence were found 6 months after Er:YAG laser treatment when compared to the baseline results (p<0.001). The battery of questionnaires administered to patients, including the UDI-6, IIQ-7, OABSS, and POPDI-6, all showed significant improvement posttreatment (P < 0.001). The treatment efficacy for the vaginal Er:YAG laser for SUI at 6 months posttreatment was 75.5% (31/41). Bladder neck mobility by perineal ultrasonography decreased significantly (16.1 ± 6.4 mm to 10.5 ± 4.6 mm) after treatment (p=0.039). No permanent adverse events were found. Conclusions. The Er:YAG vaginal laser seems to be a safe and efficacious treatment for women with mild to moderate SUI, this being partly related to the decrease of bladder neck mobility following laser treatment.

scholarly journals FEATURES OF COLLAGEN METABOLISM IN PREMENOPAUSAL WOMEN WITH STRESS URINARY INCONTINENCE ON THE BACKGROUND OF CONSERVATIVE AND LASER TREATMENT

2019 ◽  
pp. 21-30
Author(s):  
Anna Melnichenko ◽  
Maryna Puchko ◽  
Tetiana Kovaliuk ◽  
Igor Usevych
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Connective Tissue ◽  
Laser Therapy ◽  
Collagen Synthesis ◽  
Premenopausal Women ◽  
Collagen Metabolism ◽  
Average Level ◽  
Type Iii ◽  
Positive Effect

The article summarizes the arguments and counterarguments in the scientific discussion on the influence of undifferentiated connective tissue dysplasia on the development of stress urinary incontinence in premenopausal women and approaches to the treatment of this pathology. The main purpose of the study is to determine the characteristics of collagen metabolism in premenopausal women with stress urinary incontinence in order to improve treatment tactics and develop a differentiated approach to the prevention of this pathology in the future. The systematization of these literature sources and the lack of a unified approach to the treatment of stress urinary incontinence in premenopausal women showed the need to find new approaches to the treatment of this disease, which will affect the etiopathogenetic links of stress urinary incontinence in this category of gynecological patients. The relevance of the study of this pathology is that stress urinary incontinence is a problem that significantly reduces the quality of life of women in premenopause, causes isolation and self-doubt, and in certain cases can lead to psychological disorders. The methodology of the study was a prospective clinical and statistical examination, which involved 133 patients with stress urinary incontinence. Depending on the prescribed therapy observed women were divided into two groups. The main group included 57 women with premenopausal stress incontinence, which obtained laser therapy in order to correct the manifestations of the disease. A comparison group was formed by 76 premenopausal patients with stress urinary incontinence who received conservative treatment. In all patients of the examined groups, except general clinical examination we determined markers of synthesis (Total P1NP, Total P3NP) and resorption (deoxypyridinoline Pyriliks – D) of connective tissue at the initial level, immediately after treatment and after 6 months of treatment, the duration of the study was ten months. The results of a clinical study of the content of markers of synthesis and resorption of connective tissue in premenopausal women with stress urinary incontinence, which showed that this category of patients on the background of laser therapy marked a significantly positive effect obtained as a result of treatment aimed at increasing the average level of the marker of collagen synthesis type I and reducing the average level of the marker of collagen synthesis type III, as well as normalization of the average level of the marker of connective tissue resorption. The study empirically confirms and theoretically proves that the use of laser therapy is pathogenetically, because its positive effect is realized by affecting the connective tissue of the genital diaphragm, stimulating the production of collagen and type and synergistically inhibiting the production of collagen type III and Pyriliks-D. Results of the study can be useful for gynecological hospitals, General practitioners and family medicine and doctors of antenatal clinics.

Morphological substantiation of applying the Er: YAG-laser for the treatment of stress urinary incontinence in women

2014 ◽  
Vol 63 (3) ◽  
pp. 21-25 ◽  
Author(s):  
Aleksandr Aleksandrovich Bezmenko ◽  
Andrey Aleksandrovich Shmidt ◽  
Anna Andreyevna Koval ◽  
Sergey Aleksandrovich Sibirev ◽  
Zhanna Mikhaylovna Karpishchenko ◽  
...  
Keyword(s):  
Urinary Incontinence ◽  
Stress Urinary Incontinence ◽  
Connective Tissue ◽  
Stress Incontinence ◽  
Histological Changes ◽  
Yag Laser ◽  
Morphological Evaluation ◽  
Laser Technologies ◽  
Before And After ◽  
Positive Effect

The article presents the results of morphological evaluation of the vaginal tissues in women before and after treatment of stress incontinence with Er: YAG-laser (technologies IntimaLase and IncontiLase). Marked histological changes (increase of quantity and activity of fibroblasts, the increase of density of connective tissue, the emergence of neoangiogenesis plots) confirm the clinical efficacy of the method (the positive effect was obtained in 70,7 % of patients with I type of UI and 47 % with the II type of UI light and medium gravity).

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