Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study

Background: Studies conducted in elderly and frail adult populations, especially those with heart failure, have shown a consistent relationship between poor sleep and poor physical performance. Likewise, a similar association between poor sleep and lower performance has been found in extremely fit, elite athletes. However, this relationship has not been examined in healthy, middle-aged adult populations. Here, we test the cross-sectional association of daytime sleepiness with poor physical performance in our large, bi-racial cardiovascular cohort. Methods: From 2013-2016, 1,223 adults from the Bogalusa Heart Study attended follow-up visits to assess physical and cognitive performance and answer questionnaires pertaining to sleep habits. The Epworth Sleepiness Scale (ESS) was used to measure daytime sleepiness on an ordinal scale from 0-24. Short Physical Performance Battery (SPPB), which consists of chair stands, balance testing, and walk speed, was the outcome measure, with a score of <10 out of 12 being considered poor physical performance. Multivariable logistic regression, adjusted for age, race, sex, sleep duration, employment status, BMI, and symptoms of sleep apnea was used to test the association between ESS [both continuously and dichotomized to abnormal (ESS>10) vs. normal (ESS≤10)] and poor physical performance. Results: Our study population had a mean(SD) age of 48.1(5.2) and was 58.6% female and 34.7% black. Mean(SD) ESS was 6.3(4.7). 252 (20.6%) adults exhibited poor physical performance. After covariate adjustment, ESS was significantly associated with an increased risk of poor physical performance (Odds Ratio per 1 SD increase=1.17; 95% Confidence Interval=1.01-1.35; p =0.03). As a dichotomous exposure, an abnormal ESS resulted in a 53% increased risk of poor physical performance (OR=1.53; 95% CI=1.05-2.23; p =0.03). Conclusions: Even among relatively healthy middle-aged adults, daytime sleepiness appears to be associated with poor physical performance.

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Race modifies the association between animal protein metabolite 1-methylhistidine and blood pressure in middle-aged adults: the Bogalusa Heart Study

Journal of Hypertension ◽

10.1097/hjh.0000000000002571 ◽

2020 ◽

Vol 38 (12) ◽

pp. 2435-2442

Author(s):

Alexander C. Razavi ◽

Lydia A. Bazzano ◽

Jiang He ◽

Seamus P. Whelton ◽

Casey M. Rebholz ◽

...

Keyword(s):

Blood Pressure ◽

Animal Protein ◽

Middle Aged ◽

Bogalusa Heart Study ◽

Heart Study ◽

Middle Aged Adults

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The relation of BMI and skinfold thicknesses to risk factors among young and middle-aged adults: The Bogalusa Heart Study

Annals of Human Biology ◽

10.3109/03014461003641849 ◽

2010 ◽

Vol 37 (6) ◽

pp. 726-737 ◽

Cited By ~ 11

Author(s):

David S. Freedman ◽

Peter T. Katzmarzyk ◽

William H. Dietz ◽

Sathanur R. Srinivasan ◽

Gerald S. Berenson

Keyword(s):

Risk Factors ◽

Middle Aged ◽

Bogalusa Heart Study ◽

Heart Study ◽

Middle Aged Adults

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Daily consumption of milk fat globule membrane plus habitual exercise improves physical performance in healthy middle-aged adults

SpringerPlus ◽

10.1186/s40064-015-0896-8 ◽

2015 ◽

Vol 4 (1) ◽

Cited By ~ 15

Author(s):

Noriyasu Ota ◽

Satoko Soga ◽

Tadashi Hase ◽

Akira Shimotoyodome

Keyword(s):

Physical Performance ◽

Milk Fat ◽

Middle Aged ◽

Daily Consumption ◽

Milk Fat Globule Membrane ◽

Habitual Exercise ◽

Milk Fat Globule ◽

Fat Globule ◽

Middle Aged Adults

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Cross-Sectional Examination of Musculoskeletal Pain and Physical Function in a Racially and Socioeconomically Diverse Sample of Adults

The Journals of Gerontology Series A ◽

10.1093/gerona/glaa251 ◽

2020 ◽

Author(s):

Angie L Sardina ◽

Alyssa A Gamaldo ◽

Ross Andel ◽

Shanthi Johnson ◽

Tamara A Baker ◽

...

Keyword(s):

Physical Function ◽

Physical Performance ◽

Musculoskeletal Pain ◽

Performance Measures ◽

Healthy Aging ◽

Functional Limitation ◽

Future Research ◽

Middle Aged ◽

Cross Sectional ◽

Middle Aged Adults

Abstract Background Musculoskeletal pain alters physiological function, which may be evidenced as early as middle age. Previous research has concluded that middle-aged adults are a high-risk group for musculoskeletal pain and report functional limitations similar to older adults. However, few studies have examined the relationships between musculoskeletal pain and physical function, using objective performance measures in a sample of racially and socioeconomically diverse adults. Thus, this study examined musculoskeletal pain in relation to physical function in middle-aged (30–64 years) White and Black adults and investigated whether the relationship varied by sociodemographic characteristics. Methods This cross-sectional examination incorporated data from the Healthy Aging in Neighborhoods of Diversity across the Life-Span Study. Participants (n = 875) completed measures of musculoskeletal pain and objective measures of physical performance (ie, lower and upper body strength, balance, and gait abnormalities). Physical performance measures were standardized to derive a global measure of physical function as the dependent variable. Results Approximately, 59% of participants identified at least 1 pain sites (n = 518). Multivariable regression analyses identified significant relationships between greater musculoskeletal pain and poorer physical function (β = −0.07, p = .031), in mid midlife (β = −0.04, p = .041; age 40–54) and late midlife (β = −0.05, p = .027; age 55–64). Conclusions This study observed that musculoskeletal pain was associated with poorer physical function within a diverse group of middle-aged adults. Future research should longitudinally explore whether chronic musculoskeletal pain identified at younger ages is associated with greater risk for functional limitation and dependence in later life.

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O2-10-01: OMEGA-3 FATTY ACID LEVELS ARE ASSOCIATED WITH BRAIN MRI MEASURES IN MIDDLE-AGED ADULTS FROM THE FRAMINGHAM HEART STUDY

Alzheimer s & Dementia ◽

10.1016/j.jalz.2018.06.2694 ◽

2006 ◽

Vol 14 (7S_Part_11) ◽

pp. P644-P644

Author(s):

Claudia L. Satizabal ◽

Jayandra J. Himali ◽

Alexa S. Beiser ◽

Ramachandran S. Vasan ◽

Charlie S. DeCarli ◽

...

Keyword(s):

Fatty Acid ◽

Framingham Heart Study ◽

Brain Mri ◽

Omega 3 ◽

Middle Aged ◽

Omega 3 Fatty Acid ◽

Heart Study ◽

Middle Aged Adults

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Metabolites Associated with Coffee Consumption and Incident Chronic Kidney Disease

Clinical Journal of the American Society of Nephrology ◽

10.2215/cjn.05520421 ◽

2021 ◽

pp. CJN.05520421

Author(s):

William J. He ◽

Jingsha Chen ◽

Alexander C. Razavi ◽

Emily A. Hu ◽

Morgan E. Grams ◽

...

Keyword(s):

Fixed Effects ◽

Meta Analysis ◽

Coffee Consumption ◽

Cox Proportional Hazards ◽

Bile Acid Metabolism ◽

Bogalusa Heart Study ◽

Serum Metabolites ◽

Heart Study ◽

Aric Study ◽

Kidney Health

Background and objectivesModerate coffee consumption has been associated with lower risk of CKD; however, the exact biologic mechanisms underlying this association are unknown. Metabolomic profiling may identify metabolic pathways that explain the association between coffee and CKD. The goal of this study was to identify serum metabolites associated with coffee consumption and examine the association between these coffee-associated metabolites and incident CKD.Design, setting, participants, & measurementsUsing multivariable linear regression, we identified coffee-associated metabolites among 372 serum metabolites available in two subsamples of the Atherosclerosis Risk in Communities study (ARIC; n=3811). Fixed effects meta-analysis was used to pool the results from the two ARIC study subsamples. Associations between coffee and metabolites were replicated in the Bogalusa Heart Study (n=1043). Metabolites with significant associations with coffee in both cohorts were then evaluated for their prospective associations with incident CKD in the ARIC study using Cox proportional hazards regression.ResultsIn the ARIC study, mean (SD) age was 54 (6) years, 56% were daily coffee drinkers, and 32% drank >2 cups per day. In the Bogalusa Heart Study, mean (SD) age was 48 (5) years, 57% were daily coffee drinkers, and 38% drank >2 cups per day. In a meta-analysis of two subsamples of the ARIC study, 41 metabolites were associated with coffee consumption, of which 20 metabolites replicated in the Bogalusa Heart Study. Three of these 20 coffee-associated metabolites were associated with incident CKD in the ARIC study.ConclusionsWe detected 20 unique serum metabolites associated with coffee consumption in both the ARIC study and the Bogalusa Heart Study, and three of these 20 candidate biomarkers of coffee consumption were associated with incident CKD. One metabolite (glycochenodeoxycholate), a lipid involved in primary bile acid metabolism, may contribute to the favorable kidney health outcomes associated with coffee consumption. Two metabolites (O-methylcatechol sulfate and 3-methyl catechol sulfate), both of which are xenobiotics involved in benzoate metabolism, may represent potential harmful aspects of coffee on kidney health.

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