scholarly journals Genderspecific features of antioxidant protection and efficacy of atorvastatin in patients with stable forms of coronary heart disease

2017 ◽  
Vol 95 (5) ◽  
pp. 398-403
Author(s):  
K. Yu. Bondar ◽  
O. L. Belaya ◽  
O. M. Lazutina ◽  
I. S. Mikhailova ◽  
T. V. Smorkalova ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Plasma Lipids ◽  
Thiobarbituric Acid ◽  
Antioxidant Protection ◽  
Diene Conjugates ◽  
Paramagnetic Resonance ◽  
Stable Forms ◽  
Gender Specific

The gender-specific features of cardiovascular diseases (CVD) are actively being discussed which puts on the agenda the development of a differentiated approach to the treatment of cardiac diseases in men and women. Аim. To assess the gender-specific features of the antioxidant status and antioxidative activity of atorvastatin in patients with stable forms of coronary heart disease (CHD) and dyslipidemia (DLP). Material and methods. The study included 102 patients with stable forms of CHD divided into 2 groups according to sex and 40 healthy individuals. The generally accepted methods were used to determine plasma lipids, products of their peroxidation (diene conjugates, DC) and the products reacting with 2-thiobarbituric acid (TBA-RP), the antioxidant enzymes glutathione peroxidase (GP) and superoxide dismutase (SOD) in erythrocytes; the activity of the ceruloplasmin/transferrin antioxidant system (AOA AOS CP/TF) in blood plasma was measured by electron paramagnetic resonance and the final metabolites of nitric oxide with the use of the Griss reagent. The endothelial function was studied by ultrasound with the assessment of endothelium-dependent vasodilatation as described by D. Celermajer et al. (1992). All parameters were evaluated before and 6 months after the onset of the treatment. Results. The men with CHD, unlike women, underwent a reduction of AOA AOS CP/TF by 10%, SOD by 12% and GP by 19% (p<0.05) as well as excessive accumulation of DC up to 9% and TBA-RP to 11% (p<0.05). The homocysteine level in men, was 1.5 times higher (p=0.01), and that of final nitric oxide metabolites 12% lower (p=0.03) than in women. Atorvastatin administered for 6 months as a component of combined cardiac therapy more significantly increased the activity of AOS CP/TF and endothelium-dependent vasodilatation in men than in women. Conclusion. CHD is associated with significant sex differences in processes of lipid peroxidation - antioxidant protection, metabolism of nitric oxide, found, dilatation and anti-oxidation effect of atorvastatin.

scholarly journals Genderspecific differences of homocysteinemia and its influence on oxidative stress parameters and endothelial function in patients with stable forms of coronary heart disease

2017 ◽  
Vol 95 (8) ◽  
pp. 705-712
Author(s):  
Olga L. Belaya ◽  
K. Yu. Bondar ◽  
L. I. Markova ◽  
Z. V. Kuropteva ◽  
L. M. Baider ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Gas Liquid Chromatography ◽  
Men And Women ◽  
Stable Forms ◽  
Gender Specific

One of the early manifestations of atherosclerotic lesions is endothelial dysfunction developing under conditions of reduced nitric oxide production, hyperhomocysteinemia, and oxidative stress. Bearing in mind high interest shown to gender-specific peculiarities of cardiovascular diseases, it appears important to study the relationship between these features in men and women with stable forms of coronary heart disease (CHD). Material and methods. The study included 102 patients with sable COPD divided into 2 groups (men and women) and 40 practically healthy subjects. Plasma homocysteine levels were measured by high-resolution gas-liquid chromatography with fluorescent detector with the use of Eko-Novo Milikhrom A-02 apparatus (Russia). Standard methods were used to measure plasma lipids, products of their peroxidation (dienic conjugates and products reacting with 2-thibarbituric acid), antioxidant enzymes (glutathioneperoxidase, and superoxide dismutase in erythrocytes), activity of the ceruloplasmin-transferrin system (by electron paramagnetic resonance method), final metabolites of nitric oxide using the Gries reaction. The endothelial function was studies by ultrasound with the evaluation of endothelium-dependent vasodilation. Results. The mean levels of homocystein and final NO metabolites in men with stable CHD were 1.5 times higher (р=0,01) and 12% lower (р = 0,03) than in women. Endothelial dysfunction was more pronounced in men (р< 0,05). Conclusion. Patients with CHD exhibit significant gender-specific differences in blood levels of of homocystein and final NO metabolites as well as in endothelium-dependent vasoreactivity associated with intensification of lipid peroxidation and impairment of antioxidative protection.

scholarly journals Antioxidant effects of simvastatin in patients with coronary heart disease and dyslipidemia

2012 ◽  
Vol 11 (6) ◽  
pp. 16-22 ◽  
Author(s):  
N. E. Artamoshina ◽  
K. Yu. Bondar ◽  
O. L. Belaya ◽  
L. M. Bayder ◽  
Z. V. Kuropteva
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Resonance Method ◽  
Thiobarbituric Acid ◽  
Holter Monitoring ◽  
Diene Conjugates ◽  
Paramagnetic Resonance ◽  
Simvastatin Therapy ◽  
Hepatic Transaminases ◽  
Antioxidant Effects

Aim. To investigate the effects of simvastatin therapy on antioxidant enzyme activity and the correction of disturbed antioxidant status in patients with coronary heart disease (CHD) – post-infarction cardiosclerosis (PICS) – in combination with dyslipidemia (DLP). Material and methods. The study included 132 CHD patients with PICS and 20 healthy controls. All participants underwent the measurement of plasma levels of lipids, lipid peroxidation (LP) products – diene conjugates (DC) and 2-thiobarbituric acid reagents (TBAR), antioxidant enzymes – glutathione peroxidase (GP) and superoxide dismutase (SOD) in red blood cells, plasma activity of the antioxidant ceruloplasmin/transferrin system (AOS CP/TF) (electron paramagnetic resonance method), and 24-hour Holter monitoring of electrocardiogram (ECG). Results. The three-month simvastatin therapy (20 mg/day), as a component of the complex cardiac treatment, demonstrated its antioxidant effects and antiperoxidation activity in 60% of CHD patients. The subsequent therapy with 2-ethyl-6-methyl-3-hydroxypyridine sulphate (ES; 375 mg/day) and ubidecarenone (30 mg/ day) normalised the parameters of LP-antioxidant defence (AOD) and the levels of hepatic transaminases. Plasma AOS CP/TF activity inversely correlated with the duration of myocardial ischemia in CHD patients (r=-0,34; p=0,004). Conclusion. To optimise the treatment of atherogenic DLP in simvastatin-treated CHD patients, ubidecarenone and ES could be used to improve the LP-AOD parameters.

scholarly journals ROLE OF OXIDATIVE STRESS IN PATHOGENESIS AND PROGRESSION OF NON-ALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH CONCOMITANT CORONARY HEART DISEASE

2018 ◽  
Vol 18 (4) ◽  
pp. 76-79 ◽  
Author(s):  
O.S. Khukhlina ◽  
O.B. Kuzminska ◽  
T.M. Danylyshyn ◽  
O.Ye. Grinyuk ◽  
V.V. Kropyva
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Pathological Process ◽  
Reduced Form ◽  
Control Group ◽  
Antioxidant Protection ◽  
Energy Potential ◽  
Diene Conjugates ◽  
Conjugated Trienes ◽  
Group 2

The aim of the study: to investigate the state of the system of oxidant-antioxidant homeostasis in patients with NASH and comorbid coronary heart disease. Material and methods. We examined 86 patients with NASH, including 30 patients with NASH and obesity of I-II degree (group 1) and 56 patients with NASH and comorbid coronary heart disease (stable angina pectoris I-II) (group 2). The control group consisted of 30 healthy individuals of the comparable age. The average age of patients was 56,6 ± 5,74 years. Results. An essential pathogenetic factor for the onset and progression of NASH in the presence of comorbid coronary heart disease is the intensification of the processes of free radical lipids oxidation that determines the degree of activity of the pathological process in the liver: the accumulation of intermediate (isolated double bonds, diene conjugates, ketodiens and conjugated trienes) and terminal (malonic aldehyde of plasma and erythrocytes) products of lipid peroxidation against the background of disintegration of the system of antioxidant protection (reduction of the content of glutathione reduced in erythrocytes, compensatory growth of catalase activity). Insufficiency and disintegration in the system of antioxidant protection is one of the main factors resulting in the increase in metabolic intoxication, while preserving of glutathione in a reduced form is necessary to prevent the inactivation of a number of enzymes, protecting the hepatocyte membranes from the effects of oxidants. The oxidation of reduced glutathione leads to decrease in the intensity of glycolysis, lowered synthesis of ATP and decline in the energy potential of hepatocytes and cardiomyocytes that is particularly undesirable for the comorbidity of NASH and coronary heart disease.

Diet, plasma lipids, and coronary heart disease:: Author's reply

BMJ ◽  
1987 ◽  
Vol 295 (6600) ◽  
pp. 724-725
Author(s):  
J I Mann
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Plasma Lipids

Common genetic variation in the ATP-binding cassette transporter A1, plasma lipids, and risk of coronary heart disease

2007 ◽  
Vol 195 (1) ◽  
pp. e172-e180 ◽  
Author(s):  
Majken K. Jensen ◽  
Jennifer K. Pai ◽  
Kenneth J. Mukamal ◽  
Kim Overvad ◽  
Eric B. Rimm
Keyword(s):  
Coronary Heart Disease ◽  
Genetic Variation ◽  
Heart Disease ◽  
Plasma Lipids ◽  
Atp Binding ◽  
Common Genetic Variation ◽  
Atp Binding Cassette Transporter ◽  
Atp Binding Cassette
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