scholarly journals Combined Use of Hyaluronic Acid with Nano-bioactive Glass Enhanced BiocementBased Silicate Stimulated Bone Regenerative Capacity in Tibial Bone Defects of Rabbits: In-Vivo Study

2021 ◽  
pp. 5033-5038
Author(s):  
Fatema Aziz Al-Sayed ◽  
Keyword(s):  
Hyaluronic Acid ◽  
Bioactive Glass ◽  
Bone Defects ◽  
In Vivo Study ◽  
Regenerative Capacity ◽  
Tibial Bone ◽  
Combined Use

scholarly journals COMBINED USE OF HYALURONIC ACID WITH NANO-BIOACTIVE GLASS ENHANCED BIOCEMENT BASED SILICATE STIMULATED BONE REGENERATIVE CAPACITY IN TIBIAL BONE DEFECTS OF RABBITS: IN-VIVO STUDY

2021 ◽  
Vol 9 (5) ◽  
pp. 630-638
Author(s):  
Fatema Aziz Al-Sayed ◽  
◽  
Radwa Hamed Hegazy ◽  
Zeinab Amin Salem ◽  
Hanan Hassan El-Beheiry ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Bioactive Glass ◽  
Bone Regeneration ◽  
Bone Defects ◽  
Bone Area ◽  
Regenerative Capacity ◽  
Tibial Bone ◽  
Group 3 ◽  
Area Percentage ◽  
Group 1

An ideal biomaterial for bone regeneration is a longstanding quest nowadays. This study aimed to evaluate the osteogenic potentiality of nano-bioactive glass enhanced biocement based silicate with or without hyaluronic acid seeded in rabbits’ tibial bone defects. For this, 24 male rabbits with two 5 mm defects (1 defect per tibia) were divided into three equal groups. Among the predefined three groups, for the rabbits of group 1(control) bone defects were left untreated while for the members of group 2 defects received nano-bioactive glass enhanced biocement based silicate cement, and group 3 defects received nano-bioactive glass cement mixed with hyaluronic acid. Animals of each group were divided equally for euthanization after 3 and 6 weeks. Bone specimens were processed and examined histologically with histomorphometrically analysis of new bone area percentage. The bone defects in group 3 showed significantly improved osseous healing histologically as compared to the group 1&2. The morphometric analysis also revealed a significant increase in the new bone area percentage in group 3 as compared to the group 1 and 2 (P < 0.05). The results of the present study can be concluded that bone defects could be treated with nano-bioactive glass and hyaluronic acid cement. Although, nano-bioactive glass alone was capable of bone regeneration the combination of both had significant regenerative capacity.

Effect of Low-Level Laser on the Healing of Bone Defects Filled with Autogenous Bone or Bioactive Glass: In Vivo Study

2018 ◽  
Vol 33 (1) ◽  
pp. 169-174 ◽  
Author(s):  
Guilherme Moreira ◽  
Patrick Alves ◽  
Luis Esper ◽  
Michyele Sbrana ◽  
Gisele Dalben ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Defects ◽  
In Vivo Study ◽  
Autogenous Bone ◽  
Low Level ◽  
Low Level Laser ◽  
Level Laser

Regeneration of Bone Defects Using Bioactive Glass Combined with Adipose-derived Mesenchymal Stem Cells. An experimental in vivo study

2019 ◽  
Vol 70 (6) ◽  
pp. 1983-1987
Author(s):  
Cristian Trambitas ◽  
Anca Maria Pop ◽  
Alina Dia Trambitas Miron ◽  
Dorin Constantin Dorobantu ◽  
Flaviu Tabaran ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Bioactive Glass ◽  
Bone Repair ◽  
Bone Defects ◽  
Calvarial Bone ◽  
Specific Protocol ◽  
Repair Mechanisms ◽  
Male Wistar Rats

Large bone defects are a medical concern as these are often unable to heal spontaneously, based on the host bone repair mechanisms. In their treatment, bone tissue engineering techniques represent a promising approach by providing a guide for osseous regeneration. As bioactive glasses proved to have osteoconductive and osteoinductive properties, the aim of our study was to evaluate by histologic examination, the differences in the healing of critical-sized calvarial bone defects filled with bioactive glass combined with adipose-derived mesenchymal stem cells, compared to negative controls. We used 16 male Wistar rats subjected to a specific protocol based on which 2 calvarial bone defects were created in each animal, one was filled with Bon Alive S53P4 bioactive glass and adipose-derived stem cells and the other one was considered control. At intervals of one week during the following month, the animals were euthanized and the specimens from bone defects were histologically examined and compared. The results showed that this biomaterial was biocompatible and the first signs of osseous healing appeared in the third week. Bone Alive S53P4 bioactive glass could be an excellent bone substitute, reducing the need of bone grafts.

scholarly journals Guided bone regeneration of chronic non‐contained bone defects using a volume stable porous block TiO2 scaffold: An experimental in vivo study

2021 ◽  
Author(s):  
Minh Khai Le Thieu ◽  
Håvard Jostein Haugen ◽  
Javier Sanz‐Esporrin ◽  
Mariano Sanz ◽  
Ståle Petter Lyngstadaas ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defects ◽  
Guided Bone Regeneration ◽  
In Vivo Study ◽  
Porous Block

Vascular Supply and Bone Marrow Concentrate for the Improvement of Allograft in Bone Defects: A Comparative In Vivo Study

2020 ◽  
Vol 252 ◽  
pp. 1-8
Author(s):  
Marco Cavallo ◽  
Melania Maglio ◽  
Annapaola Parrilli ◽  
Stefania Pagani ◽  
Lucia Martini ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Defects ◽  
Vascular Supply ◽  
In Vivo Study ◽  
Bone Marrow Concentrate

Bone regeneration in long-bone defects: tissue compartmentalisation? In vivo study on bone defects in sheep

Injury ◽  
2009 ◽  
Vol 40 ◽  
pp. S95-S102 ◽  
Author(s):  
Kaj Klaue ◽  
Ulf Knothe ◽  
Christoph Anton ◽  
Dominik H Pfluger ◽  
Martin Stoddart ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Bone Defects ◽  
In Vivo Study ◽  
Long Bone
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