scholarly journals THE ROLE OF ANGIOPOIETIN-LIKE PROTEINS IN THE DEVELOPMENT OF RENAL DYSFUNCTION IN PATIENTS WITH RHEUMATOID ARTHRITIS AND METABOLIC CHANGES

2020 ◽  
Vol 76 (4) ◽  
pp. 37-41
Author(s):  
V.A. Aleksandrov ◽  
◽  
L.N. Shilova ◽  
A.V. Aleksandrov ◽  
◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Renal Dysfunction ◽  
Estimated Glomerular Filtration Rate ◽  
Average Duration ◽  
Metabolic Changes ◽  
Average Strength ◽  
Two Factors ◽  
Key Factor ◽  
The Relationship

The article is devoted to the assessment of the relationship between the serum concentrations of angiopoietin-like proteins of types 3 and 4 (ANGPTL 3 and 4) and the development of renal dysfunction in patients with rheumatoid arthritis (RA) with metabolic changes. We examined 158 patients with RA (91,8 % – women and 8,2 % – men) aged 21 to 80 years old with the average duration of diseases – 9 [4–15] years. Negative correlations of average strength between the indices of the estimated glomerular filtration rate (eGFR) according to the 2009 CKD-EPI formula and the level of ANGPTL 3 (r = –0,32, p < 0,001) and ANGPTL 4 (rS = –0,31, p < 0,001) were revealed. It was found that renal dysfunction and the presence of metabolic syndrome (R 2 = 0,33) are the two factors which have a direct effect on the ANGPTL 4 concentration in RA patients’ serum. ANGPTL type 4 should be considered as a key factor linking the development of renal dysfunction and metabolic changes caused by rheumatoid inflammation

Iranian Coaches Forgiveness and Relationship Quality to Their Athletes

2021 ◽  
pp. 1-8
Author(s):  
Hassan Gharayagh Zandi ◽  
Sahar Zarei ◽  
Mohammad Ali Besharat ◽  
Davoud Houminiyan sharif abadi ◽  
Ahmad Bagher Zadeh
Keyword(s):  
Relationship Quality ◽  
Structural Equation ◽  
Equation Modeling ◽  
Data Sets ◽  
Mediating Role ◽  
Interpersonal Behaviors ◽  
Key Factor ◽  
The Relationship

Coaching has often been viewed as a context within which coaches operate to largely bring about changes in athlete’s performance and flourishing. One key factor to successful outcomes in coaching is the quality of the relationship between coaches and athletes. The coach–athlete relationship is at the heart of coaching; however, limited studies have been conducted on its antecedents. The aim of this study was to investigate the relationship between coaches’ forgiveness and perceived relationship quality toward their athletes through verifying the mediating role of interpersonal behaviors of coaches. A total of 270 Iranian coaches participated in the survey, and the data sets were analyzed using structural equation modeling. Results revealed that forgiveness positively predicted the coaches’ perceived relationship quality with their athletes, and this pathway was mediated by the coaches’ interpersonal behaviors.

Enhancing radical innovation performance through intellectual capital components

2017 ◽  
Vol 18 (4) ◽  
pp. 789-806 ◽  
Author(s):  
Lara Agostini ◽  
Anna Nosella
Keyword(s):  
Intellectual Capital ◽  
Radical Innovation ◽  
Innovation Performance ◽  
Content Type ◽  
Key Factor ◽  
Ic Testing ◽  
And Performance ◽  
The Impact ◽  
The Relationship

Purpose In today’s knowledge economy the ability to innovate and develop new products is a key factor to sustain firm performance. Within this context, analysing the role of different components of intellectual capital (IC) becomes of foremost importance, as well as an under-investigated issue for small- and medium-sized enterprises (SMEs). The purpose of this paper is to investigate the impact of human, organisational and relational capital (RC) on radical innovation performance (RIP), as well as to examine whether organisational capital (OC) and RC mediate the relationship between human capital (HC) and RIP and whether OC moderates the relationship between RC and RIP. Design/methodology/approach The methodology consisted of a factor analysis and different regression models to test for mediation and moderation. The analyses are carried out on a sample of 150 micro firms and SMEs involved in the production of machinery or instruments and located in Italy. Findings Results show that HC is directly associated to RIP, as well as OC and RC that totally mediate the relationship between HC and RIP. Moreover, OC positively moderates the relationship between RC and RIP. Originality/value This study is particularly interesting because it adopts an overarching perspective on IC testing the interplay between the different components of IC. In addition, it focusses on the SME context which is under-investigated as far as IC and performance measurement is concerned.

scholarly journals Internal R&D and Acquisition Performance of Chinese Pharmaceutical Firms: Moderation Effect of Acquisition Motive and Corporate Ownership

Processes ◽  
2019 ◽  
Vol 7 (5) ◽  
pp. 292 ◽  
Author(s):  
Qi Yue ◽  
Xing Hua ◽  
Jianyuan Li
Keyword(s):  
Path Dependence ◽  
Corporate Ownership ◽  
Acquisition Performance ◽  
Moderation Effect ◽  
Pharmaceutical Firms ◽  
Key Factor ◽  
Negative Effect ◽  
The Impact ◽  
The Relationship

Although corporate capability has been recognized as a key factor affecting corporate acquisition performance, the role of R&D capability in acquisition performance has not been fully explained. The aim of this paper was to research the impact of internal R&D on acquisition performance according to a sample of 215 acquisitions of Chinese listed pharmaceutical companies from 2012 to 2016. First, it was found that R&D has a significant negative effect on acquisition performance. Furthermore, it was confirmed that the acquisition motive and the ownership of the acquiring firm have a moderating effect on the relationship between R&D and acquisition performance. Compared to non-technical acquisitions, the negative effect of internal R&D on acquisition performance was reduced for technical acquisitions. Compared with non-state-owned-enterprise acquisition, the negative effect of internal R&D on the acquisition performance of state-owned enterprises was weakened. Our study enriches the research of the path dependence theory on the acquisition performance of enterprises and also the interpretation of acquisition performance on the basis of internal and external innovation and the institutional theory.

scholarly journals The influence of a peritoneovenous shunt for cirrhotic and malignant intractable ascites on renal function

2018 ◽  
Vol 7 (3) ◽  
pp. 205846011876420 ◽  
Author(s):  
Takafumi Segawa ◽  
Kenichi Kato ◽  
Kazuya Kawashima ◽  
Tomohiro Suzuki ◽  
Shigeru Ehara
Keyword(s):  
Renal Function ◽  
Liver Cirrhosis ◽  
Renal Dysfunction ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Intractable Ascites ◽  
Peritoneovenous Shunt ◽  
Catheter Obstruction ◽  
Peritoneovenous Shunts ◽  
The Relationship

Background Peritoneovenous shunts (PVS) are widely used for palliation of intractable ascites caused by peritoneal carcinomatosis (PC) or liver cirrhosis (LC). Some patients who need PVS have renal dysfunction. However, renal dysfunction is considered a relative contraindication. Therefore, it is important to assess renal function before PVS placement. Purpose To evaluate the relationship between PVS and renal function. Material and Methods Between October 2007 and July 2015, 60 patients (PC = 47; LC = 10; others = 3) underwent PVS placement for intractable ascites. Changes in estimated glomerular filtration rate (eGFR) and other adverse events (AEs) were retrospectively analyzed. Results Changes in eGFR before, one day after, and one week after PVS placement could be evaluated in 46 patients. The median eGFR before, one day after, and one week after was 56.5, 59.1, and 64.7 mL/min/1.73 m2, respectively ( P < 0.05). These values were 61.6, 72, and 67.1 mL/min/1.73 m2, respectively, in PC patients (n = 34; P < 0.05) and 28.5, 27, and 37.2 mL/min/1.73 m2, respectively, in LC patients (n = 10; P < 0.05). In 17 patients with moderate to severe renal dysfunction (eGFR < 45), these values were 23.4, 23.7, and 30.5 mL/min/1.73 m2, respectively. The most frequent AE was PVS catheter obstruction, which occurred in 12 patients (20.7%). Clinical disseminated intravascular coagulation occurred in six patients (10.3%) and caused death in three patients (5.2%). Conclusion PVS placement for intractable ascites is associated with various AEs. However, PVS appeared to promote renal function, especially in patients with renal impairment.

Is it really a mediating construct?

2002 ◽  
Vol 21 (3) ◽  
pp. 170-183 ◽  
Author(s):  
Abubakr M.T. Suliman
Keyword(s):  
Organizational Commitment ◽  
Controversial Issues ◽  
Continuance Commitment ◽  
Mediating Role ◽  
Industrial Companies ◽  
Two Factors ◽  
And Performance ◽  
The Relationship ◽  
Self Administered Questionnaire

This paper aims at exploring the mediating role of organizational commitment that continues to be one of the most controversial issues in HRM. Using a self‐administered questionnaire, 1,000 employees from 20 industrial companies were randomly selected and surveyed in order to examine this mediating role. The results revealed that organizational commitment and its two factors (normative and continuance commitment) play different roles in mediating the relationship between perceived work climate and performance, as rated by the employees themselves and their immediate supervisors. The implications of the results for both managers and researchers are also discussed in the paper.

The family and compliance in schizophrenia: the influence of clinical variables, relatives' knowledge and expressed emotion

2002 ◽  
Vol 33 (1) ◽  
pp. 91-96 ◽  
Author(s):  
W. SELLWOOD ◽  
N. TARRIER ◽  
J. QUINN ◽  
C. BARROWCLOUGH
Keyword(s):  
Social Functioning ◽  
Expressed Emotion ◽  
Family Intervention ◽  
Psychotic Symptoms ◽  
Number Of Factors ◽  
The Family ◽  
Two Factors ◽  
The Subject ◽  
The Relationship

Background. A variety of factors are related to compliance with medication in schizophrenia, but little attention has been paid to the role of families. Carers' knowledge or expressed emotion (EE) may be related to compliance. The aim of the present study was to evaluate the relevance of these two factors, as well as their relationships with other variables for the prediction of compliance.Method. A sample of patient–carer pairs (N=79) involved in a family intervention for schizophrenia trial was recruited. Compliance, symptoms, social functioning and attitudes to their carers were assessed in patients. Carers' EE, knowledge and psychopathology were also evaluated.Results. A number of factors were related to compliance, including carers' EE and patients' psychotic symptoms, which contributed independently to not taking medication. Carers' knowledge about schizophrenia and other groups of symptoms was not related to compliance.Conclusions. EE may be an important factor to account for in the understanding of patients' compliance and the direction of the relationship between EE and compliance should be the subject of further study.

scholarly journals Local international conflicts in the age of globalization and contemporary Russia

2019 ◽  
Vol 5 (1) ◽  
pp. 38-46
Author(s):  
Aleksey Gawrilienkov
Keyword(s):  
Decision Making ◽  
International Relations ◽  
International System ◽  
International Conflicts ◽  
Key Factor ◽  
The Relationship

The article discusses the relationship between the occurrence of international conflicts and the desire of states to implement their own geopolitical interests. The key factor in the emergence of conflicts is the concept of an inter-civilization clash by Samuel Huntington, where the role of states in the formation of the international system is the trigger for decision-making. The author states that in modern conditions Russia defends its interests, which should not be perceived by other actors of international relations as a threat, but as competition.

scholarly journals Transformational Changes and Sustainability: From the Perspective of Identity, Trust, Commitment, and Withdrawal

2019 ◽  
Vol 11 (11) ◽  
pp. 3159 ◽  
Author(s):  
Ambreen Malik ◽  
Muhammad Naseer Akhtar ◽  
Usman Talat ◽  
Kirk Chang
Keyword(s):  
Organizational Identification ◽  
Affective Commitment ◽  
Sustainable Change ◽  
Commitment To Change ◽  
Overall Justice ◽  
Withdrawal Behavior ◽  
Key Factor ◽  
Relationship Of ◽  
The Relationship

Drawing upon the psychology of sustainability, effective organizations can create a sense of belongingness for people, and successfully facilitate growth and development activities for both individuals as well as the organization itself. Extending the recommendations of Zappala, Toscano, and Licciardello, the current study considers a range of variables. The role of overall justice judgements and change favorableness are taken as predictors of affective commitment to change and exit-based withdrawal. The relationship is mediated by organizational identification and moderated by trust in organization. Overall, the results support the hypothesized relationships. Specifically, findings showed that both change favorableness and overall justice judgements are positively related to affective commitment to change and negatively related to exit-based withdrawal. Organizational identification mediates the relationships between overall justice judgements–affective commitment to change, change favorableness–affective commitment to change, and change favorableness–exit-based withdrawal, whilst trust in organizations moderated the direct relationship between overall justice judgements–affective commitment to change, and change favorableness–exit-based withdrawal. Furthermore, the indirect effect of trust in organizations positively moderated the relationship of overall justice judgements and change favorableness with affective commitment to change, and at the same time, it negatively moderated the relationship between change favorableness and exit-based withdrawal via organizational identification. Crucially, for practitioners, this brings trust of employees as a key factor that should be managed to ensure sustainable change. Both trust and identity appear important in improving commitment and lowering the exit-based withdrawal behavior of employees. Future recommendations, implications, and limitations are discussed.

scholarly journals Influence of Implicit Followership Cognitive Differences on Innovation Behavior: An Empirical Analysis in China

2020 ◽  
Vol 12 (12) ◽  
pp. 4940
Author(s):  
Wei Liang ◽  
Tingyi Li ◽  
Li Lu ◽  
Jaehyoung Kim ◽  
Sanggyun Na
Keyword(s):  
Empirical Research ◽  
Formation Mechanism ◽  
Organizational Innovation ◽  
Market Competition ◽  
Individual Performance ◽  
Mediating Effect ◽  
Key Factor ◽  
The Relationship ◽  
Innovation Behavior

The innovation behavior (IB) of followers is vital for individuals and organizations. It is not only an important part of individual performance but also an essential foundation of organizational innovation. In general, understanding the formation mechanism of followers’ IB could enhance organizational innovation performance and sustainable competitiveness. The innovation of this study includes the following points. First, in the previous research on the antecedent variables of the IB of followers, the key factor of implicit follow cognitive difference (IFCD) was not examined. We add this key factor to the independent variables of our formation mechanism. Second, in the relationship between IFCD and followers’ IB, we investigate the mediating role of psychological empowerment (PE) and the moderating role of person-organization Fit (P-O Fit), further shown as a mediation model with moderating variables. Third, this study adopts a longitudinal research design, and the data were obtained from 1:1 matched leaders and their followers of large and medium-sized enterprises in China. To avoid deviation in the homologous method, this study gathers data at three-month intervals to ensure that leadership’s influence on followers is effective. In this study, Amos 24.0 and SPSS 24.0 are used for empirical research. The results show IFCD has a negative effect on the IB of followers; PE has a partial mediating effect on the relationship between IFCD and IB of followers; P-O Fit plays a positive regulatory role in the relationship between IFCD and PE, and P-O Fit moderates the mediating effect of PE on the relationship between IFCD and IB. Based on our empirical research, we put forward some feasible suggestions for company managers to increase sustainability in market competition by promoting the formation of the IB of followers.

Perspectives for change in Tunisia, Egypt and Syria: the military factor and implications of previous authoritarian regimes

2014 ◽  
Vol 7 (4) ◽  
pp. 544-564 ◽  
Author(s):  
Federico Battera
Keyword(s):  
Political Party ◽  
Authoritarian Regimes ◽  
The State ◽  
The Political ◽  
Clear Separation ◽  
Key Factor ◽  
To Come ◽  
The Military ◽  
The Relationship

This article argues that differences in Arab authoritarian regimes were mainly linked to the relationship between the state, the political party in power and the military. By exploring such differences in Tunisia, Egypt and Syria prior to the 2011 crisis, they are explained in the context of the political changes that ensued in the wake of the crisis. How the army played the dual role of instigating change while impeding it at crucial points in the transitional process is described. The mutual lack of autonomy between the state, the party and the military appears to have been a key factor in impeding change, whereas a clear separation of the functions of these institutions was more likely to enable political change to come about.

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