scholarly journals Insights into mechanisms of tumor dissemination from circulating tumor cell lines of small cell lung cancer

2016 ◽  
Vol 2 (12) ◽  
pp. 446 ◽  
Author(s):  
Gerhard Hamilton ◽  
Barbara Rath
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Circulating Tumor Cell ◽  
Small Cell ◽  
Tumor Cell Lines ◽  
Small Cell Lung ◽  
Tumor Dissemination

scholarly journals Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines

2019 ◽  
Vol 38 (4) ◽  
pp. 946-955
Author(s):  
Maximilian Hochmair ◽  
Barbara Rath ◽  
Lukas Klameth ◽  
Ernst Ulsperger ◽  
Christoph Weinlinger ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Circulating Tumor Cell ◽  
Small Cell ◽  
Tumor Cell Lines ◽  
Small Cell Lung

scholarly journals Anticancer Activity of Fascaplysin against Lung Cancer Cell and Small Cell Lung Cancer Circulating Tumor Cell Lines

Marine Drugs ◽  
2018 ◽  
Vol 16 (10) ◽  
pp. 383 ◽  
Author(s):  
Barbara Rath ◽  
Maximilian Hochmair ◽  
Adelina Plangger ◽  
Gerhard Hamilton
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cancer Cell ◽  
Cell Lung Cancer ◽  
Circulating Tumor Cell ◽  
Small Cell ◽  
Tumor Cell Lines ◽  
Lung Cancer Cell ◽  
Small Cell Lung

Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The cytotoxic activity of fascaplysin was studied using lung cancer cell lines, primary Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) cells, as well as SCLC circulating tumor cell lines (CTCs). This compound exhibited high activity against SCLC cell lines (mean IC50 0.89 µM), as well as SCLC CTCs as single cells and in the form of tumorospheres (mean IC50 0.57 µM). NSCLC lines showed a mean IC50 of 1.15 µM for fascaplysin. Analysis of signal transduction mediators point to an ATM-triggered signaling cascade provoked by drug-induced DNA damage. Fascaplysin reveals at least an additive cytotoxic effect with cisplatin, which is the mainstay of lung cancer chemotherapy. In conclusion, fascaplysin shows high activity against lung cancer cell lines and spheroids of SCLC CTCs which are linked to the dismal prognosis of this tumor type. Derivatives of fascaplysin may constitute valuable new agents for the treatment of lung cancer.

Expression of the Atrial Natriuretic Factor Gene in small Cell Lung Cancer Tumors and Tumor Cell Lines

1990 ◽  
Vol 82 (4) ◽  
pp. 305-310 ◽  
Author(s):  
D. P. Bliss ◽  
J. F. Battey ◽  
R. I. Linnoila ◽  
M. J. Birrer ◽  
A. F. Gazdar ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Atrial Natriuretic Factor ◽  
Small Cell ◽  
Tumor Cell Lines ◽  
Small Cell Lung ◽  
Factor Gene

MYC family DNA amplification in 126 tumor cell lines from patients with small cell lung cancer

1996 ◽  
Vol 63 (S24) ◽  
pp. 210-217 ◽  
Author(s):  
Bruce E. Johnson ◽  
Edward Russell ◽  
Alfreda M. Simmons ◽  
Ruby Phelps ◽  
Seth M. Steinberg ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Tumor Cell ◽  
Small Cell Lung Cancer ◽  
Cell Lines ◽  
Cell Lung Cancer ◽  
Dna Amplification ◽  
Small Cell ◽  
Tumor Cell Lines ◽  
Small Cell Lung
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