scholarly journals Aloe-emodin inhibits the proliferation, migration, and invasion of melanoma cells via inactivation of the Wnt/beta-catenin signaling pathway

2021 ◽  
Vol 9 (23) ◽  
pp. 1722-1722
Author(s):  
Maotao Du ◽  
Pan Shen ◽  
Ranjing Tan ◽  
Dengyan Wu ◽  
Shenghao Tu
Keyword(s):  
Signaling Pathway ◽  
Melanoma Cells ◽  
Migration And Invasion ◽  
Beta Catenin ◽  
Aloe Emodin

scholarly journals WNT1 Inducible Signaling Pathway Protein 1 (WISP1) stimulates melanoma cell invasion and metastasis by promoting epithelial – mesenchymal transition

2018 ◽  
Author(s):  
Wentao Deng ◽  
Audry Fernandez ◽  
Sarah L. McLaughlin ◽  
David J. Klinke
Keyword(s):  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Primary Melanoma ◽  
Gene Expression Signature ◽  
Melanoma Cells ◽  
Migration And Invasion ◽  
Matricellular Protein ◽  
Invasion And Metastasis ◽  
Mesenchymal Transition

ABSTRACTBesides intrinsic changes, malignant cells release soluble signals to reshape their microenvironment. Among the signaling factors is WNT1 inducible signaling pathway protein 1 (WISP1), a secreted matricellular protein that is elevated in a variety of cancers including melanoma and is associated with reduced overall survival of patients diagnosed with primary melanoma. In this work, we found thatWISP1knockout both increased cell proliferation and repressed wound healing, migration and invasion of mouse and human melanoma cells in an ensemble ofin vitroassays.In vivometastasis assays showed that WISP1 knockout repressed tumor metastasis in both C57BL/6Ncrl and NOD-scid IL2Rgammanull (NSG) mice with B16F10 and YUMM1.7 melanoma cells. Mechanistically, B16F10 cells that invaded in a transwell assay possessed a gene expression signature similar to Epithelial - Mesenchymal Transition (EMT), including coincident repression of E-cadherin and induction of fibronectin and N-cadherin. Upon WISP1 knockout, these EMT signature genes went in opposite directions in both mouse and human cell lines and were rescued by media containing WISP1 or recombinant WISP1 protein.In vivo,metastasis repression by WISP1 knockout was reversed by the reintroduction of either WISP1 or SNAI1. A set of EMT gene activation and inhibition experiments using recombinant WISP1 or kinase inhibitors in B16F10 and YUMM1.7 cells suggested that WISP1 activates Akt and MAP kinase signaling pathways to shift melanoma cells from a proliferative to invasive phenotype. Collectively, the results supported a model that WISP1 within the tumor microenvironment stimulates melanoma invasion and metastasis by promoting an EMT-like process.

scholarly journals ACBP suppresses the proliferation, migration, and invasion of colorectal cancer via targeting Wnt/beta-catenin signaling pathway

2021 ◽  
Vol 137 ◽  
pp. 111209
Author(s):  
Xin Tong ◽  
Zhuochen Zhuang ◽  
Xianjue Wang ◽  
Xiaoyu Yang ◽  
Liping Bai ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Signaling Pathway ◽  
Migration And Invasion ◽  
Beta Catenin

scholarly journals Inhibition of Migration and Invasion in Melanoma Cells by β-Escin via the ERK/NF-κB Signaling Pathway

2018 ◽  
Vol 41 (10) ◽  
pp. 1606-1610
Author(s):  
HyeongSeob Kwak ◽  
Hongyan An ◽  
Md Badrul Alam ◽  
Won-Sik Choi ◽  
Sang Yong Lee ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Melanoma Cells ◽  
Migration And Invasion

scholarly journals Thy-1 (CD90)-Induced Metastatic Cancer Cell Migration and Invasion Are β3 Integrin-Dependent and Involve a Ca2+/P2X7 Receptor Signaling Axis

2021 ◽  
Vol 8 ◽  
Author(s):  
Marianne Brenet ◽  
Samuel Martínez ◽  
Ramón Pérez-Nuñez ◽  
Leonardo A. Pérez ◽  
Pamela Contreras ◽  
...  
Keyword(s):  
Cell Migration ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
P2x7 Receptor ◽  
Melanoma Cells ◽  
Migration And Invasion ◽  
Cancer Cell Migration ◽  
Cell Migration And Invasion ◽  
Signaling Axis

Cancer cell adhesion to the vascular endothelium is an important step in tumor metastasis. Thy-1 (CD90), a cell adhesion molecule expressed in activated endothelial cells, has been implicated in melanoma metastasis by binding to integrins present in cancer cells. However, the signaling pathway(s) triggered by this Thy-1-Integrin interaction in cancer cells remains to be defined. Our previously reported data indicate that Ca2+-dependent hemichannel opening, as well as the P2X7 receptor, are key players in Thy-1-αVβ3 Integrin-induced migration of reactive astrocytes. Thus, we investigated whether this signaling pathway is activated in MDA-MB-231 breast cancer cells and in B16F10 melanoma cells when stimulated with Thy-1. In both cancer cell types, Thy-1 induced a rapid increase in intracellular Ca2+, ATP release, as well as cell migration and invasion. Connexin and Pannexin inhibitors decreased cell migration, implicating a requirement for hemichannel opening in Thy-1-induced cell migration. In addition, cell migration and invasion were precluded when the P2X7 receptor was pharmacologically blocked. Moreover, the ability of breast cancer and melanoma cells to transmigrate through an activated endothelial monolayer was significantly decreased when the β3 Integrin was silenced in these cancer cells. Importantly, melanoma cells with silenced β3 Integrin were unable to metastasize to the lung in a preclinical mouse model. Thus, our results suggest that the Ca2+/hemichannel/ATP/P2X7 receptor-signaling axis triggered by the Thy-1-αVβ3 Integrin interaction is important for cancer cell migration, invasion and transvasation. These findings open up the possibility of therapeutically targeting the Thy-1-Integrin signaling pathway to prevent metastasis.

scholarly journals Baicalein Inhibits the Migration and Invasion of B16F10 Mouse Melanoma Cells through Inactivation of the PI3K/Akt Signaling Pathway

2017 ◽  
Vol 25 (2) ◽  
pp. 213-221 ◽  
Author(s):  
Eun-Ok Choi ◽  
Eun-Ju Cho ◽  
Jin-Woo Jeong ◽  
Cheol Park ◽  
Su-Hyun Hong ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Melanoma Cells ◽  
Akt Signaling ◽  
Migration And Invasion ◽  
Akt Signaling Pathway ◽  
Mouse Melanoma

scholarly journals SFRP5 inhibits the migration and invasion of melanoma cells through Wnt signaling pathway

2018 ◽  
Vol Volume 11 ◽  
pp. 8761-8772 ◽  
Author(s):  
Yangmei Chen ◽  
Daopei Zou ◽  
Nan Wang ◽  
Tao Tan ◽  
Yu Liu ◽  
...  
Keyword(s):  
Wnt Signaling ◽  
Signaling Pathway ◽  
Wnt Signaling Pathway ◽  
Melanoma Cells ◽  
Migration And Invasion

scholarly journals Nuclear receptor FXR impairs SK‑Hep‑1 cell migration and invasion by inhibiting the Wnt/β‑catenin signaling pathway

2020 ◽  
Vol 20 (5) ◽  
pp. 1-1
Author(s):  
Qianqian Li ◽  
Ningbo Li ◽  
Yeting Zeng ◽  
Xinrui Wang ◽  
Jie Li ◽  
...  
Keyword(s):  
Cell Migration ◽  
Signaling Pathway ◽  
Nuclear Receptor ◽  
Migration And Invasion ◽  
Beta Catenin ◽  
Cell Migration And Invasion
Sign in / Sign up

Export Citation Format

Share Document