scholarly journals Exercise-induced hormone and blood fatigue factor responses to branched-chain amino acids administration in the recovery period after exercise: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Azade Sefidari ◽  
Mohammad Hossein Rahimi
Keyword(s):  
Meta Analysis ◽  
Recovery Period ◽  
Cortisol Concentration ◽  
Anabolic Hormone ◽  
Branched Chain Amino Acid ◽  
Internal Concentration ◽  
Comprehensive Search ◽  
Branched Chain ◽  
Exercise Induced

Abstract Purpose: Branched-chain amino acid (BCAA) can boost anabolism through an increase in the internal concentration of BCAA, which leads to facilitating anabolic hormone release to stimulate the power of the muscles. Studies on administration of BCAA to minimize fatigue substances during long periods of high intensity exercise have been conducted. However, there are disagreements concerning the results of these studies.Method: A comprehensive search was performed on electronic databases up to November 2019 for trials evaluating the effects of BCAA on recovery following exercise. Mean ± standard deviation of follow-up cortisol, insulin, ammonia, and lactate concentrations were extracted to calculate the effect size for meta-analysis.Results: A total of 146 participants for cortisol and 279 participants for lactate were found from the 7 and 15 studies, respectively. The results revealed a significant effect of BCAA supplementation on cortisol concentration during 120≤ min post exercise follow-up. Moreover, without considering follow-up times, an overall analysis showed that BCAA was effective in reducing blood lactate in aerobic exercise and the trained status of athletes.Conclusions: The advantages of BCAA administration relate to a reduction in cortisol concentration after 2h and ameliorated muscle function because of a probable attenuation of fatigue substances immediately after exercise.

scholarly journals Exercise-induced hormone and blood fatigue factor responses to branched-chain amino acids administration in the recovery period after exercise: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Azade Sefidari ◽  
Mohammad Hossein Rahimi
Keyword(s):  
Meta Analysis ◽  
Recovery Period ◽  
Cortisol Concentration ◽  
Anabolic Hormone ◽  
Branched Chain Amino Acid ◽  
Internal Concentration ◽  
Comprehensive Search ◽  
Branched Chain ◽  
Exercise Induced

Abstract Purpose: Branched-chain amino acid (BCAA) can boost anabolism through an increase in the internal concentration of BCAA, which leads to facilitating anabolic hormone release to stimulate the power of the muscles. Studies on administration of BCAA to minimize fatigue substances during long periods of high intensity exercise have been conducted. However, there are disagreements concerning the results of these studies.Method: A comprehensive search was performed on electronic databases up to November 2019 for trials evaluating the effects of BCAA on recovery following exercise. Mean ± standard deviation of follow-up cortisol, insulin, ammonia, and lactate concentrations were extracted to calculate the effect size for meta-analysis.Results: A total of 146 participants for cortisol and 279 participants for lactate were found from the 7 and 15 studies, respectively. The results revealed a significant effect of BCAA supplementation on cortisol concentration during 120≤ min post exercise follow-up. Moreover, without considering follow-up times, an overall analysis showed that BCAA was effective in reducing blood lactate in aerobic exercise and the trained status of athletes.Conclusions: The advantages of BCAA administration relate to a reduction in cortisol concentration after 2h and ameliorated muscle function because of a probable attenuation of fatigue substances immediately after exercise.

scholarly journals Outcome of endoscopic vs microsurgical transsphenoidal resection for Cushing’s disease

2018 ◽  
Vol 7 (1) ◽  
pp. R26-R37 ◽  
Author(s):  
Nidan Qiao
Keyword(s):  
Recurrence Rate ◽  
Cushing’S Disease ◽  
Meta Analysis ◽  
Cushing's Disease ◽  
Recurrence Rates ◽  
Microscopic Surgery ◽  
Significant Difference ◽  
Comprehensive Search ◽  
Definition Of

Introduction It is unclear whether the proportions of remission and the recurrence rates differ between endoscopic transsphenoidal surgery (TS) and microscopic TS in Cushing’s disease (CD); thus, we conducted a systematic review and meta-analysis to evaluate studies of endoscopic TS and microscopic TS. Methods We conducted a comprehensive search of PubMed to identify relevant studies. Remission and recurrence were used as outcome measures following surgical treatment of CD. Results A total of 24 cohort studies involving 1670 adult patients were included in the comparison. Among these studies, 702 patients across 9 studies underwent endoscopic TS, and 968 patients across 15 studies underwent microscopic TS. Similar baseline characteristics were observed in both groups. There was no significant difference in remission between the two groups: 79.7% (95% CI: 73.1–85.0%) in the endoscopic group and 76.9% (95% CI: 71.3–81.6%) in the microscopic group (P = 0.485). It appears that patients who underwent endoscopic surgery experience recurrence less often than patients who underwent microscopic surgery, with recurrence proportions of 11.0% and 15.9%, respectively (P = 0.134). However, if follow-up time is taken into account, both groups had a recurrence rate of approximately 4% per person per year (95% CI: 3.1–5.4% and 3.6–5.1%, P = 0.651). Conclusions We found that remission proportion and recurrence rate were the same in patients who underwent endoscopic TS as in patients who underwent microscopic TS. The definition of diagnosis, remission and recurrence should always be considered in the studies assessing therapeutic efficacy in CD.

scholarly journals Exercise-Induced Changes in Branched Chain Amino Acid/Aromatic Amino Acid Ratio in the Rat Brain and Plasma

1987 ◽  
Vol 45 (2) ◽  
pp. 243-248
Author(s):  
Koji OKAMURA ◽  
Futoshi MATSUBARA ◽  
Yasuyuki YOSHIOKA ◽  
Noriaki KIKUCHI ◽  
Yuko KIKUCHI ◽  
...  
Keyword(s):  
Amino Acid ◽  
Rat Brain ◽  
Aromatic Amino Acid ◽  
Branched Chain Amino Acid ◽  
Acid Ratio ◽  
Branched Chain ◽  
Exercise Induced ◽  
Induced Changes

scholarly journals Branched-Chain Amino Acid Plus Glucose Supplement Reduces Exercise-Induced Delayed Onset Muscle Soreness in College-Age Females

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Danielle T. Leahy ◽  
Stephen J. Pintauro
Keyword(s):  
Muscle Soreness ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Recovery Period ◽  
Delayed Onset Muscle Soreness ◽  
Male And Female ◽  
Delayed Onset ◽  
Branched Chain ◽  
Exercise Induced ◽  
Female Subjects

Supplementation with branched-chain amino acids (BCAAs) has been used to stimulate muscle protein synthesis following exercise. The purpose of this study was to determine if supplementation with BCAAs in combination with glucose would reduce exercise-induced delayed onset muscle soreness (DOMS). Using a double-blind crossover design, 20 subjects (11 females, 9 males) were randomly assigned to either BCAA () or placebo () groups. Subjects performed a squatting exercise to elicit DOMS and rated their muscle soreness every 24 hours for four days following exercise while continuing to consume the BCAA or placebo. Following a three-week recovery period, subjects returned and received the alternate BCAA or placebo treatment, repeating the same exercise and DOMS rating protocol for the next four days. BCAA supplementation in female subjects resulted in a significant decrease in DOMS versus placebo at 24 hours following exercise (). No significant effect of BCAA supplementation versus placebo was noted in male subjects nor when male and female results were analyzed together. This gender difference may be related to dose per body weight differences between male and female subjects.

scholarly journals Radiation Exposure Associated With Computed Tomography in Childhood and the Subsequent Risk of Cancer: A Meta-Analysis of Cohort Studies

Dose-Response ◽  
2020 ◽  
Vol 18 (2) ◽  
pp. 155932582092382
Author(s):  
Ruixue Huang ◽  
Xiaodan Liu ◽  
Li He ◽  
Ping-Kun Zhou
Keyword(s):  
Computed Tomography ◽  
Radiation Exposure ◽  
Meta Analysis ◽  
Epidemiologic Studies ◽  
Cochrane Library ◽  
Ct Radiation ◽  
Comprehensive Search ◽  
Risk Of Cancer ◽  
Subsequent Risk

Background: Computed tomography (CT) is used worldwide; however, recent studies suggest that CT radiation exposure during childhood may be a risk factor for cancer, although the data are inconsistent. Methods: A comprehensive search of electronic databases including PubMed, SpringerLink, Embase, Cochrane Library, Elsevier/ScienceDirect, Medline, Orbis, and Web of Science databases from January 1990 to November 2018 for observational epidemiologic studies reporting associations between radiation exposure from CT in childhood and the subsequent risk of cancer was conducted. A linear model was used to explore the dose–response relationship. Results: Seven studies with 1180 987 children enrolled were included. The risk of later cancer was 1.32-fold higher for children exposed to CT than those without exposure. Compared to those not exposed to pediatric CT, the relative risk (RRs) were larger for the higher doses but with wider CIs (RR for 5-10 mGy: 0.90, 95% CI: 0.69-1.12; RR for 10-15 mGy: 1.02, 95% CI: 0.86-1.18; RR for >15 mGy: 1.13, 95% CI: 0.97-1.30), the leukemia risk was higher in exposed children (RR: 1.23, 95% CI: 1.10-1.36), and brain cancer risk was higher in exposed children (RR: 1.54, 95% CI: 0.84-2.45). Conclusions: Our analysis suggested that radiation exposure from CT during childhood is associated with a subsequently elevated risk of cancer. However, caution is needed when interpreting these results because of the heterogeneity among the studies. The findings should be confirmed in further studies with longer follow-up periods.

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