scholarly journals The Value of Corrective Effect of Human Serum Albumin For The Mortality of Septic Patients With Hypoproteinemia

2022 ◽  
Author(s):  
Fei Peng ◽  
Juan Jian ◽  
Si Lei ◽  
Quan Zhang ◽  
Zhibiao He ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Independent Risk Factor ◽  
Apache Ii Score ◽  
Corrective Effect ◽  
Potential Risk Factors ◽  
The Difference

Abstract Timely and accurately evaluating the severity and prognosis of sepsis occupy an important position in septic management. The purpose of the article was to investigate the value of corrective effect of human serum albumin (HSA) in assessment on the mortality of septic patients with hypoproteinemia.A retrospective analysis was carried out. A logistic regression model was adopted to analyze the association between the mortality and related risk factors. Furthermore, the receiver operating characteristic curves (ROC) were utilized to analyze the abilities of potential risk factors in prediction of the mortality of septic patients with hypoproteinemia. The ratio of total dosage of HSA-to-the difference of serum albumin before and after albumin supplement (THSA/DALB) was significantly increased in non-survivors of septic patients with hypoproteinemia than that in survivors (P <0.001). THSA/DALB (P = 0.018) was an independent risk factor for the mortality of septic patients with hypoproteinemia. ROC analysis showed that area under curve (AUC) of THSA/DALB, SOFA score and APACHE II score were 0.800 , 0.802 and 0.766 , respectively. The data demonstrated that THSA/△ALB could be an independent risk factor in predicting the mortality of septic patients with hypoproteinemia.

scholarly journals Risk factors, outcomes and mechanisms of tigecycline non-susceptibleKlebsiella pneumoniaebacteremia

2016 ◽  
pp. AAC.01503-16 ◽  
Author(s):  
Chih-Han Juan ◽  
Yi-Wei Huang ◽  
Yi-Tsung Lin ◽  
Tsuey-Ching Yang ◽  
Fu-Der Wang
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Medical Center ◽  
Attributable Mortality ◽  
Rt Pcr ◽  
Potential Risk Factors ◽  
Matched Case ◽  
Matched Case Control Study ◽  
Control Study

A rise in tigecycline resistance inKlebsiella pneumoniaehas been reported recently worldwide. We aim to identify risk factors, outcomes, and mechanisms for adult patients with tigecycline non-susceptibleK. pneumoniaebacteremia in Taiwan. We conducted a matched case-control study (ratio of 1:1) in a medical center in Taiwan from January 2011 through June 2015. The cases were patients with tigecycline non-susceptibleK. pneumoniaebacteremia, and the controls were patients with tigecycline susceptibleK. pneumoniaebacteremia. Logistic regression was performed to evaluate the potential risk factors for tigecycline non-susceptibleK. pneumoniaebacteremia. Quantitative RT-PCR was performed to analyzeacrA,oqxA,ramA,rarA,andkpgAexpression among these isolates. A total of 43 cases were matched with 43 controls. The 14-day mortality of patients with tigecycline non-susceptibleK. pneumoniaebacteremia was 30.2%, and the 28-day mortality was 41.9%. The attributable mortality of tigecycline non-susceptibleK. pneumoniaeat 14 days and 28 days was 9.3% and 18.6%, respectively. Fluoroquinolone use within 30 days prior to bacteremia was the only independent risk factor for tigecycline non-susceptibleK. pneumoniaebacteremia. Tigecycline non-susceptibleK. pneumoniaewere mostly caused by overexpression of AcrAB and/or OqxAB efflux pumps, together with the upregulation of RamA and/or RarA respectively. One isolate has isolated overexpression ofkpgA. In conclusion, tigecycline non-susceptibleK. pneumoniaebacteremia was associated with high mortality and prior fluoroquinolone use was the independent risk factor for acquisition of tigecycline non-susceptibleK. pneumoniae. The overexpression of AcrAB and/or OqxAB contributes to tigecycline non-susceptibility inK. pneumoniae.

Kinetic Studies of Copper(II)-exchange from L-Histidine to Human Serum Albumin and Diglycyl-L-histidine, a Peptide Mimicking the Copper(II)-transport Site of Albumin

1975 ◽  
Vol 53 (5) ◽  
pp. 710-715 ◽  
Author(s):  
Show-Jy Lau ◽  
Bibudhendra Sarkar
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Exchange Rates ◽  
Human Serum ◽  
Kinetic Studies ◽  
Side Chain ◽  
Exchange Reactions ◽  
Equilibrium Study ◽  
Rate Determining Step ◽  
The Difference

The Cu(II)-exchange reactions of L-histidine with human serum albumin and diglycyl-L-histidine were studied at pH 7.53 in 0.1 MN-ethylmorpholine–HCl buffer. The exchange rates from L-histidine to albumin and peptide were determined as 0.67 and 0.42 s−1 respectively. Those from albumin and peptide to L-histidine were obtained as 0.04 and 0.07 s−1 respectively. This result is in accord with the earlier observations of the equilibrium study that the peptide has about half the Cu(II)-binding affinity as compared to albumin. The difference in the Cu(II)-exchange rates of albumin and peptide may reflect the influence of either the COOH-terminal free carboxyl group of the peptide or the side-chain residues of the Cu(II)-binding site in the native protein or both. An exchange mechanism is proposed in which the ternary complexes are shown to play the important role in the rate-determining step in the Cu(II)-exchange between a macromolecule and a small substance.

Effects of n-alkyl ligands on the difference spectra of bovine and human serum albumin

Biochemistry ◽  
1972 ◽  
Vol 11 (10) ◽  
pp. 1809-1817 ◽  
Author(s):  
Jacinto Steinhardt ◽  
Joan G. Leidy ◽  
Joan P. Mooney
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Difference Spectra ◽  
The Difference

Is Ventilator-associated Pneumonia an Independent Risk Factor for Death?

2001 ◽  
Vol 94 (4) ◽  
pp. 554-560 ◽  
Author(s):  
Fabienne Bregeon ◽  
Véronique Ciais ◽  
Vincent Carret ◽  
Régine Gregoire ◽  
Pierre Saux ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Bone Marrow Failure ◽  
Case Control ◽  
Attributable Mortality ◽  
Apache Ii Score ◽  
Age Difference ◽  
Ventilator Associated Pneumonia ◽  
Matching Criteria

Background Ventilator-associated pneumonia (VAP) has been implicitly accused of increasing mortality. However, it is not certain that pneumonia is responsible for death or whether fatal outcome is caused by other risk factors for death that exist before the onset of pneumonia. The aim of this study was to evaluate the attributable mortality caused by VAP by performing a matched-paired, case-control study between patients who died and patients who were discharged from the intensive care unit after more than 48 h of mechanical ventilation. Methods During the study period, 135 consecutive deaths were included in the case group. Case-control matching criteria were as follows: (1) diagnosis on admission that corresponded to 1 of 11 predefined diagnostic groups; (2) age difference within 10 yr; (3) sex; (4) admission within 1 yr; (5) APACHE II score within 7 points; (6) ventilation of control patients for at least as long as the cases. Precise clinical, radiologic, and microbiologic definitions were used to identify VAP. Results Analysis was performed on 108 pairs that were matched with 91% of success. There were 39 patients (36.1%) who developed VAP in each group. Multivariate analysis showed that renal failure, bone marrow failure, and treatment with corticosteroids but not VAP were independent risk factors for death. There was no difference observed between cases and controls concerning the clinical and microbiologic diagnostic criteria for pneumonia. Conclusion Ventilator-associated pneumonia does not appear to be an independent risk factor for death.

Risk factors for posttraumatic vasospasm

2011 ◽  
Vol 115 (3) ◽  
pp. 602-611 ◽  
Author(s):  
Kiarash Shahlaie ◽  
Krista Keachie ◽  
Irene M. Hutchins ◽  
Nancy Rudisill ◽  
Lori K. Madden ◽  
...  
Keyword(s):  
Risk Factors ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Univariate Analysis ◽  
Multivariate Logistic Regression Model ◽  
Potential Risk Factors ◽  
Severe Tbi ◽  
Independent Risk Factors ◽  
Clinically Significant ◽  
Underlying Mechanisms

Object Posttraumatic vasospasm (PTV) is an underrecognized cause of ischemic damage after severe traumatic brain injury (TBI) that independently predicts poor outcome. There are, however, no guidelines for PTV screening and management, partly due to limited understanding of its pathogenesis and risk factors. Methods A database review of 46 consecutive cases of severe TBI in pediatric and adult patients was conducted to identify risk factors for the development of PTV. Univariate analysis was performed to identify potential risk factors for PTV, which were subsequently analyzed using a multivariate logistic regression model to calculate odds ratios (ORs) and 95% confidence intervals (CIs). Results Fever on admission was an independent risk factor for development of PTV (OR 22.2, 95% CI 1.9–256.8), and patients with hypothermia on admission did not develop clinically significant vasospasm during their hospital stay. The presence of small parenchymal contusions was also an independent risk factor for PTV (OR 7.8, 95% CI 0.9–69.5), whereas the presence of subarachnoid hemorrhage or other patterns of intracranial injury were not. Other variables, such as age, sex, ethnicity, degree of TBI severity, or admission laboratory values, were not independent predictors for the development of clinically significant PTV. Conclusions Independent risk factors for PTV include parenchymal contusions and fever. These results suggest that diffuse mechanical injury and activation of inflammatory pathways may be underlying mechanisms for the development of PTV, and that a subset of patients with these risk factors may be an appropriate population for aggressive screening. Further studies are needed to determine if treatments targeting fever and inflammation may be effective in reducing the incidence of vasospasm following severe TBI.

II. Lokalisation der Placenta mit 113Inm- Human-Serum-Albumin

1969 ◽  
Vol 08 (01) ◽  
pp. 15-21 ◽  
Author(s):  
K. E. Scheer ◽  
J. Heep ◽  
W. Maier-Borst ◽  
W. J. Lorenz ◽  
H. Sinn ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Vena Cava ◽  
Placenta Praevia ◽  
Wird Eine

ZusammenfassungNach tierexperimentellen Voruntersuchungen wurde die Placentographie mit trägerfreiem 113Inm -HSA als klinische Methode eingeführt. Vor Amniocentesen und bei Verdacht auf Placenta praevia werden Placentographien geschrieben. Den Schwangeren wird eine Aktivität von 500 μCi in die Cubitalvene injiziert. Die der Aktivität entsprechende Indiummenge ist kleiner als 0,1 ng. Die fetale Strahlenbelastung liegt unter lOmrad. Bei Anwendung von 113Inm-HSA entfällt eine Blockade der mütterlichen und fetalen Schilddrüsen. Die genaue Abgrenzung einer Placenta praevia wird nicht durch eine Blasenaktivität beeinträchtigt.Es wurden bisher 19 Placentalokalisationen durchgeführt. In allen Fällen konnte der Placentasitz eindeutig festgestellt werden. Bedingt durch die lange Liegezeit beim Aufnehmen eines Szintigramms kam es in zwei Fällen zu einem Vena-Cava-Kompressions-Syndrom. Zur Verhinderung dieser klinischen Zwischenfälle werden inzwischen Placentographien mit der Anger-Kamera aufgenommen. Mit Hilfe des divergierenden Kollimators konnte der gesamte Abdominalbereich erfaßt werden. Die Aufnahmezeit konnte auf 7 — 10 Minuten verkürzt werden. Die intravenöse injizierte Aktivität betrug bei dieser Methode ebenfalls 500 μCi. Der diagnostische Aussagewert der Kamerabilder ist szintigraphischen Aufnahmen gleichwertig.

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