scholarly journals Relative Frequency of Islet Autoimmunity in Children and Adolescents with Autoimmune Thyroid Disease

2022 ◽  
Author(s):  
Natasa Rojnic Putarek ◽  
Nevena Krnic ◽  
Jadranka Knezevic-Cuca ◽  
Vesna Kusec ◽  
Maja Baretic ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Tyrosine Phosphatase ◽  
Family Members ◽  
Islet Autoantibodies ◽  
Islet Autoimmunity ◽  
Acid Decarboxylase ◽  
Autoimmune Thyroid ◽  
Number Of Patients ◽  
Normal Glucose

Abstract The present study aims to investigate islet autoimmunity and susceptibility to type 1 diabetes (T1D) in children/adolescents with autoimmune thyroid disease (AITD), and family members of AITD patients with islet autoimmunity. Islet-cell cytoplasmic, glutamic-acid decarboxylase and tyrosine-phosphatase autoantibodies were measured in 161 AITD patients [(127 with autoimmune thyroiditis (AT); 34 with Graves’ disease (GD)], 20 family members of AITD patients with islet autoimmunity, and 155 age-matched controls. Islet autoimmunity was found in 10.6% of AITD patients, significantly more frequent than in controls (1.9%; p=0.002). Higher prevalence of islet autoantibodies was found in females with AITD (p=0.011) but not in males (p=0.16) as well as in AT (p=0.013) but not GD patients (p=0.19), compared to corresponding controls. Two or three islet autoantibodies were found concurrently in six AITD patients with islet autoimmunity. They all developed T1D and had significantly higher islet autoantibodies titers (p=0.01) compared to AITD patients with single islet autoantibodies but normal glucose metabolism. T1D was found in 3.7% of AITD patients compared to 0.2% in age-matched, general Croatian population. Islet autoantibodies were found in 5/20 family members of AITD patients with islet autoimmunity, among which two developed T1D. None of the controls was positive to more than one islet autoantibodies or developed T1D. Conclusion: Children/adolescents with AITD (particularly females and patients with AT) represent a risk group for islet autoimmunity and T1D, as well as family members of AITD patients with positive islet autoantibodies, but last observation must be examined in a larger number of patients.

scholarly journals Autoimmune Thyroid Disease Correlates to Islet Autoimmunity on Zinc Transporter 8 Autoantibody: A Cross-Section Study

2020 ◽  
Author(s):  
Yun Cai ◽  
Jieni Yan ◽  
Yong Gu ◽  
Heng Chen ◽  
Qingfang Hu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Islet Autoantibodies ◽  
Islet Autoimmunity ◽  
Thyroid Autoantibodies ◽  
Healthy Controls ◽  
Autoimmune Thyroid ◽  
Relative Value

Abstract Background The most common coexisting organ-specific autoimmune disease in patients with Type 1 diabetes mellitus (T1DM) is autoimmune thyroid disease (AITD). Many studies have showed prevalence rate of thyroid autoantibodies range from 3.7-35% in T1DM patients, while some of them suggested the associations between thyroid autoantibodies and islet autoantibodies. However, little work has been done about the anti-islet autoimmune status in patients with autoimmune thyroid disease (AITD), and so far there have been no clinical report based on large population about zinc transporter 8 autoantibody (ZnT8A) in patients with AITD. We aimed to explore the presence of islet autoantibodies, ZnT8A, glutamic acid decarboxylase autoantibodies (GADA) and tyrosine phosphatase autoantibodies (IA-2A) compared with thyroid autoantibodies, thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TGAb) and thyrotropin receptor autoantibodies (TRAb) in AITD patients. Methods In total 740 AITD patients, 108 type 1 diabetes mellitus (T1DM) patients with AITD, 172 non-autoimmune thyroid disease (nAITD) patients and 115 healthy controls were recruited in the cross-sectional study. Islet autoantibodies, ZnT8A, GADA, IA-2A and thyroid autoantibodies, TPOAb, TGAb, TRAb were detected with Radioimmunoassay and Chemiluminescence. Islet autoantibody relative value was established to compare the distribution of the three islet autoantibodies. Results The prevalence of ZnT8A and GADA in AITD group was significantly higher than that in healthy controls (ZnT8A: 15.00% vs 1.74%, GADA: 7.97% vs 0.87%, both P<0.05). Similarly, the prevalence of IA-2A in AITD group was higher than that in healthy controls (4.19% vs 0%, P<0.05). However, any islet autoantibodies positive rate in AITD group was significantly lower than that in T1DM with AITD group. Analysis of multivariable linear regression suggested that ZnT8A relative value was positively related with GADA relative value (β=0.352, P<0.01) and TPOAb titer (β=0.002, P<0.01), and GADA relative value was also positively related with ZnT8A relative value (β=0.183, P<0.01). Conclusions An increased prevalence of ZnT8A as well as a relatively high prevalence of islet autoimmunity was found in AITD patients, indicating that there is a potential link between thyroid autoimmunity and islet autoimmunity. Trial registration Retrospectively registered.

scholarly journals Autoimmune thyroid disease correlates to islet autoimmunity on zinc transporter 8 autoantibody

2021 ◽  
Author(s):  
Yun Cai ◽  
Jieni Yan ◽  
Yong Gu ◽  
Heng Chen ◽  
Yang Chen ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Large Population ◽  
Zinc Transporter ◽  
Islet Autoantibodies ◽  
Islet Autoimmunity ◽  
Thyroid Peroxidase ◽  
Thyroid Autoantibodies ◽  
Autoimmune Thyroid ◽  
Zinc Transporter 8

Objective: The most common coexisting organ-specific autoimmune disease in patients with type 1 diabetes mellitus (T1DM) is autoimmune thyroid disease (AITD). However, there have been little clinical reports based on large population about the prevalence of zinc transporter 8 autoantibody (ZnT8A) and other islet autoantibodies in AITD patients. We aimed to explore the presence of islet autoantibodies, ZnT8A, glutamic acid decarboxylase autoantibodies (GADA) and insulinoma-associated antigen 2 autoantibodies (IA-2A) compared with thyroid autoantibodies, thyroid peroxidase autoantibodies (TPOAb) and thyroglobulin autoantibodies (TGAb) and thyrotropin receptor autoantibodies (TRAb) in patients with Graves’ disease (GD), Hashimoto’s thyroiditis (HT) and T1DM patients with AITD. Methods: Totally, 389 patients with GD, 334 patients with HT, 108 T1DM patients with AITD and 115 healthy controls (HC) were recruited in the study. Islet autoantibodies (ZnT8A, GADA and IA-2A) were detected by radioligand binding assay. Thyroid autoantibodies, TPOAb and TGAb were detected by chemiluminescence assay, and TRAb was detected by radioimmunoassay. Results: The prevalence of ZnT8A, GADA and IA-2A was higher in GD and HT patients than that of HC (ZnT8A: GD 8.48%, HT 10.8% vs HC 1.74%; GADA: GD 7.46%, HT 7.74% vs HC 0.870%; IA-2A: GD 4.88%, HT 3.59% vs HC 0%; All P<0.05); but lower than that of T1DM subjects with AITD (ZnT8A: 42.6%; IA-2A: 44.4%; GADA: 74.1%; all P<0.0001). Conclusions: An increased prevalence of ZnT8A as well as GADA and IA-2A was found in both GD and HT patients, indicating that there is a potential link between thyroid autoimmunity and islet autoimmunity.

Association of the Protein Tyrosine Phosphatase Nonreceptor 22 Haplotypes with Autoimmune Thyroid Disease in the Japanese Population

Thyroid ◽  
2010 ◽  
Vol 20 (8) ◽  
pp. 893-899 ◽  
Author(s):  
Yoshiyuki Ban ◽  
Teruaki Tozaki ◽  
Matsuo Taniyama ◽  
Yasuko Nakano ◽  
Yoshihisa Ban ◽  
...  
Keyword(s):  
Protein Tyrosine Phosphatase ◽  
Thyroid Disease ◽  
Japanese Population ◽  
Autoimmune Thyroid Disease ◽  
Tyrosine Phosphatase ◽  
Protein Tyrosine ◽  
Autoimmune Thyroid

scholarly journals Thyroid and islet autoantibodies predict autoimmune thyroid disease already at Type 1 diabetes diagnosis

2016 ◽  
pp. jc.2016-2335 ◽  
Author(s):  
Berglind Jonsdottir ◽  
Christer Larsson ◽  
Annelie Carlsson ◽  
Gun Forsander ◽  
Sten Anders Ivarsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Islet Autoantibodies ◽  
Diabetes Diagnosis ◽  
Autoimmune Thyroid

scholarly journals Autoimmune thyroid disease and type 1 diabetes mellitus: same pathogenesis; new perspective?

2020 ◽  
Vol 11 ◽  
pp. 204201882095832
Author(s):  
Liyan Li ◽  
Shudong Liu ◽  
Junxia Yu
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Autoimmune Diseases ◽  
Type 1 Diabetes Mellitus ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Current Knowledge ◽  
Tyrosine Phosphatase ◽  
Autoimmune Thyroid

Autoimmune thyroid disease (AITD) and type 1 diabetes mellitus (T1DM) are two common autoimmune diseases that can occur concomitantly. In general, patients with diabetes have a high risk of AITD. It has been proposed that a complex genetic basis together with multiple nongenetic factors make a variable contribution to the pathogenesis of T1DM and AITD. In this paper, we summarize current knowledge in the field regarding potential pathogenic factors of T1DM and AITD, including human leukocyte antigen, autoimmune regulator, lymphoid protein tyrosine phosphatase, forkhead box protein P3, cytotoxic T lymphocyte-associated antigen, infection, vitamin D deficiency, and chemokine (C-X-C motif) ligand. These findings offer an insight into future immunotherapy for autoimmune diseases.

Clinical and genetic characteristics of patients with autoimmune thyroid disease with anti-islet autoimmunity

Metabolism ◽  
2011 ◽  
Vol 60 (6) ◽  
pp. 761-766 ◽  
Author(s):  
Masanori Moriguchi ◽  
Sinsuke Noso ◽  
Yumiko Kawabata ◽  
Takaaki Yamauchi ◽  
Takeshi Harada ◽  
...  
Keyword(s):  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Islet Autoimmunity ◽  
Genetic Characteristics ◽  
Autoimmune Thyroid

Autoantibodies to Glutamic Acid Decarboxylase in Patients with IDDM and Autoimmune Thyroid Disease

Diabetes ◽  
1994 ◽  
Vol 43 (1) ◽  
pp. 80-86 ◽  
Author(s):  
E. Kawasaki ◽  
H. Takino ◽  
M. Yano ◽  
S. Uotani ◽  
K. Matsumoto ◽  
...  
Keyword(s):  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Acid Decarboxylase ◽  
Autoimmune Thyroid

scholarly journals Association of Autoimmune Thyroid Disease with Anti-GAD Antibody ELISA Test Positivity and Risk for Insulin Deficiency in Slowly Progressive Type 1 Diabetes

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Masahito Katahira ◽  
Hidetada Ogata ◽  
Takahiro Ito ◽  
Tsutomu Miwata ◽  
Megumi Goto ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Acid Decarboxylase ◽  
Insulin Deficiency ◽  
Autoimmune Thyroid ◽  
Progressive Type ◽  
Significant Difference

The presence of antiglutamic acid decarboxylase antibody (GADA) is required for the diagnosis of slowly progressive type 1 diabetes (SPT1D). We examined the factors influencing GADA determination by radioimmunoassay (GADA-RIA) and by enzyme-linked immunosorbent assay (GADA-ELISA). Sixty patients with SPT1D and 154 patients with type 2 diabetes were examined by both GADA-RIA and GADA-ELISA and for the presence of autoimmune thyroid disease (AITD). We compared the clinical characteristics of these patients based on the positivity or negativity of GADA-RIA and GADA-ELISA, and the existence or nonexistence of AITD. Thirty of 60 (50.0%) GADA-RIA-positive patients were GADA-ELISA negative, whereas none of the 154 GADA-RIA-negative patients were GADA-ELISA positive. Concomitant AITD was significantly less in patients with GADA-RIA and without GADA-ELISA and was significantly more in patients with GADA-RIA and GADA-ELISA. In GADA-RIA-positive patients, there was no significant difference in the GADA-RIA titer among the GADA-ELISA-negative patients with and without AITD, and the GADA-ELISA-positive patients without AITD; whereas the frequency of insulin deficiency was significantly higher in the patients with AITD and/or GADA-ELISA than in those without AITD and GADA-ELISA. Examination of GADA-ELISA and AITD in GADA-RIA-positive patients might be useful in predicting insulin deficiency in these patients.

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