scholarly journals High-Intensity Interval Training Improves Lipocalin-2 and Omentin-1 Levels in Men with Obesity

Author(s):  
Sirvan Atashak ◽  
Stephen R. Stannard ◽  
Ali Daraei ◽  
Mohammad Soltani ◽  
Ayoub Saeidi ◽  
...  

Abstract Objectives: We investigated the effects of 12 weeks of high-intensity interval training (HIIT) on selected circulating adipokines and other cardiovascular diseases (CVD) risks factors in males with obesity. Methods: Thirty males with obesity were randomly assigned to HIIT and control groups. The HIIT group participated in a prescribed exercise program for 12 weeks, three times per week. Blood lipids, insulin resistance, and select serum adipokines were assessed before and after 12 weeks of the intervention period. Results: HIIT improved body composition and lipid profiles (p<0.05) as well as decreased fasting insulin levels (p=0.001) and HOMA-IR (p=0.002) levels. Furthermore, HIIT increased levels of lipocalin-2 (lcn2) (p=0.002) while decreasing omentin-1 levels (p=0.001) in males with obesity. Changes in lcn2 and omentin-1 concentrations correlated with the changes in risk factors in the HIIT group (p<0.05). Conclusions: The results indicate that 12 weeks of supervised HIIT exercise significantly improves both circulating concentrations of lcn2 and omentin-1, two recently described adipokines, and markers of CVD risk in males with obesity. Further research is necessary to understand the molecular mechanisms involved with these changes.

Author(s):  
Sirvan Atashak ◽  
Stephen R. Stannard ◽  
Ali Daraei ◽  
Mohammad Soltani ◽  
Ayoub Saeidi ◽  
...  

We investigated the effects of 12 weeks of high-intensity interval training (HIIT) on selected circulating adipokines and other cardiovascular diseases risks factors in men with obesity. Thirty men with obesity (age: 24.96 ± 3.11 year, BMI: 30.92 ± 1.04 kg/m2) were randomly assigned to HIIT and control groups. The HIIT group participated in a 12-week HIIT program (5×2 min interval bout at an intensity of 85-95% HRmax interspersed by 1 min passive recovery, three times per week), while the control group maintained their usual lifestyles. Blood lipids, insulin resistance, and select serum adipokines were assessed before and after 12 weeks of the intervention period. HIIT improved body composition and lipid profiles (p<0.05) and also decreased fasting insulin levels (p=0.001) and HOMA-IR (p=0.002) levels. Furthermore, HIIT increased levels of lipocalin-2 (p=0.002) while decreasing omentin-1 levels (p=0.001) in men with obesity. Changes in lcn2 and omentin-1 concentrations correlated with the changes in risk factors in the HIIT group (p<0.05). The results indicate that 12 weeks of supervised HIIT significantly improves both circulating concentrations of lcn2 and omentin-1, two recently described adipokines, and risk markers of cardiovascular diseases in men with obesity. Further research is necessary to understand the molecular mechanisms involved with these changes.


Author(s):  
Jinshu Zeng ◽  
Jing Xu ◽  
Yuanhong Xu ◽  
Wu Zhou ◽  
Fei Xu

The aim of the study was to investigate the effects of 4-week small-sided games (SSG) and high-intensity interval training with changes of direction (HIT-COD) on physical performance and specific technical skills in female collegiate basketball players. Nineteen players were divided into SSG (n = 9) and HIT-COD (n = 10) groups, that performed either SSG or HIT-COD three times per week for 4 weeks during the pre-season. Players’ heart rate (HR) and perceived exertion responses (RPE) were assessed during the intervention. Before and after the intervention period, performances were assessed with 30-15 intermittent fitness test (30-15IFT), repeated sprint ability (RSA) test, modified agility T-test (MAT), countermovement jump (CMJ), 20-m sprint, shooting accuracy test, 1 min shooting test, passing test, defensive movement test and control dribble test. Both training interventions led to similar physiological and perceived exertion responses, showing no significant differences in HR ( P = .49, d = 0.2) and RPE ( P = .77, d = 0.1) between groups. Significant improvements were observed in 30-15IFT (SSG: 4.1%, d = 1.5; HIT-COD: 4.2%, d = 1.7), RSAmean (SSG: −2.2%, d = 1.0; HIT-COD: −1.9%, d = 1.0), RSAbest (SSG: −2.0%, d = 0.9; HIT-COD: −2.1%, d = 1.1), MAT (SSG: −7.2%, d = 1.7; HIT-COD: 5.7%, d = 1.5), defensive movement test (SSG: −5.1%, d = 2.1; HIT-COD: −5.8%, d = 1.8) and control dribble test (SSG: −3.4%, d = 1.0; HIT-COD: −2.6%, d = 1.0). The only significant group × time interaction was found ( P = .032, [Formula: see text] = 0.24), with SSG improving 1 min shooting (22.4%, d = 1.0) and HIT-COD performing slightly worse (−2.6%, d = 0.1) after a 4-week intervention. The current study suggests that using SSG is more effective than HIT-COD for female collegiate basketball players in pre-season, since SSG improves physical performance and basketball-specific movements as well as shooting abilities after a 4-week intervention.


2021 ◽  
Vol 9 (A) ◽  
pp. 871-875
Author(s):  
Susiana Candrawati ◽  
Emy Huriyati ◽  
Zaenal Muttaqien Sofro ◽  
Lantip Rujito ◽  
Aulia Nury Faza ◽  
...  

Background: Increased inflammatory mediators in obesity are associated with metabolic syndrome. Exercise is an effective effort to reduce the incidence of obesity. The High-Intensity Interval Training (HIIT) program is an exercise which include combination of high-intensity exercise and rest periods. The decrease in body fat levels due to physical training will further affect inflammatory mediators such as IL6 and TNFα. Besides training factor, genetic also play a role on obesity. One of the genes that influence obesity is the UCP2 Ala55Val gene. Objectives: This research aims to see the effect of HIIT on the levels of inflammatory mediators in obese patients based on the study of the Ala55Val UCP2 gene. Methods: This study was a Quasi-Experimental Pre and Post Design Without Control Group. Thirty obese women (BMI≥25 kg/m2) were given High-Intensity Interval Training (HIIT) as an intervention by comparing the data before and after the intervention. The training intervention was conducted for 12 weeks, consisting of two weeks of adaptation and ten weeks of HIIT intervention. The body weight, BMI and inflammatory mediators (TNFα and IL 6) before and after the intervention were analyzed using the Dependent T-Test and Wilcoxon Test as a nonparametric test. Independent T-Test and Mann Whitney test used to determine the effect of the UCP2 Ala55Val gene on changes in body weight, BMI and the inflammatory mediator. The test results were considered significantly different if p<0.05. Results: Bivariate analysis using Dependent T-Test showed that HIIT significantly improved Body Weight, BMI and IL6 with p=0.0001. Wilcoxon Test showed that HIIT significantly improved TNFα with p=0.0001. Independent T-Test showed no difference in body weight (p=0.719), BMI (p=0.663) and TNFα (p=0.264) improvement in the two genotypes of the UCP2 Ala55Val gene. Mann Whitney Test showed no difference in IL6 (p=0.288) improvement in the two genotypes of the UCP2 Ala55Val gene. Conclusion: The research concluded that the 12-week HIIT interventions improved inflammatory mediators by reducing IL6 and TNFα in obese women. There was no effect of genetic variation on the response to training intervention.


2021 ◽  
Vol 1 (4) ◽  
pp. 50-56
Author(s):  
Ana Luísa Freitas Siqueira ◽  
Gabriela Souza Faria ◽  
Pedro De Oliveira Neto ◽  
Maria Paula Fabrício de Andrade ◽  
Bruna Pereira Molina Cruz ◽  
...  

Physical training is used in the control of arterial hypertension (AH), especially in patients with higher levels of blood pressure (BP). However, there are still few studies on the effects of physical training on AH in less advanced stages of the disease. The aim of the present study was to assess the immediate and late acute effects of continuous moderate physical training (CMT) and high intensity interval training (HIIT) in patients with mild AH, and to assess which training method induces a greater hypotensive effect. A female patient, 43 years old, sedentary, diagnosed with mild AH (stage 1), taking Losartana 50 mg twice a day was studied. She underwent one CMT and one HIIT session, one week apart. BP measurements were taken before and after each session, as well as 24 hours before and after the sessions. After the physical training sessions, we observed a drop in the patient's BP that lasted up to 60 minutes, and a reduction in blood pressure levels on the day after the training. We conclude that both training modalities were efficient in reducing the BP of the patient with mild acute immediate and delayed hypertension.


2015 ◽  
Vol 309 (6) ◽  
pp. H1039-H1047 ◽  
Author(s):  
Bert Bond ◽  
Emma J. Cockcroft ◽  
Craig A. Williams ◽  
Sam Harris ◽  
Phillip E. Gates ◽  
...  

High-intensity interval training (HIIT) improves traditional cardiovascular disease (CVD) risk factors in adolescents, but no study has identified the influence of HIIT on endothelial and autonomic function in this group. Thirteen 13- to 14-yr-old adolescents (6 girls) completed six HIIT sessions over 2 wk. Each training session consisted of eight to ten 1-min repetitions of cycling at 90% peak power interspersed with 75 s of unloaded cycling. Traditional (triglycerides, cholesterol, glucose, insulin, and blood pressure) and novel [flow-mediated dilation (FMD), heart rate variability (HRV)] CVD risk factors were assessed in a fasted and postprandial state before (PRE), 1 day after (POST-1D), and 3 days after (POST-3D) training. Aerobic fitness was determined PRE and POST-3D. Two weeks of HIIT had no effect on aerobic fitness or traditional CVD risk factors determined in the fasted or postprandial state ( P > 0.15). Compared with PRE, fasted FMD was improved POST-1D [ P = 0.003, effect size (ES) = 0.70] but not POST-3D ( P = 0.32, ES = 0.22). Fasted FMD was greater POST-1D compared with POST-3D ( P = 0.04, ES = 0.48). Compared with PRE, postprandial FMD was greater POST-1D ( P < 0.001, ES = 1.01) and POST-3D ( P = 0.01, ES = 0.60). Fasted HRV was greater POST-1D ( P = 0.001, ES = 0.71) and POST-3D ( P = 0.02, ES = 0.44). The test meal lowered HRV in all laboratory visits ( P < 0.001, ES = 0.59), but there were no differences in postprandial HRV between visits ( P > 0.32 for all). Two weeks of HIIT enhanced endothelial function and HRV without improvements in traditional CVD risk factors. However, most of this favorable adaptation was lost POST-3D, suggesting that regularly performing high-intensity exercise is needed to maintain these benefits.


2020 ◽  
Vol 26 ◽  
pp. 7-15
Author(s):  
Jaak Jürimäe

Obesity is the most common chronic disease in childhood, and is a risk factor for cardiovascular diseases (CVD) later in life. Being obese is inversely associated with physical activity and cardiorespiratory fitness (CRF) in children. Increased CRF may negate the detrimental effects of obesity-associated risk factors for CVD, while poor CRF has been associated with increased arterial stiffness and higher levels of blood inflammatory markers. The use of time efficient high-intensity interval training (HIIT) to reduce CVD risk factors and body mass, improve CRF and other health parameters has become popular during the last years in adults with obesity. However, a relatively few studies have investigated the effect of HIIT on body composition, CRF and cardiometabolic biomarkers in children with obesity. It is expected that low-volume HIIT programs are feasable for community-based body mass reduction and health promotion in children with obesity.


2019 ◽  
Vol 69 (1) ◽  
pp. 249-257
Author(s):  
Alireza Rabbani ◽  
Filipe Manuel Clemente ◽  
Mehdi Kargarfard ◽  
Saeid Jahangiri

Abstract The aim of the present study was to compare combined small‐sided game (SSG) and high‐intensity interval training (HIT) with different order. Twenty‐one semi‐professional soccer players were divided into two groups: SSG+HIT (n = 10) and HIT+SSG (n = 11), and underwent similar four‐week training programs. Players completed the 30‐15 Intermittent Fitness Test (30‐15IFT) before and after the experiment; maximum speed (VIFT) was recorded. During the experiment, seven sessions of SSG (3 vs 3) and HIT (15ʺ‐15ʺ with 95‐100% VIFT) were implemented. Weekly accumulated training loads for both groups during the experiment were similar. Moderate improvements in VIFT were observed in both SSG+HIT (+6.2%, 90% confidence limits, [CL] 4.6; 7.7 and Effect Size, [ES] +0.96) and HIT+SSG (+6.9%, 90% CL 4.6; 9.3 and ES +0.97) groups. Between‐group difference in changes of VIFT was trivial (+0.7%, 90% CL ‐1.8; 3.3 and ES +0.11). Combining SSG and HIT in different order elicited the same enhancement in high‐intensity intermittent performance in soccer players.


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