scholarly journals Detection of subclinical skin manifestation in patients with psoriasis and psoriatic arthritis by fluorescence optical imaging

2020 ◽  
Author(s):  
Angelique Schmidt ◽  
Anne-Marie Glimm ◽  
Ida Kristin Haugen ◽  
Paula Hoff ◽  
Gabriela Schmittat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Psoriatic Arthritis ◽  
Optical Imaging ◽  
Correct Diagnosis ◽  
Skin Inflammation ◽  
The Body ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Fluorescence Optical Imaging

Abstract Objectives: To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors.Patients and Methods: The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses.Results: We included FOI scans of patients with Pso/PsA (n=80), RA (n=78) and healthy controls (n=25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p<0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%) and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa=0.57). No CV risk factors except body weight (kg) was associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p<0.001). Conclusion: Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.

scholarly journals Detection of Subclinical Skin Manifestation in Patients With Psoriasis and Psoriatic Arthritis by Fluorescence Optical Imaging

2020 ◽  
Author(s):  
Angelique Schmidt ◽  
Anne-Marie Glimm ◽  
Ida Kristin Haugen ◽  
Paula Hoff ◽  
Gabriela Schmittat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Psoriatic Arthritis ◽  
Optical Imaging ◽  
Correct Diagnosis ◽  
Skin Inflammation ◽  
The Body ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Fluorescence Optical Imaging

Abstract Objectives:To investigate the frequency of subclinical skin inflammation in both hands by fluorescence optical imaging (FOI) in patients with psoriasis/psoriatic arthritis (Pso/PsA) vs. rheumatoid arthritis (RA) and healthy individuals, and to correlate these findings with cardiovascular (CV) risk factors.Patients and Methods:The FOI scans were analyzed retrospectively to detect clinically invisible skin enhancement (0-3 scale) in both hands without relationship to underlying joints or blood vessels. We further characterized the FOI patterns and sorted the scans into groups based on the assumed diagnosis (Pso/PsA, RA and healthy controls), which was compared with the physician’s diagnosis. Furthermore, the associations between CV risk factors and imaging findings were investigated by regression analyses.Results:We included FOI scans of patients with Pso/PsA (n=80), RA (n=78) and healthy controls (n=25). Subclinical skin enhancement on the back of their hands was more common in Pso/PsA (72.5%) than in RA patients (20.5%) and healthy individuals (28.0%) (p<0.001). Based on the FOI pattern, the majority of patients with Pso/PsA (72.5%), RA (76.9%) and healthy controls (68.0%) were classified correctly using the physician-based diagnosis as reference (overall agreement of 74%, kappa=0.57). No CV risk factors except body weight (kg) was associated with subclinical skin enhancement (OR 1.04, 95% CI 1.02-1.06; p<0.001).Conclusion:Subclinical subdermal skin inflammation was common in Pso/PsA patients using FOI. Based on the FOI pattern, most patients with Pso/PsA and were classified with the correct diagnosis. We demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.

scholarly journals OP0311 DETECTION OF SUBCLINICAL SKIN MANIFESTATION IN PATIENTS WITH PSORIASIS AND PSORIATIC ARTHRITIS BY FLUORESCENCE OPTICAL IMAGING

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 192.1-193
Author(s):  
A. Schmidt ◽  
A. M. Glimm ◽  
P. Hoff ◽  
G. Schmittat ◽  
G. R. Burmester ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Optical Imaging ◽  
Cardiovascular Risk Factors ◽  
Skin Inflammation ◽  
The Body ◽  
Healthy Controls ◽  
Skin Involvement ◽  
Healthy Individuals ◽  
Fluorescence Optical Imaging

Background:Fluorescence optical imaging (FOI) as new imaging technique enables visualization of an impaired microcirculation in both hands caused by joint inflammation. A detection of psoriatic skin inflammation which may also signify an altered vessel composition via FOI has not yet been examined.Objectives:The aim of the present study was to investigate potential subclinical skin inflammation in both hands of psoriasis (Pso) and psoriatic arthritis (PsA) patients in comparison to rheumatoid arthritis (RA) and healthy individuals by FOI, and to correlate these findings with cardiovascular risk factors or events, since a connection to Psoriasis skin involvement is assumed.Methods:FOI scans of patients with Pso and PsA as well as RA and healthy subjects were analyzed retrospectively to detect subclinical skin enhancement in both hands that did not clinically show overt psoriasis skin changes. According to the ‘fluorescence optical imaging activity score’ (FOIAS) (1) used for evaluation of joint enhancement so far, a standardized definition was set in order to describe the degree of skin enhancement via a semi-quantitative (0-3) score (seeFigure). The score was applied for the first third of the FOI exam sequence (0-120 sec.). To be scored as potential subdermal skin enhancement, it had to be localized on the back of the hands without relationship to an underlying joint or blood vessel since the ICG enhancement was then most likely localized in the area of the (sub)dermis. Using this analysis method, we further characterized the patterns and sorted the scans into the groups PsA/Pso, RA and healthy controls to compare these with the final physician’s diagnosis. Furthermore, cardiovascular risk factors (e.g. obesity, smoking status, hypertension) were collected and correlated to imaging findings.Results:We included FOI scans of patients with PsA/Pso (n=80), patients with RA (n=78) and healthy controls (n=25). Significantly more PsA/Pso patients showed subclinical skin enhancement on the back of their hands than RA and healthy individuals (PsA/Pso: 72.5%, RA: 20.5%, healthy controls: 28.0%; p<0.001). By using the pattern of skin enhancement, it was possible to categorize 58 of 80 patients correctly as PsA/Pso (72.5%), 60 out of 78 as RA (76.9%) and seventeen out of 25 as healthy controls (68.0%; p-value <0.001). We could show an influence of the body weight (kg) (p<0.001, OR 1.04, CI 1.02; 1.06) on the FOI results; no further correlation with cardiovascular risk factors was detected.Conclusion:We were able to proof our primary hypothesis that it is possible to visualize subclinical subdermal skin inflammation in PsA/Pso patients using FOI. Furthermore, we were also able to categorize PsA/Pso and RA patients correctly by using our newly developed method. Although we could not establish a correlation between subdermal skin enhancement and cardiovascular risk factors, we demonstrated an important influence of the body weight on our FOI results. FOI may be a helpful novel tool to study microcirculation in rheumatic diseases with skin involvement.References:[1]Werner SG, et al. Inflammation assessment in patients with arthritis using a novel in vivo fluorescence optical imaging technology. Ann Rheum Dis. 2012;71(4):504-10.Figure.Left picture: The enhancement is mostly yellow on green ground classified as grade 1. Middle picture: The enhancement is red with minimal white signals classified as grade 2. Right picture: The enhancement in the marked area shows more white than red signals which presents grade 3.Disclosure of Interests:Angelique Schmidt Speakers bureau: Speakers fee from Novartis, Roche, Abbvie, BMS, Anne-Marie Glimm: None declared, Paula Hoff: None declared, Gabriela Schmittat: None declared, Gerd Rüdiger Burmester Consultant of: AbbVie Inc, Eli Lilly, Gilead, Janssen, Merck, Roche, Pfizer, and UCB Pharma, Speakers bureau: AbbVie Inc, Eli Lilly, Gilead, Janssen, Merck, Roche, Pfizer, and UCB Pharma, Jens Klotsche: None declared, Sarah Ohrndorf: None declared

scholarly journals CORRELAÇÃO ENTRE OBESIDADE/SOBREPESO E PRESSÃO ARTERIAL ELEVADA EM ESCOLARES DE UMA CIDADE DO INTERIOR DE SÃO PAULO

2019 ◽  
Vol 11 (1) ◽  
pp. 51-56
Author(s):  
Marcelo José Alves ◽  
Victor Hugo Santos Zangirolamo ◽  
Carlos Augusto Carvalho Filho ◽  
Everton Alex Carvalho Zanuto ◽  
Diane de Vasconcelos Barrionuevo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Body Mass Index ◽  
Body Weight ◽  
Standard Deviation ◽  
Physical Inactivity ◽  
Pediatric Population ◽  
The Body ◽  
Chronological Age ◽  
Hemodynamic Variables

Currently the Brazilian pediatric population has been exposed to risk factors caused by physical inactivity and poor diet, resulting in an increase in the Body Mass Index (BMI), which can lead to vascular problems even in childhood. The objectivewasto verify the influence of BMIon pressure levels. The sample consisted of 61 children of both sexes, chronological age between six and seven years and regularly enrolled/attending school. These children were evaluated in their hemodynamic variables (systolic -SBP and diastolic –DBP blood pressure), body weight, and height. Mean and standard deviation of participants' ages were 7±0.3 years, SBP had 89.4±10 and DBP of 57±6.9, eutrophic patients had 88.7±1.1 for SBP and 56±5 for DBP,and for those with overweight/obesityof109±5 for SBP and 70.7±8.2 for PAD(p=0.0001).Pearson's correlation for BMI with SBP and DBP was moderate for both, but with beta of 1.53 in linear regression for SBP and 0.96 for DBP. It was concluded thatBMI directly influences systolic and diastolic blood pressure levels and the control of overweight / obesity is necessary at the initial ages of life

scholarly journals Body Weight at Birth: The Only Risk Factor Associated with Contralateral Clavicular Fracture in Patients with Congenital Muscular Torticollis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Zeeihn Lee ◽  
Joo Young Cho ◽  
Byung Joo Lee ◽  
Jong Min Kim ◽  
Donghwi Park
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Risk Factor ◽  
The Body ◽  
Youden Index ◽  
Clavicular Fracture ◽  
Congenital Muscular Torticollis ◽  
Factors Associated ◽  
Significant Difference ◽  
Muscular Torticollis

Abstract To date and to the best of our knowledge, there have been limited studies on the risk factor of clavicle fracture combined with congenital muscular torticollis (CMT), despite it being the most common fracture in newborns. So, the aim of this study was to investigate the risk factors associated with clavicular fracture combined with CMT, and its effect on prognosis. In this study, a total of 134 infants with CMT were included. The risk factors associated with clavicular fracture combined with CMT were analyzed. To analyze the correlation between the clinical parameters and the clavicular fracture in patients with CMT, demographic data, such as body weight at birth, maternal age, gender, gestational age, delivery method, sternocleidomastoid (SCM) thickness of ipsilateral side, its ratio between the ipsilateral and contralateral side, and the first visitation date after birth were evaluated. In the results of this study, the clavicular fracture was found in 15 of 134 patients with CMT (19%). In multivariate logistic analysis, the body weight at birth was the only significant parameter for predicting clavicular fracture in patients with CMT (p-value < 0.05). However, there was no significant difference of treatment duration between CMT infants with or without clavicular fracture. In infants with CMT, the area under the ROC curve of the body weight at birth for predicting clavicular fracture was 0.659 (95% CI, 0.564–0.745.; p < 0.05). The optimal cut-off value obtained from the maximum Youden index J was 3470 g (sensitivity: 57.14%, specificity: 75.76%), and the odd ratio of clavicular fracture in patients with CMT increased by 1.244 times for every 100 g of body weight at birth. In conclusion, birth weight appears to be a clinical predictor of clavicular fracture in infants with CMT. More studies and discussions are needed on whether any screening should be recommended for detecting the concurrent clavicular fracture in subjects with CMT.

scholarly journals Distinct effects of over-general autobiographical memory on suicidal ideation among depressed and healthy people

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Wen Jiang ◽  
Guangtao Hu ◽  
Jingxuan Zhang ◽  
Ken Chen ◽  
Dongni Fan ◽  
...  
Keyword(s):  
Risk Factors ◽  
Suicidal Ideation ◽  
Autobiographical Memory ◽  
Childhood Trauma ◽  
Study Data ◽  
Path Model ◽  
Control Group ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Healthy Control

Abstract Background Childhood trauma and over-general autobiographical memory (OGM) are crucial risk factors of suicide. This study aimed to investigate whether suicidal ideation was predicted by one’s childhood trauma and OGM and the mechanism of OGM underlying suicidal ideation in depression patients and healthy controls. Methods A total of 180 depression patients and 176 matched healthy individuals were recruited in this study. Data were analyzed using descriptive statistics, and Pearson’s correlation coefficient was obtained. Path analysis was conducted to test a meditational model. The multigroup comparison was applied to find differences between groups. Results Significant differences were detected between depression patients and healthy controls with respect to childhood trauma, OGM, suicidal ideation, and suicidal behavior. OGM was positively correlated with both current and worst-point suicidal ideation in the depression group and significantly correlated with worst-point suicidal ideation in the healthy control group. The path model showed that childhood trauma had a direct impact on the current suicidal ideation directly, and an indirect influence through OGM and worst-point suicidal ideation. Multigroup analysis further demonstrated that OGM affected and mediated the current suicidal ideation due to childhood trauma in depression patients, whereas only worst-point suicidal ideation was affected in healthy controls. Conclusions The OGM mediates suicidal ideation in depression patients, but only affects the worst-point suicidal ideation in the healthy controls. As it is one of the major risk factors of suicidal ideation in depression, amelioration of OGM might be an useful method to reduce or prevent suicidal ideation in depression patients.

scholarly journals Influence of prednisone therapy on physical development of children with nephrotic syndrome

2019 ◽  
Vol 23 (5) ◽  
pp. 88-95 ◽  
Author(s):  
T. L. Nastausheva ◽  
E. E. Boeva ◽  
T. G. Zvyagina ◽  
E. N. Kulakova ◽  
N. S. Nastausheva ◽  
...  
Keyword(s):  
Risk Factors ◽  
Body Weight ◽  
Nephrotic Syndrome ◽  
Body Mass ◽  
Cumulative Dose ◽  
Physical Development ◽  
The Body ◽  
Prednisone Therapy ◽  
Steroid Sensitive ◽  
Relationship Of

THE AIM: to compare the parameters of physical development (PD) in children with idiopathic nephrotic syndrome (INS), depending on the treatment with prednisone.PATIENTS AND METHODS. The effect of treatment with prednisone on PD was analyzed in 60 children with INS aged from 2 to 17 years. The children were divided into 2 groups: 30 children who did not receive prednisone, and 30 children who received it during the last 6 months before the study (1st and 2nd group, respectively). The groups compared the anamnestic parameters and the risk factors of children in terms of length, weight, and body mass index.RESULTS. When comparing the characteristics of the risk factors of children of the above 2 groups, differences in body mass and BMI were established. In children who received prednisone for the last 6 months, body weight and BMI were significantly exceeded compared to WHO standards and similar patients who did not receive prednisone for the last 6 months. We have established a reliable association of the Z-BMI criterion with the cumulative dose of prednisone in the last 6 months: r = 0.49, p <0.05. At the same time, no reliable association of body weight with a cumulative dose of prednisone, which the child received before 6 months, has been identified. When analyzing the effectiveness of different doses of prednisone therapy for stopping relapses in children with steroid-sensitive INS, it was found that the onset and duration of remission did not significantly differ when taking standard (60mg/m2/day or 2 mg/kg/day) and half as much (1mg/kg/day) doses of prednisone.CONCLUSION. The relationship of the body mass of children with INS and the cumulative dose of prednisone in the last 6 months has been established. When treating a recurrent steroid-sensitive non-relapsing INS, a decrease in the daily dose of prednisone from 2 mg/kg/day to 1 mg/kg/day is possible in adolescents who are afraid of steroid obesity or who have had severe complications during previous courses of prednisone therapy.

scholarly journals Using Chinese Body Constitution Concepts and Measurable Variables for Assessing Risk of Coronary Artery Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Yi-Chia Huang ◽  
Chien-Jung Lin ◽  
Shu-Meng Cheng ◽  
Chi-Kuei Lin ◽  
Sunny Jui-Shan Lin ◽  
...  
Keyword(s):  
Risk Factors ◽  
Chest Pain ◽  
Prospective Observational Study ◽  
Case Control Study ◽  
Case Control ◽  
The Body ◽  
Healthy Controls ◽  
Body Constitution ◽  
Artery Disease ◽  
Control Study

Background. Identifying patients with high risk of coronary artery disease (CAD) is often difficult in outpatient clinic settings. This study aimed to explore if the measurement of body constitution can be adopted to predict the risk of CAD diagnosis. The objective of this study is to conduct a prospective observational study and a case-control study to answer the research question. Study Design. Part 1 (prospective observational study): a total of 143 patients with chest pain and admitted to receive cardiac catheterization were enrolled, and 108 of them were diagnosed with CAD. Part 2 (case-control study): the above 108 CAD patients and 476 healthy controls matched by age and gender from the participants of Taiwan Biobank were adopted for comparison. Main Outcome Measures. The body constitution of both patients and healthy controls were measured by the Body Constitution Questionnaire (BCQ). Each one received scores of Yang-Xu (Yang-deficiency), Yin-Xu (Yin-deficiency), and Stasis. These 3 scores together with demographic characteristics and CAD risk factors were used in the logistic multiple regression model to predict the risk of CAD. Results. (Part 1) No difference was found between the scores of Yang-Xu, Yin-Xu, and Stasis between the patients with and without CAD. (Part 2) The scores of Yang-Xu, Yin-Xu, and Stasis of the CAD patients were significant higher those of the healthy controls. Yang-Xu and Stasis scores were obtained with age, BMI, and hypertension in the model with prediction rate 89.0%. The area under receiver operating characteristic curve of this model was 0.896. Conclusions. This study is the first to apply Chinese body constitution concepts and measurable variables to assess the risk of having CAD of the patients with chest pain prior to receiving cardiac catheterization. The higher scores of Yang-Xu and Stasis were found to be risk factors. Our results revealed that BCQ has the potential to be a first-line diagnostic tool for patients with chest pain to facilitate early recognition and diagnosis of CAD.

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