Effects of antioxidant supplementation on oxidative stress balance in young footballers: a randomized controlled trial

Abstract Background The intensive physical exercise in which athletes take part in competitive sports can negatively affect the pro-oxidative–antioxidant balance. The use of compounds with high antioxidant potential, which certainly should include chokeberry, can prevent these adverse changes. Methods The study was conducted on a group of football players aged 16–17 years, who underwent 7 weeks of supplementation with 200 ml chokeberry juice per day. Before and after supplementation, the participants performed an intensive physical exercise test (beep test). At rest, immediately after exercise and after 3 and 24 h of rest, venous blood was taken from the subjects, in which levels of thiobarbituric acid reactive products (TBARS), hydroxy-2'-deoxyguanosine (8-OHdG), total antioxidant capacity (TAC), iron (Fe), hepcidin, ferritin, myoglobin, albumin and morphological parameters were examined. Results There was a significant impact of the intervention in response to the physical exercise test in the studied groups on parameter dynamics: 8-OHdG (t = 3.56, p = 0.0005), albumin (t = 1.98, p = 0.049), TBARS (t = 4.33, p = 0.00003), hepcidin (t = 2.21, p = 0.03), and Mono level (t = 2.14, p = 0.04) and percentage (t = 2.27, p = 0.03). The post-hoc test showed no effect of chokeberry juice supply on any of the morphological, biochemical or performance parameters analysed. Conclusions The supplementation applied to footballers showed no effects under the influence of the applied exercise stress test. Such results may be the result of both the players’ adaptation to the applied exercise loads and the insufficient antioxidant capacity of the supplement used.

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P1398 Echocardiographic continuous monitoring of exercise stress test using probe fixation device

European Heart Journal - Cardiovascular Imaging ◽

10.1093/ehjci/jez319.831 ◽

2020 ◽

Vol 21 (Supplement_1) ◽

Author(s):

K Wdowiak-Okrojek ◽

P Wejner-Mik ◽

Z Bednarkiewicz ◽

P Lipiec ◽

J D Kasprzak

Keyword(s):

Image Quality ◽

Physical Exercise ◽

Stress Test ◽

Exercise Stress Test ◽

Bicycle Ergometer ◽

Exercise Stress ◽

Fixation Device ◽

The Mean ◽

First Time

Abstract Background Stress echocardiography (SE) plays an important role among methods of noninvasive diagnosis of ischemic disease. Despite the advantages of physical exercise as the most physiologic stressor, it is difficult (bicycle ergometer) or impossible (treadmill) to obtain and maintain the acoustic window during the exercise. Recently, an innovative probe fixation device was introduced and a research plan was developed to assess the feasibility of external probe fixation during exercise echocardiography on a supine bicycle and upright treadmill exercise for the first time. Methods 37 subjects (36 men, mean age 39 ± 16 years, 21 healthy volunteers, 16 patients with suspected coronary artery disease) were included in this study. This preliminary testing stage included mostly men due to more problematic probe fixation in women. All subjects underwent a submaximal exercise stress test on a treadmill (17/37) or bicycle ergometer (11/37). Both sector and matrix probes were used. We assessed semi-quantitatively the quality of acquired apical views at each stage – the four-point grading system was used (0-no view, 1-suboptimal quality, 2-optimal quality, 3-very good quality), 2-3 sufficient for diagnosis. Results The mean time required for careful positioning of the probe and image optimization was 12 ± 3 min and shortened from 13,7 to 11,1 minutes (mean) in first vs second half of the cohort documenting learning curve. At baseline, 9 patients had at least one apical view of quality precluding reliable analysis. Those patients were excluded from further assessment. During stress, 17 patients maintained the optimal or very good quality of all apical views, whereas in 11 patients the quality significantly decreased during the stress test and required probe repositioning. The mean image quality score at baseline was 2,61 ± 0,48 and 2,25 ± 0,6 after exercise. Expectedly, good image quality was easier to obtain and maintain in the supine position (score 2,74 ± 0,44) points as compared with upright position (score 2,25 ± 0,57). Conclusion This preliminary, unique experience with external probe fixation device indicates that continuous acquisition and monitoring of echocardiographic images is feasible during physical exercise, and for the first time ever - also on the treadmill. This feasibility data stem from almost exclusively male patients and the estimated rate of sufficient image quality throughout the entire test is currently around 60%. We are hoping, that gaining more experience with the product could increase the success rate on exercise tests. Abstract P1398 Figure. Treadmill and ergometer stress test

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Effects of antioxidant supplementation on oxidative stress balance in young footballers– a randomized double-blind trial

10.21203/rs.3.rs-36705/v2 ◽

2021 ◽

Author(s):

Błażej Stankiewicz ◽

Mirosława Cieślicka ◽

Sławomir Kujawski ◽

Elżbieta Piskorska ◽

Tomasz Kowalik ◽

...

Keyword(s):

Physical Exercise ◽

Antioxidant Capacity ◽

Venous Blood ◽

Thiobarbituric Acid ◽

Double Blind ◽

Before And After ◽

Total Antioxidant ◽

Double Blinded ◽

And Control ◽

Chokeberry Juice

Abstract Background: The intensive physical exercise in which athletes take part in competitive sports can negatively affect the pro-oxidative–antioxidant balance. The use of compounds with high antioxidant potential, which certainly should include chokeberry, can prevent these adverse changes. Methods: The study was conducted as a double blinded randomized trial on a group of football players (mean age=15.8), who underwent 7 weeks of supplementation with 200 ml chokeberry juice per day. The players were randomly assigned to the experimental (supplemented, FP-S; n = 12) and control (placebo, FB-C; n = 8) groups. Before and after the supplementation period, participants performed an beep test . Venous blood was taken for serum isolation before, immediately after, 3 h, 24 h after the test Level of thiobarbituric acid reactive products (TBARS), hydroxy-2'-deoxyguanosine (8-OHdG), total antioxidant capacity (TAC), iron (Fe), hepcidin, ferritin, myoglobin, albumin and morphological parameters (RBC, HGB, HCT, MCV, MCH, MCHC and lactic acid) were measured.Results: There were no significant impact of the supplementation intervention in response to the physical exercise test in the studied groups.. The post-hoc test showed no effect of chokeberry juice supply on any of the morphological, biochemical or performance parameters analysed.Conclusions: The supplementation of Chokeberry juice shows no effects on measured parameters in studied populations. It may indicate Such results may indicate insufficient antioxidant capacity of the supplemented juice.

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Results of bicycle exercise stress test in patients with stable coronary heart disease depending on the angiographic signs of atherosclerotic lesions of coronary arteries

EUREKA Health Sciences ◽

10.21303/2504-5679.2021.001844 ◽

2021 ◽

pp. 53-60

Author(s):

Vira Tseluyko ◽

Tetiana Pylova

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Exercise Test ◽

Stress Test ◽

Exercise Stress Test ◽

Exercise Stress ◽

Bicycle Exercise ◽

Group I ◽

Group Ii ◽

Artery Disease

The aim. To identify features of exercise response in coronary heart disease (CHD) patients depending on coronary artery condition and to identify factors associated with a positive test in patients with no obstructive coronary artery disease (INOCA). Materials and methods. The study included 105 patients diagnosed with stable coronary artery disease (CAD) who were hospitalized at the City Clinical Hospital No. 8 of the Kharkiv City Council. The criteria for diagnosis of ischemia with no obstructive coronary artery disease (INOCA) were met by 53 patients who formed group I. Group II included 52 patients who were consistently hospitalized in the period from June to December 2020, and had obstructive CAD for more than 50 % according to their coronary angiography (CAG). Results. According to the results of bicycle exercise stress test, a positive test was significantly more often registered in group II – n=30 (57.7 %) patients compared to group I – n=19 (35.8 %) patients (p=0.0249). The duration of the test in patients of group I was significantly longer than 420 seconds [290–540], compared with group II – 300.0 [210.0–540.0] (р=0.0352). Also, in patients in group II, the maximum volume of the test performed was probably lower than in group I (p=0.0324). When calculating the double product, it was also found that in group I its value was significantly higher compared to group II (p=0.0292). In group I there was a significantly higher rate of chronotropic reserve (44.0 [26.0–60.0]), compared with group II (p=0.0168). Elevated total cholesterol (above 5 mmol/l) is a statistically significant and independent factor of a positive exercise test in patients with INOCA (OR, 1.98 [0.9992-3.926], p=0.05). A correlation was found between the level of exercise tolerance and smoking in INOCA-patients (r =-0.388975, p=0.010899). Patients who underwent MINOCA also showed reduced tolerance to exercise (r=-0.3104, p=0.042721) Conclusions. The sensitivity of bicycle exercise stress test in patients with CAD depends on the presence and severity of atherosclerotic lesions of the coronary arteries (63 % in stenotic atherosclerosis, 36 % in no obstructive coronary arteries. It was found that exercise test duration, double product, chronotropic and inotropic reserve of the heart in patients with a positive exercise test with INOCA were significantly higher compared with patients with obstructive CAD. Independent factors associated with a positive exercise test in patients with no obstructive CAD are an increase in total cholesterol (multivariate regression logistic analysis).

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Estimating pVO2 and prognosis through cardiac exercise stress test in a heart failure population

European Heart Journal ◽

10.1093/eurheartj/ehab724.0852 ◽

2021 ◽

Vol 42 (Supplement_1) ◽

Author(s):

J.P.L De Almeida ◽

J Milner ◽

J Rosa ◽

R Coutinho ◽

M Ferreira ◽

...

Keyword(s):

Heart Failure ◽

Exercise Testing ◽

Exercise Test ◽

Stress Test ◽

Pearson Correlation ◽

Cardiopulmonary Exercise Testing ◽

Exercise Stress Test ◽

Cardiopulmonary Exercise Test ◽

Exercise Stress ◽

Cardiopulmonary Exercise

Abstract Background Compared with the cardiac exercise stress test, more commonly used to assess the presence of ischemia, the cardiopulmonary exercise test has the advantage of providing expired gas analysis. According to current guidelines, cardiopulmonary exercise testing should be considered to stratify the risk of adverse events and to provide measures of survival improvement in heart failure populations. However, cardiac exercise stress test is more readily available and widespread than cardiopulmonary exercise testing. We aimed to compare prognostic information given by estimated pVO2 – which can be obtained from cardiac exercise stress test – and real measured pVO2 – which requires cardiopulmonary exercise test – in a heart failure population. Methods We conducted a retrospective analysis of 214 patients with HF underwent cardiac exercise stress test and accessed their 5 year survival. Non-urgent transplanted (UNOS Status 2) patients were censored alive on the date of the transplant. Duringthe cardiopulmonary exercise test, cardiac exercise stress test data simultaneously collected. Based on protocol stage achieved, estimated METs were used to calculate estimated pVO2 (pVO2 = estimated METs x 3.5). Estimated and real pVO2 were correlated using Pearson correlation and the age-adjusted prognostic power of each was determined using Cox proportional hazardsanalysis. Results 164 patients were male (77%) and the mean age of the population was 56±10 years. 78 (36%) patients had an ischemic etiology. Within 5 years from testing, 46 patients died (21.5%) and 55 patients (26%) were transplanted. Naughton modified (n=165) was the most commonly used protocol, followed by Naughton (n=39) and Bruce (n=10). Estimated pVO2 and measured pVO2 correlated significantly (R=0.66, p<0.01) (Figure 1). Both estimated (HR=0.91, 95% CI 0.86–0.95, p<0.01) and measured pVO2 (HR=0.86, 95% CI 0.80–0.91, p<0.01) strongly predicted prognosis in this population. Conclusions Estimated pVO2 correlated with measured pVO2 and strongly predicted prognosis in this heart failure population. Because it can be obtained from conventional cardiac exercise testing, it may become an alternative prognostic tool to cardiopulmonary testing. FUNDunding Acknowledgement Type of funding sources: None. Figure 1. Measured vs estimated pVO2

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Supplemental Arm Pumping Puts Adenosine Testing on Par With Exercise Stress Test

Internal Medicine News ◽

10.1016/s1097-8690(06)74459-6 ◽

2006 ◽

Vol 39 (21) ◽

pp. 43

Author(s):

PATRICE WENDLING

Keyword(s):

Stress Test ◽

Exercise Stress Test ◽

Exercise Stress

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Brugada syndrome: Eligibility for subcutaneous implantable cardioverter-defibrillator after exercise stress test

Revista Portuguesa de Cardiologia (English Edition) ◽

10.1016/j.repce.2020.05.021 ◽

2021 ◽

Vol 40 (1) ◽

pp. 33-38

Author(s):

Pedro von Hafe ◽

Bebiana Faria ◽

Geraldo Dias ◽

Filipa Cardoso ◽

Maria José Alves ◽

...

Keyword(s):

Implantable Cardioverter Defibrillator ◽

Brugada Syndrome ◽

Stress Test ◽

Exercise Stress Test ◽

Exercise Stress ◽

Cardioverter Defibrillator

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Cardiac Rehabilitation and Physical Performance in Patients after Myocardial Infarction: Preliminary Research

Journal of Clinical Medicine ◽

10.3390/jcm10112253 ◽

2021 ◽

Vol 10 (11) ◽

pp. 2253

Author(s):

Agnieszka Grochulska ◽

Sebastian Glowinski ◽

Aleksandra Bryndal

Keyword(s):

Myocardial Infarction ◽

Cardiac Rehabilitation ◽

Physical Performance ◽

Stress Test ◽

Maximal Oxygen Consumption ◽

Exercise Stress Test ◽

Health Condition ◽

Exercise Stress ◽

Test Time ◽

Before And After

(1) Background: Cardiovascular diseases, in particular, myocardial infarction (MI), are the main threats to human health in modern times. Cardiac rehabilitation (CR), and especially increased physical activity, significantly prevent the consequences of MI. The aim of this study was to assess physical performance in patients after MI before and after CR. (2) Methods: 126 patients after MI were examined. They were admitted to the cardiac rehabilitation ward twice: in the 3rd month after MI, and then in the 6th month after the last rehabilitation session. CR lasted 20 treatment days (4 weeks with 5 treatment days and 2 days’ break). The exercise stress test on the treadmill and a 6-minute walk test (6MWT) were used to assess physical performance. Patients were assigned to an appropriate rehabilitation model due to their health condition. (3) Results: In the studied group, the exercise stress test time and the metabolic equivalent of task (MET), the maximal oxygen consumption (VO2max), and 6MWT score increased significantly (p = 0.0001) at two time-points of observation. (4) Conclusion: CR significantly improves physical performance in patients after MI.

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