Adiponectin and 8-epi-PGF2α as intermediate influence factors in weight reduction after legumes consumption: a 12-week randomized controlled trial
Abstract Background and Aims: The current nutritional intervention study was designed to determine the effect of legume on body weight in obese subjects. Methods Randomized controlled study of 12 weeks with 383 participants (body mass index ≥ 25 kg/m2) was enrolled for the study. The intervention program consisted of replacing 1/3 refined rice intake with legumes three times per day as a carbohydrate source in high fat diet group. In contrast, low fat diet group was recommended to eat as their usual diet. Results In high fat diet group, intake of energy and carbohydrate were lower, while the intake of fat and protein were higher. Mean weight loss at 12 weeks was 2.87 ± 0.21 kg and 0.17 ± 0.11 kg in the high fat diet group and low fat diet group, respectively, and was significantly different between groups (P < 0.001). HDL-cholesterol and adiponectin were increased, while glucose, insulin, triglyceride, HOMA-IR index, and 8-epi-PGF2α were decreased at 12 weeks in the high fat diet group compared with baseline. Conclusions The conclusion is that the consumption of legumes may accelerate weight loss accompanied by regulation of adiponectin and 8-epi-PGF2α in obese subjects. Also, increases in plasma adiponectin induced by a larger amount of weight loss may relate to greater activation of insulin resistance. Trial registrations: NCT04392882 (Registered 19 May 2020 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT04392882?cond=NCT04392882&draw=2&rank=1)