Reduction of Testosterone Levels in Schistosoma Haematobium or Schistosoma Mansoni Infected Men: A Cross-Sectional Study in Two Schistosomiasis-Endemic Areas of the Adamawa Region of Cameroon

Abstract Background: The incidence of schistosomiasis‐induced male reproductive dysfunction and infertility is probably underestimated comparing to female genital schistosomiasis. This study aimed to investigate the impact of S. haematobium or S. mansoni infection on the reproductive function of adult men in Tibati and Wouldé, two schistosomiasis endemic areas in the Adamawa region of Cameroon.Methods: A total of 89 men in the reproductive age (range: 14 – 56 years) from two localities were enrolled in the study with 51 in Tibati and 38 in Wouldé. Each participant was submitted to a questionnaire to document data on sociodemographic and stream contact behaviors. A medical examination was performed to measure the circumference of the testes and to evaluate genital tract pathologies. Stool and urine samples were collected and screened for the presence of S. haematobium or S. mansoni ova. Blood serum was use to evaluate the level of transaminases and testosterone.Results: S. haematobium was present only in Tibati with a prevalence of 31.37%. S. mansoni prevalence was 3.92% at Tibati and 44.71% in Wouldé. The intensity of infection was 22.12 ± 9.57 eggs/10 mL for S. haematobium and 128.10 ± 3.76 epg for S. mansoni. Serum transaminases activity and the mean testicular circumference of Schistosoma-positive individuals were close to those of negative ones. The testes size was however higher in S. mansoni-positive individuals than in S. haematobium-positive ones (P < 0.05). The serum testosterone level of S. haematobium and S. mansoni-positive men was significantly reduced by 56.07% (P < 0.001) and 51.94% (P < 0.01) respectively in comparison to that of Schistosoma-negative ones. A significant and negative correlation was established between schistosomiasis and the low level of serum testosterone. Male genital tract pathologies such as scrotal abnormalities, varicocele, nodular epididymis, inguinal hernia and hydrocele were recorded in both Schistosoma-positive and Schistosoma-negative men. However, no significant link was established between schistosomiasis infection and these pathologies.Conclusion: These results demonstrated that infection with S. haematobium or S. mansoni is associated with a low production of the reproductive hormone testosterone, and may be a major cause of male infertility.

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The Impact of Bariatric Surgery on Menstrual Abnormalities—a Cross-Sectional Study

Obesity Surgery ◽

10.1007/s11695-020-04840-6 ◽

2020 ◽

Vol 30 (11) ◽

pp. 4505-4509

Author(s):

Anna Różańska-Walędziak ◽

Paweł Bartnik ◽

Joanna Kacperczyk-Bartnik ◽

Krzysztof Czajkowski ◽

Maciej Walędziak

Keyword(s):

Bariatric Surgery ◽

Menstrual Cycle ◽

Cross Sectional Study ◽

Reproductive Age ◽

Obese Women ◽

Sectional Study ◽

Cross Sectional ◽

Contraception Use ◽

Before And After ◽

The Impact

Abstract Introduction Obesity is associated with hyperestrogenism along with other hormonal abnormalities affecting the menstrual cycle. The most effective and decisive method of obesity treatment is bariatric surgery. The aim of this study was to analyze the impact of bariatric surgery on menstrual cycle, the incidence of menstrual abnormalities, hyperandrogenism manifestation, and contraception use. Materials and Methods It was a cross-sectional study of 515 pre-menopausal women who had undergone bariatric surgery between 1999 and 2017 in a bariatric center. Data was collected via anonymous questionnaire, and the questions covered a 1-year period before the surgery and the last year before questionnaire completion. Results Before the surgery, 38.6% of the patients reported irregular menstruations in comparison with 25.0% after bariatric surgery (RR = 0.65; 95%CI 0.53–0.79). The mean number of menstruations per year did not differ before and after surgery (10.2 ± 3.9 vs 10.4 ± 3.3; p < .45). There were no statistically significant differences in terms of prolonged menstruations, acne, and hirsutism prevalence. A total of 14.4% of patients before surgery reported estrogen-based contraception use in comparison with 15.0% after the surgery (p < .95). There were no significant differences in the frequency of OC use (11.0% before surgery vs 13.6% 12 months after the surgery vs 11.5% at the moment of survey administration; p < 0.46). Conclusion Bariatric surgery improves the regularity of the menstrual cycle in obese women in reproductive age. The lack of any changes in the combined hormonal contraception (CHC) use, especially OC, before and after bariatric surgery may be a result of a possibly low level of contraception counseling.

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Comparison of Plasma Neurosteroid and Prolactin Levels in Patients with Schizophrenia and Healthy Individuals

Scientifica ◽

10.1155/2016/3108689 ◽

2016 ◽

Vol 2016 ◽

pp. 1-6 ◽

Cited By ~ 3

Author(s):

Forough Riahi ◽

Maryam Izadi-mazidi ◽

Ali Ghaffari ◽

Elham Yousefi ◽

Shahram Khademvatan

Keyword(s):

Analysis Of Variance ◽

Serum Testosterone ◽

Cross Sectional Study ◽

Serum Testosterone Level ◽

First Episode ◽

Healthy Individuals ◽

Sectional Study ◽

Cross Sectional ◽

Hormone Levels ◽

First Episode Schizophrenia

Background.The present study aimed to compare plasma levels of cortisol, testosterone, dehydroepiandrosterone (DHEA), and prolactin in patients with schizophrenia and healthy individuals.Method.A total of 100 patients with schizophrenia disorder (69 men and 31 women) and 190 healthy individuals (94 men and 96 women) participated in this cross-sectional study. They were tested for hormone levels and completed demographic questionnaires. Data were analyzed using multivariate analysis of variance (MANOVA) and one-way analysis of variance.Results.Serum testosterone level was significantly higher in men with schizophrenia than in healthy men. Women with schizophrenia had a significantly higher level of testosterone and lower level of prolactin compared to healthy women. There were no significant differences in hormone levels across various subtypes of schizophrenia. No significant differences also were observed in hormones levels in patients with first-episode schizophrenia disorder compared to those in patients with recurrent episodes.Conclusion.This study indicated that abnormal testosterone and prolactin levels might be associated with pathophysiology of schizophrenia disorder.

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Anti-Mullerian hormone levels in female cancer patients of reproductive age in Indonesia: A cross-sectional study

F1000Research ◽

10.12688/f1000research.15728.2 ◽

2019 ◽

Vol 8 ◽

pp. 159

Author(s):

Achmad Kemal Harzif ◽

Budi Wiweko ◽

Putri Addina ◽

Kartika Iswaranti ◽

Melisa Silvia ◽

...

Keyword(s):

Cancer Therapy ◽

Cancer Patients ◽

Reproductive Function ◽

Cross Sectional Study ◽

Reproductive Age ◽

Cancer Treatments ◽

Cross Sectional ◽

Cancer Group ◽

Anti Cancer ◽

Female Cancer Patients

Background: Efforts in reproductive preservation for cancer patients have become one of the important aspects of cancer management. In fact, decline in reproductive function is known to occur after exposure to anti-cancer treatments. Measuring anti-Müllerian hormone (AMH) levels is known to be the best parameter in predicting ovarian reserves, which indicates reproductive function. In total, 68% of cancer survivors of reproductive age who underwent anti-cancer treatments suffer from infertility. Meanwhile, ovarian reserves also decrease with increasing age. There is ongoing debate on whether the ovarian reserves of cancer patients could be reduced long before exposure to anti-cancer therapy. Therefore, it is important to know whether ovarian reserves in cancer patients decrease before or after anti-cancer therapy. This can help predict the reproductive function in such cases and the effectiveness of ovarian preservation efforts. Methods: A cross-sectional study was conducted, comparing the AMH levels of 44 female cancer patients of reproductive age before cancer therapy, to 44 non-cancer patients of reproductive age (age matched). The biological ages from both groups were adjusted using the Indonesian Kalkulator of Oocytes. Results: The median age in both groups was 28 years old. The AMH levels in the cancer group were found to be significantly lower in contrast to those in the non-cancer group (1.11 [0.08-4.65] ng/ml vs. 3.99 [1.19- 8.7]; p- value <0.001). Therefore, the biological age in the cancer group was 10 years older than that of the non-cancer group, indicating that ovarian aging occurs earlier in cancer patients. Conclusions: AMH levels of cancer patients of reproductive age were already reduced before cancer therapy, given an older biological age, in contrast to that of the non-cancer patients. Proper counseling and implementation of fertility-preserving methods is highly recommended in this group of patients.

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Anti-Mullerian hormone levels in female cancer patients of reproductive age in Indonesia: A cross-sectional study

F1000Research ◽

10.12688/f1000research.15728.3 ◽

2020 ◽

Vol 8 ◽

pp. 159

Author(s):

Achmad Kemal Harzif ◽

Budi Wiweko ◽

Putri Addina ◽

Kartika Iswaranti ◽

Melisa Silvia ◽

...

Keyword(s):

Cancer Therapy ◽

Cancer Patients ◽

Reproductive Function ◽

Cross Sectional Study ◽

Reproductive Age ◽

Cancer Treatments ◽

Cross Sectional ◽

Cancer Group ◽

Anti Cancer ◽

Female Cancer Patients

Background: Efforts in reproductive preservation for cancer patients have become one of the important aspects of cancer management. In fact, decline in reproductive function is known to occur after exposure to anti-cancer treatments. Measuring anti-Müllerian hormone (AMH) levels is known to be the best parameter in predicting ovarian reserves, which indicates reproductive function. In total, 68% of cancer survivors of reproductive age who underwent anti-cancer treatments suffer from infertility. Meanwhile, ovarian reserves also decrease with increasing age. There is ongoing debate on whether the ovarian reserves of cancer patients could be reduced long before exposure to anti-cancer therapy. Therefore, it is important to know whether ovarian reserves in cancer patients decrease before or after anti-cancer therapy. This can help predict the reproductive function in such cases and the effectiveness of ovarian preservation efforts. Methods: A cross-sectional study was conducted, comparing the AMH levels of 44 female cancer patients of reproductive age before cancer therapy, to 44 non-cancer patients of reproductive age (age matched). The AMH was determined from blood.The biological ages from both groups were adjusted using the Indonesian Kalkulator of Oocytes. Results: The median age in both groups was 28 years old. The AMH levels in the blood of the cancer group were found to be significantly lower in contrast to those in the non-cancer group (1.11 [0.08-4.65] ng/ml vs. 3.99 [1.19- 8.7]; p- value <0.001). Therefore, the biological age in the cancer group was 10 years older than that of the non-cancer group, indicating that ovarian aging occurs earlier in cancer patients. Conclusions: AMH levels of cancer patients of reproductive age were already reduced before cancer therapy, given an older biological age, in contrast to that of the non-cancer patients. Proper counseling and implementation of fertility-preserving methods is highly recommended in this group of patients.

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MISCARRIAGES AND ITS RELATIONSHIP WITH DEPRESSION & QUALITY OF LIFE: A COMPARATIVE STUDY

Journal of University Medical & Dental College ◽

10.37723/jumdc.v11i4.439 ◽

2020 ◽

Vol 11 (4) ◽

pp. 47-54

Author(s):

Lubna Soomro ◽

Parvasha Memon ◽

Muniza Malik ◽

Saira Almas

Keyword(s):

Quality Of Life ◽

Family System ◽

Cross Sectional Study ◽

Cross Sectional ◽

Sample Mean ◽

Perceived Quality Of Life ◽

Mean Differences ◽

Age Range ◽

The Impact

ABSTRACT BACKGROUND & OBJECTIVE: Quality of life describes the way of perception of an individual’s position in life. The objective of this study was to assess the impact of miscarriages on quality of life and depression in women with or without miscarriages. METHODOLOGY: Descriptive Cross sectional study was conducted at different hospitals of Hyderabad, Sindh in six months among 200 participants (100 without miscarriage & 100 with miscarriages). The age range of the participants was 18–40 years. Demographic information was taken to get information about the participants like age, family system, education. Two validated, structured questionnaire namely; Quality of Life (QOL) and Beck Depression Inventory (BDI) were administered. Data was analyzed by SPSS version 23.0, independent sample t-test was applied to observe difference of depression and quality of life among women with or without miscarriages. RESULTS: In the sample among women with miscarriages 42 % were in the age range of 18-30 years and 58 % were of age 31-40 years. Among females without miscarriages 63% were aged 18-30 years and 37% were 31-40 years. Females without miscarriages have education up to masters (20%) and graduation (23%) and most females with miscarriages have primary education (38%). The independent sample mean differences revealed females with miscarriages more depressive (t = 24.407, p<0.05) than females without miscarriages (women without miscarriage =27.52±5.43; women with miscarriage =8.08±5.82). Females with miscarriages feel hopeless 73.3%, guilty 70.3%, highly self-blaming 68.3, and have feeling of complete failure 88.1%. 98% females reported that they don’t cry even they want to, on the other hand only 3% females without miscarriages reported this feeling. The perceived quality of life is higher in women without miscarriages (t =11.75, p= .000), 58.1% females with miscarriages have emotional problems, feeling nervous 59.4% and lack of cheerfulness 63.8%. CONCLUSION: Depression is increasing rapidly in the women that loss their fetus. They feel high sadness, grief and low quality of life as compared to women without miscarriages.

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Study on the Acceptance of Contraceptive Devices Among Married Female Workers of a Garments Factory of Dhaka City

Bangladesh Journal of Physiology and Pharmacology ◽

10.3329/bjpp.v24i1.5731 ◽

1970 ◽

pp. 10-13

Author(s):

Mahjabeen Sultana Begum ◽

Md Altaf Hussain

Keyword(s):

Health Workers ◽

Cross Sectional Study ◽

Reproductive Age ◽

Contraceptive Methods ◽

Cross Sectional ◽

Female Workers ◽

Contraceptive Devices ◽

Desired Family Size ◽

Married Female ◽

The Impact

Over the last decade, the number of garments factories in Bangladesh had increased and employed around 1.5 million women, most of them in their reproductive age, therefore, desired family size and child spacing influenced contraceptive prevalence among the married women.This cross sectional study was conducted in Chancellor Garments Factory, Rayer Bazar, Dhaka, to find out the acceptance of contraceptive methods among the married female workers.Out of 121 workers interviewed, the knowledge of respondents on contraceptive methods was found adequate in 83.47%, some knowledge in 15.70% and no knowledge in 0.83%. 27.5% respondents acquired their knowledge from clinics and 25.83% from health workers. Only 13.22% respondents had the knowledge on non contraceptive uses of condom and 50% of them got this knowledge from radio and television. Of the 88.43% respondents who used contraceptive devices, maximum number used oral pill (57.94%) and only 0.93% used condom. Among the non users of contraceptive methods, 28.56% did not use because their husbands did not agree. Among the contraceptive users, 90.65% had consent of both the partners and 2.8% had the desire of their husbands only.Low income, lack of motivation by health workers, lack of information on contraception, less accessibility and availability of devices, cost of the devices, side effects, misconception, etc. have the impact on the contraceptive acceptance among the female garments workers. Key words: Married female workers, Garments factory, Acceptance of contraceptive method. DOI: 10.3329/bjpp.v24i1.5731Bangladesh J Physiol Pharmacol 2008; 24(1&2) : 10-13

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Anti-Mullerian hormone levels in female cancer patients of reproductive age in Indonesia: A cross-sectional study

F1000Research ◽

10.12688/f1000research.15728.1 ◽

2019 ◽

Vol 8 ◽

pp. 159

Author(s):

Achmad Kemal Harzif ◽

Budi Wiweko ◽

Putri Addina ◽

Kartika Iswaranti ◽

Melisa Silvia ◽

...

Keyword(s):

Cancer Therapy ◽

Cancer Patients ◽

Reproductive Function ◽

Cross Sectional Study ◽

Reproductive Age ◽

Cancer Treatments ◽

Cross Sectional ◽

Cancer Group ◽

Anti Cancer ◽

Female Cancer Patients

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Serum testosterone levels and clinical signs of hypogonadism in men with type 2 diabetes

International Journal of Community Medicine and Public Health ◽

10.18203/2394-6040.ijcmph20213002 ◽

2021 ◽

Vol 8 (8) ◽

pp. 3777

Author(s):

Manouchehr Iranparvar ◽

Firouz Amani ◽

Md. Javad Naghizadeh

Keyword(s):

Clinical Signs ◽

Serum Testosterone ◽

Free Testosterone ◽

Cross Sectional Study ◽

Cross Sectional ◽

Testosterone Levels ◽

Drug History ◽

Male Patients ◽

Age Range

Background: Diabetes mellitus is a common metabolic disease that its association with low level of testosterone has already been shown in many studies. Considering the role of testosterone hormone in impotency, fatigue, and bone mass deficiency this study aimed to evaluate the total and free testosterone levels and clinical signs of hypogonadism in male patients with type 2 diabetes.Methods: In this descriptive-cross sectional study, sixty-five diabetic male patients aged 35-70 years were randomly selected and enrolled to the study. The necessary information such as patient demographics, BMI, past medical history, drug history, and history of smoking, education level and employment were completed by a checklist. Then, the patients were evaluated for total and free testosterone levels and symptoms related to decreased testosterone, hypogonadism symptoms by ADAM questionnaire. Finally, the data were statistical analyzed by spss version 21.Results: The mean age of patients was 57.12±4.7 years with age range of 38-69 years. According to the ADAM questionnaire, 51 (78.4%) of the patients were positive and 14 (21.6%) were negative. 16 (24.6%) of all patients had hypogonadism. Among ADAM positive patients, 46 (90.1%) had erectile dysfunction and 33 (64.7%) had decreased libido. Most people (75%) with hypogonadism had BMI more than 30.Conclusions: Testosterone levels are commonly found low in diabetic men, most of whom have symptoms of hypogonadism. Body mass index is known as an independent risk factor for hypogonadism in T2D men. There was also a significant correlation between free testosterone levels and hypogonadism.

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The Impact of Intervention on Pharmacists’ Counselling on Patients’ Knowledge and Opinion of Antibacterial Usage

Journal of Advances in Medical and Pharmaceutical Sciences ◽

10.9734/jamps/2020/v22i430164 ◽

2020 ◽

pp. 1-15

Author(s):

Adeola Adebisi Michael ◽

Omole Moses Kayode ◽

Itiola Oludele Adelanwa

Keyword(s):

Cross Sectional Study ◽

Baseline Survey ◽

Post Intervention ◽

Cross Sectional ◽

Healthcare Facilities ◽

Ogun State ◽

The Mean ◽

Two Phases ◽

Age Range ◽

The Impact

The knowledge and opinion of patients on antibacterial usage depends on pharmacist’s counselling. In Nigeria, study assessing patients’ perception of pharmacists’ antibacterial counselling is scarce. This study assessed the knowledge and opinion of patients on antibacterial usage as a result of pharmacists’ counselling pre and post intervention. The study was a cross sectional study among 409 outpatients with antibacterial prescriptions in 17-government-owned secondary healthcare facilities in Ogun State of Nigeria between July 2017 and May 2018. The knowledge and the opinion of the patients were determined via structured questionnaire and deficiency was addressed via intervention training for the pharmacists. Re-assessment was carried out after a month. Four hundred and nine patients participated at each of the two phases of the study. The mean age at the baseline survey, was 43.9 ± 14.9 and the age range was 19 - 87 years while at the post intervention survey, the mean age was 44.1 ± 15.7 and the age range was from 18 to 91 years. The patients that were probed on drugs they had at hand or at home increased from 20 (4.9%) to 263 (64.3%) between the two phases. Seventeen, (4.2%) and 171 (41.8) claimed to receive counselling on necessity of completing the course of therapy at the two phases respectively. The survey confirmed that 284 (69.4%) and 319 (77.9%) at the two phases respectively were of the view that counselling on drugs is best done by pharmacists. Two hundred and fifty six (62.7%) and 262 (64.1%) patients rated the counselling they received as ≥ 70% at the two phases respectively. There was significant improvement in the knowledge and opinion of patients on antibacterial usage due to pharmacists’ counselling post intervention p < .05. Constant training on antibacterial counselling should therefore be encouraged among pharmacists.

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Exposure to Bisphenol A Analogs and the Thyroid Function and Volume in Women of Reproductive Age—Cross-Sectional Study

Frontiers in Endocrinology ◽

10.3389/fendo.2020.587252 ◽

2021 ◽

Vol 11 ◽

Author(s):

Justyna Milczarek-Banach ◽

Dominik Rachoń ◽

Tomasz Bednarczuk ◽

Katarzyna Myśliwiec-Czajka ◽

Andrzej Wasik ◽

...

Keyword(s):

Bisphenol A ◽

Thyroid Function ◽

Thyroid Disease ◽

Cross Sectional Study ◽

Reproductive Age ◽

Sectional Study ◽

Women Of Reproductive Age ◽

Cross Sectional ◽

The Impact ◽

The Relationship

Bisphenols (BPs) are commonly known plastifiers that are widely used in industry. The knowledge about the impact of BPs on thyroid function is scarce. Proper thyroid functioning is especially important for women of reproductive age, as hypothyroidism affects fertility, pregnancy outcomes and the offspring. There are no studies analyzing the influence of BPs on thyroid function and volume in non-pregnant young women. The aim of this cross-sectional study was to evaluate the relationship between bisphenol A and its 10 analogs (BPS, BPC, BPE, BPF, BPG, BPM, BPP, BPZ, BPFL, and BPBP) on thyroid function and volume in women of reproductive age. Inclusion criteria were: female sex, age 18–40 years. Exclusion criteria were history of any thyroid disease, pharmacotherapy influencing thyroid function, pregnancy or puerperium, and diagnosis of autoimmune thyroid disease during this study. Venous blood was drawn for measurement of thyrotropin (TSH), free thyroxine, thyroid peroxidase antibodies, thyroglobulin antibodies, BPs. Urine samples were analyzed for: ioduria and BPs. Ultrasound examination of thyroid gland was performed. One hundred eighty participants were included into the study. A negative correlation was found between urine BPC and the thyroid volume (R = −0.258; p = 0.0005). Patients with detected urine BPC presented smaller thyroid glands than those with not-detected urine BPC (p = 0.0008). A positive correlation was found between TSH and urine BPC (R = 0.228; p = 0.002). Patients with detected urine BPC presented higher concentrations of TSH versus those with not-detected urine BPC (p = 0.003). There were no relationships between any of serum BPs as well as the other urine BPs and thyroid function and its volume. The only BP that demonstrated the relationship between thyroid function and its volume was BPC, probably because of its chemical structure that most resembles thyroxine. Exposure to this BP may result in the development of hypothyroidism that could have a negative impact on pregnancy and the offspring.

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