scholarly journals Semiquantitative Assessment of 99mTc-MIBI Uptake in Parathyroids of Secondary Hyperparathyroidism Patients from Chronic Renal Failure

2021 ◽  
Author(s):  
Dafu Yu ◽  
Lin Zou ◽  
Yao Jin ◽  
Mingxiang Wei ◽  
Xiaoqun Wu ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Oral Administration ◽  
Patient Age ◽  
Semiquantitative Assessment ◽  
Significant Group ◽  
Patient Âgé ◽  
Grouping Method ◽  
Group 2 ◽  
Group 1

Abstract Purpose Basing on semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism (SHPT) patients from chronic renal failure, objective guidance could be given to improve the qualitative diagnosis accuracy of MIBI uptake.Methods MIBI uptake intensiveness was semiquantitatively calculated with software ImageJ. MIBI uptake intensiveness and clinical indices were compared in 3-level grouping method consisting of slight (group 1), medium (group 2) and high (group 3) MIBI uptake groups and 2-level grouping method consisting of insignificant and significant MIBI uptake groups.Results Patient age, renal failure course, hemodialysis vintage, glomerular filtration rate (GFR), serum parathyroid hormone (PTH) and alkaline phosphatase (AKP) were positively, but serum uric acid (UA) was negatively, significantly related to MIBI uptake intensiveness; patient age was negatively, but serum phosphorus (P) and calcium (Ca) ´ P were positively, significantly related to MIBI washout; oral administration of calcitriol and calcium would significantly reduce MIBI uptake and washout. MIBI uptake tendency might alter during specified course. In 3-level grouping method, such 7 indices as the MIBI uptake intensiveness, renal failure course, hemodialysis vintage, serum AKP, Ca, cysteine proteinase inhibitor C and PTH were comparable between group 1 and 2, but were significantly different between group 1 and 3, and between group 2 and 3. In 2-level grouping method, above 7 indices plus blood urine nitrogen (BUN)/Creatinine were all significantly different between insignificant and significant group with these indices except BUN/Creatinine being greater in significant group than in insignificant group. All above significant relations or differences were with p < 0.05.Conclusions Patient age, renal failure course, hemodialysis vintage, GFR, serum PTH, AKP, UA, phosphorus and Ca ´ P, oral administration of calcitriol and calcium, and parathyroids themselves could significantly influence MIBI uptake in parathyroids of SHPT patients. 2-level grouping method should be adopted to qualitatively diagnosis MIBI uptake.

Calcium phosphate product level as a predictor for arteriovenous fistula re-operations in patients with chronic renal failure

Vascular ◽  
2018 ◽  
Vol 27 (3) ◽  
pp. 284-290 ◽  
Author(s):  
Mehmet Erin Tüysüz ◽  
Mehmet Dedemoğlu
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Calcium Phosphate ◽  
Arteriovenous Fistula ◽  
Product Level ◽  
Increased Risk ◽  
High Calcium ◽  
Phosphate Product ◽  
Group 2 ◽  
Group 1

Objectives There is an increased calcium phosphate product level causing the formation of calcification in the arterial wall and thus decreased quality of fistula in patients with chronic renal failure. The purpose of our study is to verify the relationship between arteriovenous fistula re-operation and high calcium phosphate product level. Methods Seventy-nine consecutive patients with chronic renal failure between April 2016 and February 2018 were included in the study. Patients having calcium phosphate product level ≥50 mg2/dl2 were defined as group 1, whereas those having <50 mg2/dl2 were defined as group 2. Primary outcome of interest was the need for re-operation during the follow-up and to determine the risk factors for re-operation. To determine independent predictors for re-operation, multivariate logistic regression model was used. Results The rates of redo and tredo operation were significantly higher in group 1 compared to group 2 ( p = 0.01 and 0.04). In multivariate analysis, phosphate (OR: 1.84, 95% CI: 1.00–3.40, p = 0.05) and triglyceride (OR: 1.01, 95% CI: 1.00–1.02, p = 0.04) levels for redo operation and calcium phosphate product level (OR: 1.11, 95% CI: 1.01–1.22, p = 0.03) for tredo operation were found to be independent predictors. Conclusions High calcium phosphate product level leads to increased risk of arteriovenous fistula re-operation by causing arterial stiffness in this patient group. Additionally, these re-operations place additional burden on morbidity and cost efficacy. Thus, we recommend keeping the calcium phosphate product level at the optimal level in these patients to avoid both the risk of arteriovenous fistula re-operation and the other cardiovascular problems.

Age and Left Ventricular Impairment Predict Reopening for Bleeding

2003 ◽  
Vol 11 (2) ◽  
pp. 147-152 ◽  
Author(s):  
Yongzhi Deng ◽  
Karen Byth ◽  
Hugh S Paterson
Keyword(s):  
Renal Failure ◽  
Coronary Artery ◽  
Chronic Renal Failure ◽  
Multiple Logistic Regression Analysis ◽  
Left Ventricular ◽  
Older Age ◽  
Redo Surgery ◽  
Prophylactic Measures ◽  
Group 2 ◽  
Group 1

Statistical analysis of data collected prospectively from all patients undergoing surgery under cardiopulmonary bypass from September 1994 to November 1998 (group 1) was performed to identify preoperative risk factors for reopening for bleeding. Multiple logistic regression analysis of 19 preoperative variables was carried out with reoperation for bleeding as the endpoint. The protocol for intraoperative use of aprotinin was then changed to include high-risk patients. Data collected from all subsequent patients from May 1999 to March 2002 (group 2) were analyzed. Subgroup analyses on primary isolated coronary artery surgery were also performed. Data were obtained from 1,946 patients aged 22 to 88 years (mean, 62.5 years). Older age, severe left ventricular impairment, redo surgery, and chronic renal failure were the independent predictors of reopening for bleeding in group 1. There were no independent predictors of reopening in group 2. Older age and chronic renal failure were the predictors of reexploration for bleeding in patients undergoing primary isolated coronary artery grafting. Prophylactic measures to prevent excessive bleeding should be used in elderly patients and those with severe left ventricular impairment, redo surgery, and chronic renal failure.

Increased Levels of Low Affinity Platelet Factor 4 in Plasma and Urine of Patients With Chronic Renal Failure.

1979 ◽  
Author(s):  
S. Niewiarowski ◽  
J. Guzzo ◽  
A.K. Rao ◽  
I. Berman ◽  
P. James
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Platelet Rich Plasma ◽  
Secretory Protein ◽  
Platelet Factor 4 ◽  
Platelet Factor ◽  
Specific Radioimmunoassay ◽  
Normal Individuals ◽  
Group 2 ◽  
Group 1

Low affinity platelet factor 4 (LA-PF4) is a specific platelet secretory protein immunologically related to β-thromboglobulin and to platelet basic protein that stimulates cell growth. The level of LA-PF4 antigen was determined by specific radioimmunoassay in platelet poor plasma (PPP) and platelet rich plasma (PRP) of 17 normal individuals (NI), 9 patients on hemodialysis (HD) and 18 patients with chronic renal failure (CRF) who were not dialysed. Eight patients with glomerular filtration rate (GFR) 5-20 ml/min were included to group 1 and 10 patients with GFR 30-50 ml/min were included to group 2. Levels of LA-PF4 in ng/ml PPP were 31.9 ± 2.8 in NI, 291.8 ± 26.3 in HD, 149.4 ± 45.2 in group 1 of CRF and 103.7 ± 11.1 in group 2 of CRF. Differences between patients and NI were significant at P <0.05. After 3 hours of hemodialysis LA-PF4 increased to 505.0 ± 92.3 (P < 0.05), however, there was no changes in PPP level across the artifical kidney at one hour. The levels of LA-PF4 in PRP of patients with CRF and HD did not differ from NI. Mean LA-PF4 excretion in urine (ng/day/100mg creatinine) was 57.7 ± 6.4 (range 33.3-75.7) in 6 NI with GFR >60 ml/min and 1461.5 ± 674.6 (range 105.3-7041.6) in 10 CRF patients. In conclusion, elevation of LA-PF4 in PPP of patients with CRF and its increased urinary excretion suggest stimulation of platelet secretion and/or decreased metabolism of LA-PF4 in the kidney.

A proposed radiosurgery-based grading system for arteriovenous malformations

2002 ◽  
Vol 96 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Bruce E. Pollock ◽  
John C. Flickinger
Keyword(s):  
Multivariate Analysis ◽  
Patient Outcomes ◽  
Arteriovenous Malformations ◽  
Grading System ◽  
Patient Age ◽  
Content Type ◽  
Patient Âgé ◽  
Group 2 ◽  
Fine Print ◽  
Group 1

Object. Radiosurgery is an effective treatment strategy for properly selected patients harboring arteriovenous malformations (AVMs). Grading scales that are currently used to predict patient outcomes after AVM resection are unreliable tools for the prediction of the results of AVM radiosurgery. Methods. A grading system was developed to predict outcomes following AVM radiosurgery, based on the multivariate analysis of data obtained in 220 patients treated between 1987 and 1991 (Group 1). The dependent variable in all analyses was excellent patient outcome (complete AVM obliteration without any new neurological deficit). The grading scale was tested on a separate set of 136 patients with AVMs treated between 1990 and 1996 at a different center (Group 2). One hundred twenty-one (55%) of 220 Group 1 patients had excellent outcomes. Multivariate analysis identified five variables related to excellent patient outcomes: AVM volume (p = 0.001), patient age (p < 0.001), AVM location (p < 0.001), previous embolization (p = 0.02), and number of draining veins (p = 0.001). Regression analysis modeling permitted removal of two significant variables (previous embolization and number of draining veins) and resulted in the following equation to predict patient outcomes after AVM radiosurgery: AVM score = (0.1)(AVM volume in cm3) + (0.02)(patient age in years) + (0.3)(location of lesion: frontal or temporal) = 0; parietal, occipital, intraventricular, corpus callosum, cerebellar = 1; or basal ganglia, thalamic, or brainstem = 2). Seventy-nine (58%) of 136 Group 2 patients had excellent outcomes. All variables in the model remained significant for the Group 2 patients: AVM volume (p = 0.01), patient age (p = 0.01), and AVM location (p < 0.001). Testing of the entire model on the Group 2 patients demonstrated that the AVM score could be used to predict patient outcomes after radiosurgery (p < 0.0001). All patients with an AVM score of 1 or lower had an excellent outcome compared with only 39% of patients with an AVM score higher than 2. The Spetzler—Martin grade (p = 0.13), the K index (p = 0.26), and the obliteration prediction index (p = 0.21) did not correlate with excellent patient outcomes. Conclusions. Despite significant differences in preoperative patient characteristics and dose prescription guidelines at the two centers, the proposed AVM grading system strongly correlated with patient outcomes after single-session radiosurgery for both patient groups. Although further testing of this model by independent centers using prospective methodology is still required, this system allows a more accurate prediction of outcomes from radiosurgery to guide choices between surgical and radiosurgical management for individual patients with AVMs.

Effect of Adventitial Dissection in Brachiobasilic Arteriovenous Fistulae Opened in Children as Vascular Access for Hemodialysis on Patency and Maturation of Fistulae

2004 ◽  
Vol 52 (5) ◽  
pp. 330-334 ◽  
Author(s):  
Ozalp Karabay ◽  
Mustafa Bak ◽  
Erdem Silistreli ◽  
Sebnem Calkavur ◽  
Ismail Yurekli ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Arteriovenous Fistula ◽  
Patency Rate ◽  
Pediatric Patients ◽  
Arteriovenous Fistulae ◽  
Initiation Of Dialysis ◽  
Group 2 ◽  
Group 1

BackgroundRecently, therapy of pediatric patients with chronic renal failure has been carried out using hemodialysis, peritoneal dialysis, or renal transplant. In this study, we prospectively investigated the role of adventitial dissection (performed on brachiobasilic arteriovenous fistulae in the antecubital area) in the patency rate, maturation, and early initiation of dialysis among pediatric cases undergoing chronic hemodialysis.MethodsThirty children (7 male and 23 females) were included in this study. They were operated on at the Department of Cardiovascular Surgery of Alsancak State Hospital and Dokuz Eylul University between March 2001 and June 2003. Their mean age was 12.3 ± 2.9 years (range 7-17 years), and their mean weight was 25.5 ± 7.9 kg (range 16-44 kg). Children who underwent only brachiobasilic arteriovenous fistula operation were included. Group 1 (n = 15) consisted of those who underwent adventitial dissection, and group 2 (n = 15) consisted of those not receiving the adventitial dissection procedure.ResultsThe procedure was conducted by the same surgeon, and follow-up examinations were done at the Department of Pediatric Nephrology by investigators masked to treatment groups.ConclusionThere were no significant differences in age, sex, existence of preoperative hypertension, diameter of vein measured preoperatively, and first day of dialysis between the groups. In 29 cases, a palpable thrill was noted at the operation site. Hemodialysis had been initiated after the fourth week, when the fistulae had matured. The mean duration of follow-up was 12.53 ± 8.98 months in group 1 and 11.85 ± 7.55 months in group 2 (p = .880). In group 1, one case developed fistula infection in the second month and one case developed lymphatic drainage. In group 2, one case developed early thrombosis, one case developed hematoma, and one case developed transient ischemia owing to arterial spasm in the ipsilateral limb. One case in each group developed minimal edema in the forearm, which was treated conservatively. The primary patency rate was 93.3% in both groups, whereas the secondary patency rate was 100% in group 1. Adventitial dissection performed on the vein during arteriovenous fistula formation does not result in any additional benefit with respect to fistula maturation, early initiation of dialysis, and patency. Among pediatric patients with chronic renal failure, in cases of inappropriate forearm veins, brachial arteriovenous fistulae performed with a meticulous surgical technique should be the procedure of choice because it is associated with minimal complications and a high patency rate.

Predialytic versus Intradialytic Nutrition: A Study to Assess Effects on Intradialytic Blood Pressure, Dialysis Adequacy, and Urea Removal

2021 ◽  
pp. 1-6
Author(s):  
Namrata S. Rao ◽  
Abhilash Chandra ◽  
Sai Saran ◽  
Manish Raj Kulshreshta ◽  
Prabhakar Mishra ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Dialysis Adequacy ◽  
Fasting Period ◽  
Significant Group ◽  
Protein Requirements ◽  
Dialysis Vintage ◽  
Oral Nutritional Supplements ◽  
Blood Pressures ◽  
Group 2 ◽  
Group 1

<b><i>Background:</i></b> Provision of oral protein in hemodialysis (HD) is desirable due to improved compliance to protein requirements and better nutritional status, but the risks of hypotension and underdialysis need to be considered. This study compared 2 different timings for administering oral nutritional supplements (ONS), predialysis and mid-dialysis, with respect to hemodynamics, dialysis adequacy, urea removal, and tolerability. <b><i>Methods:</i></b> This single-center, prospective crossover study analyzed 72 stable patients with ESRD on twice a week maintenance HD with a mean age of 38.7 (±11.2) years and a dialysis vintage of 28.2 (±13.1) months. In the first week, all the patients received ONS (450 kcal energy, 20 g protein) 1 h prior to start of dialysis (group 1) and in the next week, the supplement was administered after 2 h of start of dialysis (group 2), with a predialysis fasting period of at least 3 h in both groups. Blood pressures, serum, and spent dialysate samples were collected and nausea occurrence was noted by severity. <b><i>Results:</i></b> Predialytic intake (group 1) was associated with higher predialysis and 1st hour blood urea, dialysis adequacy, and urea removal than group 2. Both groups achieved mean Kt/V &#x3e; 1.2, and the occurrence of symptomatic hypotensive episodes and nausea was not significantly different between the groups. On repeated measures ANOVA, changes in blood urea over time showed significant group effect. <b><i>Conclusions:</i></b> Predialytic supplementation was associated with better dialysis adequacy and urea removal than intradialytic supplementation. However, both timings were equally tolerated and not associated with underdialysis.

Abstract 677: Inhibition of Receptor-interacting Protein Kinase 1 With Necrostatin-1 and -1s Ameliorates Aneurysm Progression in the Elastase-induced Mouse Model of Abdominal Aortic Aneurysms (AAAs)

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Qiwei Wang ◽  
Zhenjie Liu ◽  
Jun Ren ◽  
Stephanie Morgan ◽  
Carmel Assa ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Aortic Aneurysms ◽  
Aortic Dilatation ◽  
Significant Group ◽  
Interacting Protein ◽  
Aneurysm Formation ◽  
Abdominal Aortic ◽  
Aneurysm Growth ◽  
Group 2 ◽  
Group 1

Objective: Abdominal aortic aneurysm (AAA) is a common vascular disease with a progressive nature. Currently, no pharmacological treatment is approved to effectively slow aneurysm growth or prevent rupture. We have recently demonstrated that receptor interacting protein kinase 3 (RIP3), a critical mediator of necroptosis, contributes to smooth muscle depletion and vascular inflammation associated with AAA. In this study, we tested the hypothesis that inhibition of necroptosis may mitigate aneurysm progression using Necrostatin-1 (Nec-1) or an optimized form of Nec-1 called Nec-1s (7-Cl-O-Nec-1), known inhibitors of another necroptosis mediator RIP1. Approach and Results: Using elastase perfusion model, we first demonstrated that Nec-1 attenuated aneurysm formation when administered daily by intraperitoneal (IP) injection started 30 min before aneurysm induction. Nec-1 also profoundly reduced elastin fragmentation, macrophage infiltration and SMC necrosis after elastase perfusion. To test whether RIP1 inhibitors can inhibit AAA progression, we randomly divided mice to four groups 7 days after elastase perfusion when aortic dilatation is small but significant. Group 1 was sacrificed to obtain a baseline aortic dilatation, while Group 2, 3, and 4 received daily IP injections of DMSO, Nec-1 (3.2 mg/kg/day) or Nec-1s (1.6mg/kg/day), respectively. 14 days after perfusion, mice in Group 2 displayed larger aneurysmal expansion as compared to Group 1 ( P <0.05), a reflection of aneurysm growth. In contrast, mice in Group 3 and 4 showed similar aortic dilatations compared to mice in Group 1 ( P >0.05), indicating insignificant aneurysmal growth. Furthermore, real-time PCR and histological analyses demonstrated that RIP1 inhibition significantly reduced aortic accumulation of proinflammatory cytokines and inflammatory cell infiltration. Conclusions: Taken together, our study suggests that necroptosis may serve as a therapeutic target for AAAs. Pharmacological inhibition of RIP1 kinase activity prevented aneurysm formation and stabilized pre-existing aneurysms in mice.

scholarly journals Erectogenic Effect of Thyme (Thymus vulgaris) Extract in Normal and 5-Fluorouracil induced Oxidative Stressed Adult Male Wistar Rats

2021 ◽  
pp. 22-34
Author(s):  
O. Abimbola Akintemi ◽  
R. O. Babalola ◽  
S. O. Babatunde
Keyword(s):  
Vitamin C ◽  
Oral Administration ◽  
Thymus Vulgaris ◽  
Male Wistar Rats ◽  
Group 3 ◽  
Group 5 ◽  
Group 2 ◽  
Phosphodiesterase 5 ◽  
Thiol Level ◽  
Group 1

This study determined the effect of oral administration of aqueous extract from Thyme (Thymus vulgaris) extract (TVE) on the antioxidant status and activity of some penile function enzymes (acetylcholinesterase (AChE), phosphodiesterase-5 (PDE-5), adenosine diaminase (ADA), and arginase) activity in normal and 5- Fluorouracil- induced oxidative stressed rats. Sixty adult Wister rats (210-225)g were divided into ten (10) groups (n=6): Group 1: received oral administration  of normal saline (NC), Group 2: received 100 mg/kg of thyme extract orally (TE 100 mg/kg), Group 3: received 200 mg/kg of thyme extract orally (TE 200 mg/kg), rats in group four were treated with 400 mg/kg of thyme extract orally (TE 400 mg/kg), Those in group 5: received 25 mg/kg of Vitamin C orally, while group 6 to 10 were induced with 150 mg/kg of 5-Fluorouracil solution (5-FLU, i.p), but group 7-10 were treated 100 mg/kg, 200 mg/kg, 400 mg/kg and Vitamin C (25mg/kg), respectively. After fourteen (14) days of treatment, the rats were sacrificed and the penile tissue was carefully isolated and prepared into homogenate, which was used for antioxidant and enzymes biochemical analysis. The result revealed that i.p induction of 5-FLU caused a significant increase in malondialdehyde level, as well as AChE, ADA, PDE-5 and arginase activities wth concomitant decrease in thiol level when compared to control rats. However, the administration of TVE was found to reverse the effect of 5-FLU. The TVE was also found the reduced MDA level and all the enzyme activities, but boosted the thiol level in the normal rats when compared to control rats. Interestingly the effect of the TVE was found dose-dependently, and 400 mg/kg TVE was found to be more potent among all the doses used in both normal and 5-FLU-induced oxidative stress rats.

P–687 Impact of medroxyprogesterone acetate (MPA) as pituitary suppression on oocyte quality and clinical outcomes in egg donation recipients

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
I Ortega ◽  
P Alamá ◽  
M Cruz ◽  
J Giles ◽  
J A García-Velasco
Keyword(s):  
Oral Administration ◽  
Ovarian Stimulation ◽  
Gnrh Antagonist ◽  
Oocyte Quality ◽  
Follicular Phase ◽  
Egg Donation ◽  
Ovum Donation ◽  
Gnrh Analogues ◽  
Group 2 ◽  
Group 1

Abstract Study question To compare the impact on oocyte quality and reproductive outcomes in patients who received oocytes from donors stimulated with MPA versus GnRH antagonist protocol. Summary answer Compared to GnRH antagonist, MPA does not exert a major effect on oocyte quality and yields similar reproductive outcomes in egg donation recipients. What is known already Conventional ovarian stimulation (OS) protocols have classically used GnRH analogues, both agonists and antagonists, to avoid premature follicular luteinization. The oral administration of MPA or micronized progesterone during the follicular phase of OS has emerged as an attractive alternative to conventional protocols in the prevention of early luteinization. Compared to progesterone, MPA is characterized by a moderate-strong progestanic action, lower androgenic properties and does not interfere with the measurement of endogenous progesterone. In our group, administration of MPA during the follicular phase of OS has been included in the routine clinical practice of our donor program since late 2019. Study design, size, duration Multicentre, retrospective, observational, cohort study carried out in eleven private university-affiliated IVF centers. The present study included a total of 14,282 fresh ovum donation cycles performed from October 2017 to March 2020. Oocyte donors were recruited and stimulated under either MPA (n = 4,665) or GnRHa (n = 9,617) to suppress the pituitary during the follicular phase of OS, and GnRH agonist was administered to trigger final oocyte maturation in all the participants. Participants/materials, setting, methods Recipients were divided according to the protocol used for premature luteinization prevention during the follicular phase of the ovum donation matched-cycle: Group 1, recipients who received oocytes from donors treated with 10 mg/day of MPA (ProgeveraÒ); Group 2, recipients who received oocytes from GnRH antagonist (FyremadelÒ) down-regulated donor cycles. All the procedures were approved by an Institutional Review Board (1910-VLC–091-JG) and complied with Spanish law on assisted reproductive technologies (14/2006). Main results and the role of chance Regarding donoŕs baseline characteristics, age and antral follicle count were significantly different between groups, but not clinical differences. The length of ovarian stimulation was similar in both groups (10.7 days [95% Confidence Interval (CI) 10.5–10–8] vs 10.5 days [95% CI 10.0–11.00]). Despite slightly higher mean total dose of FSH administered in Group 1 compared to Group 2 (1.841 IU [95% CI 1.813–1.868] vs 1.739 IU [95% CI 1.723–1.754]), there were no differences in the total dose of hMG administered between both groups (967 IU [95% CI 901–1.034] vs 971 IU [95% CI 944–998]). With regard to IVF data, both the number of retrieved oocytes (22.9 [95% CI 22.4–23.4] vs 24.1 [95% CI 23.8–24.3]), and mature oocytes (18.7 [95% CI 18.3–19.1] vs 19.3 [95% CI 19.1–19.6]), were slightly lower in Group 1 compared to Group 2, whereas fertilization rate was significantly higher in Group 1 compared to Group 2 (82.1% [95% CI 81.7–82.6] vs 80.8% [95% CI 80.6–81.2]),. Regarding the clinical outcomes, no differences were observed in either implantation rate (58.7% [95% CI 56.7–60.7] vs 59.3% [95% CI 57.3–61.3]) or clinical pregnancy rate (59.5% vs 59.8%, P = 0.04) between both groups. Limitations, reasons for caution As a consequence of being a retrospective study, only association, and not causation, can be inferred from the results. A further limitation is that donors are healthy young women and do not perfectly match other populations, as infertile patients who may be older, low or high responders to OS. Wider implications of the findings: MPA emerges as an effective oral alternative to GnRH analogues for preventing premature luteinizing hormone surges in donors undergoing OS in ovum donation program. Compared with GnRH antagonists, MPA has advantages of being an oral administration route and providing easy access, yielding similar clinical results. Trial registration number 1910-VLC–091-JG

scholarly journals Assessment of consistency in the dimension of gutta-percha cones of ProTaper Next and WaveOne with their corresponding number files

2017 ◽  
Vol 11 (02) ◽  
pp. 201-205 ◽  
Author(s):  
Nitika Bajaj ◽  
Prashant Monga ◽  
Pardeep Mahajan
Keyword(s):  
Significant Group ◽  
Gutta Percha ◽  
Group 2 ◽  
Group 1

ABSTRACT Objectives: To compare the dimensions of gutta-percha (GP) cones of ProTaper Next (25/0.06) and WaveOne (25/0.08) in relation to their corresponding instruments of the same dimension, respectively. Materials and Methods: Two groups of GP cones were made with 25 cones in each group. Group 1 consisted of 25 GP cones # 25/0.06 (ProTaper Next). Group 2 consisted of 25 GP cones # 25/0.08 (WaveOne). Measurements were done at D1 (1 mm short of the tip), D3 (3 mm short of the tip), and D11 (11 mm short of the tip) for GP cones of both groups and were compared with their corresponding instruments. Results: Group 1 (ProTaper) 25/.06 GP points showed greater diameters than those of the corresponding instrument, which was statistically significant. Group 2 (WaveOne) 25/0.08 GP points showed greater diameters than those of the corresponding instrument which was statistically significant whereas it was nonsignificant at level D1. Conclusion: Diameters of both ProTaper Next and WaveOne GP cones were greater than their corresponding instruments. Hence, there are chances of under obturation with both systems.

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