FUNCTIONAL SIGNIFICANCE OF DRUG-INDUCED CHANGES IN BRAIN MONOAMINE LEVELS

Author(s):  
Arvid Carlsson
Author(s):  
Sarah A. Luse

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.


1969 ◽  
Vol 18 (6) ◽  
pp. 1315-1324 ◽  
Author(s):  
L. Beani ◽  
C. Bianchi ◽  
P. Megazzini ◽  
L. Ballotti ◽  
G. Bernardi

PROTEOMICS ◽  
2018 ◽  
Vol 18 (24) ◽  
pp. 1800118 ◽  
Author(s):  
Pierre Sabatier ◽  
Amir Ata Saei ◽  
Shiyu Wang ◽  
Roman A. Zubarev

1980 ◽  
Vol 5 (6) ◽  
pp. 599-609 ◽  
Author(s):  
K. Negishi ◽  
M. Laufer ◽  
B. D. Drujan

1973 ◽  
Vol 89 (1) ◽  
pp. 105-112 ◽  
Author(s):  
Ashley Levantine ◽  
John Almeyda
Keyword(s):  

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