Integrative Analysis of Genome-wide Gene Expression for Prostate Cancer Prognosis

2011 ◽  
Author(s):  
Jiyoung Ahn
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Integrative Analysis ◽  
Cancer Prognosis ◽  
Genome Wide ◽  
Genome Wide Gene Expression ◽  
Prostate Cancer Prognosis

Molecular Features of Hormone-Refractory Prostate Cancer Cells by Genome-Wide Gene Expression Profiles

2007 ◽  
Vol 67 (11) ◽  
pp. 5117-5125 ◽  
Author(s):  
Kenji Tamura ◽  
Mutsuo Furihata ◽  
Tatsuhiko Tsunoda ◽  
Shingo Ashida ◽  
Ryo Takata ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Hormone Refractory Prostate Cancer ◽  
Prostate Cancer Cells ◽  
Molecular Features ◽  
Genome Wide ◽  
Hormone Refractory ◽  
Genome Wide Gene Expression

scholarly journals Advances in Prognostic Methylation Biomarkers for Prostate Cancer

2020 ◽  
Author(s):  
Dilys Lam ◽  
Susan Clark ◽  
Clare Stirzaker ◽  
Ruth Pidsley
Keyword(s):  
Prostate Cancer ◽  
Dna Methylation ◽  
Specific Antigen ◽  
Treatment Strategies ◽  
Cancer Prognosis ◽  
Comprehensive Overview ◽  
Current State ◽  
Genome Wide ◽  
Indolent Disease ◽  
Prostate Cancer Prognosis

There is a major clinical need for accurate biomarkers for prostate cancer prognosis, to better inform treatment strategies and disease monitoring. Current clinically recognised prognostic factors, including prostate-specific antigen (PSA) levels, lack sensitivity and specificity in distinguishing aggressive from indolent disease, particularly in patients with localised intermediate grade prostate cancer. There has therefore been a major focus on identifying molecular biomarkers that can add prognostic value to existing markers, including investigation of DNA methylation, which has a known role in tumorigenesis. In this review, we will provide a comprehensive overview of the current state of DNA methylation biomarker studies in prostate cancer prognosis, and highlight the advances that have been made in this field. We cover the numerous studies into well-established candidate genes, and explore the technological transition that has enabled hypothesis-free genome-wide studies and the subsequent discovery of novel prognostic genes.

scholarly journals Advances in Prognostic Methylation Biomarkers for Prostate Cancer

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2993 ◽  
Author(s):  
Dilys Lam ◽  
Susan Clark ◽  
Clare Stirzaker ◽  
Ruth Pidsley
Keyword(s):  
Prostate Cancer ◽  
Dna Methylation ◽  
Specific Antigen ◽  
Treatment Strategies ◽  
Cancer Prognosis ◽  
Comprehensive Overview ◽  
Current State ◽  
Genome Wide ◽  
Indolent Disease ◽  
Prostate Cancer Prognosis

There is a major clinical need for accurate biomarkers for prostate cancer prognosis, to better inform treatment strategies and disease monitoring. Current clinically recognised prognostic factors, including prostate-specific antigen (PSA) levels, lack sensitivity and specificity in distinguishing aggressive from indolent disease, particularly in patients with localised intermediate grade prostate cancer. There has therefore been a major focus on identifying molecular biomarkers that can add prognostic value to existing markers, including investigation of DNA methylation, which has a known role in tumorigenesis. In this review, we will provide a comprehensive overview of the current state of DNA methylation biomarker studies in prostate cancer prognosis, and highlight the advances that have been made in this field. We cover the numerous studies into well-established candidate genes, and explore the technological transition that has enabled hypothesis-free genome-wide studies and the subsequent discovery of novel prognostic genes.

Abstract 4471: Commercial gene expression tests for prostate cancer prognosis provide paradoxical estimates of race-specific risk

2019 ◽  
Author(s):  
Jordan H. Creed ◽  
Anders E. Berglund ◽  
Robert J. Rounbehler ◽  
Shivanshu Awasthi ◽  
John L. Cleveland ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Prognosis ◽  
Specific Risk ◽  
Prostate Cancer Prognosis

Abstract 4471: Commercial gene expression tests for prostate cancer prognosis provide paradoxical estimates of race-specific risk

2019 ◽  
Author(s):  
Jordan H. Creed ◽  
Anders E. Berglund ◽  
Robert J. Rounbehler ◽  
Shivanshu Awasthi ◽  
John L. Cleveland ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Prognosis ◽  
Specific Risk ◽  
Prostate Cancer Prognosis

scholarly journals Commercial Gene Expression Tests for Prostate Cancer Prognosis Provide Paradoxical Estimates of Race-Specific Risk

2019 ◽  
Vol 29 (1) ◽  
pp. 246-253 ◽  
Author(s):  
Jordan H. Creed ◽  
Anders E. Berglund ◽  
Robert J. Rounbehler ◽  
Shivanshu Awasthi ◽  
John L. Cleveland ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prostate Cancer ◽  
Cancer Prognosis ◽  
Specific Risk ◽  
Prostate Cancer Prognosis
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