scholarly journals A CASE OF CONCURRENT LUNG CANCER AND FIBROUS-CAVERNOUS PULMONARY TUBERCULOSIS

2019 ◽  
Vol 97 (1) ◽  
pp. 35-40 ◽  
Author(s):  
V. P. PLOTNIKOV ◽  
◽  
I. V. PERMINOVА ◽  
E. E. CHERNYKH ◽  
S. P. LАPTEV ◽  
...  
Author(s):  
Harveen Kaur

Tuberculosis (TB) is known to mimic several clinical conditions, especially malignancy. Pulmonary TB can present with pulmonary infiltration with or without mediastinal lymphadenopathy. TB often gets misdiagnosed in the countries having a low incidence of TB with a high incidence of lung cancer and varying clinical presentations, which results in delay in treatment initiation and unnecessary diagnostic procedures. We present a case of a 52-year old female, with a presumptive diagnosis of malignancy, which was subsequently proved as pulmonary tuberculosis with no evidence of malignancy instead.


2017 ◽  
Vol 14 (3) ◽  
pp. 2180-2188 ◽  
Author(s):  
Shan Lang ◽  
Junping Sun ◽  
Xuning Wang ◽  
Yongjiu Xiao ◽  
Juan Wang ◽  
...  

1989 ◽  
Vol 36 (3) ◽  
pp. 238-245
Author(s):  
Young Chun Choi ◽  
Dae Hyun Yoo ◽  
Jin Lee ◽  
Jin Choi ◽  
Woo Jin Lew ◽  
...  

2021 ◽  
Vol 11 ◽  
Author(s):  
Sheng-Kai Liang ◽  
Li-Hsin Chien ◽  
Gee-Chen Chang ◽  
Ying-Huang Tsai ◽  
Wu-Chou Su ◽  
...  

ObjectivesLung cancer in never-smokers is a distinct disease associated with a different genomic landscape, pathogenesis, risk factors, and immune checkpoint inhibitor responses compared to those observed in smokers. This study aimed to identify novel single nucleotide polymorphisms (SNPs) of programmed death-1 (encoded by PDCD1) and its ligands, programmed death ligand 1 (CD274) and 2 (PDCD1LG2), associated with lung cancer risk in never-smoking women.Materials and MethodsDuring September 2002 and July 2012, we enrolled never-smoking female patients with lung adenocarcinoma (LUAD) (n=1153) and healthy women (n=1022) from six tertiary hospitals in Taiwan. SNP data were obtained and analyzed from the genome-wide association study dataset and through an imputation method. The expression quantitative trait loci (eQTL) analysis was performed in both tumor and non-tumor tissues for the correlation between genetic expression and identified SNPs.ResultsA total of 12 PDCD1LG2 SNPs related to LUAD risk were identified in never-smoking women, including rs2381282, rs4742103, rs4237162, rs4742104, rs12237624, rs78096119, rs6476988, rs7857315, rs10975178, rs7854413, rs56001683, and rs7858319. Among them, six tagged PDCD1LG2 SNPs rs2381282, rs4742103, rs4237162, rs4742104, rs78096119, and rs56001683 were significantly associated with LUAD risk. Specifically, two PDCD1LG2 SNPs, rs12237624 and rs78096119, were associated with previous pulmonary tuberculosis infection in relation to LUAD susceptibility. Through an eQTL assay, we found that rs2381282 (p < 0.001), rs12237624 (p = 0.019), and rs78096119 (p = 0.019) were associated with the expression levels of programed death ligand 2.ConclusionsNovel SNPs of programed death ligand 2 associated with lung adenocarcinoma risk were identified. Among them, two SNPs were associated with pulmonary tuberculosis infection in relation to lung adenocarcinoma susceptibility. These SNPs may help to stratify high-risk populations of never-smokers during lung cancer screening.


Haigan ◽  
2005 ◽  
Vol 45 (2) ◽  
pp. 127-132 ◽  
Author(s):  
Tatsuo Kato ◽  
Masanori Nakashima ◽  
Motohiro Imao ◽  
Chihito Komaki ◽  
Kimiyasu Sano ◽  
...  

2020 ◽  
Vol 12 (3) ◽  
pp. 375-382
Author(s):  
Soo Jeong An ◽  
Young-Ju Kim ◽  
Seon-Sook Han ◽  
Jeongwon Heo

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