Opium As a Risk Factor for Coronary Artery Disease in Young Iranians: Results from the Premature Coronary Artery Disease Milano-Iran (MIran) Study

2019 ◽  
Author(s):  
Alberto Maino ◽  
Saeed Sadeghian ◽  
Ilaria Mancini ◽  
Seyed Hesameddin Abbasi ◽  
Hamidreza Poorhosseini ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

scholarly journals CORONARY ARTERY DISEASE

2009 ◽  
Vol 16 (02) ◽  
pp. 192-197
Author(s):  
FIDA MUHAMMAD ◽  
Nadeem Hayat Mallick, ◽  
ABDUL REHMAN ABID ◽  
AJAZ AHMAD ◽  
Shahid Imran
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Clinical Presentation ◽  
Systolic Function ◽  
Left Ventricular ◽  
Premature Coronary Artery Disease ◽  
Common Risk Factor ◽  
Artery Disease ◽  
Lv Systolic Function

Objectives: This study was designed to evaluate the pattern of clinical presentation, risk factors and angiographic findingsin young males presenting with acute myocardial infarction (AMI).Materials and methodsThis cross-sectional descriptive study wasconducted at the Cardiology Department, Punjab Institute of Cardiology, Lahore from May 2005 till February 2006. After fulfilling the inclusioncriteria 200 male patients <40 years with coronary artery disease (CAD) were studied. Results: Mean age of the study population was31.5±9.2 years with an age range of 31 to 40 years. Most common risk factor was smoking present in 60% patients. Family history ofischemic heart disease (IHD) was present in 44.5% patients, hyperlipidemia in 35.5% patients, hypertension in 25.5% and diabetes mellitusin 17.5% of patients.Common mode of clinical presentation was AMI 42.5% patients. Left anterior descending (LAD) was diseased in 73.5%,followed by Left Circumflex (LCx) 51% and Right Coronary Artery (RCA) in 39% patients. Left Main Stem (LMS) disease occurred in 9.5%patients. Good left ventricular (LV) systolic function was observed in 38%, moderate LV systolic function in 34% and poor LV systolic functionin 14.5% patients. Conclusion: Patients with premature coronary artery disease have unheralded acute onset of symptoms. Smoking isthe most common risk factor. Young patients have single vessel CAD with frequent involvement of LAD and commonly have good leftventricular systolic function.

scholarly journals Serum Uric Acid Is Not an Independent Risk Factor for Premature Coronary Artery Disease

2013 ◽  
Vol 3 (4) ◽  
pp. 246-253 ◽  
Author(s):  
Sara Zand ◽  
Akbar Shafiee ◽  
Mohammadali Boroumand ◽  
Arash Jalali ◽  
Younes Nozari
Keyword(s):  
Coronary Artery Disease ◽  
Uric Acid ◽  
Risk Factor ◽  
Coronary Artery ◽  
Serum Uric Acid ◽  
Independent Risk Factor ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

Rare genotypes of protein Z gene are a risk factor for premature myocardial infarction but not protein Z plasma level

2009 ◽  
Vol 102 (07) ◽  
pp. 131-136 ◽  
Author(s):  
Claudine Soria ◽  
Claire dit Sollier ◽  
Jeanne-Yvonne Borg ◽  
Mathieu Coudert ◽  
Gilles Montalescot ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Plasma Level ◽  
Premature Coronary Artery Disease ◽  
Protein Z ◽  
Number Of Patients ◽  
Premature Cad ◽  
Artery Disease

SummaryProtein Z (PZ) is the cofactor of PZ dependent inhibitor (ZPI) that inhibits activated coagulation factor X. PZ was expected to play a role in coronary artery disease (CAD) but with inconsistent clinical findings. We therefore evaluated whether PZ plasma level and/or three genetic variants encoding for low PZ plasma level were associated with premature CAD in stable young post-myocardial infarction (MI) patients. PZ plasma level and three polymorphisms A-13G, G-103A and G79A were determined in 176 young stable post-MI patients and in 176 sex- and age-matched controls (FITE-NAT population). Moreover the genotypes, resulting from the combination of the three polymorphisms (A-13G/G-103A/G79A), were studied. PZ plasma level and the number of patients disclosing a PZ deficiency did not differ between post-MI patients and controls. The presence of the mutated allele for each polymorphism was associated with a significantly reduced level of PZ. The A-13G polymorphism was associated with premature CAD only in univariate analysis. Whereas, the presence of rare genotypes of PZ gene was an independent risk factor for premature CAD. In conclusion, PZ plasma level is not a key player in the pathophysiology of premature coronary artery disease. But, rare genotypes of PZ gene were found to be associated with premature CAD.

Elevated Lp(a) with a small apo(a) isoform in children: risk factor for the development of premature coronary artery disease

2008 ◽  
Vol 97 (12) ◽  
pp. 1653-1657 ◽  
Author(s):  
Albert Dirisamer ◽  
Harald Widhalm ◽  
Elsie Aldover-Macasaet ◽  
Sylvia Molzer ◽  
Kurt Widhalm
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Premature Coronary Artery Disease ◽  
Artery Disease

No Association between the 20210 G/A Prothrombin Gene Mutation and Premature Coronary Artery Disease

1998 ◽  
Vol 80 (12) ◽  
pp. 878-880 ◽  
Author(s):  
J. W. Eikelboom ◽  
R. Parsons ◽  
R. R. Taylor ◽  
F. M. van Bockxmeer ◽  
R. I. Baker
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Gene Mutation ◽  
Odds Ratio ◽  
Premature Coronary Artery Disease ◽  
Prothrombin Gene Mutation ◽  
Prothrombin Gene ◽  
Artery Disease

SummaryThe 20210 G/A prothrombin gene mutation is associated with an increased risk of venous thrombosis but whether there is an association of the mutation with premature coronary artery disease and acute myocardial infarction remains unclear.To further assess the role of the G/A genotype as a risk factor for arterial vascular disease, we performed a case-control study of 644 patients aged less than 50 years with angiographically proven coronary artery disease, 402 of whom had myocardial infarction, and 679 unrelated healthy control subjects aged less than 50 years, randomly selected from the electoral roll.The prevalence of the G/A genotype was 2.5% in patients with coronary artery disease, and 3.2% in control subjects (odds ratio 0.8; 95% confidence interval 0.35 to 1.83). The mutation was not more frequent among patients with a history of myocardial infarction (2.2%, odds ratio 0.7; 95% confidence interval 0.27 to 2.05), and there was no evidence of an interaction between the prothrombin mutation and conventional cardiovascular disease risk factors. There was no association between genotype and extent of angiographic coronary artery disease (p = 0.73).We conclude that the 20210 G/A prothrombin gene mutation is not a major risk factor for premature coronary artery disease in our predominantly Caucasian Australian population.

ID: 68: CORONARY ARTERY DISEASE AND ACUTE CORONARY SYNDROME IN PATIENTS ≤40 YEAR OLD

2016 ◽  
Vol 64 (4) ◽  
pp. 913.2-914
Author(s):  
H Alkhawam ◽  
R Sogomonian ◽  
N Vyas ◽  
A Al-khazraji ◽  
S Ahmed ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Premature Coronary Artery Disease ◽  
Modifiable Risk Factors ◽  
Coronary Syndrome ◽  
Vessel Disease ◽  
Single Vessel ◽  
Artery Disease

BackgroundCoronary artery disease (CAD) in the younger adult population has been commonly under-represented in clinical practice and research studies given its early latent asymptomatic course, in addition to the underestimation of this population's CHD lifetime risk by commonly used CHD risk predictors such as Framingham's score.ObjectiveTo assess the risk factor profile for premature coronary artery disease CAD and ACS presentation in younger adults.MethodsRetrospective chart analysis of 393 patient's ≤40 years old admitted from 2005 to 2014 for chest pain and underwent coronary angiography. The implication of modifiable risk factors and non-modifiable risk factors were evaluated in those with obstructive CAD (LM stenosis of ≥50% or stenosis of ≥70% in a major epicardial vessel), non-obstructive CAD (≥1 stenosis ≥20% but no stenosis ≥70%) and normal coronaries (no stenosis >20%). Additionally we evaluated the impact of the same risk factors on ACS presentation (NSTEMI vs STEMI) and the extent of CAD (single-vessel/multi vessel).ResultsOf 9012 patients who underwent cardiac catheterization, 393 (4.3%) patients were ≤40 years old.Out of 393, 212 (54%) had CAD (153 obstructive versus 59 non-obstructive) while 185 (46%) had normal coronaries.Fifty two (25%) patients presented with STEMI while 140 (66%) patients presented with NSTEMI.Of 153 patients with obstructive CAD, 87 (57%) patients had single vessel disease vs 66 (43%) multiple vessel disease.When compared to patients with normal coronaries patients with CAD were more likely to be smokers (p<0.0001), dyslipidemia (p<0.0001), Diabetic (p<0.0001) cocaine users (p 0.4) have a family history of premature CHD (<0.0001) and be males (p<0.0001) (figure=1).Smokers were more likely to present with acute coronary syndrome; 5 times more likely to present with STEMI (p<0.0001) and 1.7 with NSTEMI (p 0.0003) compared to the control group.When compared head to head, smokers were 2.2 times more likely to present with STEMI compared to NSTEMI (p<0.001).Smoking also, alone and with another risk factor increased the risk of obstructive versus no obstructive CAD (p=0.04 and 0.015, respectively).No significant difference was noted in the single vessel vs multi vessel CAD subgroups.Coronary artery disease was highest in South Asian population (38.4%), followed by Hispanic (13.7%), African-American (10%) and Caucasian (9%). The main in risk factors in African–American was Hyperlipidemia +/− Diabetes (47.8%) while the main risk factors in Hispanic and white were smoking alone (24.14% and 47.4% respectively). In East Asia population, Smoking with hyperlipidemia was the main risk factors (44%).ConclusionIn our population of young adults, smoking as a single risk factor was the most prevalent for earlier CAD. It was also associated with more STEMIs and obstructive CAD. Healthcare intervention in the general population through screening, counseling and education regarding smoking cessation is warranted to reduce premature coronary artery disease. Abstract ID: 68 Figure 1

scholarly journals Homocysteine: Chemistry, metabolism and roles in pathophysiology processes

2003 ◽  
Vol 22 (2) ◽  
pp. 127-140 ◽  
Author(s):  
Dusko Mirkovic ◽  
Nada Majkic-Singh ◽  
Svetlana Ignjatovic
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
Chemical Structure ◽  
Independent Risk Factor ◽  
Homocysteine Level ◽  
Premature Coronary Artery Disease ◽  
Severe Mental Retardation ◽  
Vascular Changes ◽  
Artery Disease

In 1962, 30 years after chemical structure discovery of homocysteine, Carson and Neil reported work in which they described cases of two young people with severe mental retardation and high homocysteinuria. In 1975 McCully emphasized the association between homocysteinuria and thrombus-occlusive vascular changes. Period 1991-98, is the time of very extensive comparative studies, with aim of establishing links between premature coronary artery disease and high homocysteine level in plasma. These results in a whole show that biochemical findings of a mild increase of homocysteine plasma levels in span of 15-45 mmol/L, are independent risk factor for premature coronary artery disease appearance. So far mechanism of direct homociysteine uninfluenced on endothelial vascular vessels cells, or influence of any other factor, which play role in methionine-homocysteine-cysteine path (vitamins B6, B12, folic acid) are not strictly elucidated.

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