scholarly journals Are Generalized Reduced Cerebrospinal Fluid Dynamics and Optic Nerve Sheath Compartmentation Sequential Steps in the Pathogenesis of Normal-Tension Glaucoma? [Response to Letter]

Eye and Brain ◽  
2021 ◽  
Vol Volume 13 ◽  
pp. 157-158
Author(s):  
Hanspeter E Killer ◽  
Achmed Pircher
Keyword(s):  
Fluid Dynamics ◽  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Normal Tension Glaucoma ◽  
Optic Nerve Sheath ◽  
Cerebrospinal Fluid Dynamics ◽  
Nerve Sheath

scholarly journals Lipocalin-type Prostaglandin D Synthase Concentration Gradients in the Cerebrospinal Fluid in Normal-tension Glaucoma Patients with Optic Nerve Sheath Compartmentation

Eye and Brain ◽  
2021 ◽  
Vol Volume 13 ◽  
pp. 89-97
Author(s):  
Achmed Pircher ◽  
Albert Neutzner ◽  
Margherita Montali ◽  
Andreas Huber ◽  
Hendrik PN Scholl ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Normal Tension Glaucoma ◽  
Optic Nerve Sheath ◽  
Concentration Gradients ◽  
Nerve Sheath ◽  
Prostaglandin D Synthase

scholarly journals Impaired cerebrospinal fluid dynamics along the entire optic nerve in normal-tension glaucoma

2018 ◽  
Vol 96 (5) ◽  
pp. e562-e569 ◽  
Author(s):  
Achmed Pircher ◽  
Margherita Montali ◽  
Peter Wostyn ◽  
Joachim Pircher ◽  
Jatta Berberat ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Normal Tension Glaucoma ◽  
Cerebrospinal Fluid Dynamics

Sonography of the optic nerve sheath diameter before and after microsurgical closure of a dural CSF fistula in patients with spontaneous intracranial hypotension – a consecutive cohort study

Cephalalgia ◽  
2018 ◽  
Vol 39 (2) ◽  
pp. 306-315 ◽  
Author(s):  
Jens Fichtner ◽  
Christian T Ulrich ◽  
Christian Fung ◽  
Debora Cipriani ◽  
Jan Gralla ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Intracranial Hypotension ◽  
Spontaneous Intracranial Hypotension ◽  
Cerebrospinal Fluid Leak ◽  
Optic Nerve Sheath Diameter ◽  
Optic Nerve Sheath ◽  
Cerebrospinal Fluid Leakage ◽  
Nerve Sheath ◽  
Fluid Leak

Objective Spontaneous intracranial hypotension is caused by spinal cerebrospinal fluid leakage. Patients with orthostatic headaches and cerebrospinal fluid leakage show a decrease in optic nerve sheath diameter upon movement from supine to upright position. We hypothesized that the decrease in optic nerve sheath diameter upon gravitational challenge would cease after closure of the leak. Methods We included 29 patients with spontaneous intracranial hypotension and refractory symptoms admitted from 2013 to 2016. The systematic workup included: Optic nerve sheath diameter sonography, spinal MRI and dynamic myelography with subsequent CT. Microsurgical sealing of the cerebrospinal fluid leak was the aim in all cases. Results Of 29 patients with a proven cerebrospinal fluid leak, one declined surgery. A single patient was lost to follow-up. In 27 cases, the cerebrospinal fluid leak was successfully sealed by microsurgery. The width of the optic nerve sheath diameter in supine position increased from 5.08 ± 0.66 mm before to 5.36 ± 0.53 mm after surgery ( p = 0.03). Comparing the response of the optic nerve sheath diameter to gravitational challenge, there was a significant change from before (−0.36 ± 0.32 mm) to after surgery (0.00 ± 0.19 mm, p < 0.01). In parallel, spontaneous intracranial hypotension-related symptoms resolved in 26, decreased in one and persisted in a single patient despite recovery of gait. Conclusions The sonographic assessment of the optic nerve sheath diameter with gravitational challenge can distinguish open from closed spinal cerebrospinal fluid fistulas in spontaneous intracranial hypotension patients. A response to the gravitational challenge, that is, no more collapse of the optic nerve sheath while standing up, can be seen after successful treatment and correlates with the resolution of clinical symptoms. Sonography of the optic nerve sheath diameter may be utilized for non-invasive follow-up in spontaneous intracranial hypotension.

Optic nerve sheath diameter in normal-tension glaucoma patients

2011 ◽  
Vol 96 (1) ◽  
pp. 53-56 ◽  
Author(s):  
Gregor Peter Jaggi ◽  
Neil Richard Miller ◽  
Josef Flammer ◽  
Robert N Weinreb ◽  
Luca Remonda ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Normal Tension Glaucoma ◽  
Optic Nerve Sheath Diameter ◽  
Optic Nerve Sheath ◽  
Nerve Sheath

Cerebrospinal fluid and optic nerve sheath compartment syndrome: A common pathophysiological mechanism in five different cases?

2019 ◽  
Vol 48 (2) ◽  
pp. 212-219 ◽  
Author(s):  
Jie Hao ◽  
Achmed Pircher ◽  
Neil R. Miller ◽  
Jiemei Hsieh ◽  
Luca Remonda ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Optic Nerve ◽  
Compartment Syndrome ◽  
Optic Nerve Sheath ◽  
Pathophysiological Mechanism ◽  
Nerve Sheath
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