scholarly journals Synthesis of three-arm block copolymer poly(lactic-co-glycolic acid)–poly(ethylene glycol) with oxalyl chloride and its application in hydrophobic drug delivery

2016 ◽  
Vol Volume 11 ◽  
pp. 6065-6077 ◽  
Author(s):  
Xiaowei Zhu ◽  
Chao Liu ◽  
Jianwei Duan ◽  
Xiaoyu Liang ◽  
Xuanling Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Glycolic Acid ◽  
Oxalyl Chloride ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Copolymer Poly

Star-shaped self-assembled micelles of block copolymer [chitosan-co-poly(ethylene glycol) methyl ether methacrylate] hydrogel for hydrophobic drug delivery

2017 ◽  
Vol 75 (6) ◽  
pp. 2243-2264 ◽  
Author(s):  
Faheem Ullah ◽  
Fatima Javed ◽  
Muhammad Bisyrul Hafi Othman ◽  
Saif Ur Rehman ◽  
Zulkifli Ahmad ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Methyl Ether ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Self Assembled ◽  
Poly Ethylene ◽  
Glycol Methyl Ether

A block copolymer of zwitterionic polyphosphoester and polylactic acid for drug delivery

2015 ◽  
Vol 3 (7) ◽  
pp. 1105-1113 ◽  
Author(s):  
Rong Sun ◽  
Xiao-Jiao Du ◽  
Chun-Yang Sun ◽  
Song Shen ◽  
Yang Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Block Copolymers ◽  
Ethylene Glycol ◽  
Polylactic Acid ◽  
Anticancer Drug ◽  
Poly Ethylene Glycol ◽  
Anticancer Drug Delivery ◽  
Poly Ethylene

Zwitterionic polyphosphoester containing polymers are synthesized and evaluated as an alternative to poly(ethylene glycol) block copolymers for anticancer drug delivery.

Poly(lactic acid)/poly(ethylene glycol) block copolymer based shell or core cross-linked micelles for controlled release of hydrophobic drug

RSC Advances ◽  
2015 ◽  
Vol 5 (25) ◽  
pp. 19484-19492 ◽  
Author(s):  
Junjie Li ◽  
Shuangzhuang Guo ◽  
Min Wang ◽  
Lei Ye ◽  
Fanglian Yao
Keyword(s):  
Lactic Acid ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Release Behavior ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles ◽  
Poly Ethylene

The syntheses, structures, and drug release behavior of shell or core cross-linked poly(lactic acid)/poly(ethylene glycol) block copolymer micelles.

Methoxy-Poly(ethylene glycol)-block-Poly(ε-caprolactone) Bearing Pendant Aldehyde Groups as pH-Responsive Drug Delivery Carrier

2013 ◽  
Vol 66 (12) ◽  
pp. 1576 ◽  
Author(s):  
Gejun Ma ◽  
Deshan Li ◽  
Ji Wang ◽  
Xuefei Zhang ◽  
Haoyu Tang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Ethylene Glycol ◽  
In Vitro Release ◽  
Amphiphilic Block Copolymer ◽  
Poly Ethylene Glycol ◽  
Ph Change ◽  
Poly Ethylene ◽  
Aldehyde Groups

A biodegradable amphiphilic block copolymer of methoxy poly(ethylene glycol)-block-poly(ϵ-caprolactone) bearing pendant aldehyde groups was synthesised by a combination of ring-opening polymerisation and thio-bromo ‘click’ chemistry. The free aldehyde groups on the copolymer were reacted with hydrophobic payloads (p-methoxylaniline as a model drug) by a benzoic–imine linker, which was responsive to pH change. NMR, FTIR, and gel permeation chromatography analysis confirmed the copolymer structures. In vitro release studies revealed that under acid stimulus, hydrolysis of the benzoic–imine bond resulted in a rapid drug release. This new amphiphilic block copolymer is expected to have promising applications in biodegradable controlled drug delivery systems.

Sign in / Sign up

Export Citation Format

Share Document