scholarly journals Knockdown of HOXA transcript at the distal tip suppresses the growth and invasion and induces apoptosis of oral tongue squamous carcinoma cells

2018 ◽  
Vol Volume 11 ◽  
pp. 8033-8044 ◽  
Author(s):  
Mingkui Mu ◽  
Yue Li ◽  
Yuanbo Zhan ◽  
Xin Li ◽  
Bin Zhang
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Oral Tongue ◽  
Squamous Carcinoma Cells ◽  
Tongue Squamous Carcinoma

scholarly journals Synthetic Isoliquiritigenin Inhibits Human Tongue Squamous Carcinoma Cells through Its Antioxidant Mechanism

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Cuilan Hou ◽  
Wenguang Li ◽  
Zengyou Li ◽  
Jing Gao ◽  
Zhenjie Chen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Fluorescence Microscopy ◽  
Gelatin Zymography ◽  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Migration And Invasion ◽  
Antioxidant Mechanism ◽  
Squamous Carcinoma Cells ◽  
Human Tongue ◽  
Tongue Squamous Carcinoma

Isoliquiritigenin (ISL), a natural antioxidant, has antitumor activity in different types of cancer cells. However the antitumor effect of ISL on human tongue squamous carcinoma cells (TSCC) is not clear. Here we aimed to investigate the effects of synthetic isoliquiritigenin (S-ISL) on TSCC and elucidate the underlying mechanisms. S-ISL was synthesized and elucidated from its nuclear magnetic resonance spectrum and examined using high performance liquid chromatography. The effects of S-ISL on TSCC cells (Tca8113) were evaluated in relation to cell proliferation, apoptosis and adhesion, migration, and invasion using sulforhodamine B assay, fluorescence microscopy technique, flow cytometry (FCM) analysis, and Boyden chamber assay. The associated regulatory mechanisms were examined using FCM and fluorescence microscopy for intracellular reactive oxygen species (ROS) generation, Gelatin zymography assay for matrix metalloproteinase (MMP) activities, and Western blot for apoptosis regulatory proteins (Bcl-2 and Bax). Our data indicated that S-ISL inhibited Tca8113 cell proliferation, adhesion, migration, and invasion while promoting the cell apoptosis. Such effects were accompanied by downregulation of Bcl-2 and upregulation of Bax, reduction of MMP-2 and MMP-9 activities, and decreased ROS production. We conclude that S-ISL is a promising agent targeting TSCC through multiple anticancer effects, regulated by its antioxidant mechanism.

TGF-β1 inhibits the growth and metastasis of tongue squamous carcinoma cells through Smad4

Gene ◽  
2011 ◽  
Vol 485 (2) ◽  
pp. 160-166 ◽  
Author(s):  
Xiumei Wang ◽  
Wenjing Sun ◽  
Chengren Zhang ◽  
Guohua Ji ◽  
Yana Ge ◽  
...  
Keyword(s):  
Squamous Carcinoma ◽  
Carcinoma Cells ◽  
Squamous Carcinoma Cells ◽  
Tongue Squamous Carcinoma ◽  
Tgf Β1
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