scholarly journals Clinical Application of Tumor Vascular Disrupting Therapy: A Systematic Review and Meta-Analysis

2021 ◽  
Vol Volume 14 ◽  
pp. 5085-5093
Author(s):  
Wen Tsang ◽  
Lu Gan ◽  
Zhikun Zhang ◽  
Tong Li ◽  
Yiqun Luo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Clinical Application ◽  
Meta Analysis ◽  
Vascular Disrupting

Clinical application of stem cell therapy in neurogenic bladder: a systematic review and meta-analysis

2021 ◽  
Author(s):  
Hanieh Salehi-pourmehr ◽  
Ozra Nouri ◽  
Amirreza Naseri ◽  
Leila Roshangar ◽  
Reza Rahbarghazi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Cell Therapy ◽  
Neurogenic Bladder ◽  
Clinical Application ◽  
Stem Cell Therapy ◽  
Meta Analysis

The clinical application of the ratio of transmitral early filling velocity to early diastolic strain rate: a systematic review and meta-analysis

2020 ◽  
Vol 18 (2) ◽  
pp. 94-104
Author(s):  
Mats Christian Højbjerg Lassen ◽  
Flemming Javier Olsen ◽  
Kristoffer Grundtvig Skaarup ◽  
Kirsten Tolstrup ◽  
Atif N. Qasim ◽  
...  
Keyword(s):  
Systematic Review ◽  
Strain Rate ◽  
Clinical Application ◽  
Meta Analysis ◽  
Diastolic Strain Rate ◽  
Early Filling

scholarly journals Clinical Application of Tumor Vascular Disrupting Therapy: A Systematic Review

2021 ◽  
Author(s):  
Wen Zeng ◽  
Pan Wu ◽  
Liping Zhong ◽  
Jian He ◽  
Yong Huang
Keyword(s):  
Systematic Review ◽  
Clinical Application ◽  
Vascular Disrupting

Clinical application of mesenchymal stem cells in periodontal regeneration: A systematic review and meta‐analysis

2019 ◽  
Vol 55 (1) ◽  
pp. 1-12 ◽  
Author(s):  
Solen Novello ◽  
Alexandre Debouche ◽  
Marie Philippe ◽  
Florian Naudet ◽  
Sylvie Jeanne
Keyword(s):  
Systematic Review ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Clinical Application ◽  
Meta Analysis ◽  
Periodontal Regeneration

scholarly journals The Effects of Rhubarb for the Treatment of Diabetic Nephropathy in Animals: A Systematic Review and Meta-analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing-Yi Zeng ◽  
Yu Wang ◽  
Miao Miao ◽  
Xiao-Rong Bao
Keyword(s):  
Systematic Review ◽  
Diabetic Nephropathy ◽  
Clinical Application ◽  
Transforming Growth Factor ◽  
Smooth Muscle Actin ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Tubulointerstitial Injury ◽  
Alpha Smooth Muscle Actin ◽  
Cad Protein

Background: Rhubarb, also known as Da Huang, is a traditional Chinese medicine, and it was often used as a laxative in the past. Recently, multiple studies have applied rhubarb to treat diabetic nephropathy (DN). Anthraquinones, including emodin and rhein, have been extracted from rhubarb and used to explore the effective components and possible mechanisms of rhubarb for DN. Evaluating the efficacy of rhubarb may provide a scientific reference for the clinical application of rhubarb for the treatment of DN.Objective: 1) To evaluate the efficacy of rhubarb in the treatment of DN; 2) To identify the most effective ingredient of rhubarb for DN; 3) To explore the specific mechanism of rhubarb in treating DN.Methods: Data sources: related studies were identified by searching Cochrane Library, Ovid-EMBASE, PubMed, SinoMed, WanFang, VIP, CNKI, and other Chinese magazines.Assessment and analysis: SYRCLE’s risk of bias tool for animal studies was used to assess the quality of articles. The meta-analysis was performed in accordance with the Cochrane Handbook for Systematic Reviews of Interventions. Data analysis adopted RevMan 5.3 and STATA 12.0 software.This study was published in the register with PROSPERO, number CRD42020204701.Results: Aggregated data were collected from 27 eligible studies. The results illustrated an intense improvement in the following outcomes in rhubarb-treated animals with DN (p < 0.05): blood glucose, serum creatinine (Scr), blood urea nitrogen (BUN), albumin creatinine ratio (ACR), urine protein (UP), urinary albumin excretion (UAE), renal index (two kidneys weight/body weight, KW/BW), tubulointerstitial injury index (TII), transforming growth factor-beta1 (TGF-β1) mRNA and protein, alpha-smooth muscle actin (α-SMA) protein, and E-cadherin (E-cad) protein. Of these, DN animals with rhubarb exhibited a significantly higher level of E-cad protein. In addition, the level of the other outcomes mentioned above decreased significantly, while there was no significant association between the intervention and nephrin protein (p > 0.05).Conclusion: This systematic review and meta-analysis demonstrated that rhubarb has a positive therapeutic effect on animals with DN, which may provide confidence and some theoretical reference for clinical application to a certain extent.

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