scholarly journals NADPH oxidase-derived reactive oxygen species are essential for differentiation of a mouse macrophage cell line (RAW264.7) into osteoclasts

2009 ◽  
Vol 56 (1,2) ◽  
pp. 33-41 ◽  
Author(s):  
Hideyuki Sasaki ◽  
Hironori Yamamoto ◽  
Kumiko Tominaga ◽  
Kiyoshi Masuda ◽  
Tomoko Kawai ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Nadph Oxidase ◽  
Cell Line ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mouse Macrophage ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Mouse Macrophage Cell Line

scholarly journals Anaphylatoxin C3a but not C3a(desArg) is a chemotaxin for the mouse macrophage cell line J774

1998 ◽  
Vol 28 (5) ◽  
pp. 1570-1577 ◽  
Author(s):  
Jörg Zwirner ◽  
Thomas Werfel ◽  
Hans-Christian Wilken ◽  
Elgin Theile ◽  
Otto Götze
Keyword(s):  
Cell Line ◽  
Mouse Macrophage ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Anaphylatoxin C3a ◽  
Mouse Macrophage Cell Line

scholarly journals Proteome dataset of mouse macrophage cell line infected with tick-borne encephalitis virus

Data in Brief ◽  
2020 ◽  
Vol 28 ◽  
pp. 105029
Author(s):  
A.L. Rusanov ◽  
A.A. Stepanov ◽  
V.G. Zgoda ◽  
A.L. Kaysheva ◽  
M. Selinger ◽  
...  
Keyword(s):  
Cell Line ◽  
Encephalitis Virus ◽  
Mouse Macrophage ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Tick Borne Encephalitis ◽  
Tick Borne Encephalitis Virus ◽  
Mouse Macrophage Cell Line

scholarly journals Antileishmanial Activities of Several Classes of Aromatic Dications

2002 ◽  
Vol 46 (3) ◽  
pp. 797-807 ◽  
Author(s):  
James J. Brendle ◽  
Abram Outlaw ◽  
Arvind Kumar ◽  
David W. Boykin ◽  
Donald A. Patrick ◽  
...  
Keyword(s):  
Cell Line ◽  
Leishmania Donovani ◽  
Pneumocystis Carinii ◽  
Antileishmanial Activity ◽  
Microbial Pathogens ◽  
Mouse Macrophage ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Mouse Macrophage Cell Line

ABSTRACT Aromatic dicationic molecules possess impressive activity against a broad spectrum of microbial pathogens, including Pneumocystis carinii, Cryptosporidium parvum, and Candida albicans. In this work, 58 aromatic cations were examined for inhibitory activity against axenic amastigote-like Leishmania donovani parasites. In general, the most potent of the compounds were substituted diphenyl furan and thiophene dications. 2,5-Bis-(4-amidinophenyl)thiophene was the most active compound. This agent displayed a 50% inhibitory concentration (IC50) of 0.42 ± 0.08 μM against L. donovani and an in vitro antileishmanial potency 6.2-fold greater than that of the clinical antileishmanial dication pentamidine and was 155-fold more toxic to the parasites than to a mouse macrophage cell line. 2,4-Bis-(4-amidinopheny)furan was twice as active as pentamidine (IC50, 1.30 ± 0.21 μM), while 2,5-bis-(4-amidinopheny)furan and pentamidine were essentially equipotent in our in vitro antileishmanial assay. Carbazoles, dibenzofurans, dibenzothiophenes, and benzimidazoles containing amidine or substituted amidine groups were generally less active than the diphenyl furans and thiophenes. In all cases, aromatic dications possessing strong antileishmanial activity were severalfold more toxic to the parasites than to a cultured mouse macrophage cell line. These structure-activity relationships demonstrate the potent antileishmanial activity of several aromatic dications and provide valuable information for the future design and synthesis of more potent antiparasitic agents.

scholarly journals Introduction of a human colony stimulating factor-1 gene into a mouse macrophage cell line induces CSF-1 independence but not tumorigenicity

Blood ◽  
1988 ◽  
Vol 71 (5) ◽  
pp. 1218-1225 ◽  
Author(s):  
MF Roussel ◽  
CW Rettenmier ◽  
CJ Sherr
Keyword(s):  
Cell Line ◽  
Retroviral Vector ◽  
Gene Products ◽  
Mouse Macrophage ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Multiple Copies ◽  
Membrane Bound ◽  
Stimulating Factor ◽  
Mouse Macrophage Cell Line

Abstract The SV40-immortalized mouse macrophage cell line, BAC1.2F5, is strictly dependent on CSF-1 for its survival and proliferation in culture. Introduction of a retroviral vector containing a 1.6 kilobase (kb) pair human CSF-1 cDNA into these cells abrogated their growth factor dependence but did not render the cells tumorigenic in nude mice. The infected macrophages contained multiple copies of the vector provirus, expressed both membrane-bound and secreted forms of CSF-1, and exhibited constitutive down modulation of the murine CSF-1 receptor. Because insertion of the v-fms gene has previously been shown to abrogate factor dependence and induce tumorigenicity in BAC1.2F5 macrophages, the failure of these cells to express a fully transformed phenotype after persistent stimulation by endogenous CSF-1 suggests that the v-fms and c-fms gene products provide different signals for cell proliferation.

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