scholarly journals VALUE OF MRI (DWI &ADC) IN DIFFERENTIATING BENIGN AND MALIGNANT ORBITAL LESIONS

2021 ◽  
Vol 72 (2) ◽  
pp. 227-237
Author(s):  
Eman Geneidi ◽  
Eman Darwish ◽  
Selvia Isacc
Keyword(s):  
Orbital Lesions

scholarly journals New Targeted Therapies and Immunotherapies for Locally Advanced Periocular Malignant Tumours: Towards a New ‘Eye-Sparing’ Paradigm?

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2822
Author(s):  
Arnaud Martel ◽  
Sandra Lassalle ◽  
Alexandra Picard-Gauci ◽  
Lauris Gastaud ◽  
Henri Montaudie ◽  
...  
Keyword(s):  
Targeted Therapies ◽  
Paradigm Shift ◽  
Adjuvant Radiotherapy ◽  
Locally Advanced ◽  
Second Step ◽  
Malignant Tumours ◽  
New Paradigm ◽  
Eye Pain ◽  
Almost All ◽  
Orbital Lesions

The management of periocular skin malignant tumours is challenging. Surgery remains the mainstay of treatment for localised eyelid cancers. For more locally advanced cancers, especially those invading the orbit, orbital exenteration has long been considered the gold standard; however, it is a highly disfiguring and traumatic surgery. The last two decades have been marked by the emergence of a new paradigm shift towards the use of ‘eye-sparing’ strategies. In the early 2000s, the first step consisted of performing wide conservative eyelid and orbital excisions. Multiple flaps and grafts were needed, as well as adjuvant radiotherapy in selected cases. Although being incredibly attractive, several limitations such as the inability to treat the more posteriorly located orbital lesions, as well as unbearable diplopia, eye pain and even secondary eye loss were identified. Therefore, surgeons should distinguish ‘eye-sparing’ from ‘sight-sparing’ strategies. The second step emerged over the last decade and was based on the development of targeted therapies and immunotherapies. Their advantages include their potential ability to treat almost all tumours, regardless of their locations, without performing complex surgeries. However, several limitations have been reported, including their side effects, the appearance of primary or secondary resistances, their price and the lack of consensus on treatment regimen and exact duration. The aim of this article was to review the evolution of the management of locally advanced periocular malignant tumours over the last three decades and highlight the new paradigm shift towards the use of ‘eye-sparing’ strategies.

scholarly journals Role of Quantitative Diffusion-Weighted Imaging in Differentiating Benign and Malignant Orbital Masses

2021 ◽  
Author(s):  
Preeti Mundhada ◽  
Sudarshan Rawat ◽  
Ullas Acharya ◽  
Dhananjay Raje
Keyword(s):  
Roc Curve ◽  
Diffusion Weighted Imaging ◽  
Care Hospital ◽  
Adc Value ◽  
Diffusion Weighted ◽  
Significant Difference ◽  
Orbital Masses ◽  
Adc Values ◽  
Orbital Lesions

Abstract Aim To determine the role of diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) values in differentiating benign and malignant orbital masses. Materials and Methods After obtaining institutional ethical board approval and informed consent from all patients, an observational study was done for a period of 24 months in the radiology department of a tertiary care hospital in South India. Conventional magnetic resonance imaging and DWI using a 3T scanner was done for all patients with suspected orbital mass lesion. ADC value and clinicohistopathological correlation were studied for every patient. Chi-square test was used to compare the signal characteristics of DWI and ADC maps between benign and malignant lesions. A comparison of mean ADC values for benign and malignant masses was performed using Student’s t-test for independent samples. The cut-off value for ADC was obtained using the receiver operating characteristic (ROC) curve. Results Of 44 patients with orbital lesions, 70% were benign and 30% were malignant. There was a significant difference in the mean ADC values of benign and malignant orbital masses. Using ROC curve analysis, an optimal ADC threshold of 1.26 × 10−3 mm2/s was calculated for the prediction of malignancy with 100% sensitivity, 80.65% specificity, and 86.36% accuracy (95% confidence interval: 0.872, 1.00, p < 0.0001). Two ADC thresholds were used to characterize the orbital masses with more than 90% confidence. Conclusion Quantitative assessment of ADC is a useful noninvasive diagnostic tool for differentiating benign and malignant orbital masses. Malignant orbital lesions demonstrate significantly lower ADC values as compared with benign lesions.

scholarly journals “Push–Pull Technique” for the Management of a Selected Superomedial Intraorbital Lesion

2018 ◽  
Vol 04 (03) ◽  
pp. e105-e109 ◽  
Author(s):  
Paolo Castelnuovo ◽  
Giacomo Fiacchini ◽  
Francesca Fiorini ◽  
Iacopo Dallan
Keyword(s):  
Venous Malformation ◽  
Complete Resection ◽  
Safe Procedure ◽  
Combined Approach ◽  
Main Approach ◽  
Transnasal Approach ◽  
Superior Eyelid Approach ◽  
Push Down ◽  
Orbital Lesions

Orbital lesions are traditionally managed through external approaches when laterally located, and through a transnasal approach or other external approaches when medially located. However, when the lesion is superomedially located, it may determine a technical challenge.In this study, we present the case of a patient with a superomedial intraconal venous malformation of the left eye. We addressed the mass through a combined approach, using the transnasal route as the main approach, and the superior eyelid approach to push down the lesion to facilitate the excision. We have called this approach “push–pull technique.”We achieved a complete resection of the lesion and did not observe any intraoperative or postoperative complications. The last follow-up at 6 months postoperatively showed no recurrence, and the patient was satisfied and completely recovered.According to our experience, the “push–pull” technique seems to be a safe procedure and might be considered a valid alternative to address selected superomedial intraconal lesions.

Doppler Ultrasonic Flow Detector: An Adjunct In Evaluation of Orbital Lesions

1980 ◽  
Vol 17 (4) ◽  
pp. 268-271
Author(s):  
R Michael Nisbet ◽  
John C Barber ◽  
Paul G Steinkuller
Keyword(s):  
Orbital Lesions ◽  
Flow Detector

Computer Assisted Tomography of Orbital Lesions in Wegenerʼs Granulomatosis

1978 ◽  
Vol 2 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Michael Vermess ◽  
Barton F. Haynes ◽  
Anthony S. Fauci ◽  
Sheldon M. Wolff
Keyword(s):  
Computer Assisted ◽  
Computer Assisted Tomography ◽  
Orbital Lesions

Gamma Knife Radiosurgery for Orbital Lesions

2008 ◽  
Vol 49 (4) ◽  
pp. 555 ◽  
Author(s):  
Young-Joo Choi ◽  
Jung-Il Lee ◽  
Yoon-Duck Kim
Keyword(s):  
Gamma Knife ◽  
Gamma Knife Radiosurgery ◽  
Orbital Lesions

scholarly journals Spheno-orbital Lesions—A Major Review of Nonmeningioma Causes

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Alan A. McNab ◽  
Randall S. Jones ◽  
Thomas G. Hardy
Keyword(s):  
Major Review ◽  
Orbital Lesions

scholarly journals STUDY OF ROLE OF FINE NEEDLE ASPIRATION CYTOLOGY (FNAC) IN EYELID AND ORBITAL LESIONS

2016 ◽  
Vol 3 (69) ◽  
pp. 3771-3774
Author(s):  
Ashok Kumar P ◽  
Kalpana V.M ◽  
Faraz Ali M ◽  
Subhashini M ◽  
Rajavelu Indira
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Orbital Lesions

Fine-Needle Aspiration Biopsy in Orbital Lesions: A Retrospective Study of 225 Cases

2016 ◽  
Vol 166 ◽  
pp. 37-42 ◽  
Author(s):  
Anna C.H. Wiktorin ◽  
Eva M.E. Dafgård Kopp ◽  
Edneia Tani ◽  
Boel Söderén ◽  
Richard C. Allen
Keyword(s):  
Retrospective Study ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Biopsy ◽  
Needle Aspiration ◽  
Aspiration Biopsy ◽  
Fine Needle ◽  
Needle Aspiration Biopsy ◽  
Orbital Lesions
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