scholarly journals Physiological consequence of sleep deprivation on healthy volunteers

2020 ◽  
Vol 49 (2) ◽  
pp. 28-36
Author(s):  
N. El_Sawi ◽  
M. Edrees ◽  
G. M.
Keyword(s):  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Physiological Consequence

Antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in 12 healthy volunteers

1991 ◽  
Vol 6 (2) ◽  
pp. 93-97 ◽  
Author(s):  
G Bensimon ◽  
D Benoit ◽  
L Lacomblez ◽  
E Weiller ◽  
D Warot ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Controlled Study ◽  
Long Term Memory ◽  
Double Blind ◽  
Flicker Fusion Frequency ◽  
Short And Long Term ◽  
Psychotropic Compound

SummaryModafinil is a new psychotropic compound with central α1, adrenergic-stimulant activity in animals. In the present study, its pharmacological activity in man was evaluated in the sleep-deprivation induced psychomotor and cognitive impairment paradigm. This was a double-blind placebo-controlled study involving 12 healthy volunteers. Standard psychomotor and memory tasks were used, including critical flicker fusion frequency determination (CFF), choice reaction time and short- and long-term memory evaluation. Results revealed a clear antagonism by modafinil of the psychomotor and cognitive impairment induced by sleep-deprivation in most tasks 6 h after drug administration, and marginal effects 18 h after. These results therefore support a psychostimulant activity of modafinil in man.

Effects of different sleep deprivation protocols on sleep perception in healthy volunteers

2014 ◽  
Vol 15 (10) ◽  
pp. 1219-1224 ◽  
Author(s):  
Leonardo I. Goulart ◽  
Luciano R. Pinto ◽  
Michael L. Perlis ◽  
Raquel Martins ◽  
Luis Otavio Caboclo ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Healthy Volunteers

Effects of Total Sleep Deprivation on Cardiovascular Parameters: An Absence of Biologically Significant Findings?

2002 ◽  
Vol 16 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Elena Miró ◽  
Carmen Cano ◽  
Gualberto Buela-Casal
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Repeated Measures ◽  
Clinical Relevance ◽  
Vigilance Task ◽  
Mean Values ◽  
Total Sleep Deprivation ◽  
The Third

Abstract The present study analyzes the variations of heart rate (HR) and systolic and diastolic blood pressure (SBP and DBP) during 60 h of total sleep deprivation (TSD). All variables were evaluated every 2 h in a resting condition, during the performance of a vigilance task. Thirty healthy volunteers (15 men and 15 women) from 18 to 24 years old participated in the experiment. The analyses of variance (ANOVAS) with repeated measures showed some modifications of HR and SBP mean values mainly marked by circadian oscillations. The circadian oscillations had a smaller amplitude for SBP than for HR. HR showed a slight decrease on the second night of TSD and a slight increase on the third day of TSD. SBP decreased during the first 24 h of TSD and after that maintained its values without significant changes. DBP did not show any significant variations during TSD. In addition, there were no differences in function of gender for the TSD effect on the studied variables. All these statistically significant findings, however, seem to have no biological or clinical relevance. These aspects as well as the possible relationships between our results and activation or stress levels during TSD are discussed.

Neurobehavioral and Cognitive Changes Induced by Sleep Deprivation in Healthy Volunteers

2016 ◽  
Vol 15 (7) ◽  
pp. 777-801 ◽  
Author(s):  
Catherine Cassé-Perrot ◽  
Laura Lanteaume ◽  
Julie Deguil ◽  
Régis Bordet ◽  
Alexandra Auffret ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Cognitive Changes

Hemodynamic, autonomic and baroreflex changes after one night sleep deprivation in healthy volunteers

2009 ◽  
Vol 145 (1-2) ◽  
pp. 76-80 ◽  
Author(s):  
Massimo Pagani ◽  
Paolo Pizzinelli ◽  
Anne Pavy-Le Traon ◽  
Cinzia Ferreri ◽  
Silvia Beltrami ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Night Sleep

Sleep Deprivation Affects Thermal Pain Thresholds but Not Somatosensory Thresholds in Healthy Volunteers

2004 ◽  
Vol 66 (6) ◽  
pp. 932-937 ◽  
Author(s):  
Bernd Kundermann ◽  
Julia Spernal ◽  
Martin Tobias Huber ◽  
Jürgen-Christian Krieg ◽  
Stefan Lautenbacher
Keyword(s):  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Pain Thresholds ◽  
Thermal Pain

scholarly journals Repeated lumbar punctures within 3 days may affect CSF biomarker levels

2019 ◽  
Vol 16 (1) ◽  
Author(s):  
Martin Olsson ◽  
Johan Ärlig ◽  
Jan Hedner ◽  
Kaj Blennow ◽  
Henrik Zetterberg
Keyword(s):  
Alzheimer’S Disease ◽  
Cerebrospinal Fluid ◽  
Sleep Deprivation ◽  
Healthy Volunteers ◽  
Lumbar Puncture ◽  
Methodological Problem ◽  
Csf Biomarkers ◽  
Sharp Rise ◽  
Csf Biomarker ◽  
The Relationship

AbstractLumbar puncture (LP) is a common way of collecting cerebrospinal fluid (CSF) both in the clinic and in research. In this extension of a study on the relationship between sleep deprivation and CSF biomarkers for Alzheimer’s disease, we investigated CSF biomarker dynamics in relation to rebound sleep after sleep deprivation. Two LPs were performed within 3 days in 13 healthy volunteers. We noticed an unexpected sharp rise in biomarker concentrations in the second sample and therefore repeated the experiment, but without sleep intervention, in four additional individuals. The findings were similar in these subjects, suggesting an inherent methodological problem with repeated LPs. The result corroborates findings in studies with repeated CSF collection via indwelling lumbar catheters, and needs to be addressed in, for instance, pharmacodynamic studies employing these techniques.

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