Genetic Screening in Infertile Mexican Men: Chromosomal Abnormalities, Y Chromosome Deletions, and Androgen Receptor CAG Repeat Length

2008 ◽  
Vol 29 (6) ◽  
pp. 654-660 ◽  
Author(s):  
S. G. Martinez-Garza ◽  
M. C. Gallegos-Rivas ◽  
M. Vargas-Maciel ◽  
J. M. Rubio-Rubio ◽  
M. E. de los Monteros-Rodriguez ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Y Chromosome ◽  
Genetic Screening ◽  
Chromosomal Abnormalities ◽  
Repeat Length ◽  
Cag Repeat ◽  
Chromosome Deletions ◽  
Mexican Men

Androgen Receptor CAG Repeat Length in Relation to Phenotype Among Females with Nonclassical 21-Hydroxylase Deficiency

2014 ◽  
Vol 47 (07) ◽  
pp. 491-496
Author(s):  
S. Ben-Shachar ◽  
I. Ayalon ◽  
H. Reznik-Wolf ◽  
Y. Tenenbaum-Rakover ◽  
N. Zuckerman-Levin ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Repeat Length ◽  
Cag Repeat ◽  
Hydroxylase Deficiency ◽  
21 Hydroxylase Deficiency

scholarly journals Is the effect of testosterone on body composition modulated by the androgen receptor gene CAG repeat polymorphism in elderly men?

2007 ◽  
Vol 156 (3) ◽  
pp. 395-401 ◽  
Author(s):  
B Lapauw ◽  
S Goemaere ◽  
P Crabbe ◽  
J M Kaufman ◽  
J B Ruige
Keyword(s):  
Body Composition ◽  
Androgen Receptor ◽  
Effect Modification ◽  
Community Dwelling ◽  
Repeat Length ◽  
Fat Free Mass ◽  
Cag Repeat ◽  
Repeat Polymorphism ◽  
Elderly Men ◽  
Body Composition Assessment

Objective: The androgen receptor (AR) gene contains a CAG repeat polymorphism coding for a polyglutamine chain, the length of which is inversely correlated with AR transcriptional activity. We explored whether this polymorphism modulates the activities of testosterone (T) related to body composition in elderly men. Design: We performed cross-sectional analyses using data from a 4-year follow-up study in community-dwelling men aged 75–89 years (n=159). Methods: Body composition was assessed by dual-energy X-ray absorptiometry and its relation with T and the AR gene CAG repeat length was assessed by multiple linear regression analyses, adjusting for confounding and exploring effect modification. Results: AR gene CAG repeat length was not directly related to body composition, either with or without adjustment for confounding variables like age, weight, total T or sex hormone binding globulin (SHBG) levels. However, exploration of effect modification showed that CAG repeat length modulated the relation between T and body composition (standardized regression coefficients of interaction term: β=0.12, P<0.01 and β=−0.09, P<0.05 for fat-free mass and fat mass respectively). These results were confirmed using similar models and data of mean T, SHBG and weight of the 2 years’ preceding body composition assessment instead of data of the same year (β=0.09, P<0.05 and β=−0.09, P<0.05 respectively). Conclusion: These findings suggest that the AR gene CAG polymorphism contributes, albeit modestly, to the between-subject variation of T action on body composition in community-dwelling elderly men.

CAG repeat length in androgen-receptor gene and reproductive variables in fertile and infertile men

The Lancet ◽  
2002 ◽  
Vol 359 (9300) ◽  
pp. 44-46 ◽  
Author(s):  
Ewa Rajpert-De Meyts ◽  
Henrik Leffers ◽  
Jørgen H Petersen ◽  
Anne-Grethe Andersen ◽  
Elisabeth Carlsen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Receptor Gene ◽  
Androgen Receptor Gene ◽  
Repeat Length ◽  
Cag Repeat ◽  
Infertile Men
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