scholarly journals A STUDY OF THE PHARMACOLOGICAL ACTIVITY OF A MONTMORILLONITE-BASED ENTEROSORBENT ON THE MODEL OF ACUTE TOXIC HEPATITIS

2018 ◽  
Author(s):  
A. N. Tishin ◽  
◽  
M. V. Pokrovskiy ◽  
Keyword(s):  
Pharmacological Activity ◽  
Toxic Hepatitis ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Action of sodium aurothiomalate in acute toxic hepatitis

1977 ◽  
Vol 83 (5) ◽  
pp. 637-640
Author(s):  
T. A. Korolenko ◽  
V. A. Shkurupii ◽  
V. M. Subbotin ◽  
G. S. Yakobson
Keyword(s):  
Toxic Hepatitis ◽  
Sodium Aurothiomalate ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Acute Toxic Hepatitis Induced by Herbal Medicine in Assam: A Pilot Study

2018 ◽  
Vol 113 (Supplement) ◽  
pp. S567 ◽  
Author(s):  
Bhabadev Goswami ◽  
Preeti Sharma ◽  
Snigdha Saikia ◽  
Prajjalendra Barooah ◽  
Mallika Bhattacharyya ◽  
...  
Keyword(s):  
Pilot Study ◽  
Herbal Medicine ◽  
Toxic Hepatitis ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

scholarly journals Acute Hepatitis after Ingestion of a Preparation of Chinese Skullcap and Black Catechu for Joint Pain

2016 ◽  
Vol 2016 ◽  
pp. 1-3 ◽  
Author(s):  
Charilaos Papafragkakis ◽  
Mel A. Ona ◽  
Madhavi Reddy ◽  
Sury Anand
Keyword(s):  
Side Effects ◽  
Acute Hepatitis ◽  
Joint Pain ◽  
Toxic Hepatitis ◽  
Herbal Preparations ◽  
Wide Range ◽  
Herbal Medications ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

Many herbal preparations are routinely used and have been occasionally associated with a wide range of side effects, from mild to severe. Chinese skullcap and black catechu are herbal medications commonly used for their hepatoprotective and other properties. We report a case of acute toxic hepatitis associated with ingestion of Chinese skullcap and black catechu in one preparation for the alleviation of joint pain.

Aloe vera-induced acute toxic hepatitis in a healthy young man

2006 ◽  
Vol 17 (8) ◽  
pp. 589 ◽  
Author(s):  
Ozkan Kanat ◽  
Ahmet Ozet ◽  
Selmin Ataergin
Keyword(s):  
Toxic Hepatitis ◽  
Aloe Vera ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic

scholarly journals EVALUATION OF ANTIOXIDANT PROPERTIES OF MEDGERM IN ACUTE SIMULATED HEPATITIS

2020 ◽  
Vol 20 (1) ◽  
pp. 59-66
Author(s):  
O. L. Tymchishin ◽  
V.V. Godovan ◽  
N.V. Kresyun
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant System ◽  
Liver Tissue ◽  
Toxic Hepatitis ◽  
Antioxidant Properties ◽  
Male Rats ◽  
Group I ◽  
Acute Toxic Hepatitis ◽  
Main Components ◽  
Acute Toxic

Disruption in redox processes plays a significant role in the pathogenesis of hepatitis. A balance between peroxidation, on the one hand, and the antioxidant system, on the other, is a prerequisite for maintaining normal cell activity. The modern arsenal of effective hepatoprotective drugs is not so wide therefore, the development of new hepatoprotectors is one of the topical issues in pharmacology. The purpose of the work is study the antioxidant properties of medgerma in acute experimental hepatitis. Material and methods. The experiments were performed on male rats weighing 180-220 g. Acute toxic hepatitis in rats was induced by intraperitoneal administration of D-galactosamine in a dosage of 400 mg / kg (LD50). The experimental animals were divided into 4 groups: group I (n = 10) included intact animals that were injected 0.9% sodium chloride solution (control group) intraperitoneally, II group (n = 40) involved the animals receiving only D-galactosamine; group III (n = 40) included rats, which received were administered Medmerg intraperitoneally in a dose of 0.4 mg / kg 7 days before D-galactosamine administration and 7 days after D-galactosamine administration. Group IV (n = 40) included rats, which received the comparison medicine, Essentiale® N, in at a dosage of 5 mg / kg in the same mode. The assessment of lipid peroxidation indices and the antioxidant system indices were carried out on days 1, 3, and 7 after the administration of hepatotoxin in the blood serum and the liver tissue homogenate supernatant. The condition of lipid peroxidation processes in the animals with galactosamine hepatitis was assessed by the content of lipid peroxidation end products in the blood and liver tissue that react with 2-thiobarbituric acid (TBA reactants). The condition of the main components of the antioxidant system was evaluated by the level of reduced glutathione and by the activity of catalase and superoxide dismutase. Results and discussion. It has been established that medgerm enhances the liver resistance to hepatotoxicant, as evidenced by a decrease in the level of lipid peroxidation products and the consumption of main components of the antioxidant system on the first day of hepatitis. Moreover, in the rats, which received Medgerm according to prevention scheme under acute toxic hepatitis, the course of the disease was milder than in the animals that did not receive this therapy. Conclusions and prospects for further research. Medgerm possesses hepatoprotective properties, which underlay positive effects on the state of lipid peroxidation and the main components of the antioxidant system.

Plasma enzyme activity in rats with various types of acute toxic hepatitis

1968 ◽  
Vol 65 (5) ◽  
pp. 526-528
Author(s):  
A. A. Pokrovskii ◽  
A. I. Archakov ◽  
A. M. Gerasimov ◽  
I. I. Karuzina ◽  
M. L. Sorokina
Keyword(s):  
Enzyme Activity ◽  
Toxic Hepatitis ◽  
Plasma Enzyme ◽  
Acute Toxic Hepatitis ◽  
Acute Toxic
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