Anti-Inflammatory Properties of Plant Derived Natural Products – A Systematic Review

2019 ◽  
Vol 26 (24) ◽  
pp. 4506-4536 ◽  
Author(s):  
Iris E. Allijn ◽  
René P. Brinkhuis ◽  
Gert Storm ◽  
Raymond M. Schiffelers
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Positive Control ◽  
Therapeutic Effects ◽  
Reference Compound ◽  
Individual Molecular Species ◽  
The Past ◽  
Anti Inflammatory ◽  
The Individual ◽  
Natural Medicines

Traditionally, natural medicines have been administered as plant extracts, which are composed of a mixture of molecules. The individual molecular species in this mixture may or may not contribute to the overall medicinal effects and some may even oppose the beneficial activity of others. To better control therapeutic effects, studies that characterized specific molecules and describe their individual activity that have been performed over the past decades. These studies appear to underline that natural products are particularly effective as antioxidants and anti-inflammatory agents. In this systematic review we aimed to identify potent anti-inflammatory natural products and relate their efficacy to their chemical structure and physicochemical properties. To identify these compounds, we performed a comprehensive literature search to find those studies, in which a dose-response description and a positive control reference compound was used to benchmark the observed activity. Of the analyzed papers, 7% of initially selected studies met these requirements and were subjected to further analysis. This analysis revealed that most selected natural products indeed appeared to possess anti-inflammatory activities, in particular anti-oxidative properties. In addition, 14% of the natural products outperformed the remaining natural products in all tested assays and are attractive candidates as new anti-inflammatory agents.

scholarly journals Immunoregulation by Artemisinin and Its Derivatives: A New Role for Old Antimalarial Drugs

2021 ◽  
Vol 12 ◽  
Author(s):  
Feifei Qiu ◽  
Junfeng Liu ◽  
Xiumei Mo ◽  
Huazhen Liu ◽  
Yuchao Chen ◽  
...  
Keyword(s):  
Autoimmune Diseases ◽  
Molecular Mechanisms ◽  
Transplant Rejection ◽  
Antimalarial Drugs ◽  
Therapeutic Effects ◽  
Immunomodulatory Effects ◽  
Clinical Safety ◽  
The Past ◽  
Tremendous Progress ◽  
Anti Inflammatory

Artemisinin and its derivatives (ARTs) are known as conventional antimalarial drugs with clinical safety and efficacy. Youyou Tu was awarded a Nobel Prize in Physiology and Medicine due to her discovery of artemisinin and its therapeutic effects on malaria. Apart from antimalarial effects, mounting evidence has demonstrated that ARTs exert therapeutic effects on inflammation and autoimmune disorders because of their anti-inflammatory and immunoregulatory properties. In this aspect, tremendous progress has been made during the past five to seven years. Therefore, the present review summarizes recent studies that have explored the anti-inflammatory and immunomodulatory effects of ARTs on autoimmune diseases and transplant rejection. In this review, we also discuss the cellular and molecular mechanisms underlying the immunomodulatory effects of ARTs. Recent preclinical studies will help lay the groundwork for clinical trials using ARTs to treat various immune-based disorders, especially autoimmune diseases.

scholarly journals Allium sativum L. (Garlic) Role in Osteoarthritis: A Systematic Review of Clinical Trials

2021 ◽  
Vol 11 (4) ◽  
pp. 12104-12119
Keyword(s):  
Systematic Review ◽  
Clinical Trials ◽  
Side Effects ◽  
Allium Sativum ◽  
Inflammatory Diseases ◽  
Control Group ◽  
Therapeutic Effects ◽  
Inflammatory Factor ◽  
Anti Inflammatory ◽  
Over Time

Osteoarthritis is a chronic degenerative disease involving the joints and bones, causing their degradation over time. Inflammation, pain, and stiffness in joints are indicators of the disease. Pharmacotherapy cannot always be efficient and may cause side effects. So, adjuncts such as complementary herbs have become of note. Garlic is a herb well-known for its various therapeutic effects such as anti-bacterial, anti-hypertension, antioxidant and anti-inflammatory effects. Due to garlic's widespread use, studying its effects and mechanisms on inflammatory diseases such as osteoarthritis has been noteworthy. We searched Science Direct, Pubmed, Cochrane, and Google Scholar databases for all articles published until October 2020, based on PRISMA. Searched keywords were the following: [(garlic and arthritis), (garlic and osteoarthritis), (Garlic and OA), (Allium sativum and arthritis), (Allium sativum and osteoarthritis), (Allium sativum and OA)]. The results showed garlic, and its constituents have remarkable effects on improving OA symptoms through antioxidant and anti-inflammatory pathways. Our review shows that groups receiving garlic as a treatment showed a significant reduction in pain and inflammatory factor levels and an improved physical function instead of the control group.

scholarly journals A Scoping Review of Telehealth

2013 ◽  
Vol 22 (01) ◽  
pp. 51-58 ◽  
Author(s):  
Y. Liu ◽  
P. A. Abbott
Keyword(s):  
Systematic Review ◽  
Scoping Review ◽  
Health Service Utilization ◽  
Review Process ◽  
Therapeutic Effects ◽  
Science Methods ◽  
Future Trends ◽  
User Centered Design ◽  
The Past ◽  
Micro Level

Summary Objectives: This scoping review of the telehealth literature over the past year was conducted to provide a snapshot of some of the current developments in the field. As with any scoping review, only a subset of papers was examined, and the rigorous methods of a systematic review are not applied. Methods: We surveyed selected dimensions of the current literature, specifically targeting telehealth or eHealth interventions at the patient (or micro) level in this scoping review. Considering the lack of clarity around the terms like mHealth, eHealth, telehealth, and telemedicine, efforts were made understand and harmonize the terminology as part of the review process. Results: A total of 171 papers that matched the search criteria were culled from the literature. After discussion and debate, a total of 26 papers were retained and classified into at least one of 5 conceptual categories that were derived form a concept analysis. The five categories are Preventive and Therapeutic Effects; Health Service Utilization; Challenges & Opportunities for Enhanced User Centered Design; Low-powered studies/inconclusive evidence; and Future trends in telehealth. Each of these 5 concept categories are discussed to provide a better understanding of present opportunities, challenges, and the overall prospects for telehealth advancement. Conclusions: The field is expanding and maturing rapidly. There is a need for larger scale studies that balance rigor while reducing translational latency. Additional attention to implementation science methods is recommended as global telehealth projects accelerate.

Anti-inflammatory natural products as potential therapeutic agents of rheumatoid arthritis: A systematic review

Phytomedicine ◽  
2021 ◽  
pp. 153766
Author(s):  
Gopalsamy Rajiv Gandhi ◽  
Gnanasekaran Jothi ◽  
Thiruchenduran Mohana ◽  
Alan Bruno Silva Vasconcelos ◽  
Monalisa Martins Montalvão ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systematic Review ◽  
Natural Products ◽  
Therapeutic Agents ◽  
Anti Inflammatory

scholarly journals Mulinane- and Azorellane-Type Diterpenoids: A Systematic Review of Their Biosynthesis, Chemistry, and Pharmacology

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1333 ◽  
Author(s):  
Angel de Jesús Dzul-Beh ◽  
Andrés Humberto Uc-Cachón ◽  
Jorge Bórquez ◽  
Luis A. Loyola ◽  
Luis Manuel Peña-Rodríguez ◽  
...  
Keyword(s):  
Systematic Review ◽  
Natural Products ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Biological Properties ◽  
Pharmacological Activities ◽  
Wide Range ◽  
Anti Inflammatory

Mulinane- and azorellane-type diterpenoids have unique tricyclic fused five-, six-, and seven-membered systems and a wide range of biological properties, including antimicrobial, antiprotozoal, spermicidal, gastroprotective, and anti-inflammatory, among others. These secondary metabolites are exclusive constituents of medicinal plants belonging to the Azorella, Laretia, and Mulinum genera. In the last 30 years, more than 95 mulinanes and azorellanes have been reported, 49 of them being natural products, 4 synthetics, and the rest semisynthetic and biotransformed derivatives. This systematic review highlights the biosynthetic origin, the chemistry, and the pharmacological activities of this remarkably interesting group of diterpenoids.

scholarly journals CURRENT DEVELOPMENTS ON ANTI-INFLAMMATORY NATURAL MEDICINES

2018 ◽  
Vol 11 (8) ◽  
pp. 61 ◽  
Author(s):  
Sayanna Das ◽  
Sudip Kumar Mandal
Keyword(s):  
Natural Products ◽  
Molecular Mechanisms ◽  
Biological Activities ◽  
Marine Sponges ◽  
The Novel ◽  
Plant Products ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Natural Medicines ◽  
Anti Inflammation

New anti-inflammatory substances are still vitally necessary due to intolerable side effects of the marketed anti-inflammatory drugs; however, the search for the novel entity against inflammation is challenging because of the complexity of the inflammatory process and its role in host defense to infections. Nature is the source of remedies for the mankind. Among the different biological activities of natural products that have been published till date, anti-inflammation is one of the most reported effects. In this review, we have discussed the current (2009–2018) information of some single natural products (quercetin, parthenolide, resveratrol, curcumin, cucurbitacin, capsicin, 1,8-cineole, bromelain, boswellic acid, lyprinol, and coumarin), plant products (garlic, ginger, papaya, blueberry, aloe, broccoli, olive, and rosemary), and non-plant products (marine sponges, mushrooms, and honey) having anti-inflammatory effects. Current information is mainly based on the molecular mechanisms of the above-mentioned products.

Anti-inflammatory and anti-tubercular properties screening of natural products from Plectranthus species

2017 ◽  
Author(s):  
J Marçalo ◽  
C Garcia ◽  
L Custódio ◽  
M Nicolai ◽  
C Reis ◽  
...  
Keyword(s):  
Natural Products ◽  
Anti Inflammatory

A literature review on firms' internationalisation through e-commerce

2019 ◽  
pp. 121-143
Author(s):  
Riccardo Resciniti ◽  
Federica De Vanna
Keyword(s):  
Systematic Review ◽  
Literature Review ◽  
International Business ◽  
Decision Process ◽  
Foreign Markets ◽  
New Markets ◽  
Integrative Framework ◽  
The Past ◽  
The Relationship

The rise of e-commerce has brought considerable changes to the relationship between firms and consumers, especially within international business. Hence, understanding the use of such means for entering foreign markets has become critical for companies. However, the research on this issue is new and so it is important to evaluate what has been studied in the past. In this study, we conduct a systematic review of e-commerce and internationalisation studies to explicate how firms use e-commerce to enter new markets and to export. The studies are classified by theories and methods used in the literature. Moreover, we draw upon the internationalisation decision process (antecedents-modalities-consequences) to propose an integrative framework for understanding the role of e-commerce in internationalisation

The importance and significance of gene polymorphisms in preeclampsia

2016 ◽  
pp. 45-49
Author(s):  
P.N. Veropotvelyan ◽  
◽  
I.S. Tsehmistrenko ◽  
N.P. Veropotvelyan ◽  
N.S. Rusak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Systematic Review ◽  
Early Diagnosis ◽  
Gene Polymorphisms ◽  
Individual Risk ◽  
Extended Study ◽  
Stress Genes ◽  
Detoxification System ◽  
The Individual ◽  
The Relationship

Was to conduct a systematic review of data on the relationship between polymorphisms genes of detoxification system and development of preeclampsia (РЕ). Рresents the main genes of detoxification system (GSTPI, GSTМI, GSTТI, GРХI, ЕРНХI, SOD-2, SOD-3, CYPIAL, MTHЕR, MTR) and their functions. Of interest is the possibility of calculating the individual risk of PE based on the results about the presence of a combination of different polymorphisms in the genotype of the female. Question about early diagnosis of РЕ remains controversial and not fully understood. It is necessary to conduct further in-depth, extended study of this problem. Key words: preeclampsia, oxidative stress, genes of the detoxification system.

POLITICAL IDEOLOGY AS AN EVOLUTIONARY SYSTEM (TO THE THEORY OF COGNITIVE-IDEOLOGICAL MATRICES)

2020 ◽  
Author(s):  
Mikhail Konstantinov
Keyword(s):  
Political Ideology ◽  
Evolutionary System ◽  
Consciousness Level ◽  
The Past ◽  
Political Ideologies ◽  
Morphological Approach ◽  
Main Gene ◽  
Individual Consciousness ◽  
The Individual ◽  
Sociological Studies

The aim of the article is to concretize the concept of political ideology in the aspect of its matrix structure and in the context of the cognitive-evolutionary approach. Based on Michael Frieden's morphological approach to the analysis of ideological consciousness, the concept of cognitive-ideological matrices is introduced, which allows us to describe the process of transition from proto-ideological to ideological concepts proper, especially at the level of individual consciousness. The identification of the ideological concept as the main “gene” of conceptual variability and inheritance made it possible to describe the main parameters of the evolution of political ideologies and associate it with changes taking place at the individual consciousness level. The described concept was tested in a series of sociological studies of youth consciousness conducted in 2015-2016 and 2018-2020. As a result of the study, it was possible to first identify the “zero level” of ideology, at which the minds of young respondents are potentially open to the influence of diverse and often mutually exclusive ideological orientations, and second, to pinpoint the changes that have occurred in the cognitive ideological matrices of Rostov-on-Don students over the past five years. This study was conducted by scientists from the southern Federal University.

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