Vitamin D and Sleep Regulation: Is there a Role for Vitamin D?

2020 ◽  
Vol 26 (21) ◽  
pp. 2492-2496 ◽  
Author(s):  
Fiammetta Romano ◽  
Giovanna Muscogiuri ◽  
Elea Di Benedetto ◽  
Volha V. Zhukouskaya ◽  
Luigi Barrea ◽  
...  
Keyword(s):  
Vitamin D ◽  
Sleep Disorders ◽  
Vitamin D Deficiency ◽  
Sleep Apnea Syndrome ◽  
Regulatory Mechanisms ◽  
Sleep Regulation ◽  
Vitamin D Receptors ◽  
Obstructive Sleep ◽  
The Impact

Background: Vitamin D exerts multiple pleiotropic effects beyond its role in calcium-phosphate metabolism. Growing evidence suggests an association between hypovitaminosis D and sleep disorders, thus increasing the interest in the role of this vitamin in the regulatory mechanisms of the sleep-wake cycle. Objective: The study aimed to explore and summarize the current knowledge about the role of vitamin D in sleep regulation and the impact of vitamin D deficiency on sleep disorders. Methods: The main regulatory mechanisms of vitamin D on sleep are explained in this study. The literature was scanned to identify clinical trials and correlation studies showing an association between vitamin D deficiency and sleep disorders. Results: Vitamin D receptors and the enzymes that control their activation and degradation are expressed in several areas of the brain involved in sleep regulation. Vitamin D is also involved in the pathways of production of Melatonin, the hormone involved in the regulation of human circadian rhythms and sleep. Furthermore, vitamin D can affect sleep indirectly through non-specific pain disorders, correlated with alterations in sleep quality, such as restless legs syndrome and obstructive sleep apnea syndrome. Conclusions: : Vitamin D has both a direct and an indirect role in the regulation of sleep. Although vitamin D deficiency has been associated to sleep disorders, there is still scant evidence to concretely support the role of vitamin D supplementation in the prevention or treatment of sleep disturbances; indeed, more intervention studies are needed to better clarify these aspects.

scholarly journals 0956 Vitamin D and Sleep in Children

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A363-A363
Author(s):  
B Al-Shawwa ◽  
Z Ehsan ◽  
D G Ingram
Keyword(s):  
Vitamin D ◽  
Sleep Apnea ◽  
Vitamin D Deficiency ◽  
Sleep Duration ◽  
Tertiary Care ◽  
Central Sleep Apnea ◽  
Sleep Efficiency ◽  
Sleep Study ◽  
Obstructive Sleep ◽  
The Impact

Abstract Introduction The impact of vitamin D on human health including sleep has been well described in adults. Its deficiency has been associated with multiple sleep disorders such as decrease in sleep duration, worsening of sleep quality and even obstructive sleep apnea. Such correlation is less evident in pediatric population. In the current study, we examined the relationship between sleep architecture and vitamin D status in children referred to a sleep clinic. Methods Retrospective-cohort study in a tertiary care children’s hospital over a one-year period. Children who underwent an in-laboratory-overnight-polysomnogram and had a 25-hydroxy vitamin D level (25-OH-vitD) obtained within 120 days of the sleep study were included. Patients with obstructive or central sleep apnea were excluded. Data from polysomnograms (PSG) and Pediatric Sleep Questionnaires (PSQ) were collected and analyzed. Results A total of 39 patients were included in the study with mean age of 6.6 years and 46% females. Twenty (51%) patients had vitamin D deficiency (25-OH-vitD less than 30 ng/ml). Children with vitamin D deficiency had less total sleep time (470.3 minutes +/-35.6 vs 420.3 minutes +/-61.7, p=0.004) and poorer sleep efficiency (91.9 % +/-5.6 vs 84.5 % +/-9.5, p=0.015) compared to vitamin D sufficient children. In addition, vitamin D deficient children had later weekday bedtimes (21:02 +/- 1:01 vs 20:19 +/- 0:55, p=0.037) and later weekend bedtimes (21:42 +/- 0:59 vs 20:47 +/- 1:08, p=0.016) with tendency for later wake up time that did not reach statistical significance. The remainder of polysomnographic findings and PSQ data were not different between the two groups. Conclusion Vitamin D deficiency in children is associated with objectively measured decreased sleep duration and poorer sleep efficiency. Furthermore, vitamin D deficiency was associated with delayed bedtimes, suggesting that vitamin D may influence circadian rhythm. Future prospective studies in children would be helpful in validating the effect of vitamin D on sleep. Support None

Autonomic dysfunction and sleep disorders

2017 ◽  
Author(s):  
Giovanna Calandra-Buonaura ◽  
Pietro Cortelli
Keyword(s):  
Sleep Disorders ◽  
Sleep Disorder ◽  
Autonomic Dysfunction ◽  
Sleep Apnea Syndrome ◽  
Rem Sleep Behavior Disorder ◽  
Causal Mechanism ◽  
Sleep Behavior ◽  
Obstructive Sleep ◽  
Autonomic Dysfunctions ◽  
The Impact

Autonomic dysfunctions are frequently associated with sleep disorders, as the autonomic nervous system and sleep are closely related from anatomical, physiological, and neurochemical points of view. The autonomic dysfunctions described in this chapter may result from a common pathogenetic mechanism that affects both the autonomic and the sleep functions, as in fatal familial insomnia, or from a prevalent expression of a primary disorder of autonomic regulation during sleep, as in congenital central hypoventilation syndrome. Alternatively, the autonomic dysfunction may be mainly caused by the sleep disorder, as observed in obstructive sleep apnea syndrome, or the causal mechanism resulting in the association between the autonomic dysfunction and the sleep disorder has yet to be identified with certainty, as in narcolepsy with cataplexy and in REM sleep behavior disorder. The impact of the autonomic dysfunction on health and on patients’ quality of life is also reviewed.

The association between obstructive sleep apnea syndrome and vitamin D deficiency

2016 ◽  
Author(s):  
Banu Musaffa Salepçi ◽  
Benan Caglayan ◽  
Elif Torun Parmaksiz ◽  
Nesrin Kiral ◽  
Ali Fidan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Vitamin D Deficiency ◽  
Obstructive Sleep Apnea Syndrome ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Risk assessment of obstructive sleep apnea syndrome in pediatric patients with vitamin D deficiency

Medicine ◽  
2016 ◽  
Vol 95 (39) ◽  
pp. e4632 ◽  
Author(s):  
Gamze Ozgurhan ◽  
Aysel Vehapoglu ◽  
Oznur Vermezoglu ◽  
Rabia Nur Temiz ◽  
Asuman Guney ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Vitamin D ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Vitamin D Deficiency ◽  
Obstructive Sleep Apnea Syndrome ◽  
Pediatric Patients ◽  
Sleep Apnea Syndrome ◽  
Obstructive Sleep ◽  
Apnea Syndrome

scholarly journals Non-Musculoskeletal Benefits of Vitamin D beyond the Musculoskeletal System

2021 ◽  
Vol 22 (4) ◽  
pp. 2128
Author(s):  
Sicheng Zhang ◽  
Duane D. Miller ◽  
Wei Li
Keyword(s):  
Risk Factors ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Musculoskeletal System ◽  
Neurological Disorders ◽  
The Body ◽  
Health Maintenance ◽  
Vitamin D Receptors ◽  
Beneficial Effects

Vitamin D, a fat-soluble prohormone, is endogenously synthesized in response to sunlight or taken from dietary supplements. Since vitamin D receptors are present in most tissues and cells in the body, the mounting understanding of the role of vitamin D in humans indicates that it does not only play an important role in the musculoskeletal system, but has beneficial effects elsewhere as well. This review summarizes the metabolism of vitamin D, the research regarding the possible risk factors leading to vitamin D deficiency, and the relationships between vitamin D deficiency and numerous illnesses, including rickets, osteoporosis and osteomalacia, muscle weakness and falls, autoimmune disorders, infectious diseases, cardiovascular diseases (CVDs), cancers, and neurological disorders. The system-wide effects of vitamin D and the mechanisms of the diseases are also discussed. Although accumulating evidence supports associations of vitamin D deficiency with physical and mental disorders and beneficial effects of vitamin D with health maintenance and disease prevention, there continue to be controversies over the beneficial effects of vitamin D. Thus, more well-designed and statistically powered trials are required to enable the assessment of vitamin D’s role in optimizing health and preventing disease.

scholarly journals Impact of Vitamin D on Physical Efficiency and Exercise Performance—A Review

Nutrients ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 2826 ◽  
Author(s):  
Michał Wiciński ◽  
Dawid Adamkiewicz ◽  
Monika Adamkiewicz ◽  
Maciej Śniegocki ◽  
Marta Podhorecka ◽  
...  
Keyword(s):  
Vitamin D ◽  
Exercise Performance ◽  
Strong Relationship ◽  
High Quality Research ◽  
Vitamin D Receptors ◽  
Cell Proliferation And Differentiation ◽  
Proliferation And Differentiation ◽  
Strongly Connected ◽  
The Impact

Vitamin D deficiency amongst athletes and the general population seems to be a prominent problem. The most recognized role of vitamin D is its regulation of calcium homeostasis; there is a strong relationship between vitamin D and bone health. Moreover, its concentrations are associated with muscle function and immune response in both the general and athletic populations. Vitamin D level is strongly connected with the presence of VDRs (vitamin D receptors) in most human extraskeletal cells. Expression of multiple myogenic transcription factors enhancing muscle cell proliferation and differentiation is caused by an exposure of skeletal muscles to vitamin D. The aim of this review is to summarize current understanding of the significance of vitamin D on exercise performance and physical efficiency, as well to analyze the impact of vitamin D on multiple potential mechanisms. More high-quality research studies, considering free 25(OH)D as a better marker of vitamin D status, the baseline level of 25(OH)D and multiple pathways of vitamin D acting and usage in athletes are required.

scholarly journals Rotating shift workers with vitamin D deficiency have a higher risk of obstructive sleep apnea

2021 ◽  
Author(s):  
Luiz Antonio Alves Menezes Júnior ◽  
Virgínia Capistrano Fajardo ◽  
Sílvia Nascimento de Freitas ◽  
Fausto Aloisio Pedrosa Pimenta ◽  
George Luiz Lins Machado-Coelho ◽  
...  
Keyword(s):  
Vitamin D ◽  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
Vitamin D Deficiency ◽  
Sleep Apnea Syndrome ◽  
Berlin Questionnaire ◽  
Healthy Population ◽  
Shift Workers ◽  
Obstructive Sleep ◽  
Chi Square Analysis

Abstract Objectives The aim of the study is evaluate the association of obstructive sleep apnea syndrome (OSA) and vitamin D deficiency (VDD) in shift workers. Methods This cross-sectional study included rotating shift workers in an iron ore extraction company. Participants were classified as VDD when 25(OH)D < 20 ng/mL for a healthy population and 25(OH)D < 30 ng/mL for groups at risk for VDD. Risk of developing OSA classified by Berlin Questionnaire (BQ) and NoSAS score. Data were compared using chi-square analysis with Cramer's V as effect size, and Bonferroni correction. Multivariate logistic regression analysis was performed to investigate whether VDD was associated with OSA risk assessment. Results Among 1461 workers, mostly male (97.4%), younger, aged 30 to 39 years (53.9%), worked shifts for more than 5 years (75.8%). A prevalence of high risk of OSA by BQ was 15.9%, and 32.5% by NoSAS score. Besides, 28.9% had VDD. In multivariate analysis, controlled for confounding factors, workers with VDD had a 79% increased chance of OSA by BQ (OR: 1.79; CI95%: 1.27-2.51) and an 85% increased chance of OSA by NoSAS score (OR: 1.85; CI95% 1.35-2.53). After subgroup analyses, similar results were not observed in workers aged 20-29 years. Conclusion Rotating shift workers with vitamin D deficiency are more likely to have obstructive sleep apnea, assesed by Berlin questionnaire and NoSAS score.

scholarly journals Excessive Daytime Sleepiness in Sleep Apnea: Any Role of Testosterone or Vitamin D?

2020 ◽  
pp. 907-917
Author(s):  
P ŠIARNIK ◽  
M JURÍK ◽  
M HARDOŇOVÁ ◽  
K KLOBUČNÍKOVÁ ◽  
J VEVERKA ◽  
...  
Keyword(s):  
Vitamin D ◽  
Regression Analysis ◽  
Vitamin D Deficiency ◽  
Excessive Daytime Sleepiness ◽  
Daytime Sleepiness ◽  
Testosterone Levels ◽  
Independent Variables ◽  
Independent Association ◽  
The Impact

Recent studies reported association of sleep-disordered breathing (SDB) with testosterone and vitamin D deficiency. Low testosterone and vitamin D levels have been linked to fatigue and excessive daytime sleepiness (EDS). However, the impact of testosterone and vitamin D deficiency on EDS in subjects with SDB remains unknown. The aim of this study was to explore the predictors of EDS in habitual snorers. Role of testosterone, and vitamin D was studied in detail. We also looked for associations between testosterone, vitamin D, and sleep-related indices. We prospectively enrolled 291 consecutive male patients with habitual snoring. Baseline clinical characteristics were recorded on admission. Standard overnight polysomnography was performed to detect SDB, and Epworth Sleepiness Scale (ESS) was used to assess EDS. Blood samples were obtained in a fasting condition in the morning after polysomnography to determine levels of testosterone and vitamin D. Respiratory disturbance index (RDI) (95 % CI: 1.004-1.024, p=0.005) and the use of antihistamines (95 % CI: 1.083-11.901, p=0.037) were the only independent variables significantly associated with EDS in binary logistic regression analysis. In linear multiple regression analysis, body mass index (BMI) (Beta=-0.282, p˂0.001) and oxygen desaturation index (Beta=-0.150, p=0.043) were the only independent variables significantly associated with testosterone levels, and BMI (Beta=-0.142, p=0.016) was the only independent variable significantly associated with vitamin D. We failed to find any independent association of testosterone and vitamin D with subjectively rated EDS among habitual snorers. Our results suggest an independent association between the magnitude of nocturnal desaturation and testosterone levels.

scholarly journals Role of stress in development of cardiovascular pathology in extreme professions

2019 ◽  
Vol 2 (27) ◽  
pp. 42-44
Author(s):  
N. V. Orlova ◽  
A. Ya. Starokozheva ◽  
A. V. Timoshchenko
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Stress Resistance ◽  
Stress Reactions ◽  
Stress Studies ◽  
Industrial Sectors ◽  
High Prevalence ◽  
High Level ◽  
The Impact

Psychoemotional stress is a risk factor for cardiovascular diseases, including arterial hypertension and coronary heart disease. Neurohumoral mechanisms are involved in the development of hypertensive reactions to stress. The severity of stress reactions depends on the stress resistance of people. The study of stress resistance is carried out in industrial sectors associated with the impact of professional psycho-emotional stress. Studies in locomotive drivers reveal a high level of cardiovascular disease. Stress helps to reduce vitamin D. Vitamin D deficiency helps reduce stress resistance. Studies conducted among locomotive drivers have revealed a high prevalence of vitamin D deficiency, requiring medical correction.

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