Antioxidant as Talented Drug Applicants for the Treatment of Alzheimer’s Disease and their Molecular Mechanism Insights
: Alzheimer's disease (AD), with no preventive or curative therapy, is the most prevalent neurodegenerative condition to date. Histopathological features of AD include β-amyloid plate deposition and neurofibrillary tangles development. Extensive pathology studies have provided significant results concerning disease processes and therapeutic objectives. Some cellular changes, including oxidative stress, Ca2 + homeostasis, flame retardation, metabolic disorders, and protein accumulation, that lead to programmed cell death. AD is a cause of cellular changes. Despite extensive study, only five licensed medicines for AD management are available. Alternative therapies must also be considered. Over the last years, it has gained interest through the use of natural ingredients and culinary herbs. Many natural substances have been extensively researched with neuroprotective effects. Some of these compound products have amazing antioxidant properties and are primarily used by free radical species. Others enhance cell survival and cognition by influencing amyloidogenesis and programmed cell death. Further research on these natural products and their modes of action, along with the application of new drug design and methods of delivery; allow us to add conventional medicine. In this report, many natural antioxidant products with possible neuroprotective characteristics against Aβ were discussed in their mechanism of action.