Essential oils as alternative promising anti-Candidal agents: progress and prospects

2021 ◽  
Vol 27 ◽  
Author(s):  
Awad Shala ◽  
Shweta Singh ◽  
Saif Hameed ◽  
.M.P. Khurana
Keyword(s):  
Essential Oils ◽  
Antioxidant Properties ◽  
Therapeutic Agents ◽  
Antifungal Drugs ◽  
Fungal Resistance ◽  
Antifungal Compounds ◽  
Candida Spp ◽  
Conventional Antibiotics ◽  
Opportunistic Pathogenic

: Candida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects as well as treatment costs are considered as major limitations for antifungal drugs. It has drawn scientists' attention to search for potential substitution and therapeutic reliable alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Essential oils (EO) apart from having lower toxicity and better biodegradability are eco-friendly in nature as compared with conventional antibiotics. Furthermore, extracted essential oils have been reported to possess potent antimicrobial, anti-inflammatory and antioxidant properties that nominate them as natural promising candidates to combat numerous fungal ailments. Thus, determination of antifungal efficacy of essential oil-bearing plants on Candida spp. will provide miscellaneous knowledge for future clinical studies that are required for development of new formulations as alternative therapeutic agents to control the growth of Candida species. Therefore, this review summarizes the gist of major essential oils that have been investigated for their anti- Candida potential with some recommendations for further study.

scholarly journals In Vitro and In Vivo Anti-Candida spp. Activity of Plant-Derived Products

Plants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 494 ◽  
Author(s):  
Reginaldo dos Santos Pedroso ◽  
Brenda Lorena Balbino ◽  
Géssica Andrade ◽  
Maria Cecilia Pereira Sacardo Dias ◽  
Tavane Aparecida Alvarenga ◽  
...  
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
Gallic Acid ◽  
Antifungal Drugs ◽  
Citrus Limon ◽  
Cupressus Sempervirens ◽  
Candida Spp ◽  
Fungistatic Activity

Candidiasis therapy, especially for candidiasis caused by Candida non-albicans species, is limited by the relatively reduced number of antifungal drugs and the emergence of antifungal tolerance. This study evaluates the anticandidal activity of 41 plant-derived products against Candida species, in both planktonic and biofilm cells. This study also evaluates the toxicity and the therapeutic action of the most active compounds by using the Caenorhabditis elegans–Candida model. The planktonic cells were cultured with various concentrations of the tested agents. The Cupressus sempervirens, Citrus limon, and Litsea cubeba essential oils as well as gallic acid were the most active anticandidal compounds. Candida cell re-growth after treatment with these agents for 48 h demonstrated that the L. cubeba essential oil and gallic acid displayed fungistatic activity, whereas the C. limon and C. sempervirens essential oils exhibited fungicidal activity. The C. sempervirens essential oil was not toxic and increased the survival of C. elegans worms infected with C. glabrata or C. orthopsilosis. All the plant-derived products assayed at 250 µg/mL affected C. krusei biofilms. The tested plant-derived products proved to be potential therapeutic agents against Candida, especially Candida non-albicans species, and should be considered when developing new anticandidal agents.

scholarly journals Synergistic Activity of New Diclofenac and Essential Oils Combinations against Different Candida spp.

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 688
Author(s):  
Antonio Rosato ◽  
Elisabetta Altini ◽  
Sabina Sblano ◽  
Lara Salvagno ◽  
Filippo Maggi ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Essential Oils ◽  
Diclofenac Sodium ◽  
Synergistic Activity ◽  
Candida Spp ◽  
Pelargonium Graveolens ◽  
Mentha X Piperita ◽  
Inflammatory Drugs ◽  
Antimicrobial And Antifungal Activity

According to recent studies, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) have shown a good antimicrobial and antifungal activity. Their association with essential oils (EOs) could be useful for the treatment of infections caused by Candida spp. The aim of this studyis to evaluate the synergistic antifungal activity of new combinations between Diclofenac Sodium Salt (DSS), a widely used NSAID, with EOs of Mentha x piperita, Pelargonium graveolens and Melaleuca alternifolia. The in-vitroantifungal activity was determined on different Candida strains. The determination of the chemical composition of EOs was carried out by gaschromatography-massspectrometry (GC-MS). Susceptibility testing of planktonic cells was performed by using the broth microdilution assay and checkerboard methods. Minimum Inhibitory Concentrations (MIC) of DSS was in a range from 1.02 to 2.05 mg/mL reaching a MIC value of 0.05 mg/mL when combined with Pelargonium graveolens (FICI= 0.23–0.35) or Menthapiperita (FICI= 0.22–0.30) EOs. These preliminary results show thatthe combination of the EOs with DSS improves the antifungal activity on all the tested Candida strains.

scholarly journals Development of HPTLC method for determination of α-terpinyl acetate, and evaluation of antioxidant properties of essential oils in Elettaria cardamomum

2021 ◽  
Vol 18 (10) ◽  
pp. 2139-2145
Author(s):  
Aftab Alam ◽  
Rita Singh Majumdar ◽  
Pravej Alam
Keyword(s):  
Essential Oil ◽  
Essential Oils ◽  
High Performance ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Antioxidant Property ◽  
Good Resolution ◽  
Elettaria Cardamomum ◽  
Hptlc Method

Purpose: To develop a simple and reliable protocol for high performance thin layer chromatography (HPTLC) quantification of α-terpinyl acetate in oils extracted from Elettaria cardamomum, and to study relative antioxidant potential of oils obtained from three varieties of fruits of E. cardamomum. Methods: Essential oil was extracted separately from the fruits of three varieties of E. cardamomum, viz, Valley-green, Palakuzhi, and ICRI-2, using hydro-distillation method. In the development of an HPTLC method, standard α-terpinyl acetate was subjected to chromatography on aluminium-backed silica gel 60 F254 plates using a mobile phase of n-hexane: ethyl acetate (8:2, v/v), and quantified at 665 nm through densitometric analysis. The antioxidant property of essential oil of each cultivar was determined with respect to 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3- ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging assays, as well as ferric reducing assay. Results: The developed HPTLC method showed a good resolution for α-terpinyl acetate, with Rf of 0.64 ± 0.01, and also showed good linearity of the calibration plots (r2 = 0.9982). The HPTLC method was validated as per ICH guidelines, and used for the determination of α-terpinyl acetate in the essential oils. The valley green variety of E. cardamomum had the highest content of α-terpinyl acetate (55.36 ± 1.33 %w/w). The inhibitory capacity (IC50 value) for the oil of valley green variety as determined using DPPH and ABTS methods was 378.2 and 19.87 μg/mL, respectively. Conclusion: The proposed HPTLC method is suitable for routine analysis of α-terpinyl acetate in medicinal herbs, and it reveals the role of α-terpinyl acetate in the antioxidant efficacy of cardamom oil.

scholarly journals Synergistic Anticandidal Effects of Six Essential Oils in Combination with Fluconazole or Amphotericin B against Four Clinically Isolated Candida Strains

Antibiotics ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1049
Author(s):  
Bouchra Soulaimani ◽  
Elena Varoni ◽  
Marcello Iriti ◽  
Nour-Eddine Mezrioui ◽  
Lahcen Hassani ◽  
...  
Keyword(s):  
Synergistic Effect ◽  
Essential Oils ◽  
Amphotericin B ◽  
Medical Problem ◽  
Candida Spp ◽  
Promising Alternative ◽  
Major Health ◽  
Synergistic Interactions ◽  
Origanum Compactum ◽  
Opportunistic Pathogenic

The development of opportunistic pathogenic Candida strains insensitive to several classes of antifungals has emerged as a major health care problem during the last years. Combinational therapy of natural products (e.g., essential oils, EOs) with conventional antifungals has been suggested as a promising alternative to overcome this medical problem. The present study investigates the potential antifungal activity of EOs extracted from some selected medicinal plants, alone and in combination with two common conventional antifungals (fluconazole and amphotericin B) against four clinical Candida isolates. MIC assays indicated that EOs induced strong anticandidal activities with MIC values ranging from 0.162 to 4.950 mg/mL. The combination of amphotericin B with Thymus leptobotrys, Origanum compactum and Artemisia herba alba EOs provided a synergistic effect against C. krusei only, with MIC gain of four-fold, and additive effect against remaining strains (MIC gain = two-fold). Interesting synergistic interactions were observed by combining all studied EOs with fluconazole, with reduction rates of their MICs ranging from 16 to 512-fold. This synergistic effect was very pronounced with the combination of T. leptobotrys EO and fluconazole. These findings indicate that studied EOs can be used as anti-candidals in combination with antifungals, particularly fluconazole, to counteract the emergence of resistant Candida spp.

Sign in / Sign up

Export Citation Format

Share Document