Release Kinetics from Bio-Polymeric Nanoparticles Encapsulating Protein Synthesis Inhibitor- Cycloheximide, for Possible Therapeutic Applications

2005 ◽  
Vol 6 (2) ◽  
pp. 121-130 ◽  
Author(s):  
Anita Verma ◽  
Kumar Sachin ◽  
Anita Saxena ◽  
H. Bohidar
Keyword(s):  
Protein Synthesis ◽  
Polymeric Nanoparticles ◽  
Release Kinetics ◽  
Protein Synthesis Inhibitor ◽  
Synthesis Inhibitor ◽  
Therapeutic Applications ◽  
Protein Synthesis Inhibitor Cycloheximide

scholarly journals Acidiscalide, A New Glycosylated Macrolide from the Marine Actinomycete Streptomyces Acidiscabies

2016 ◽  
Vol 11 (2) ◽  
pp. 1934578X1601100
Author(s):  
Akihisa Agena ◽  
Idam Hermawan ◽  
Takeshi Fujiwara ◽  
Akihiko Kanamoto ◽  
Junichi Tanaka
Keyword(s):  
Protein Synthesis ◽  
Spectroscopic Analysis ◽  
Culture Broth ◽  
Membered Ring ◽  
Protein Synthesis Inhibitor ◽  
Synthesis Inhibitor ◽  
Molecular Scaffold ◽  
Protein Synthesis Inhibitor Cycloheximide ◽  
Marine Actinomycete ◽  
Streptomyces Acidiscabies

A new macrolide named acidiscalide (2), and a known protein synthesis inhibitor, cycloheximide (1), were isolated from the culture broth of a strain of actinomycete, Streptomyces acidiscabies, coded SCTA0002 collected from the coast of Okinawa. The structure of acidiscalide (2) was elucidated to be a glycosylated macrolide having a 24-membered ring on the basis of spectroscopic analysis. Although the stereochemistry could not be determined due to decomposition in the course of the study, it was confirmed that acidiscalide (2) possessed a new molecular scaffold.

(14C-Methyl)-L-methionine uptake in rat brain tumors before and after treatment with the protein synthesis inhibitor cycloheximide

1993 ◽  
Vol 15 (3) ◽  
pp. 229-233 ◽  
Author(s):  
Katsuyoshi Mineura ◽  
Toshio Sasajima ◽  
Naoyuki Kuwahara ◽  
Masayoshi Kowada ◽  
Matsutarou Murakami ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Brain Tumors ◽  
Rat Brain ◽  
Protein Synthesis Inhibitor ◽  
Synthesis Inhibitor ◽  
Protein Synthesis Inhibitor Cycloheximide ◽  
Methionine Uptake ◽  
Before And After
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