Fluorescence Molecular Imaging of Small Animal Tumor Models

2004 ◽  
Vol 4 (4) ◽  
pp. 419-430 ◽  
Author(s):  
E. Graves ◽  
R. Weissleder ◽  
V. Ntziachristos
Keyword(s):  
Molecular Imaging ◽  
Small Animal ◽  
Tumor Models ◽  
Animal Tumor ◽  
Fluorescence Molecular Imaging

Visualization of pulmonary inflammation using noninvasive fluorescence molecular imaging

2008 ◽  
Vol 104 (3) ◽  
pp. 795-802 ◽  
Author(s):  
Jodi Haller ◽  
Damon Hyde ◽  
Nikolaos Deliolanis ◽  
Ruben de Kleine ◽  
Mark Niedre ◽  
...  
Keyword(s):  
Molecular Imaging ◽  
Quantitative Imaging ◽  
Pulmonary Inflammation ◽  
Small Animal ◽  
Mouse Lung ◽  
Chronic Obstructive ◽  
Therapy Assessment ◽  
Fluorescence Molecular Imaging

The ability to visualize molecular processes and cellular regulators of complex pulmonary diseases such as asthma, chronic obstructive pulmonary disease (COPD), or adult respiratory distress syndrome (ARDS), would aid in the diagnosis, differentiation, therapy assessment and in small animal-based drug-discovery processes. Herein we report the application of normalized transillumination and fluorescence molecular tomography (FMT) for the noninvasive quantitative imaging of the mouse lung in vivo. We demonstrate the ability to visualize and quantitate pulmonary response in a murine model of LPS-induced airway inflammation. Twenty-four hours prior to imaging, BALB/c female mice were injected via tail vein with 2 nmol of a cathepsin-sensitive activatable fluorescent probe (excitation: 750 nm; emission: 780 nm) and 2 nmol of accompanying intravascular agent (excitation: 674 nm; emission: 694 nm). Six hours later, the mice were anesthetized with isoflurane and administered intranasal LPS in sterile 0.9% saline in 25 μl aliquots (one per nostril). Fluorescence molecular imaging revealed the in vivo profile of cysteine protease activation and vascular distribution within the lung typifying the inflammatory response to LPS insult. Results were correlated with standard in vitro laboratory tests (Western blot, bronchoalveolar lavage or BAL analysis, immunohistochemistry) and revealed good correlation with the underlying activity. We demonstrated the capacity of fluorescence tomography to noninvasively and longitudinally characterize physiological, cellular, and subcellular processes associated with inflammatory disease burden in the lung. The data presented herein serve to further evince fluorescence molecular imaging as a technology highly appropriate for the biomedical laboratory.

Cerenkov Light Tomography of 131I-labeled Ligands in Small Animal Tumor Models

2014 ◽  
Author(s):  
Alexander D. Klose ◽  
Yared Tekabe ◽  
Alejandro Garcia ◽  
Arul Thirumoorthi ◽  
John P. Andrews ◽  
...  
Keyword(s):  
Small Animal ◽  
Tumor Models ◽  
Animal Tumor ◽  
Cerenkov Light

A submillimeter resolution fluorescence molecular imaging system for small animal imaging

2003 ◽  
Vol 30 (5) ◽  
pp. 901-911 ◽  
Author(s):  
Edward E. Graves ◽  
Jorge Ripoll ◽  
Ralph Weissleder ◽  
Vasilis Ntziachristos
Keyword(s):  
Molecular Imaging ◽  
Imaging System ◽  
Small Animal Imaging ◽  
Small Animal ◽  
Animal Imaging ◽  
Fluorescence Molecular Imaging

scholarly journals A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models

2013 ◽  
Vol 40 (2) ◽  
pp. 022304 ◽  
Author(s):  
Ergys Subashi ◽  
Everett J. Moding ◽  
Gary P. Cofer ◽  
James R. MacFall ◽  
David G. Kirsch ◽  
...  
Keyword(s):  
Temporal Resolution ◽  
Small Animal ◽  
Tumor Models ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Animal Tumor ◽  
Contrast Enhanced Mri

P-161 EGFR-targeted fluorescence molecular imaging for postoperative lymph node assessment in patients with oral cancer

Oral Oncology ◽  
2021 ◽  
Vol 118 ◽  
pp. 17
Author(s):  
J. Vonk ◽  
J.G. deWit ◽  
F.J. Voskuil ◽  
Y.H. Tang ◽  
W.T.R. Hooghiemstra ◽  
...  
Keyword(s):  
Lymph Node ◽  
Molecular Imaging ◽  
Oral Cancer ◽  
Lymph Node Assessment ◽  
Fluorescence Molecular Imaging

scholarly journals Interspecies Comparative Genomic Hybridization (I-CGH): A New Twist to Study Animal Tumor Models

Cell Cycle ◽  
2007 ◽  
Vol 6 (7) ◽  
pp. 836-842
Author(s):  
Sivakumar Jaikumar ◽  
Zhengping Zhuang ◽  
Poonam Mannan ◽  
Alexander O. Vortmeyer ◽  
Makoto Furuta ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Tumor Models ◽  
Animal Tumor
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