Biophysics of Venous Return from the Brain from the Perspective of the Pathophysiology of Chronic Cerebrospinal Venous Insufficiency

2012 ◽  
Vol 7 (2) ◽  
pp. 88-92 ◽  
Author(s):  
Maciej Zaniewski ◽  
Marian Simka
2019 ◽  
Vol 14 (4) ◽  
pp. 235-236 ◽  
Author(s):  
Marian Simka ◽  
Marcin Skuła

About 10 years ago, the so-called chronic cerebrospinal venous insufficiency syndrome was discovered. This clinical entity, which is associated with extracranial venous abnormalities that impair venous outflow from the brain, was initially found exclusively in multiple sclerosis patients. Currently, we know that such venous lesions can also be revealed in other neurological pathologies, including Alzheimer’s and Parkinson’s diseases. Although direct causative role of chronic cerebrospinal venous insufficiency in these neurological diseases still remains elusive, in this paper, we suggest that perhaps an abnormal venous drainage of the brain affects functioning of the glymphatic system, which in turn results in the accumulation of pathological proteins in the cerebral tissue (such as β-synuclein, β-amyloid and α-synuclein) and triggers the venous outflow from the cranial cavity and circulation of the cerebrospinal fluid in the settings of neurodegenerative disease.


2021 ◽  
Vol 17 (1) ◽  
pp. 42-49
Author(s):  
O.Ye. Kovalenko ◽  
N.G. Prityko

The article presents an analytical review of the results of domestic and foreign studies on chronic disorders of cerebral venous circulation, which is given less attention against the arterial system due to blurred manifestations, especially early, anatomical variability of the venous system, even in healthy, difficulty in diagnosis. When the balance of arterial and venous inflow is disturbed and this state exa­cerbates, irreversible changes evolve other structures of the cranial ca­vity — primarily in the brain (consistent with the concept of Monroe-Kelly). Chronic disorders of cerebral venous circulation may have different causes and varying degrees of severity. The equivalent of chronic cerebral venous insufficiency (SCVD), terminologically accepted in our country, in some countries is considered as chronic venous cerebrospinal insufficiency, which emphasizes the pathogenetic link of disorders of cerebral venous blood flow and extracranial veins, which is, in our opinion, is logical and reasonable. Recognition of chronic cerebrospinal venous insufficiency has aroused intense interest for a better understanding of the role of extracranial venous pathology and developmental options. Although the diagnosis was originally based on Doppler sonography, there are currently no diagnostic imaging methods, non-invasive or invasive, that can serve as the gold standard for detecting venous abnormalities indicative of chronic cerebrospinal venous insufficiency. The results of some studies are discussed, in particular, the hypothesis that chronic cerebrospinal venous insufficiency plays a role in the pathoge-nesis of multiple sclerosis or in many concomitant clinical manifestations. The affinity of the pathogenesis of idiopathic intracranial hypertension, Ménière’s disease, spondylotic vertebrobasilar insufficiency syndrome is analyzed. Attention is also focused on the other opinion of scientists when the increase in venous blood supply to the brain and other formations in the head cavity under certain conditions is considered as a compensatory reaction. The anatomical and physiological features of the venous system of the cranial cavity are considered, which substantiate the clinical manifestations of venous dysfunction, methods of diagnosis and treatment of pathology. Summarizing the above, chronic venous blood circulation in the cranial cavity, which is largely associated with problems of extracranial venous blood flow, not only in itself is a very characteristic syndrome complex t that adversely affects neurological functions due to cerebral hypoxia and metabolic changes, deteriorates the quality of life, but also has a negative impact on the course of the disease or has a pathogenetic link with other diseases, in particular, may be accompanied by different levels of blood pressure.


Author(s):  
Shelly Benjaminy ◽  
Anthony Traboulsee

The field of neuroethics aims to align neurotechnologies with societal values. To achieve this goal, the field must be responsive to the priorities of diverse publics. Researchers have developed many initiatives aimed at fostering reciprocal and inclusive dialogue between neuroscientists and publics that bring the voices of end-users to the forefront of innovation in the brain sciences. This chapter explores the opportunities and challenges of community engagement in the neurosciences. It draws on the contentious case study of the chronic cerebrospinal venous insufficiency (CCSVI) research trajectory that generated both hope and skepticism, galvanized substantial international attention, and was heavily criticized for privileging scientific inquiry driven more by public pressure than by evidence. It concludes with lessons learned from the cautionary CCSVI tale, and discusses opportunities for reciprocal and impactful engagement that the field of neuroethics may foster as novel neurotechnologies are developed.


BMC Neurology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Roberta Lanzillo ◽  
Marcello Mancini ◽  
Raffaele Liuzzi ◽  
Orlando Di Donato ◽  
Elena Salvatore ◽  
...  

2012 ◽  
Vol 117 (5) ◽  
pp. 855-864 ◽  
Author(s):  
R. Floris ◽  
D. Centonze ◽  
S. Fabiano ◽  
M. Stefanini ◽  
S. Marziali ◽  
...  

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