Harnessing Pluripotency from Differentiated Cells: A Regenerative Source for Tissue-Specific Stem Cell Therapies

2006 ◽  
Vol 1 (3) ◽  
pp. 325-331 ◽  
Author(s):  
Ilham Saleh Abuljadayel
2020 ◽  
pp. 1-5
Author(s):  
Darren Ioos ◽  
◽  
Vincent Gallicchio ◽  

Myelin, a modified plasma membrane wrapped around axons, is an essential part of signal propagation in the nervous system. Formed by oligodendrocytes in the central nervous system (CNS) and Schwann cells in the peripheral nervous system (PNS), myelin lowers the amount of energy needed to send or receive signals. Multiple Sclerosis (MS) is an autoimmune, hyperinflammatory disease that attacks the nervous system, specifically myelin. MS is characterized by three types of lesions in the brain and along the blood brain barrier, making it very difficult to diagnose through conventional magnetic resonance imaging (MRI) and even more difficult to treat. It has an unpredictable pathophysiology that cannot be cured by current drug therapies. Stem cell therapies have been heavily researched in recent years to try to combat the autoimmune disease by stopping demyelination and recovering lost function through the regeneration of differentiated cells


2014 ◽  
Vol 62 (S 01) ◽  
Author(s):  
M. Arar ◽  
A. Rotärmel ◽  
A.-K. Knoefel ◽  
H. Baraki ◽  
I. Kutschka ◽  
...  

2019 ◽  
Vol 14 (6) ◽  
pp. 454-459
Author(s):  
Xuejing Hou ◽  
Ying Liu ◽  
Isabelle Streuli ◽  
Patrick Dällenbach ◽  
Jean Dubuisson ◽  
...  

Asherman’s Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman’s syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman’s Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.


2016 ◽  
Vol 5 (2) ◽  
pp. 145-151
Author(s):  
Ana Muñoz ◽  
Víctor Galvez ◽  
María Camarasa

Author(s):  
Richard N. Puzzitiello ◽  
Jeremy Dubin ◽  
Mariano E. Menendez ◽  
Michael A. Moverman ◽  
Nicholas R. Pagani ◽  
...  

2017 ◽  
Vol 25 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Aimée C. Colbath ◽  
David D. Frisbie ◽  
Steven W. Dow ◽  
John D. Kisiday ◽  
C. Wayne McIlwraith ◽  
...  

2014 ◽  
Vol 168 (3) ◽  
pp. 328-337 ◽  
Author(s):  
Paola Cipriani ◽  
Piero Ruscitti ◽  
Roberto Giacomelli

2012 ◽  
Vol 44 (5) ◽  
pp. 1439-1441 ◽  
Author(s):  
J. Adamowicz ◽  
T. Kloskowski ◽  
J. Tworkiewicz ◽  
M. Pokrywczyńska ◽  
T. Drewa

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