Non-Monoamine-Based Approach for the Treatment of Depression and Anxiety Disorders

2012 ◽  
Vol 1 (1) ◽  
pp. 1-27
Author(s):  
Shigeyuki Chaki ◽  
Taketoshi Okubo ◽  
Yoshinori Sekiguchi
Keyword(s):  
Anxiety Disorders ◽  
Depression And Anxiety ◽  
Treatment Of Depression

Gene–environment interactions in animal models of depression and anxiety

2019 ◽  
pp. 63-76
Author(s):  
Daniela Felice ◽  
Anand Gururajan ◽  
Olivia F O’Leary ◽  
John F Cryan
Keyword(s):  
Anxiety Disorders ◽  
Target Genes ◽  
Preclinical Studies ◽  
Depression And Anxiety ◽  
Complex Interactions ◽  
Gene Environment ◽  
Animal Models Of Depression ◽  
Treatment Of Depression ◽  
Candidate Target ◽  
The Individual

Depression and anxiety disorders cause the greatest global disability in terms of impact on the individual, family, and society at large. The etiology of these disorders is multifactorial and includes complex interactions between genetic and environmental risk factors. This chapter reviews preclinical studies assessing the importance of gene–environment (G×E) interaction. Specifically, we focus on G×E studies assessing the roles of the hypothalamic–pituitary–adrenal (HPA) axis, serotonergic system, GABAergic system, and brain-derived neurotrophic factor (BDNF) system. Finally, novel candidate target genes for the treatment of depression and anxiety disorders are considered.

scholarly journals Improving Access to Psychological Therapies (IAPT) - The Need for Radical Reform

2018 ◽  
Vol 23 (9) ◽  
pp. 1136-1147 ◽  
Author(s):  
Michael J Scott
Keyword(s):  
Anxiety Disorders ◽  
Psychological Treatment ◽  
Structured Interview ◽  
Diagnostic Interview ◽  
Personal Injury ◽  
Depression And Anxiety ◽  
Modus Operandi ◽  
Radical Reform ◽  
Psychological Therapies ◽  
Treatment Of Depression

Improving Access to Psychological Therapies is a UK government-funded initiative to widen access to the psychological treatment of depression and anxiety disorders. The author has had the opportunity to independently assess 90 Improving Access to Psychological Therapies clients, using a standardised semi-structured interview, the Structured Clinical Diagnostic Interview for DSM Disorders (SCID) and to listen to their account of interaction with the service. The results suggest that only the tip of the iceberg fully recovers from their disorder (9.2%) whether or not they were treated before or after a personal injury claim. There is a pressing need to re-examine the modus operandi of the service.

Diagnosis and treatment of depression and anxiety disorders in GP practice

2021 ◽  
Vol 14 (2) ◽  
pp. 158-161
Author(s):  
Bartosz Sapilak ◽  
Anna Antosik-Wójcińska
Keyword(s):  
Anxiety Disorders ◽  
Early Stage ◽  
Systemic Disease ◽  
Diagnosis And Treatment ◽  
Depression And Anxiety ◽  
Family Doctors ◽  
Pain Syndromes ◽  
Treatment Of Depression ◽  
The Family ◽  
Somatic Diseases

Depressive and anxiety disorders are nowadays the most common chronic psychiatric disorders, its diagnosis and treatment is the competence of family doctors. The family doctors have the best chance to find the symptoms of the disease, make decision to initiate the therapy, and, in difficult cases, refer the patient to a specialist. Depression is a systemic disease affecting life of the patient and his family, including the symptomatology of somatic diseases (pain syndromes, stenocardia, arrhythmias and gastric ailments). This disease should be treated at an early stage. It is a serious mistake both to ignore the symptoms and conservatively refer all patients for specialist consultation, without first attempting to start therapy. A large group of patients will simply not take advantage of this option and will be left without treatment.

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