A Survey on Computational Methods for Essential Proteins and Genes Prediction

2019 ◽  
Vol 14 (3) ◽  
pp. 211-225 ◽  
Author(s):  
Ming Fang ◽  
Xiujuan Lei ◽  
Ling Guo
Keyword(s):  
Computational Methods ◽  
Drug Targets ◽  
Disease Genes ◽  
Essential Proteins ◽  
Experimental Identification ◽  
Cellular Life ◽  
Different Types ◽  
The Stability ◽  
Human Disease Genes ◽  
Biology Research

Background: Essential proteins play important roles in the survival or reproduction of an organism and support the stability of the system. Essential proteins are the minimum set of proteins absolutely required to maintain a living cell. The identification of essential proteins is a very important topic not only for a better comprehension of the minimal requirements for cellular life, but also for a more efficient discovery of the human disease genes and drug targets. Traditionally, as the experimental identification of essential proteins is complex, it usually requires great time and expense. With the cumulation of high-throughput experimental data, many computational methods that make useful complements to experimental methods have been proposed to identify essential proteins. In addition, the ability to rapidly and precisely identify essential proteins is of great significance for discovering disease genes and drug design, and has great potential for applications in basic and synthetic biology research. Objective: The aim of this paper is to provide a review on the identification of essential proteins and genes focusing on the current developments of different types of computational methods, point out some progress and limitations of existing methods, and the challenges and directions for further research are discussed.

ASSESSMENT OF PINE CROPS GROWTH IN BAIMAK FORESTRY

2020 ◽  
Vol 37 (3) ◽  
pp. 83-90
Author(s):  
T.Z. Mutallapov ◽  
Keyword(s):  
Scots Pine ◽  
Forest Ecosystem ◽  
Distribution Curve ◽  
Comparative Assessment ◽  
Tree Distribution ◽  
Entire Structure ◽  
Structure Changes ◽  
Large Trees ◽  
Different Types ◽  
The Stability

The article presents the results of evaluating the growth of Scots pine in the Baymak forest area. The analysis of forestry and taxation indicators of Scots pine crops on the studied sample areas is carried out, and a comparative assessment of the growth of forest crops growing in different types of forest is given. Increased competition in plantings leads to the natural decline of stunted trees, which is the result of differentiation in the stand. As a result, its structure changes, the number of large trees increases, and, accordingly, the stability of the forest ecosystem increases. In this regard, the appearance of the tree distribution curve by thickness levels also changes. It becomes more "flat", and its competitive load is more evenly distributed over the entire structure of the stand, and competition is weakened.

A Review of Computational Methods for Predicting Drug Targets

2018 ◽  
Vol 19 (6) ◽  
pp. 562-572 ◽  
Author(s):  
Guohua Huang ◽  
Fengxia Yan ◽  
Duoduo Tan
Keyword(s):  
Computational Methods ◽  
Drug Targets

Carbazole Derivatives as Kinase-Targeting Inhibitors for Cancer Treatment

2020 ◽  
Vol 20 (6) ◽  
pp. 444-465 ◽  
Author(s):  
Jessica Ceramella ◽  
Domenico Iacopetta ◽  
Alexia Barbarossa ◽  
Anna Caruso ◽  
Fedora Grande ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Drug Targets ◽  
Mechanisms Of Action ◽  
Biological Pathways ◽  
G Protein Coupled Receptors ◽  
Ability To Act ◽  
Different Types ◽  
Activity Of Enzymes ◽  
Intercalating Agents ◽  
G Protein Coupled

Protein Kinases (PKs) are a heterogeneous family of enzymes that modulate several biological pathways, including cell division, cytoskeletal rearrangement, differentiation and apoptosis. In particular, due to their crucial role during human tumorigenesis and cancer progression, PKs are ideal targets for the design and development of effective and low toxic chemotherapeutics and represent the second group of drug targets after G-protein-coupled receptors. Nowadays, several compounds have been claimed to be PKs inhibitors, and some of them, such as imatinib, erlotinib and gefitinib, have already been approved for clinical use, whereas more than 30 others are in various phases of clinical trials. Among them, some natural or synthetic carbazole-based molecules represent promising PKs inhibitors due to their capability to interfere with PK activity by different mechanisms of action including the ability to act as DNA intercalating agents, interfere with the activity of enzymes involved in DNA duplication, such as topoisomerases and telomerases, and inhibit other proteins such as cyclindependent kinases or antagonize estrogen receptors. Thus, carbazoles can be considered a promising this class of compounds to be adopted in targeted therapy of different types of cancer.

Systematic genome-wide approach to positional candidate cloning for identification of novel human disease genes

2004 ◽  
Vol 34 (3) ◽  
pp. 79-90 ◽  
Author(s):  
H. Kiyosawa ◽  
T. Kawashima ◽  
D. Silva ◽  
N. Petrovsky ◽  
Y. Hasegawa ◽  
...  
Keyword(s):  
Human Disease ◽  
Disease Genes ◽  
Positional Candidate ◽  
Genome Wide ◽  
Human Disease Genes ◽  
Positional Candidate Cloning

scholarly journals Novel thick brane solutions with U(1) symmetry breaking

2021 ◽  
Vol 81 (3) ◽  
Author(s):  
Marzieh Peyravi ◽  
Nematollah Riazi ◽  
Francisco S. N. Lobo
Keyword(s):  
Symmetry Breaking ◽  
Scalar Fields ◽  
Einstein Tensor ◽  
Vacuum Structure ◽  
Different Types ◽  
Dimensional Gravity ◽  
Breaking Parameter ◽  
Symmetry Breaking Term ◽  
The Stability ◽  
Breaking Term

AbstractIn this work, using two scalar fields ($$\phi $$ ϕ , $$\psi $$ ψ ) coupled to 4 + 1 dimensional gravity, we construct novel topological brane solutions through an explicit U(1) symmetry breaking term. The potential of this model is constructed so that two distinct degenerate vacua in the $$\phi $$ ϕ field exist, in analogy to the $$\phi ^{4}$$ ϕ 4 potential. Therefore, brane solutions appear due to the vacuum structure of the $$\phi $$ ϕ field. However, the topology and vacuum structure in the $$\psi $$ ψ direction depends on the symmetry breaking parameter $$\beta ^{2}$$ β 2 , which leads to different types of branes. As a result, one can interpret the present model as a combination of a $$\phi ^{4}$$ ϕ 4 brane with an auxiliary field, which leads to deviations from the $$\phi ^{4}$$ ϕ 4 system with the brane achieving a richer internal structure. Furthermore, we analyse in detail the behaviour of the superpotentials, the warp factors, the Ricci and Kretschmann scalars and the Einstein tensor components. In addition to this, we explore the stability of the brane in terms of the free parameters of the model. The analysis presented here complements previous work and is sufficiently novel to be interesting.

Fading Time Study on Prepared Thymolphthalein, Phenolphthalein and their Mixture Disappearing Ink

2008 ◽  
Vol 12 (1) ◽  
pp. 9-18
Author(s):  
S.A. Shama ◽  
M.M. El-Molla ◽  
Riad F. Basalah ◽  
S. El-Sayed Saeed
Keyword(s):  
Thermal Effect ◽  
Time Study ◽  
High Concentration ◽  
Different Types ◽  
The Stability ◽  
Fading Time

Disappearing ink was prepared using different concentrations of thymolphthalein, phenolphthalein and their mixture, applying to different types of handwriting surfaces such as cotton, polyester and polyamide. The effects of thymolphthalein, phenolphthalein and alkali concentrations (i.e. pH) on the fading time were studied. The handwriting stability increased when the concentration of thymolphthalein or phenolphthalein was increased. At a high concentration of alkali with phenolphthalein and its mixture with thymolphthalein, the handwriting stability decreased with polyester or polyamide handwriting surfaces and the stability increased in the case of cotton. When the faded handwriting surfaces were subject to the thermal effect in a thermostatically controlled oven at 100°C for 10 minutes by hanging them with suitable hooks, there was no change in the faded handwriting. When they were at 150°C for 20 minutes, the faded phenolphthalein ink, which contained 0.5ml of 1N NaOH, was visible and shown red on the polyester and polyamide handwriting surfaces, but there was no change on the faded cotton handwriting surface.

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