The Combined Impact of Exhaled Nitric Oxide and Sputum Eosinophils Monitoring in Asthma Treatment: A Prospective Cohort Study

2015 ◽  
Vol 21 (32) ◽  
pp. 4752-4762 ◽  
Author(s):  
Mario Malerba ◽  
Alessandro Radaeli ◽  
Alessia Olivini ◽  
Beatrice Ragnoli ◽  
Fabio Ricciardolo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Exhaled Nitric Oxide ◽  
Asthma Treatment ◽  
Sputum Eosinophils ◽  
Combined Impact

scholarly journals Combined impact of traditional and non-traditional health behaviors on mortality: a national prospective cohort study in Spanish older adults

BMC Medicine ◽  
2013 ◽  
Vol 11 (1) ◽  
Author(s):  
David Martínez-Gómez ◽  
Pilar Guallar-Castillón ◽  
Luz M León-Muñoz ◽  
Esther López-García ◽  
Fernando Rodríguez-Artalejo
Keyword(s):  
Older Adults ◽  
Cohort Study ◽  
Health Behaviors ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Traditional Health ◽  
Combined Impact

scholarly journals A systematic review and meta-analysis: tailoring asthma treatment on eosinophilic markers (exhaled nitric oxide or sputum eosinophils)

Thorax ◽  
2010 ◽  
Vol 67 (3) ◽  
pp. 199-208 ◽  
Author(s):  
H L Petsky ◽  
C J Cates ◽  
T J Lasserson ◽  
A M Li ◽  
C Turner ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Systematic Review ◽  
Meta Analysis ◽  
Exhaled Nitric Oxide ◽  
Asthma Treatment ◽  
Sputum Eosinophils

scholarly journals Combined impact of smoking and heavy alcohol use on cognitive decline in early old age: Whitehall II prospective cohort study

2013 ◽  
Vol 203 (2) ◽  
pp. 120-125 ◽  
Author(s):  
Gareth Hagger-Johnson ◽  
Séverine Sabia ◽  
Eric John Brunner ◽  
Martin Shipley ◽  
Martin Bobak ◽  
...  
Keyword(s):  
Cohort Study ◽  
Alcohol Consumption ◽  
Cognitive Decline ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Reference Group ◽  
Heavy Alcohol ◽  
Age Related ◽  
Heavy Alcohol Consumption ◽  
Combined Impact

BackgroundIdentifying modifiable risk factors for cognitive decline may inform prevention of dementia.AimsTo examine the combined impact of cigarette smoking and heavy alcohol consumption on cognitive decline from midlife.MethodProspective cohort study (Whitehall II cohort) with three clinical examinations in 1997/99, 2002/04 and 2007/09. Participants were 6473 adults (72% men), mean age 55.76 years (s.d. = 6.02) in 1997/99. Four cognitive tests, assessed three times over 10 years, combined into a global z-score (mean 0, s.d. = 1).ResultsAge-related decline in the global cognitive score was faster in individuals who were smoking heavy drinkers than in non-smoking moderate alcohol drinkers (reference group). The interaction term (P = 0.04) suggested that the combined effects of smoking and alcohol consumption were greater than their individual effects. Adjusting for age, gender, education and chronic diseases, 10-year decline in global cognition was −0.42 z-scores (95% Cl −0.45 to −0.39) for the reference group. In individuals who were heavy alcohol drinkers who also smoked the decline was −0.57 z-scores (95% Cl −0.67 to −0.48); 36% faster than the reference group.ConclusionsIndividuals who were smokers who drank alcohol heavily had a 36% faster cognitive decline, equivalent to an age-effect of 2 extra years over 10-year follow-up, compared with individuals who were non-smoking moderate drinkers.

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